Article
Oncology
Ruolan Zhang, Can Hu, Jiaqing Zhang, Yanqiang Zhang, Li Yuan, Pengcheng Yu, Yi Wang, Zhehan Bao, Mengxuan Cao, Rongwei Ruan, Xiangdong Cheng, Zhiyuan Xu
Summary: This study analyzed the significance of inflammatory and nutritional marker alterations during neoadjuvant chemotherapy in long-term prognosis of advanced gastric cancer patients. The results showed that several biomarkers changed during NACT and were associated with overall survival. PLR (alpha) may be a reliable marker for predicting prognosis.
Article
Environmental Sciences
Sunil Sharma, Owias Iqbal Dar, Kirpal Singh, Sharad Thakur, Anup Kumar Kesavan, Arvinder Kaur
Summary: This study found that Triclosan has significant toxicity to hatchlings of Labeo rohita, inducing alterations in antioxidant/detoxification, metabolic, and neurological genes as well as DNA damage. Principal component analysis identified OTM, TL, TM, TDNA, SOD, and GR as biomarkers for Triclosan toxicity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Oncology
Tiuri E. Kroese, Hanneke W. M. Van Laarhoven, Magnus Nilsson, Florian Lordick, Matthias Guckenberger, Jelle P. Ruurda, Domenico D'Ugo, Karin Haustermans, Eric Van Cutsem, Richard Van Hillegersberg, Peter S. N. Van Rossum
Summary: Local treatment may improve overall survival in patients with esophagogastric cancer and oligometastatic disease (OMD). The current literature defines OMD as the presence of metastases limited to one organ with no more than three lesions and the presence of an extra-regional lymph node station. Local treatment appears to be associated with improved OS compared to systemic therapy alone.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Medicine, Research & Experimental
Dong Li, Yi Yin, Muqun He, Jianfeng Wang
Summary: The study identified 119 DEGs associated with the prognosis of GC patients, with 21 upregulated genes mainly enriched in extracellular matrix-receptor interaction pathways and 98 downregulated genes linked to processes like gastric acid secretion. Of the 30 hub DEGs, 25 were significantly associated with GC prognosis, with 21 showing consistent expression trends.
MEDICAL SCIENCE MONITOR
(2021)
Article
Biochemistry & Molecular Biology
Goro Terai, Kiyoshi Asai
Summary: This paper proposes a method for extracting secondary structure features that affect the functional activity of RNA from sequence-activity data. The method is applied to different experimental systems and provides detailed insights into the structure-activity relationships of RNA.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Oncology
Hannah C. Puhr, Thorsten J. Reiter, Mohamed El-Mahrouk, Lena Saliternig, Peter Wolf, Maximilian J. Mair, Ariane Steindl, Matthias Paireder, Reza Asari, Sebastian F. Schoppmann, Anna S. Berghoff, Matthias Preusser, Ayseguel Ilhan-Mutlu
Summary: Thyroid hormones and their therapeutic interventions may be associated with the overall survival in patients with resectable gastroesophageal cancer. There is a tendency towards prolonged survival in hypothyroid patients and a significant positive correlation of thyroid hormone replacement therapy with the overall survival. The study suggests that thyroid disorders and their therapeutic interventions could serve as potential prognostic tools, warranting further prospective analyses.
Review
Oncology
Nour M. Darwish, Mooza Kh. Al-Hail, Youssef Mohamed, Rafif Al Saady, Sara Mohsen, Amna Zar, Layla Al-Mansoori, Shona Pedersen
Summary: Apolipoproteins (APOs) are important components in blood responsible for fat management. Recent discoveries suggest a potential link between APOs and various cancers, though the specific role of certain APOs remains unknown. This review summarizes evidence supporting the involvement of APOs in cancer onset and explores the potential clinical significance of inhibiting APOs.
Review
Nanoscience & Nanotechnology
Joshua J. Rennick, Angus P. R. Johnston, Robert G. Parton
Summary: Endocytosis is crucial for the cellular uptake of therapeutic nanomedicines, but current understanding and study of these mechanisms are limited. The use of nonspecific inhibitors presents challenges, and alternative genetic approaches may offer more robust insights into endocytic pathways. Future studies at the intersection of cell biology and nanomedicine are needed to improve nanoparticle therapies.
NATURE NANOTECHNOLOGY
(2021)
Article
Oncology
Tianshu Liu, Yuxian Bai, Xiaoyan Lin, Wei Li, Jufeng Wang, Xiaochun Zhang, Hongming Pan, Chunmei Bai, Li Bai, Ying Cheng, Jingdong Zhang, Haijun Zhong, Yi Ba, Wenwei Hu, Ruihua Xu, Weijian Guo, Shukui Qin, Nong Yang, Jianwei Lu, Kohei Shitara, Ming Lei, Mingshun Li, Nicole Bao, Tian Chen, Lin Shen
Summary: Chinese patients in the global CheckMate 649 study showed improved efficacy and safety with nivolumab plus chemotherapy as first-line treatment for GC/GEJC/EAC.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Rehabilitation
Flavia Belavenuto Rangon, Jessica da Silva, Almir Vieira Dibai-Filho, Rinaldo Roberto de Jesus Guirro, Elaine Caldeira de Oliveira Guirro
Summary: This study comprehensively evaluated the effects of complex physical therapy and multimodal approaches on lymphedema secondary to breast cancer. The findings suggest that complex physical therapy has favorable short-term and long-term effects in controlling lymphedema. Future research should aim to determine the specific effects of different therapeutic modalities in different time periods.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Medicine, Research & Experimental
Zexing Shan, Wentao Wang, Yilin Tong, Jianjun Zhang
Summary: This study investigated the gene expression and prognostic biomarkers in gastric cancer using multiple datasets. The validation results showed upregulated NID2, SPARC, and MFAP2 expression in gastric tumor tissues, which were significantly associated with poor outcomes. The risk score model, incorporating these three genes, could improve the predictive value for gastric cancer prognosis.
MEDICAL SCIENCE MONITOR
(2021)
Review
Genetics & Heredity
Sangjun Lee, Han-Kwang Yang, Hyuk-Joon Lee, Do Joong Park, Seong-Ho Kong, Sue K. Park
Summary: This study aimed to elucidate the biological mechanisms involved in gastric cancer (GC) development and identify candidate drug target genes. By conducting a systematic review of GWAS and applying various analysis methods, we identified genes associated with GC and revealed their regulatory relationships and related signaling pathways. The findings suggest that the PRKAA1 gene may be a potential target gene for drug development associated with GC.
FRONTIERS IN GENETICS
(2022)
Article
Multidisciplinary Sciences
Lijun Shi, Huihui Li, Xiaoyu Huang, Ze Shu, Jingna Li, Ligang Wang, Hua Yan, Lixian Wang
Summary: Understanding the molecular mechanisms of sow pregnancy development is crucial for genetic improvement of pig breeding traits and provides resources for biomedical research on human pregnancy diseases. However, there is a lack of transcriptome and metabolome data across different stages of sow pregnancy. In this study, we analyzed 84 RNA sequencing and 42 metabolome datasets from pig blood samples across six developmental stages. The findings revealed the sequence features, stage-specific molecules, expression patterns, regulatory mechanisms, and important pregnancy-related metabolites in both pigs and humans. These results are expected to contribute essential resources for pig breeding and biomedical research on human pregnancy diseases.
Review
Nutrition & Dietetics
Mijoo Choi, Jong-Yeup Kim, Hyun-Hi Kang, Eunju Park, Sung Ryul Shim
Summary: This systematic review and meta-analysis found that oral nutritional supplements (ONSs) can significantly reduce body weight loss after gastrectomy in patients with gastric cancer, and they are more effective in patients with lower nutritional intake.
Article
Oncology
Bum Jun Kim, Hee-Jung Jee, Sun Young Rha, Hye Sook Han, Min-Hee Ryu, Se Hoon Park, Jong Gwang Kim, Woo Kyun Bae, Keun-Wook Lee, Do-Youn Oh, Ji-Hye Byun, Dong Sook Kim, Young Ju Suh, Hyonggin An, Dae Young Zang
Summary: In patients with HER2-positive gastric or gastro-esophageal junction adenocarcinoma, second-line treatment with ramucirumab plus paclitaxel showed a significantly higher objective response rate compared to patients with HER2-negative disease. However, the increased response to treatment did not correlate with an improvement in overall survival (OS).
Article
Oncology
Hyun Cheol Chung, Victor C. Kok, Rebecca Cheng, Yanzhi Hsu, Mauro Orlando, Charles Fuchs, Jae Yong Cho
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2018)
Article
Oncology
Minkyu Jung, Min-Hee Ryu, Do Youn Oh, Myounghee Kang, Dae Young Zang, In Gyu Hwang, Keun-Wook Lee, Ki Hyang Kim, Byoung Yong Shim, Eun Kee Song, Sun Jin Sym, Hye Sook Han, Young Lee Park, Jin Soo Kim, Hyun Woo Lee, Moon Hee Lee, Dong-Hoe Koo, Hong Suk Song, Namsu Lee, Sung Hyun Yang, Dae Ro Choi, Young Seon Hong, Kyoung Eun Lee, Chi Hoon Maeng, Jin Ho Baek, Samyong Kim, Yeul Hong Kim, Sun Young Rha, Jae Yong Cho, Yoon-Koo Kang
Article
Multidisciplinary Sciences
Sang Cheul Oh, Bo Hwa Sohn, Jae-Ho Cheong, Sang-Bae Kim, Jae Eun Lee, Ki Cheong Park, Sang Ho Lee, Jong-Lyul Park, Yun-Yong Park, Hyun-Sung Lee, Hee-Jin Jang, Eun Sung Park, Sang-Cheol Kim, Jeonghoon Heo, In-Sun Chu, You-Jin Jang, Young-Jae Mok, WonKyung Jung, Baek-Hui Kim, Aeree Kim, Jae Yong Cho, Jae Yun Lim, Yuki Hayashi, Shumei Song, Elena Elimova, Jeannelyn S. Estralla, Jeffrey H. Lee, Manoop S. Bhutani, Yiling Lu, Wenbin Liu, Jeeyun Lee, Won Ki Kang, Sung Kim, Sung Hoon Noh, Gordon B. Mills, Seon-Young Kim, Jaffer A. Ajani, Ju-Seog Lee
NATURE COMMUNICATIONS
(2018)
Article
Respiratory System
Hye Jung Park, Heae Surng Park, Yoon Jin Cha, Sungsoo Lee, Hei-Cheul Jeung, Jae Yong Cho, Hyung Jung Kim, Min Kwang Byun
JOURNAL OF THORACIC DISEASE
(2018)
Article
Oncology
Keun-Wook Lee, Chi Hoon Maeng, Tae-You Kim, Dae Young Zang, Yeul Hong Kim, In Gyu Hwang, Sang Cheul Oh, Joo Seop Chung, Hong Suk Song, Jin Won Kim, Su Jin Jeong, Jae Yong Cho
Article
Oncology
Tae-Yong Kim, Hye Sook Han, Keun-Wook Lee, Dae Young Zang, Sun Young Rha, Young Lee Park, Jin-Soo Kim, Kyung-Hun Lee, Se Hoon Park, Eun-Kee Song, Soo-A Jung, NaMi Lee, Yeul Hong Kim, Jae Yong Cho, Yung-Jue Bang
Article
Oncology
Taroh Satoh, Yoon-Koo Kang, Yee Chao, Min-Hee Ryu, Ken Kato, Hyun Cheol Chung, Jen-Shi Chen, Kei Muro, Won Ki Kang, Kun-Huei Yeh, Takaki Yoshikawa, Sang Cheul Oh, Li-Yuan Bai, Takao Tamura, Keun-Wook Lee, Yasuo Hamamoto, Jong Gwang Kim, Keisho Chin, Do-Youn Oh, Keiko Minashi, Jae Yong Cho, Masahiro Tsuda, Mitsunobu Tanimoto, Li-Tzong Chen, Narikazu Boku
Article
Oncology
Li-Tzong Chen, Taroh Satoh, Min-Hee Ryu, Yee Chao, Ken Kato, Hyun Cheol Chung, Jen-Shi Chen, Kei Muro, Won Ki Kang, Kun-Huei Yeh, Takaki Yoshikawa, Sang Cheul Oh, Li-Yuan Bai, Takao Tamura, Keun-Wook Lee, Yasuo Hamamoto, Jong Gwang Kim, Keisho Chin, Do-Youn Oh, Keiko Minashi, Jae Yong Cho, Masahiro Tsuda, Hiroki Sameshima, Yoon-Koo Kang, Narikazu Boku
Article
Oncology
Jin Won Kim, Sae Won Han, Jae Yong Cho, Ik-Joo Chung, Jong Gwang Kim, Kyung Hee Lee, Keon Uk Park, Sun Kyung Baek, Sang Cheul Oh, Myung Ah Lee, Doyeun Oh, Byoungyong Shim, Joong Bae Ahn, Dongbok Shin, Jae Won Lee, Yeul Hong Kim
EUROPEAN JOURNAL OF CANCER
(2020)
Article
Oncology
Narikazu Boku, Taroh Satoh, Min-Hee Ryu, Yee Chao, Ken Kato, Hyun Cheol Chung, Jen-Shi Chen, Kei Muro, Won Ki Kang, Kun-Huei Yeh, Takaki Yoshikawa, Sang Cheul Oh, Li-Yuan Bai, Takao Tamura, Keun-Wook Lee, Yasuo Hamamoto, Jong Gwang Kim, Keisho Chin, Do-Youn Oh, Keiko Minashi, Jae Yong Cho, Masahiro Tsuda, Taihei Nishiyama, Li-Tzong Chen, Yoon-Koo Kang
Summary: The study confirmed the long-term efficacy of nivolumab in patients with advanced gastric cancer, showing a longer overall survival compared to placebo. Nivolumab also demonstrated potential benefits in the treatment beyond disease progression.
Article
Medicine, General & Internal
Boyeon Kim, Yoonjung Kim, Inho Park, Jae Yong Cho, Kyung-A Lee
Summary: Gastric cancer is a major global health concern, and the detection of molecular aberrations, such as fusions, through next-generation sequencing and cfDNA analysis, may provide valuable insights for personalized treatment strategies. The identification of an EGFR-SEPT14 fusion in a patient with gastric cancer highlights the potential for targeted therapies in similar cases, demonstrating the importance of cfDNA analysis in advancing precision medicine for advanced gastric cancer patients.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Article
Oncology
Boyeon Kim, Yoonjung Kim, Saeam Shin, Seung-Tae Lee, Jae Yong Cho, Kyung-A Lee
Summary: CRISPR-CPPC is a useful mutant enrichment tool for the sensitive detection of target mutation. When tested in patients with progressive disease, the diagnostic performance of CRISPR-CPPC assay is exceptionally better than that of any other currently available methods.
CANCER CELL INTERNATIONAL
(2022)
Article
Virology
Mohd Imran Khan, Mohammad Hassan Baig, Tanmoy Mondal, Mohammed Alorabi, Tanuj Sharma, Jae-June Dong, Jae Yong Cho
Summary: The novel SARS-CoV-2 variants from the B.1.617 lineage (kappa and delta) carry double mutations that enhance their binding capability to the human host receptor, while also affecting their binding with monoclonal antibodies. The study suggests that these double mutants might be the main contributors to the surge in COVID-19 cases.
Article
Oncology
Imran Khan, Mohammad Hassan Baig, Sadaf Mahfooz, Mohammad Azhar Imran, Mohd Imran Khan, Jae-June Dong, Jae Yong Cho, Mustafa Aziz Hatiboglu
Summary: Glioblastoma, the most aggressive form of brain tumor, has poor prognosis despite aggressive treatment strategies. The blood-brain barrier (BBB) hinders drug delivery to the tumor site, but nanomedicine strategies hold promise in enhancing drug permeability.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Roshan Vaid, Akram Mendez, Ketan Thombare, Rebeca Burgos-Panadero, Remy Robinot, Barbara F. Fonseca, Nikhil R. Gandasi, Johan Ringlander, Mohammad Hassan Baig, Jae-June Dong, Jae Yong Cho, Bjorn Reinius, Lisa A. Chakrabarti, Kristina Nystrom, Tanmoy Mondal
Summary: Research reveals that SARS-CoV-2 variants infection leads to the loss of m(6)A in cellular RNAs, accompanied by abnormal localization of METTL3. Furthermore, down-regulation of transcripts with m(6)A modification is observed postinfection. Inhibition of XPO1 restores METTL3 localization, m(6)A modification, and mRNA expression, as well as stress granule formation, resulting in reduced viral infection in vitro.