Article
Biophysics
Kristine M. Fischenich, Stephanie E. Schneider, Corey P. Neu, Karin A. Payne, Virginia L. Ferguson
Summary: The study evaluated the bulk material properties and depth-dependent strain distribution of bovine growth plate cartilage. The findings suggest that moduli and strain distribution are highly dependent on depth, orientation, and location. Heterogeneity in cellular organization may serve as a biological toughening mechanism.
JOURNAL OF BIOMECHANICS
(2022)
Article
Medicine, General & Internal
Adrien Frommer, Maike Niemann, Georg Gosheger, Maria Eveslage, Gregor Toporowski, Andrea Laufer, Thomas Ackmann, Robert Roedl, Bjoern Vogt
Summary: The study analyzed the controversy of concomitant PFE when correcting LLD with PTE in children, and found no significant difference in proximal fibular overgrowth or peroneal nerve discomfort between patients with or without PFE. The authors concluded that PFE may not be routinely performed if the proximal fibula is within physiological radiographic margins determined by reference values.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Yajie Lu, Xin Xiao, Minghui Li, Guojing Chen, Mengquan Huang, Chuanlei Ji, Zhen Wang, Jing Li
Summary: The combination of vascularized fibula epiphyseal transfer with massive allograft bone provides a reliable oncologic reconstruction of proximal humerus in children, offering longitudinal growth, hypertrophy, and osseous union while decreasing reconstructive complications and improving shoulder function. The study retrospectively investigated five pediatric patients who underwent this composite approach, finding positive outcomes with improved growth and shoulder function postoperatively.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Dexter Zirkle, Richard S. Meindl, C. Owen Lovejoy
Summary: A unique vascular canal system in hominins, associated with a specific physeal growth plate in the ilium, has been identified. This system, characterized by a significantly enlarged foramen in modern humans and hominin fossils, may serve as an indicator of specialized pelvic growth for bipedality in fossil hominins.
Review
Engineering, Biomedical
Aleczandria S. Tiffany, Brendan A. C. Harley
Summary: This review provides an overview of growth plates, their role in skeletal development, injuries and diseases associated with growth plates, and the opportunities and challenges for developing biomaterial models for studying growth plate biology and diseases. It also describes the potential of sophisticated in vitro biomaterial models for studying growth plate remodeling and developing tissue engineering applications.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Engineering, Biomedical
Charlotte Struwe, Sebastian G. Walter, Claudia Druschel, Rahel Bornemann, Milena Ploeger, Sebastian Koob, Richard Placzek
Summary: This study aimed to compare biomechanical features of different devices used in clinical routine for temporary epiphysiodesis, the results showed that eight-Plate (R) demonstrated superior biomechanical stability when implanted anteriorly, with higher maximum load forces and axial physis distance until implant failure compared to FlexTack(TM). There is no clear advantage of either implant and the choice remains within the individual preference of the surgeon at this stage of research.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Karel Frydrysek, Daniel Cepica, Tomas Halo, Ondrej Skoupy, Leopold Pleva, Roman Madeja, Jana Pometlova, Monika Losertova, Jan Koutecky, Pavel Michal, Vojtech Havlas, Simon Kraus, Dominik Durica, Katerina Peterek Dedkova, Marek Pagac, Pavel Krpec, Pawel Osemlak
Summary: This article analyzes the performance of Blount bone staples for bone growth arrest and confirms their safety and usability through finite element analysis and experimentation.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Massimiliano Mancini, Lavinia Bargiacchi, Claudia De Vitis, Michela D'Ascanio, Chiara De Dominicis, Mohsen Ibrahim, Erino Angelo Rendina, Alberto Ricci, Arianna Di Napoli, Rita Mancini, Andrea Vecchione
Summary: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrotic lung disorder. Current research has found that IPF patients with higher D-f values are associated with worse prognosis and higher fibroblastic foci density, indicating that D-f may serve as a potential novel prognostic marker for IPF.
Article
Orthopedics
Richard T. Epperson, Dustin L. Williams, Brady Rogers, John Maxwell, Peter Stevens
Summary: The study showed that obtaining a small biopsy of the epiphyseal plate is safe and does not lead to growth arrest or angular deformities. Analyzing biopsy samples at an earlier stage could be a significant advancement in diagnosing, treating, and monitoring at-risk children with diseased or damaged physes.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Orthopedics
B. Vogt, R. Roedl, G. Gosheger, A. Frommer, A. Laufer, M-T Kleine-Koenig, C. Theil, G. Toporowski
Summary: Temporary epiphysiodesis (ED) is commonly used in children and adolescents for leg length discrepancies (LLDs) and tall stature. This study evaluated the outcomes of ED using a novel rigid staple and found it to be a feasible strategy with lower rates of deformities compared to traditional treatment options. Further studies are needed to investigate potential complications.
BONE & JOINT JOURNAL
(2021)
Article
Endocrinology & Metabolism
Otto Lennartsson, Maria Lodefalk, Henrik Wehtje, Eva-Lena Stattin, Lars Saevendahl, Ola Nilsson
Summary: This study presents a rare clinical case of a patient with Tatton-Brown-Rahman syndrome who underwent bilateral epiphysiodesis surgery for tall stature management. The surgery resulted in an increase in height, with a more modest increase in leg length.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Engineering, Biomedical
Kevin N. Eckstein, Stacey M. Thomas, Adrienne K. Scott, Corey P. Neu, Nancy A. Hadley-Miller, Karin A. Payne, Virginia L. Ferguson
Summary: Fractures in the growth plate can lead to the loss of bone lengthening function. Our understanding of growth plate fractures and mechanobiology is limited by the lack of information on the microscale spatial gradients in mechanical properties. In this study, we characterized the mechanical properties of the growth plate and found differences between different zones, which correlated with the content of extracellular matrix.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Orthopedics
Christopher B. Erickson, Jake P. Newsom, Nathan A. Fletcher, Yangyi Yu, Francisco Rodriguez-Fontan, Shane A. Weatherford, Nancy Hadley-Miller, Melissa D. Krebs, Karin A. Payne
Summary: The study shows that quick release of alpha-VEGF in rats can reduce bony bar and vessel formation, while increasing cartilage repair tissue. This treatment does not affect limb lengthening and does not lead to detrimental side effects in the adjacent, uninjured area. This approach could have positive implications for children with physeal injuries.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Marisa Esteves-Monteiro, Daniela Menezes-Pinto, Mariana Ferreira-Duarte, Patricia Dias-Pereira, Manuela Morato, Margarida Duarte-Araujo
Summary: Diabetes mellitus is associated with gastrointestinal complications, and a rat model of diabetes showed structural remodelling of the gut wall and decreased contractile response to AngII.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Orthopedics
Andrea Laufer, Gregor Toporowski, Georg Gosheger, Ava von der Heiden, Jan Duedal Roelfing, Adrien Frommer, Anna Rachbauer, Carina Antfang, Robert Roedl, Bjoern Vogt
Summary: This study evaluates the preliminary results of using two novel devices for temporary and permanent epiphysiodesis to reduce excessive predicted height. The results show that both methods are effective at reducing predicted height, but temporary epiphysiodesis is associated with a higher risk of angular deformities in the knee. Therefore, the study group has discontinued the use of temporary epiphysiodesis for treating tall stature.
JOURNAL OF ORTHOPAEDICS AND TRAUMATOLOGY
(2022)