Review
Hematology
Caroline Donze, Audrey Benoit, Isabelle Thuret, Cindy Faust, Alexandra NaThalY Network, Alexandra Gauthier, Julie Berbis, Catherine Badens, Valentine Brousse
Summary: Beta-thalassemia is a blood disorder characterized by a defective synthesis of the beta-globin chain. A study was conducted using data from the French national registry to assess the health status of pediatric patients with beta-thalassemia. The study found high survival rates and successful outcomes for patients who received a hematopoietic stem cell transplant, while those who did not undergo transplant showed moderate iron overload and few clinical complications. The study also observed no significant impact of the disease on growth or academic achievement.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Surgery
Deepak Kumar Gupta, Satinder Pal Singh, Ashok Utreja, Sanjeev Verma
Summary: The study evaluated the quantitative aspects of craniofacial deformities in transfusion-dependent beta-thalassemia patients. The findings showed a prevalence of skeletal class II tendency and diminished mandibular growth in these patients, along with thickened calvarium.
JOURNAL OF CRANIOFACIAL SURGERY
(2022)
Article
Pediatrics
Yuhang Zhou, Yaxuan Cao, Zhenhua Fang, Ken Huang, Mengxing Yang, Guanxiu Pang, Jie Zhao, Yang Liu, Jianming Luo
Summary: Genotype and corrected QT interval are predictive factors for cardiac iron deposition in children with beta-thalassemia who cannot undergo MRI T2* testing.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Hematology
Ludovica Aliberti, Irene Gagliardi, Maria Rita Gamberini, Andrea Ziggiotto, Martina Verrienti, Aldo Carnevale, Marta Bondanelli, Maria Chiara Zatelli, Maria Rosaria Ambrosio
Summary: This study evaluated the prevalence, risk factors, and clinical consequences of hypercalciuria in adult patients with beta-thalassemia major. The results showed that hypercalciuria is common in adequately treated thalassemia patients, especially in those using deferasirox. A significant proportion of hypercalciuric patients developed kidney stones.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Environmental Sciences
Mohammad Abdul Momin Siddique, Tasnia Tahsin, Imtiaz Hossain, Md. Shahadat Hossain, Nururshopa Eskander Shazada
Summary: Plastic pollution has become a global issue, and there is limited research on microplastic contamination in commercial fish feeds. This study in Bangladesh identified, quantified, and characterized microplastics in commercial fish feeds, and assessed potential health risks for fish consuming these feeds. The study found widespread contamination of fish feed samples with microplastics, with fiber being the dominant shape and red being the dominant color. The study recommends avoiding plastic materials in the packaging and storing processes of feed ingredients to ensure contamination-free fish feeds for sustainable aquaculture.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Antonella Meloni, Riccardo Righi, Massimiliano Missere, Stefania Renne, Nicolo Schicchi, Maria Rita Gamberini, Liana Cuccia, Roberto Lisi, Anna Spasiano, Maria Grazia Roberti, Angelo Zuccarelli, Lamia Ait-Ali, Pierluigi Festa, Giovanni Donato Aquaro, Maurizio Mangione, Valerio Barra, Vincenzo Positano, Alessia Pepe
Summary: This study established normal ranges for left ventricular and right ventricular volumes, ejection fraction, and mass in well-treated beta-thalassemia major patients using cardiac MRI. Males with beta-TM showed significantly higher LV end-diastolic volume in all age groups, while females had comparable volumes. In beta-TM patients, all biventricular volume indexes were significantly larger in males than females.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Genetics & Heredity
Taher Mahmoud, Chaima Sahli, Sondess Hadj Fredj, Yessine Amri, Rim Othmani, Ghaber S. Mohamed, Ekhtelbenina Zein, Taieb Messaoud
Summary: This study aimed to analyze hemoglobinopathies in Mauritanian patients, and identified different gene mutations and haplotype types. The findings provide important insights for the establishment of strategies for prevention and management of hemoglobinopathies in this population.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2022)
Review
Cell Biology
Nikolai Jaschke, Andrew Wang, Lorenz C. Hofbauer, Martina Rauner, Tilman D. Rachner
Summary: As life expectancy continues to increase, there is a growing scientific interest in finding medical interventions to alleviate age-related pathologies. Testosterone replacement therapy (TRT) is seen by some as a potential solution for aging men, although its safety remains uncertain. Data from the animal kingdom highlights the plasticity of individual testosterone trajectories across the lifespan.
AGEING RESEARCH REVIEWS
(2021)
Article
Pathology
Ralph Huits, Anne-Marie Feyens, Niels Lonneville, Xavier Peyrassol, Anne-Sophie Adam, Beatrice Gulbis, Marjan Van Esbroeck
Summary: This article reports on a Pashtun family affected by haemoglobin D-Punjab/beta+-thalassemia, aiming to increase the awareness of primary care physicians about the increasing prevalence of haemoglobinopathies. The diagnostic approach to these conditions and the benefits of genetic counselling are highlighted.
JOURNAL OF CLINICAL PATHOLOGY
(2022)
Review
Medicine, General & Internal
Francesca Polverino, Farrah Kheradmand
Summary: SARS-CoV-2, the virus causing COVID-19, tends to affect older patients with pre-existing cardiovascular conditions and COPD more severely, potentially leading to ARDS. COVID-19 may represent the ultimate cause of AECOPD, with further research exploring its pathobiological processes, epidemiological data, and therapeutic targets.
FRONTIERS IN MEDICINE
(2021)
Article
Education & Educational Research
Shehla R. R. Arifeen
Summary: This study examines the online learning experiences of 22 undergraduate business students in Pakistan during the COVID-19 lockdown. It reveals that online learning is a multi-level phenomenon influenced by the environment. The study highlights the interaction between the Community of Inquiry framework and the context, providing insights into the individual's interaction with the broader environment. The findings contribute to a better understanding of online learning and demonstrate the importance of considering the macro and meso levels in addition to the micro level.
EDUCATION AND INFORMATION TECHNOLOGIES
(2023)
Article
Medicine, General & Internal
Thunwarat Suriyun, Pranee Winichagoon, Suthat Fucharoen, Orapan Sripichai
Summary: This study investigated the characteristics of erythroid maturation in patients with β(0)-thalassemia/HbE and found delayed maturation and impaired mitochondrial clearance. The study also revealed increased transcript levels of BNIP3L and PINK1, genes related to erythroid mitophagy, in erythroblasts of these patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Irene Gagliardi, Mariella Celico, Maria Rita Gamberini, Margherita Pontrelli, Monica Fortini, Aldo Carnevale, Nicola Napoli, Maria Chiara Zatelli, Maria Rosaria Ambrosio
Summary: This study retrospectively evaluated the efficacy and safety of teriparatide (TP) in the treatment of TM-associated osteoporosis in real-life clinical practice. The results showed that TP significantly improved bone mineral density, especially at the lumbar spine, and prevented fractures. However, some patients experienced side effects such as muscle and bone pain.
CALCIFIED TISSUE INTERNATIONAL
(2022)
Article
Pharmacology & Pharmacy
Xinyu Li, Shuting Hu, Yong Liu, Junjiu Huang, Weicong Hong, Luhong Xu, Honggui Xu, Jianpei Fang
Summary: The study found that a dose of thalidomide between 2.5 mg·kg(-1)·d(-1) and 3.6 mg·kg(-1)·d(-1) is effective in children with TDT, with severe side effects being uncommon. The HbF concentration of 47.298 g·L-1 in the third month of treatment is recommended as the predictor for further major responders.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Dermatology
D. Li, E. Ryu, A. H. Saeidian, L. Youssefian, E. Oliphant, S. F. Terry, P. L. Tong, J. Uitto, N. K. Haass, Q. Li
Summary: Pseudoxanthoma elasticum (PXE) is a multisystem disorder characterized by ectopic mineralization of connective tissues, typically caused by mutations in the ABCC6 gene. Cutis laxa (CL) presents with loose and sagging skin. Mutations in the GGCX gene were found to be associated with overlapping PXE/CL skin phenotypes.
BRITISH JOURNAL OF DERMATOLOGY
(2021)