Article
Multidisciplinary Sciences
Carlotta Peruzzi, Silvia Battistoni, Daniela Montesarchio, Matteo Cocuzza, Simone Luigi Marasso, Alessio Verna, Laura Pasquardini, Roberto Verucchi, Lucrezia Aversa, Victor Erokhin, Pasquale D'Angelo, Salvatore Iannotta
Summary: The novel gate electrode composed of graphene, gold nanoparticles, and aptamers achieves high selectivity and sensitivity in a biosensor, with a limit of detection in the picomolar range. The hierarchical organization reduces steric hindrance and false positives, making it suitable for various biomedical applications.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Analytical
Mohd Afaque Ansari, Wei Juen Liew, Chitra Padmakumari Kurup, Minhaz Uddin Ahmed
Summary: In this study, a nanocomposite consisting of carboxyl-functionalized graphene nanoplatelets (GNPs), carbon nano-onions (CNOs), and chitosan (CS) was synthesized for the development of an electrochemical aptasensor for selective detection of thrombin. The nanocomposite modified glassy carbon electrode (GCE) exhibited remarkable electrochemical response and increased surface area. The designed aptasensor demonstrated sensitive detection of thrombin with excellent sensitivity and specificity.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Analytical
Hibba Yousef, Yang Liu, Lianxi Zheng
Summary: This paper reviews the recent advances in label-free electrochemical aptasensors for thrombin detection, with a focus on the application of nanomaterials and nanostructures. The performance, advantages, and limitations of these aptasensors are summarized and compared, highlighting the impact of nanomaterials and nanostructures on sensor performance.
Article
Chemistry, Analytical
Zehao Wang, Ningning Gao, Zhenmao Chen, Feng Gao, Qingxiang Wang
Summary: An electroactive metal-organic coordination polymer was prepared for immobilizing the bioprobe and constructing label-free biosensors. The biosensor was characterized using AFM, ATR-FTIR, and electrochemical methods. The aptasensor showed high sensitivity and selectivity for thrombin detection in complex samples.
Article
Biochemistry & Molecular Biology
Jiafeng Sun, Guixiang Wang, Hao Cheng, Yinfeng Han, Qun Li, Cheng Jiang
Summary: A universal strategy for sensitive detection of thrombin in complex biological media has been developed using hyaluronic acid functionalized polydopamine. This strategy shows good sensitivity and selectivity with a low detection limit of 0.03 pM. The presence of hyaluronic acid within the sensing interface greatly reduces the side effect of non-specific adsorption, allowing accurate detection of thrombin in diluted human serum.
BIOELECTROCHEMISTRY
(2022)
Article
Chemistry, Analytical
Yan Huang, Xiaoying Pei, Shina Du, Zhongfang Li, Xiangling Gu, Wei Sun, Xueliang Niu
Summary: In this study, we designed and explored a simple ratiometric electrochemical aptasensor for thrombin detection using a signal on-off strategy. We synthesized and characterized AuNPs-MXene as a signal amplified sensing platform, and introduced hairpin probes labeled with ferrocene and thrombin aptamer labeled with methyl blue to fabricate a highly selective and ratiometric dual-signal readout aptasensor.
MICROCHEMICAL JOURNAL
(2022)
Article
Engineering, Environmental
Jiajun Yu, Xiao Wang, Lu Chen, Guanhong Lu, Gansheng Shi, Xiaofeng Xie, Yan Wang, Jing Sun
Summary: The development of photocatalytic materials with both promising adsorption capacity and high visible-light activity is important for efficient and stable degradation of toluene. In this study, carbon quantum dots (CQDs) decorated UiO-66 metal-organic-frameworks gel (MOG) composites with hierarchical pore structures were prepared. The introduction of CQDs improved light utilization and promoted the separation of photo-induced electrons and holes, leading to the generation of active free radicals. The composite demonstrated high toluene adsorption capacity and enhanced degradation efficiency compared to the pristine MOG. In-situ Fourier transform infrared (FTIR) and Gas Chromatography-Mass Spectrometer (GC-MS) analyses revealed the degradation pathways and mineralization of toluene. The results highlight the potential of CQDs decoration for efficient mineralization of toluene in low-concentration flows.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Maryam Konari, Esmaeil Heydari-Bafrooei, Mohammad Dinari
Summary: LDH-based aptasensors have been established as sensitive and reliable devices for serum and cerebrospinal fluid (CSF) analysis, with 5'-NH2 DNA aptamer probes immobilized on the surfaces in a vertical conformation without any linker materials. The combination of carbon nanotubes with LDH has helped enhance electronic conductivity for improved sensing of proteins like thrombin.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Analytical
Xiuxiu Zhang, Fusheng Liao, Mei Wang, Jie Zhang, Binxiang Xu, Ling Zhang, Jun Xiong, Wei Xiong
Summary: A sensitive electrochemical thrombin aptasensor was proposed in this work, utilizing CHA and bisferrocene to detect thrombin concentration. The sensor demonstrated a wide linear range and high detection limit, making it suitable for monitoring thrombin in human serum samples.
Article
Chemistry, Applied
Seyedeh Fatemeh Ahmadi, Mohammad Hojjatoleslamy, Hossein Kiani, Hooman Molavi
Summary: In this study, a label-free electrochemical aptasensor was developed for accurate and rapid detection of Aflatoxin M1. By optimizing aptamer immobilization time, concentration, and binding time, the sensor showed a linear range and limit of detection. Compared to traditional HPLC methods, this sensor offers a faster and more accurate way to detect Aflatoxin M1.
Article
Chemistry, Analytical
Jingyi Guo, Mei Zhao, Chen Chen, Fang Wang, Zilin Chen
Summary: This study developed a novel biosensor for the detection of N6-methyladenosine and 5-methylcystosine-single strand DNA using a laser-induced graphene electrode. The biosensor exhibited low detection limits, a wide linear detection range, and good selectivity, stability, and reproducibility. The successful application of this method suggests its potential for clinical diagnosis and the development of point-of-care testing techniques.
Article
Chemistry, Analytical
Chao Wu, Qiaran Zhang, Duo Li, Xuehui Tang, Fei Xie, Yue Zhang, Yizhong Lu
Summary: The electrochemical aptasensor constructed based on PB-Au@MoS2 demonstrated excellent performance for thrombin detection, with a detection linear range from 0.01 pM to 30 nM and a detection limit down to 1 fM. This work may offer a strategy to develop effective and sensitive sensing devices for thrombin in clinical diagnosis.
Article
Chemistry, Physical
Xiao-Hong Wen, Xue-Feng Zhao, Bo-Fang Peng, Kai-Ping Yuan, Xiao-Xi Li, Li-Yuan Zhu, Hong-Liang Lu
Summary: An electrochemical biosensor based on Hcy aptamer/Au nano-particles/graphene sponge was designed for the detection of homocysteine. The biosensor showed good selectivity and reproducibility in experimental results, with potential applications in the preliminary detection of various diseases associated with Hcy.
APPLIED SURFACE SCIENCE
(2021)
Article
Chemistry, Analytical
Adel Al Fatease, Wenjuan Guo, Ahmad Umar, Chengxian Zhao, Yahya Alhamhoom, Abdullatif Bin Muhsinah, Mater H. Mahnashi, Zubaida A. Ansari
Summary: A dual-mode electrochemical aptasensor for the detection of MUC1 was proposed. AuNPs-MG composite was synthesized and exhibited the ability to absorb methylene blue and behave like a peroxidase. The aptasensor showed satisfactory detection results with wide linear ranges and exhibited good reproducibility, stability, and the potential for clinical analysis applications.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Fanli Kong, Jinping Luo, Luyi Jing, Yiding Wang, Huayu Shen, Rong Yu, Shuai Sun, Yu Xing, Tao Ming, Meiting Liu, Hongyan Jin, Xinxia Cai
Summary: A sensitive electrochemical aptasensor for detecting the concentration of Doxorubicin (DOX) was developed. The sensor utilized a gold wire as the working electrode and was modified with reduced graphene oxide (rGO)/gold nanoparticles (AuNPs) to enhance sensitivity. An aptamer was used as the recognition element and changes in electron transfer rate induced by the aptamer-DOX binding resulted in current changes correlated with DOX concentration. The aptasensor exhibited good linearity in the concentration range of 0.3 μM to 6 μM with a detection limit of 0.1 μM. Moreover, the aptasensor demonstrated good recovery in real samples, indicating its potential for DOX detection.
Article
Chemistry, Multidisciplinary
Sattwick Haldar, Preeti Bhauriyal, Anthony R. Ramuglia, Arafat H. Khan, Sunel De Kock, Arpan Hazra, Volodymyr Bon, Dominik L. Pastoetter, Sebastian Kirchhoff, Leonid Shupletsov, Ankita De, Mark A. Isaacs, Xinliang Feng, Michael Walter, Eike Brunner, Inez M. Weidinger, Thomas Heine, Andreas Schneemann, Stefan Kaskel
Summary: The chelating ability of quinoxaline cores and the redox activity of organosulfide bridges in covalent organic frameworks (COFs) provide dual active sites for reversible lithium storage. Combining these properties, the designed COFs exhibit a stable Li-OrS battery mechanism, mitigating the issues of Li-polysulfide dissolution in Li-S batteries.
ADVANCED MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Maomao Xie, Meng Gao, Yang Yun, Martin Malmsten, Vincent M. M. Rotello, Radek Zboril, Omid Akhavan, Aliaksandr Kraskouski, John Amalraj, Xiaoming Cai, Jianmei Lu, Huizhen Zheng, Ruibin Li
Summary: Antimicrobial resistance (AMR) is a major threat to the environment and health, and antimicrobial nanomaterials are being explored as alternatives to conventional antibiotics. Some antimicrobial nanomaterials show AMR-independent antimicrobial effects, while others trigger the evolution of AMR. This review compares the mechanisms and relationships of antibiotics and antimicrobial nanomaterials, examines nano-microbe interactions, and provides an outlook on future antimicrobial nanomaterials.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Olivier Henrotte, Eva Yazmin Santiago, Artur Movsesyan, Luca Mascaretti, Morteza Afshar, Alessandro Minguzzi, Alberto Vertova, Zhiming M. Wang, Radek Zboril, Stepan Kment, Alexander O. Govorov, Alberto Naldoni
Summary: The investigation of photocatalytic systems at the nanoscale is crucial for understanding their fundamental principles, improving their design, and enhancing their applicability. A photochemical nanoscopy technique has been developed to detect the molecular products of plasmonic hot-carrier-driven photocatalytic reactions with nanometric precision. Applying this methodology to Au/TiO2 plasmonic photocatalysts, it was discovered that smaller and denser Au nanoparticle arrays have lower optical contribution but higher quantum efficiency in hot-hole-driven photocatalysis, which is closely related to population heterogeneity. This study also revealed the areas of oxidation and reduction product evolution in a single plasmonic nanodiode, demonstrating the bipolar behavior of such nanosystems. These findings enable quantitative investigations at the nanoscale to evaluate the photocatalytic reactivity of low-dimensional materials in various chemical reactions.
Review
Chemistry, Multidisciplinary
Iosif Tantis, Smita Talande, Vasileios Tzitzios, Georgia Basina, Vishal Shrivastav, Aristides Bakandritsos, Radek Zboril
Summary: This review focuses on recent advances in electrochemical energy storage (EES) technologies related to 2D crystals originating from non-layered 3D solids (non-van der Waals; nvdW) and their influence on the materials' features. The methods and challenges in top-down and bottom-up strategies towards nvdW 2D sheets and their applications in EES are discussed. Moreover, the opportunities and challenges of nvdW 2D systems in various applications are highlighted.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Physical
Tomas Malina, Cordula Hirsch, Alexandra Rippl, David Panacek, Katerina Polakova, Veronika Sedajova, Magdalena Scheibe, Radek Zboril, Peter Wick
Summary: Graphene oxide (GO) is a promising delivery nanoplatform, but its non-specific surface properties and heterogeneity in stability limit its commercial application. Evaluating the interaction of emerging graphene derivatives with endothelial and immune cells is important. The study demonstrated that graphene acid (GA) and cyanographene (GCN) have better biocompatibility and potential for drug/gene delivery compared to GO.
Article
Chemistry, Physical
Ankita De, Sattwick Haldar, Stefan Michel, Leonid Shupletsov, Volodymyr Bon, Nikolaj Lopatik, Lili Ding, Lukas M. Eng, Gunter K. Auernhammer, Eike Brunner, Andreas Schneemann
Summary: This study explores the tunability of covalent organic frameworks (COFs) and their processability. Anchoring alkoxy side chains to the COF backbone elongates the interlayer distance, leading to the successful exfoliation into nanosheets. The nanosheets show stability in dispersion, hydrophobic surface properties, and potential applications in lithium-ion battery separators.
CHEMISTRY OF MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Sattwick Haldar, Andreas Schneemann, Stefan Kaskel
Summary: Redox-active covalent organic frameworks (COFs) have recently emerged as advanced electrodes in polymer batteries. COFs provide molecular precision for understanding redox mechanisms and increasing the charge-storage capacities. The functional groups on COFs' pore surface provide easily accessible interaction sites and can be used to establish structure-property relationships, combining experimental and computational methods.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Chemistry, Physical
En Zhao, Wenjun Zhang, Lin Dong, Radek Zboril, Zupeng Chen
Summary: Transfer hydrogenation using liquid hydrogen carriersas the direct proton sources under mild conditions has attracted considerable attention in the field of organic synthesis. Photocatalytic water-donating transfer hydrogenation (PWDTH) has emerged as an eco-friendly alternative to conventional hydrogenation technology. This paper discusses recent advances in PWDTH reactions, including the mechanism of hydrogen transfer and the design principles of efficient photocatalysts. It also explores the current challenges and future opportunities in this rapidly developing field.
Review
Chemistry, Multidisciplinary
Oksana Smirnova, Subham Ojha, Ankita De, Andreas Schneemann, Frederik Haase, Alexander Knebel
Summary: This article discusses the current state of reticular chemistry in the synthesis of highly porous nanomaterials for gas separation, with a focus on membrane technology. It explores the design of narrow pore windows for high-resolution molecular sieving and presents promising concepts such as neat materials and mixed matrix membranes. The article sheds light on the potential use of reticular materials as membrane components and provides strategies and guiding principles for the future development of reticular nanomaterials-based membranes.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Sattwick Haldar, Arafat H. Khan, Ankita De, Fanny Reichmayr, Ahiud Morag, Minghao Yu, Andreas Schneemann, Stefan Kaskel
Summary: In this study, sulfur is covalently integrated into a polymer through a chemical reaction, enabling it to be used as an electrode material in batteries. This novel electrode material mitigates the dissolution and shuttle effect of sulfur in the batteries, leading to improved cycling stability and reduced overpotential.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Physical
Olivier Henrotte, Stepan Kment, Alberto Naldoni
Summary: The impact of surface defects on the photoactivity of plasmonic hybrid nanostructures was investigated using scanning photoelectrochemical microscopy (SPECM). It was found that mild reduction treatment significantly enhances the photoactivity of TiO2 ultrathin films under visible light. Plasmonic photoactivity mapping using Au nanoparticle arrays deposited on different reduced TiO2 films revealed the effect of interfacial defects on hot charge carriers and the role of electron leakage.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Chemistry, Physical
Rabindranath Lo, Martin Pykal, Andreas Schneemann, Radek Zboril, Roland A. Fischer, Kolleboyina Jayaramulu, Michal Otyepka
Summary: Covalent hybrids of graphene and metal-organic frameworks (MOFs) have great potential in various technologies, especially catalysis and energy applications, due to their combination of conductivity and porosity. The formation of an amide bond between carboxylate-functionalized graphene acid (GA) and amine-functionalized UiO-66-NH2 MOF is an efficient strategy for creating such hybrids. This study used density functional theory (DFT) calculations to elucidate the mechanism of amide bond formation between GA and UiO-66-NH2, highlighting the crucial role of zirconium within UiO-66 as a catalyst. Insight into the binding interactions between graphene derivatives and MOFs can lead to tailored synthesis strategies for these nanocomposite materials.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Chemistry, Physical
Yu Zhang, Luca Mascaretti, Michele Melchionna, Olivier Henrotte, Stepan Kment, Paolo Fornasiero, Alberto Naldoni
Summary: A fabrication approach was developed to create TiN/F-doped carbon hybrids with high catalytic activity for H2O2 production. These hybrids showed a maximum H2O2 selectivity of 90% and achieved a H2O2 productivity of 207 mmol g(TiN) (-1) h(-1) at 0.2 V vs RHE. The formation of nanocomposites played a key role in achieving high currents, with increased TiO x N y surface content promoting higher H(2)O(2) selectivity and fluorinated nanocarbon imparting good stability to the electrodes due to their superhydrophobic properties.
Article
Nanoscience & Nanotechnology
Morteza Afshar, Andrea Schirato, Luca Mascaretti, S. M. Hossein Hejazi, Mahdi Shahrezaei, Giuseppe Della Valle, Paolo Fornasiero, Stepan Kment, Alessandro Alabastri, Alberto Naldoni
Summary: We report the development of high aspect ratio, nanoporous titanium oxynitride nanotubes with quasi-unitary broadband absorption. The efficient light-heat conversion is explained in terms of localized field distribution and heat dissipation within the nanopores. A numerical model is developed to describe the space-dependent electric permittivity distribution, which can explain the large broadband absorption observed. The potential application of these nanotubes as solar absorbers is explored through photothermal experiments.
Article
Chemistry, Physical
Nikolaj Lopatik, Ankita De, Silvia Paasch, Andreas Schneemann, Eike Brunner
Summary: This study demonstrates the usefulness of high-field and fast-spinning H-1 MAS NMR spectroscopy in resolving and quantifying different H-1 species, including edge sites and defects, within 2D covalent organic frameworks (COFs). H-1-C-13 heteronuclear correlation (HETCOR) spectroscopy provides improved resolution and further information about stacking effects and edge sites/defects.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)