Editorial Material
Multidisciplinary Sciences
Sam Jones
Summary: When infections spread globally, what are the chances of completely eliminating the pathogen responsible?
Article
Green & Sustainable Science & Technology
Alexis Rulisa, Luuk van Kempen, Dirk-Jan Koch
Summary: Interactions between SDGs are often overlooked in relation to the wealth status of the concerned population. This study explores the relationship between rice production intensification and the fight against malaria, highlighting that rice-cultivating households faced higher malaria risk and the distributional effects are biased against the poor.
Article
Endocrinology & Metabolism
Ruban Dhaliwal, Rocio Pereira, Alicia M. Diaz-Thomas, Camille E. Powe, Licy L. Yanes Cardozo, Joshua J. Joseph
Summary: The Endocrine Society identifies racism as the underlying cause of health disparities affecting racial/ethnic minority communities worldwide. Their policy aims to address this issue by educating and engaging healthcare professionals, researchers, educators, policymakers, and leaders to promote an equitable and diverse healthcare system.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Gastroenterology & Hepatology
Ravi Jhaveri, Lynn M. Yee, Swati Antala, Margaret Murphy, William A. Grobman, Seema K. Shah
Summary: HCV infections have been on the rise due to injection drug use and the opioid epidemic in recent years. While HCV cure has become achievable with the advent of direct-acting antivirals, pregnant individuals have been systematically excluded from HCV clinical research and treatment programs. Therefore, there is a need to ethically consider how to responsibly include pregnant individuals in order to advance the goal of HCV eradication.
Review
Medicine, Research & Experimental
Celia Sahli, Sergio E. Moya, John S. Lomas, Christine Gravier-Pelletier, Romain Briandet, Miryana Hemadi
Summary: This article introduces the spatially-organized communities of microorganisms called biofilms and their interactions with antimicrobials. The limitations of antibiotic treatments are discussed, and alternative approaches using nanoparticles are presented. The aim of this article is to eradicate bacterial biofilms and fight antimicrobial tolerance using nanobiotechnology-based approaches.
Article
Chemistry, Multidisciplinary
Yong Liu, Yuanfeng Li, Linqi Shi
Summary: Drug delivery systems have made significant progress in eradicating bacteria in biofilms while minimizing side effects, but guidelines for controlled DDS development are limited. By summarizing classical mechanisms and mathematical models, proposing strategies based on biofilm formation, challenges in DDS design were discussed and future directions suggested.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Biochemistry & Molecular Biology
Tao Yang, Ning Liang, Jing Li, Pan Hu, Qian Huang, Zifeng Zhao, Qian Wang, Hongxin Zhang
Summary: This review summarizes the complex role of MDSCs in the modulation of cancer stemness and discusses the relationship mechanism between CSCs and MDSCs, as well as potential therapeutic strategies for targeting MDSCs to eliminate CSCs.
CYTOKINE & GROWTH FACTOR REVIEWS
(2022)
Article
Engineering, Biomedical
Sanjana Gopalakrishnan, Aarohi Gupta, Jessa M. V. Makabenta, Jungmi Park, John J. Amante, Aritra Nath Chattopadhyay, Dorcas Matuwana, Cathal J. Kearney, Vincent M. Rotello
Summary: Bacterial biofilms are a major healthcare concern, and a combination treatment involving ultrasound and antimicrobial polymeric nanoparticles has shown promise in effectively eradicating biofilms while minimizing damage to healthy tissue.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Weiwei Feng, Shangqian Zhang, Yichen Wan, Zelong Chen, Yun Qu, Jiahui Li, Tony D. James, Zhichao Pei, Yuxin Pei
Summary: A phototherapeutic nanococktail has been developed to enhance the efficacy of photodynamic therapy (PDT) and photothermal therapy (PTT) by alleviating hypoxia and thermal resistance. The nanococktail demonstrated synergistic effects in both in vitro and in vivo experiments, showing promise for the eradication of tumors while maintaining good biosafety.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Editorial Material
Oncology
Yelena Y. Janjigian, Jedd D. Wolchok, Charlotte E. Ariyan
Summary: Immune checkpoint blockade (ICB) has revolutionized cancer treatment, starting with metastatic melanoma patients and now extending to various types of cancer at different stages. Research is ongoing to understand the history and mechanisms behind the response variations, as well as the integration of ICB into different treatment approaches.
Article
Chemistry, Multidisciplinary
Wei Guan, Lei Tan, Xiangmei Liu, Zhenduo Cui, Yufeng Zheng, Kelvin Wai Kwok Yeung, Dong Zheng, Yanqin Liang, Zhaoyang Li, Shengli Zhu, Xianbao Wang, Shuilin Wu
Summary: Sonodynamic therapy (SDT) is limited by the hypoxia environment of deep tissues, but a potential solution, sonothermal therapy, has been proposed in this study. By developing ultrasonic interfacial engineering of metal-red phosphorus (RP), the sonothermal ability is significantly improved. The mechanical energy of ultrasound activates the motion of interfacial electrons to efficiently transfer the energy into phonons, resulting in stronger ultrasound absorption of metal-RP.
ADVANCED MATERIALS
(2021)
Article
Environmental Sciences
Ankur Singh, Anja Mizdrak, Lyrian Daniel, Tony Blakely, Emma Baker, Ludmila Fleitas Alfonzo, Rebecca Bentley
Summary: This study simulates the potential health gains from raising indoor temperatures in cold homes in Australia to reduce cardiovascular disease burden. The findings show that eradicating cold housing can result in significant cardiovascular health benefits comparable to real-life lifestyle and dietary interventions.
ENVIRONMENTAL HEALTH
(2022)
Review
Microbiology
Ronni A. G. da Silva, Irina Afonina, Kimberly A. Kline
Summary: Biofilm formation is a complex process involving multiple factors, and antibiotics are still the main choice for treating bacterial biofilm infections. However, a holistic and multi-faceted approach is needed to eliminate hard-to-treat antibiotic-resistant biofilm infections.
CURRENT OPINION IN MICROBIOLOGY
(2021)
Article
Medicine, Research & Experimental
Shuolin Cui, Jing Qiao, May P. Xiong
Summary: This study demonstrates that pH-responsive vesicles can effectively eradicate established biofilms by releasing antibiotics in response to the acidic environment of biofilm bacteria. The dynamic charge density of the vesicles allows for differential interactions with the biofilm and bacterial membrane, resulting in enhanced antibacterial and antibiofilm properties.
MOLECULAR PHARMACEUTICS
(2022)
Article
Biodiversity Conservation
Aysegul Birand, Phillip Cassey, Joshua Ross, Paul Q. Thomas, Thomas A. A. Prowse
Summary: CRISPR-based gene drives offer solutions for controlling invasive species, but their feasibility varies among different sized species.
