Article
Multidisciplinary Sciences
Mohit P. Dalwadi, Philip Pearce
Summary: Bacteria use quorum sensing to collectively respond to their environment, with their autoinducers affected by factors such as fluid flow. Understanding how genetic architectures in cells promote population-level phenotypes in varying flow conditions reveals that positive feedback in cells can lead to a robust collective response. By accounting for dynamic flow, positive feedback acts as a low-pass filter in oscillatory flow, allowing populations to respond to changes over slow timescales.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Engineering, Environmental
Chunxiao Dai, Yuanyuan Qu, Weize Wu, Shuzhen Li, Zhuo Chen, Shengyang Lian, Jiawei Jing
Summary: This study established a QS-related protein database and an automatic annotation pipeline for rapid and accurate annotation and classification of QS-related sequences in aquatic environments. It provides a useful tool for understanding bacterial communication in water environments.
Review
Microbiology
Evgeniya V. Prazdnova, Andrey V. Gorovtsov, Nikita G. Vasilchenko, Maxim P. Kulikov, Varvara N. Statsenko, Anna A. Bogdanova, Alexandr G. Refeld, Yaroslav A. Brislavskiy, Vladimir A. Chistyakov, Michael L. Chikindas
Summary: This review focuses on the mechanisms of quorum-sensing suppression by Gram-positive microorganisms and its practical applications in food fermentation, probiotics, and biotechnology. It also discusses the possible evolutionary role of quorum-quenching mechanisms during the development of interspecies interactions of bacteria.
Article
Engineering, Environmental
Hong-Xin Shi, Jing Wang, Shao-Yang Liu, Jin-Song Guo, Fang Fang, You-Peng Chen, Peng Yan
Summary: The underlying microcosmic mechanisms of non-filamentous bulking are still unclear, and quorum sensing is a potentially effective strategy to prevent and control non-filamentous bulking.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Multidisciplinary Sciences
Avaneesh V. Narla, David Bruce Borenstein, Ned S. Wingreen
Summary: Bacteria form complex immobile communities called biofilms, where they interact and compete via quorum sensing (QS) by producing and detecting small molecules called autoinducers (AIs). A study explored the competitive advantage of QS in biofilms and found that the effectiveness of QS strategies is influenced by nutrient availability and the dynamic range of AI concentrations in biofilms is limited by biophysical constraints.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Multidisciplinary
Yu Chen, Weipeng Lu, Yanchuan Guo, Yuntao Xie, Yi Zhu, Yeping Song
Summary: Combining ROS-scavenging and antibacterial activities, multifunctional gelatin/chitosan composite microspheres effectively alleviate oxidative stress and bacterial invasion in chronic wounds. The gelatin/chitosan scaffold with good biocompatibility promotes cell proliferation.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Andrea Muras, Ana Parga, Celia Mayer, Ana Otero
Summary: Interfering with quorum sensing systems of bacteria is a promising strategy to control biofilm formation, and the xCELLigence(R) system is proposed as an efficient method for quantifying biofilm formation.
Review
Dentistry, Oral Surgery & Medicine
Andrea Muras, Natalia Mallo, Paz Otero-Casal, Jose M. Pose-Rodriguez, Ana Otero
Summary: This study summarizes the role of bacterial extracellular signaling systems, namely quorum sensing (QS), in oral biofilm formation, and explores the potential of blocking these communication systems as a new approach to prevent and treat oral infectious diseases. Current evidence suggests that QS molecules play an important role in the oral microbial ecosystem. Targeting the mechanisms that regulate gene expression through bacterial communication systems shows promise in controlling oral biofilm formation. However, there is still limited knowledge about microbial interactions and signaling processes within multispecies biofilms in the oral cavity.
Review
Chemistry, Multidisciplinary
Bernadette Tse Sum Bui, Tiffany Auroy, Karsten Haupt
Summary: Infections caused by antibiotic-resistant bacteria are a major public health problem. Molecularly imprinted polymers (MIPs) offer a promising solution by recognizing and binding target molecules with high affinity and selectivity, similar to antibodies. This review aims to explore the potential of MIPs in combating resistant superbugs, filling a gap in current research.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Fisheries
P. Snega Priya, Seenivasan Boopathi, Raghul Murugan, B. Haridevamuthu, Aziz Arshad, Jesu Arockiaraj
Summary: Bacteria produce virulence factors that cause mortality in fish and crustaceans, and these factors require abundant quorum sensing (QS) signals and high cell density. QS signals not only interfere with cellular pathways and induce cell death in mammalian cells, but also impair the immune system, indicating their importance as a major virulence factor. In aquatic organisms, the impact of QS signals is still being explored. However, aquatic organisms produce enzymes that degrade and detoxify these signals, and physical and chemical factors also affect their stability. Understanding the influence of QS signals on aquatic organisms is crucial for controlling disease progression.
REVIEWS IN AQUACULTURE
(2023)
Review
Microbiology
Patricia P. Wright, Srinivas Sulugodu Ramachandra
Summary: Quorum sensing plays a crucial role in the pathogenicity and virulence of biofilms. This review focuses on the role of quorum sensing in cariogenic and periodontopathic biofilms and highlights the potential of quorum quenching as an antimicrobial tool to attenuate biofilm pathogenicity. Further research is needed to determine the clinical value of quorum sensing inhibitors against oral polymicrobial biofilms in vivo.
Article
Chemistry, Multidisciplinary
Zhiyuan Luo, Tingwang Shi, Zesong Ruan, Cheng Ding, Rentai Huang, Wenbo Wang, Zhao Guo, Zeming Zhan, Yunlong Zhang, Yunfeng Chen
Summary: Biofilms provide bacteria with enhanced tolerance to external stress, making conventional antimicrobial treatment less effective. Quorum sensing has been linked to biofilm's stress response, and a new therapeutic strategy is presented that combines quorum sensing interference assisted therapy (QSIAT) with thermal therapy and immunomodulation. The strategy weakens the biofilm's stress response, destroys the biofilm, and improves the penetration of nanoparticles. The decomposed hyaluronic acid helps with tissue regeneration and healing. QSIAT enhances the bactericidal effects of conventional therapy and shows promise in treating persistent biofilm infections.
Review
Agricultural Engineering
Catarina M. Paquete, Miriam A. Rosenbaum, Lluis Baneras, Amelia-Elena Rotaru, Sebastia Puig
Summary: Electroactive microorganisms have the ability to exchange electrons and promote communication among cells in biofilms. Understanding and addressing knowledge gaps will contribute to the development of novel technologies.
BIORESOURCE TECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jyoti Yadav, Satyajeet Das, Suraj Singh, Anupam Jyoti, Vijay Kumar Srivastava, Vinay Sharma, Sanjit Kumar, Sujeet Kumar, Sanket Kaushik
Summary: S-adenosylhomocysteine nucleosidase (MTAN) is a protein that plays a crucial role in bacteria, including quorum sensing and biofilm formation. Inhibiting MTAN may block biofilm formation and other critical metabolic processes in pathogenic bacteria.
CURRENT PROTEIN & PEPTIDE SCIENCE
(2022)
Review
Microbiology
Veronica Lazar, Alina Maria Holban, Carmen Curutiu, Mariana Carmen Chifiriuc
Summary: Pathogenic bacteria have the ability to adapt to their environment and develop biofilms, increasing their resistance to stress factors such as antibiotics. Targeting quorum sensing and biofilm formation is a promising approach for discovering novel antibiofilm strategies.
FRONTIERS IN MICROBIOLOGY
(2021)
