Article
Pharmacology & Pharmacy
Longkuo Xia, Jianhuan Qi, Mingming Tang, Jing Liu, Da Zhang, Yanbing Zhu, Baoyang Hu
Summary: Continual deletion of microglia using pexidartinib reduces the production of collagen I and reforms the astrocyte scar, allowing for axon regeneration.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Tetsuya Tamaru, Kazu Kobayakawa, Hirokazu Saiwai, Daijiro Konno, Ken Kijima, Shingo Yoshizaki, Kazuhiro Hata, Hirotaka Iura, Gentaro Ono, Yohei Haruta, Kazuki Kitade, Kei-Ichiro Iida, Ken-Ichi Kawaguchi, Yoshihiro Matsumoto, Kensuke Kubota, Takeshi Maeda, Seiji Okada, Yasuharu Nakashima
Summary: Spinal cord injury causes different phenotypic changes in astrocytes, leading to glial scar formation. The characteristics of glial scars change over time, but scar-forming astrocytes have autonomous function to form and maintain glial scars.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Neurosciences
Shao-Ming Wang, Jung-Yu C. Hsu, Chiung-Yuan Ko, Hsiang-En Wu, Yu-Wei Hsiao, Ju-Ming Wang
Summary: Fibrotic scars caused by spinal cord injury hinder neuronal regeneration, resulting in paralysis. The role of astrocytes in fibrotic scar formation is not well understood. This study showed that astrocytic Cebpd promotes fibroblast migration and fibrotic scar formation through the Ptx3/NF kappa B/Mmp3 axis pathway. The RI37 peptide was identified as a potential therapeutic agent to inhibit fibrotic scar formation.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Immunology
Qi-Ming Pang, Si-Yu Chen, Qi-Jing Xu, Sheng-Ping Fu, Yi-Chun Yang, Wang-Hui Zou, Meng Zhang, Juan Liu, Wei-Hong Wan, Jia-Chen Peng, Tao Zhang
Summary: Inflammatory response and glial scar formation play crucial roles in spinal cord injury and repair. The role of MSCs in regulating neuroinflammation and glial scar formation after SCI is also significant.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, Research & Experimental
Yi Ding, Qin Chen
Summary: Spinal cord injury (SCI) is a common disabling spinal injury, and the mTOR signaling pathway plays a crucial role in the pathological process. Chinese herbal medicine has been shown to promote nerve repair after SCI by inhibiting the mTOR pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cell Biology
Jesus Chato-Astrain, Olga Roda, David Sanchez-Porras, Esther Miralles, Miguel Alaminos, Fernando Campos, Oscar Dario Garcia-Garcia, Victor Carriel
Summary: Growth-associated protein 43 plays a key role in neurite outgrowth through cytoskeleton remodeling. In this study, it was found that growth-associated protein 43 is expressed not only in the regenerating nerve tissue but also in the spinal cord after peripheral nerve transection. These findings suggest that growth-associated protein 43 could be used as a marker to monitor changes in the central nervous system after peripheral nerve injury.
NEURAL REGENERATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Byeong Gwan Song, Su Yeon Kwon, Jae Won Kyung, Eun Ji Roh, Hyemin Choi, Chang Su Lim, Seong Bae An, Seil Sohn, Inbo Han
Summary: Synaptic cell adhesion molecules (SynCAMs), specifically SynCAM3, play a crucial role in synapse formation and maintenance as well as synaptic plasticity regulation. Through its involvement in the connection between axons and astrocytes, SynCAM3 has been found to be associated with astrocytic scar formation following central nervous system (CNS) injuries. This study explores the impact of selective removal of SynCAM3 on spinal cord injury (SCI) outcomes, highlighting its role in the prevention of scar-forming astrocytes and promoting extracellular matrix (ECM) reconstitution, ultimately leading to improved functional recovery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
Areez Shafqat, Ibrahem Albalkhi, Hamzah M. Magableh, Tariq Saleh, Khaled Alkattan, Ahmed Yaqinuddin
Summary: Poor axonal regeneration and functional recovery after SCI is not primarily due to the injury scar, but rather a failure to stimulate axon growth adequately. Targeting neuroinflammation and glial scarring may not be as effective as neuron-directed approaches. This raises questions about the viability of these translational avenues.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Cell Biology
R. Vivian Allahyari, Nicolette M. Heinsinger, Daniel Hwang, David A. Jaffe, Javad Rasouli, Stephanie Shiers, Samantha J. Thomas, Theodore J. Price, Abdolmohamad Rostami, Angelo C. Lepore
Summary: This study investigates the astrocyte heterogeneity in the spinal cord and its potential role in synaptic generation. The results suggest that the distribution of astrocyte subpopulations and the expression of synapse formation-associated genes did not change significantly after spinal cord injury in mice. These findings indicate a possible conservation of spinal cord astrocyte heterogeneity across species.
Article
Multidisciplinary Sciences
Jacob Matthews, Sarina Surey, Liam M. Grover, Ann Logan, Zubair Ahmed
Summary: A novel injectable hydrogel composed of bovine collagen and fibrinogen has been developed for delivering reparative drugs like Decorin to spinal cord injury sites in adult rats. This hydrogel promotes neuron regeneration and repair, leading to improved motor and sensory function recovery.
SCIENTIFIC REPORTS
(2021)
Review
Emergency Medicine
Yu Zhang, Shuhai Yang, Chang Liu, Xiaoxiao Han, Xiaosong Gu, Songlin Zhou
Summary: Spinal cord injury often results in permanent disability due to the loss of functional recovery. The formation of a glial scar around the damaged tissue can interrupt the healing process, and therapeutic treatments targeting scar components are important for improving functional recovery.
Article
Biotechnology & Applied Microbiology
Jiaying Cai, Hui Zhang, Yangnan Hu, Zhichun Huang, Yan Wang, Yu Xia, Xiaoyan Chen, Jiamin Guo, Hong Cheng, Lin Xia, Weicheng Lu, Chen Zhang, Jingdun Xie, Huan Wang, Renjie Chai
Summary: The GelMA-MXene hydrogel nerve conduit with microgroove structures showed effective promotion of NSCs adhesion, proliferation, and differentiation. When loaded with NSCs and implanted into the injured spinal cord site, it demonstrated an effective repair capability for complete transection of SCI, resulting in remarkable nerve recovery.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Immunology
Dunja Bijelic, Marija Adzic, Mina Peric, Igor Jakovcevski, Eckart Foerster, Melitta Schachner, Pavle R. Andjus
Summary: The study found that different fragments of TnC can affect astrocyte proliferation and GFAP expression levels after spinal cord injury. These results may explain the delayed reaction of astrocytes and their localization to the injury site border to allow microglia/macrophages to form a lesion core during the initial stages of glial scar formation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Behavioral Sciences
Tao Jiang, Shitong Li, Benchang Xu, Kun Liu, Tong Qiu, Honglian Dai
Summary: PNPP-IKVAV can improve spinal cord injury by inhibiting scar formation and reducing the impact of fibrous scar on functional recovery.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Review
Immunology
Qi-Ming Pang, Si-Yu Chen, Qi-Jing Xu, Meng Zhang, Da-Fei Liang, Sheng-Ping Fu, Jiang Yu, Zu-Lin Liu, Qian Zhang, Tao Zhang
Summary: This study reviews the effects of neuroinflammation on SCI, with a focus on the contributions and interactions of microglia and astrocytes. It also discusses therapeutic strategies to regulate their immunophenotype in order to suppress inflammation and improve injury prognosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jian-Long Zou, Sheng Liu, Jia-Hui Sun, Wei-Hong Yang, Yi-Wei Xu, Zi-Long Rao, Bin Jiang, Qing-Tang Zhu, Xiao-Lin Liu, Jin-Lang Wu, Calvin Chang, Hai-Quan Mao, Eng-Ang Ling, Da-Ping Quan, Yuan-Shan Zeng
ADVANCED FUNCTIONAL MATERIALS
(2018)
Article
Polymer Science
Jia-Long Wu, Chi Zhang, Wei Qin, Da-Ping Quan, Ming-Liang Ge, Guo-Dong Liang
CHINESE JOURNAL OF POLYMER SCIENCE
(2019)
Article
Nanoscience & Nanotechnology
Shihao Chen, Zhaoyi Du, Jianlong Zou, Shuai Qiu, Zilong Rao, Sheng Liu, Xiumin Sun, Yiwei Xu, Qingtang Zhu, Xiaolin Liu, Hai-Quan Mao, Ying Bai, Daping Quan
ACS APPLIED MATERIALS & INTERFACES
(2019)
Article
Cell Biology
Xiaowei Li, Brian Cho, Russell Martin, Michelle Seu, Chi Zhang, Zhengbing Zhou, Ji Suk Choi, Xuesong Jiang, Long Chen, Gurjot Walia, Jerry Yan, Megan Callanan, Huanhuan Liu, Kevin Colbert, Justin Morrissette-McAlmon, Warren Grayson, Sashank Reddy, Justin M. Sacks, Hai-Quan Mao
SCIENCE TRANSLATIONAL MEDICINE
(2019)
Article
Materials Science, Biomaterials
Xiumin Sun, Chi Zhang, Jinghui Xu, Hong Zhai, Sheng Liu, Yiwei Xu, Yong Hu, Houqing Long, Ying Bai, Daping Quan
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2020)
Article
Polymer Science
Chi Zhang, Peng Dong, Ying Bai, Daping Quan
EUROPEAN POLYMER JOURNAL
(2020)
Article
Engineering, Biomedical
Xiaowei Li, Chi Zhang, Agnes E. Haggerty, Jerry Yan, Michael Lan, Michelle Seu, Mingyu Yang, Megan M. Marlow, Ines Maldonado-Lasuncion, Brian Cho, Zhengbing Zhou, Long Chen, Russell Martin, Yohshiro Nitobe, Kentaro Yamane, Hua You, Sashank Reddy, Da-Ping Quan, Martin Oudega, Hai-Quan Mao
Article
Engineering, Biomedical
Yiwei Xu, Jing Zhou, Cuicui Liu, Sheng Zhang, Fenglin Gao, Wenjing Guo, Xiumin Sun, Chi Zhang, Heying Li, Zilong Rao, Shuai Qiu, Qingtang Zhu, Xiaolin Liu, Xiaodong Guo, Zengwu Shao, Ying Bai, Xiao Zhang, Daping Quan
Summary: The repair of spinal cord injury depends on remodeling the microenvironment and supporting the recruitment and differentiation of endogenous stem/progenitor cells. Decellularized tissue matrices have shown promise in promoting neural tissue regeneration, especially when derived from nervous system tissues. This study compared a DTM hydrogel derived from spinal cord (DSCM-gel) and one derived from peripheral nerves (DNM-gel), with results showing that DSCM-gel promotes NSPC viability, proliferation, migration, and differentiation into neurons in early 3D culturing stages.
Review
Engineering, Biomedical
Calvin Chang, Jerry Yan, Zhicheng Yao, Chi Zhang, Xiaowei Li, Hai-Quan Mao
Summary: This review focuses on the bioactivity and secretome of mesenchymal stem cells, as well as the engineering approaches to tune the MSC secretome. It also discusses the recent advances in biomaterials-based therapeutic strategies for delivering MSCs and MSC-derived secretome in extracellular vesicles, along with their advantages and challenges.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Cell Biology
Agnes E. Haggerty, Ines Maldonado-Lasuncion, Yohshiro Nitobe, Kentaro Yamane, Megan M. Marlow, Hua You, Chi Zhang, Brian Cho, Xiaowei Li, Sashank Reddy, Hai-Quan Mao, Martin Oudega
Summary: The study found that combining MSC and NHC for treating spinal cord injuries can reduce the number of inflammatory cells, promote a shift from pro-inflammatory to anti-inflammatory environment at the injury site, decrease injury size, increase the presence of astrocytes and axons, but has no significant impact on MSC transplant survival and hind limb function.
Article
Engineering, Electrical & Electronic
Xianglin Hao, Jianlong Zou, Ke Yin, Xikui Ma, Tianyu Dong
Summary: This article introduces a GaN-based cross-quadrant mode Class-E amplifier, which achieves both high power and high efficiency with low-voltage-rating devices by utilizing the reverse conduction of GaN transistors.
IEEE TRANSACTIONS ON POWER ELECTRONICS
(2022)
Article
Physics, Multidisciplinary
Xianglin Hao, Ke Yin, Jianlong Zou, Ruibin Wang, Yuangen Huang, Xikui Ma, Tianyu Dong
Summary: Significant progress has been made in nonradiative wireless power transfer (WPT) technology with the utilization of the parity-time (PT) symmetry concept. In this study, we extend the standard second-order PT-symmetric Hamiltonian to a high-order symmetric tridiagonal pseudo-Hermitian Hamiltonian, allowing for the relaxation of limitations in multisource/multiload systems based on non-Hermitian physics. We propose a three-mode pseudo-Hermitian dual-transmitter-single-receiver circuit and demonstrate that robust efficiency and stable frequency WPT can be achieved without the presence of PT symmetry. Furthermore, no active tuning is required when the coupling coefficient between the intermediate transmitter and the receiver is changed. The application of pseudo-Hermitian theory to classical circuit systems provides new possibilities for expanding the application of coupled multicoil systems.
PHYSICAL REVIEW LETTERS
(2023)
Proceedings Paper
Green & Sustainable Science & Technology
Piao Xingye, Zou Jianlong, Wang Pingfan
Summary: This article proposes a constant power angle control strategy for energy storage type UPQC, which can coordinate the power distribution of series and shunt converters to avoid load phase changes caused by power supply voltage variations, achieving uninterrupted power supply function.
2021 POWER SYSTEM AND GREEN ENERGY CONFERENCE (PSGEC)
(2021)