Article
Oncology
Matthew C. Hynes, Paul Nguyen, Patti A. Groome, Yuka Asai, Meaghan E. Mavor, Tara D. Baetz, Timothy P. Hanna
Summary: This study validates the effectiveness of the 8th edition TNM melanoma staging system (TNM8) using a large population-based database. The results show that TNM8 provides more even separation of stage subgroups and improves predictive ability compared to the 7th edition TNM (TNM7).
Article
Oncology
Huapyong Kang, Seung-seob Kim, Min Je Sung, Jung Hyun Jo, Hee Seung Lee, Moon Jae Chung, Jeong Youp Park, Seung Woo Park, Si Young Song, Mi-Suk Park, Seungmin Bang
Summary: The suitability of the 8th edition AJCC staging system for clinical staging of pancreatic cancer remains uncertain. This study validated the prognostic performance and suitability of the current staging system and found that it is not validated for clinical staging. Separate criteria more suitable for clinical staging should be considered.
Article
Surgery
Takatsugu Matsumoto, Takehiro Okabayashi, Kenta Sui, Jiro Kimura, Sojiro Morita, Jun Iwata, Tatsuo Iiyama, Keiichi Kubota, Yasuhiro Shimada
Summary: This study aimed to validate and improve the 8th edition of UICC staging system for pancreatic ductal adenocarcinoma. It found that the 8th edition provides a more even distribution among stages and better stage discriminations compared to the 7th edition. Additionally, in the 8th edition, subcategories within the pT2 category based on portal vein invasion status may allow for more precise patient prognostication.
LANGENBECKS ARCHIVES OF SURGERY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Christian K. Pedersen, Aparna S. Babu
Summary: Involvement of lymph nodes is critical for accurate tumor staging, management, and prognosis. Understanding of nodal nomenclature and anatomy is essential for every cross-sectional imaging study. This article reviewed the key changes in the American Joint Committee on Cancer 8th edition TNM classification for urogenital cancers.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2021)
Article
Oncology
Miaoquan Zhang, Chao Ding, Lin Xu, Biyi Ou, Shoucheng Feng, Guoqiang Wang, Wei Wang, Yao Liang, Yingbo Chen, Zhiwei Zhou, Haibo Qiu
Summary: By evaluating the prognostic value of lymph node ratio (LNR) and establishing a novel tumor-ratio-metastasis (TRM) staging system, the study demonstrated improved homogeneity and discriminatory ability in predicting the prognosis of gastric cancer patients compared with the AJCC TNM staging system.
FRONTIERS IN ONCOLOGY
(2021)
Review
Pathology
Diego F. Sanchez, Maria Jose Fernandez-Nestosa, Sofia Canete-Portillo, Ingrid Rodriguez, Antonio L. Cubilla
Summary: The TNM classification model has been a main resource for clinicians and public health professionals in the classification and management of malignant tumors, including penile cancer. Recent changes in the classification system reflect advancements in understanding the prognostic factors of penile cancer, but further studies are needed to improve the current classification.
ADVANCES IN ANATOMIC PATHOLOGY
(2021)
Article
Gastroenterology & Hepatology
Prakasit Sa-Ngiamwibool, Chaiwat Aphivatanasiri, Sakkarn Sangkhamanon, Piyapharom Intarawichian, Waritta Kunprom, Malinee Thanee, Piya Prajumwongs, Watcharin Loilome, Narong Khuntikeo, Attapol Titapun, Apiwat Jareanrat, Vasin Thanasukarn, Tharatip Srisuk, Vor Luvira, Kulyada Eurboonyanun, Julaluck Promsom, Aileen Wee, Supinda Koonmee
Summary: This study aimed to improve prognostic prediction and patient stratification for iCCA by creating the KKU staging system. The incorporation of growth patterns as independent prognostic factors and modification of AJCC stages in the KKU staging system resulted in better prediction of patient survival. The KKU staging system may serve as an alternative model for iCCA staging to enhance the accuracy of survival prognostication.
Article
Otorhinolaryngology
Giuseppe Mercante, Francesca Gaino, Caterina Giannitto, Fabio Ferreli, Armando De Virgilio, Ciro Franzese, Andrea Marrari, Luca Malvezzi, Giovanni Colombo, Marta Scorsetti, Giuseppe Spriano
Summary: This study highlighted the discrepancies between UICC and AJCC TNM classifications in oral cavity cancer, with the key update being the introduction of depth of infiltration which is associated with the proximity of the tumor to lymphovascular tissues and nodal metastases. Different versions of the TNM classification can be confusing for the scientific community, and clinicians and researchers are advised to always refer to the latest updates of each classification.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Elisa Dal Cin, Alberto Vito Marcuzzo, Ferruccio Degrassi, Tiziana Volo, Roberto Spinato, Doriano Politi, Vincenzo Capriotti, Paolo Boscolo-Rizzo, Giancarlo Tirelli
Summary: The agreement between pathological and radiological staging in oropharyngeal cancer was evaluated by comparing the 7th and 8th editions of the AJCC TNM system. The study included 57 cases of oropharyngeal cancer with lymph node metastases, and significant differences were found in the distribution of early and advanced stages between HPVpos and HPVneg patients in the 8th edition. However, no significant differences were found in comparing all diagnostic methods for T and N. The 8th edition of the AJCC TNM system seems to provide better pretreatment staging.
Article
Multidisciplinary Sciences
Yu Liang, Xingxiang Huang, Zhe Song, Yang Yang, Ju Lei, Mei Ren, Li Tan, Hui Zhang
Summary: Ultrasound has good consistency and high accuracy in assessing the T-stage of differentiated thyroid carcinoma (DTC). However, it shows poor consistency and accuracy in N-staging. It can be used as a reference for reducing excessive surgical treatment of DTC.
Article
Otorhinolaryngology
Jos M. J. A. A. Straetmans, Marijn Stuut, Martin Lacko, Frank Hoebers, Ernst-Jan M. Speel, Bernd Kremer
Summary: This study found that the 8th edition UICC TNM classification was more accurate in predicting prognosis for HPV-positive TSCCs compared to the 7th edition. Smoking status was also found to be a more significant prognostic factor than UICC staging. Age, cN3, and M1 classification were also important predictors of prognosis.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Oncology
Tao He, Ruo-Nan Yan, Hua-Ying Chen, Yuan-Yuan Zeng, Zhong-Zheng Xiang, Fang Liu, Bian-Fei Shao, Jia-Chun Ma, Xi-Ran Wang, Lei Liu
Summary: The 8th edition of the UICC/AJCC staging system has shown superior prognostic value in nonmetastatic nasopharyngeal carcinoma patients treated with SIB-IMRT compared to the 7th edition.
Article
Otorhinolaryngology
Beatriz Godoi Cavalheiro, Leandro Luongo de Matos, Ana Kober Nogueira Leite, Marco Aurelio Vamondes Kulcsar, Claudio Roberto Cernea, Luiz Paulo Kowalski
Summary: The study found that the initial risk stratification system (IRSS) is effective in predicting disease-free survival (DFS) but not overall survival (OS). The TNM 8th edition is more suitable for OS analysis compared to the TNM 7th edition and IRSS.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Endocrinology & Metabolism
Jingzhe Xiang, Zhihong Wang, Wei Sun, Hao Zhang
Summary: The study compared the impact of AJCC TNM-7 and TNM-8 on patients with ATC. It found that the TNM-8 T staging more effectively predicted survival, but the clinical stage remained almost unchanged. The new T classification is an effective predictor of survival for ATC patients, supporting the use of T definitions as per those of differentiated thyroid cancer.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Oncology
Taro Oshikiri, Hironobu Goto, Takashi Kato, Ryuichiro Sawada, Hitoshi Harada, Naoki Urakawa, Hiroshi Hasegawa, Shingo Kanaji, Kimihiro Yamashita, Takeru Matsuda, Yasuhiro Fujino, Masahiro Tominaga, Yoshihiro Kakeji
Summary: The study aims to provide a simpler and more precise predictive system after neoadjuvant chemotherapy by integrating the AJCC and Japanese systems.