Article
Cardiac & Cardiovascular Systems
Santeri Tarvainen, Galina Wirth, Greta Juusola, Olli Hautero, Kari Kalliokoski, Tanja Sjoros, Veikko Nikulainen, Jouni Taavitsainen, Jarkko Hytonen, Crister Frimodig, Krista Happonen, Tuomas Selander, Tomi Laitinen, Harri H. Hakovirta, Juhani Knuuti, Nihay Laham-Karam, Juha Hartikainen, Kimmo Makinen, Seppo Yla-Herttuala, Petra Korpisalo
Summary: This explorative study aimed to investigate the role of microvasculature in critical limb-threatening ischaemia (CLTI) pathology. High-resolution imaging of CLTI patients and muscle samples from amputated limbs were used to describe microvascular pathology. The findings suggest that CLTI muscles have altered blood flow dynamics and tissue damage due to hypoxia-driven capillary enlargement.
EUROPEAN HEART JOURNAL
(2023)
Article
Endocrinology & Metabolism
Qi Yang, Liang Li, Yunfei Zha, Yuchen Yan, Dong Xing, Huan Liu, Liu Yang, Lin Peng, Yubiao Zhang
Summary: Quantitative DCE-MRI parameters can evaluate microvascular permeability of skeletal muscles in diabetic rabbits with critical limb ischemia, and texture analysis based on DCE-MRI K-trans allows for evaluation of early slight skeletal muscle structural changes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Virology
Mohammad Kazem Vakil, Yaser Mansoori, Ghaidaa Raheem Lateef Al-Awsi, Ali Hosseinipour, Samaneh Ahsant, Sedigheh Ahmadi, Mohammad Ekrahi, Zahra Montaseri, Babak Pezeshki, Poopak Mohaghegh, Mojtaba Sohrabpour, Maryam Bahmanyar, Abdolreza Daraei, Tahereh Dadkhah Jouybari, Alireza Tavassoli, Abdolmajid Ghasemian
Summary: Innate and acquired immunity responses are crucial for eliminating viral infections. However, genetic variations in coding genes may exacerbate inflammation or initiate devastating cytokine storms, leading to severe respiratory conditions in COVID-19. Host genetic variations, particularly those related to immune responses, determine patients' susceptibility and the severity and pathophysiology of COVID-19.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Polymer Science
Caroline Herron, Conn L. Hastings, Clodagh Herron-Rice, Helena M. Kelly, Joanne O'Dwyer, Garry P. Duffy
Summary: The study showed that the chitosan/beta-GP hydrogel has the potential to alleviate critical limb ischaemia, significantly improving blood flow and increasing vessel number.
Article
Biochemistry & Molecular Biology
Lei Zhang, Guangshuai Liu, Tian Xia, Xiufeng Yang, Guolei Sun, Chao Zhao, Chunzhu Xu, Honghai Zhang
Summary: The study analyzed TLR genes from the genomes and transcriptomes of 102 amphibian species to understand their evolutionary patterns. Results showed that TLR genes can be divided into seven subfamilies, with TLR4 subfamily found only in Anura. Purification selection played a leading role in amphibian TLR evolution, and different domains had different evolution rates. Positive selection patterns and single-nucleotide polymorphisms were observed in TLR genes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Biochemistry & Molecular Biology
Arturo Orlacchio, Pellegrino Mazzone
Summary: Pancreatic cancer is a lethal form of cancer characterized by its aggressiveness and metastatic potential. Toll-like receptors play a pivotal role in inflammation and immune response, and can be potential targets for cancer therapy. Studies have shown that TLRs play an important role in the progression of pancreatic cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Xin Zhi, Peipei Yang, Yunxue Xu, Zhifei Dai, Xiuli Yue, Linxue Qian
Summary: This review discusses the functions of Toll-like receptors (TLRs) in the tumor microenvironment and the pathways that activate immune responses. It also summarizes recent developments in nanotechnology for immunomodulation with TLR agonists. Nanotechnology can improve the efficacy of TLR agonist-based immunotherapy and address its limitations.
Review
Biochemistry & Molecular Biology
Yuan-Tung Chu, Min-Tser Liao, Kuo-Wang Tsai, Kuo-Cheng Lu, Wan-Chung Hu
Summary: A comprehensive framework has been established to understand immunological pathways, and specific associations between immune responses and immune receptors have been identified. These findings contribute to the identification of biomarkers for immune cells and provide insights into host immunological pathways.
Review
Cell Biology
Stavros Garantziotis, Rashmin C. Savani
Summary: The extracellular matrix (ECM) is not only a structure but also plays key roles in cellular responses. Proteoglycans (PGs), a component of ECM, have been found to be crucial in both health maintenance and disease development by activating the innate immune system and influencing cell fate.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Aarti Yadav, Anil Dahuja, Rajesh Dabur
Summary: The review highlights the TLR signaling mediated muscle loss and the interaction between inflammation and skeletal muscle growth, identifying TLR2 and TLR4 as key players in exacerbating pro-inflammatory cytokine release and disrupting synchronized muscle programming.
CURRENT MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Katarzyna Wicherska-Pawlowska, Tomasz Wrobel, Justyna Rybka
Summary: The innate immune system recognizes pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) through pattern recognition receptors (PRRs), activating immune cells and initiating inflammatory and immune responses. This system also plays a role in cancer immunosurveillance, with potential for natural and synthetic agonists of PRRs to be used as adjuvants in cancer immunotherapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Yingchi Zhang, Jia Liu, Changlun Wang, Junxian Liu, Wei Lu
Summary: Toll-like receptor gene polymorphisms can increase the risk of autoimmune diseases, and studying these variations can expand our understanding of the pathogenesis of autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Xiaoqin Tang, Qian Xu, Shuo Yang, Xinwu Huang, Long Wang, Feihong Huang, Jiesi Luo, Xiaogang Zhou, Anguo Wu, Qibing Mei, Chunling Zhao, Jianming Wu
Summary: Platelets, as the second most abundant blood component, play a crucial role in various physiological and pathological functions. In addition to its traditional role in hemostasis and thrombosis, platelets also have an indispensable role in inflammatory diseases. Thrombocytopenia, a common hematologic problem, is closely related to the fatality of many diseases, highlighting the significance of its prevention and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Domenico Supino, Luna Minute, Andrea Mariancini, Federica Riva, Elena Magrini, Cecilia Garlanda
Summary: This article explores the roles of interleukin-1 (IL-1) family members and their receptors in regulating immune and inflammatory processes at the molecular level. It discusses their significance in the development of diseases and their potential therapeutic applications.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Cristina Vazquez-Carballo, Melania Guerrero-Hue, Cristina Garcia-Caballero, Sandra Rayego-Mateos, Lucas Opazo-Rios, Jose Luis Morgado-Pascual, Carmen Herencia-Bellido, Mercedes Vallejo-Mudarra, Isabel Cortegano, Maria Luisa Gaspar, Belen de Andres, Jesus Egido, Juan Antonio Moreno
Summary: Acute kidney injury (AKI) is a significant health issue, particularly in low- and middle-income countries. Studies suggest that inflammation plays a crucial role in the development of AKI, and anti-inflammatory agents targeting Toll-like receptors may help reduce kidney damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dermatology
Theodosios Bisdas, Nikolaos Patelis, Georgia Argyrakopoulou, Dimitrios Tsiachris, Aristotelis Kurtis, Panagiotis Gargalianos-Kakoliris, Christodoulos Stefanadis
Summary: The complexity of critical limb ischemia (CLI) requires a dedicated multidisciplinary team for treatment. This study aimed to assess the effectiveness of referring CLI patients scheduled for major amputation elsewhere to a dedicated CLI center. The analysis showed that patients in severe stages of CLI who received a second opinion from a dedicated multidisciplinary team had high limb salvage and survival rates after major amputation.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2022)
Article
Pharmacology & Pharmacy
Dimitris Tsiachris, Ioannis Doundoulakis, Panagiotis Tsioufis, Eirini Pagkalidou, Christos-Konstantinos Antoniou, Stefanos M. Zafeiropoulos, Konstantinos A. Gatzoulis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: This systematic review compares the effectiveness and safety of class Ic agents for cardioversion of paroxysmal AF and finds that intravenous flecainide is the most effective option. Class Ic agents appear to be safe for pharmacologic cardioversion of AF regardless of the presence of SHD.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Surgery
Jonathan Houdmont, Prita Daliya, Elena Theophilidou, Alfred Adiamah, Juliet Hassard, Dileep N. Lobo
Summary: The study found that during the COVID-19 pandemic, there is a high prevalence of burnout among surgeons in the UK, particularly in the domains of emotional exhaustion and depersonalisation. Burnout prevalence was not related to COVID-19 infection status, but was associated with the perceived impact of the pandemic on work. Concerns about contracting COVID-19 oneself and about family and friends getting infected were positively associated with burnout across all three domains.
WORLD JOURNAL OF SURGERY
(2022)
Article
Economics
Jay Pil Choi, Christodoulos Stefanadis
Summary: This article examines tippy network markets that allow price discrimination and finds that under certain conditions, network competition may lead to a unique subgame-perfect equilibrium where the winner's identity is fully determined by its product features. The concept of the dominant value margin is introduced as a metric for the effectiveness of divide-and-conquer strategies. However, the outcome of a market where suppliers with larger dominant value margins can sell to all customers does not necessarily result in social efficiency.
INTERNATIONAL ECONOMIC REVIEW
(2022)
Letter
Cardiac & Cardiovascular Systems
Christodoulos Stefanadis, Christina Chrysohoou, Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Panagiota Manolakou, Gerasimos Siasos, Konstantinos Tsioufis, George Panagiotakopoulos, Theoklis Zaoutis, Demosthenes Panagiotakos
HELLENIC JOURNAL OF CARDIOLOGY
(2022)
Article
Surgery
Daryll M. Baker, Lebeth Jacob, Andrew Busuttil
Summary: The study presents a stepwise intraoperative protocol aimed at reducing post-CEA haematoma rates. Results show a significant reduction in neck haematoma rate and the number of patients requiring reoperation for haematoma evacuation by implementing this protocol.
VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Article
Surgery
Anthousa Kythreotou, Ruwan A. Weerakkody, Kantida Koysombat, Natalie Marzouqa, Daryll M. Baker
Summary: This study retrospectively analyzed the clinical characteristics of a regional cohort of carotid fibromuscular dysplasia (FMD) patients, and found that patients had multivessel involvement and vascular complications, indicating the need for careful screening and surveillance.
ANNALS OF VASCULAR SURGERY
(2023)
Review
Surgery
Melissa Hanger, Daryll M. Baker
Summary: Infective native extracranial carotid artery aneurysms are rare and there is a lack of evidence assessing outcomes. This systematic literature review identified 193 cases of infective native extracranial carotid artery aneurysms, predominantly in male patients. The most common presenting features were a neck mass and fever, and the internal carotid artery was the most common location. Treatment strategies involved open surgical methods and endovascular approaches, with fewer complications in the endovascular group.
ANNALS OF VASCULAR SURGERY
(2023)
Review
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Ioannis Doundoulakis, Panagiota Manolakou, Demetrios Sougiannis, Athanasios Kordalis, Konstantinos A. Gatzoulis, Gian-Battista Chierchia, Carlo de Asmundis, Christodoulos Stefanadis, Konstantinos Tsioufis
Summary: Nowadays, cryoballoon (CB) has become an established alternative to radio frequency (RF) ablation for pulmonary vein isolation (PVI), with the ability to isolate PVs in a single application. In a study on over 1000 consecutive patients, our center optimized the CB PVI procedure. It is expected that future guidelines will recommend CB as the first-line PVI for patients with paroxysmal AF and a class I indication. In a long-term follow-up of the EARLY-AF trial, CB showed a lower incidence of persistent atrial fibrillation compared to anti-arrhythmic drugs.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Meeting Abstract
Surgery
M. Hanger, W. Baker, D. M. Baker
BRITISH JOURNAL OF SURGERY
(2022)
Meeting Abstract
Surgery
A. Hussein, L. Songra, D. Baker
BRITISH JOURNAL OF SURGERY
(2022)
Meeting Abstract
Surgery
L. Songra, D. Baker, M. Davis, J. Constantinou, H. Hamilton, O. Agu, N. Hynes
BRITISH JOURNAL OF SURGERY
(2022)
Meeting Abstract
Surgery
Lalana Songra, Daryll M. Baker, Meryl Davis, Jason Constantinou, Hamish Hamilton, Obiekezie Agu, Niamh Hynes
JOURNAL OF VASCULAR SURGERY
(2022)
Meeting Abstract
Surgery
Melissa Hanger, George Hamilton, Daryll M. Baker
JOURNAL OF VASCULAR SURGERY
(2022)
Meeting Abstract
Surgery
Daryll M. Baker, Ruwan Weerakkody, Natalie Marzouqa, Anthous Kythreotou
JOURNAL OF VASCULAR SURGERY
(2022)