Article
Nutrition & Dietetics
Hae Sou Kim, Joo Weon Lim, Hyeyoung Kim
Summary: In this study, it was found that Korean red ginseng extract (RGE) suppresses the expression of IL-8 and alleviates mitochondrial dysfunction in H. pylori-infected cells through the activation of Nrf2, induction of SOD-1 and HO-1, and reduction of ROS.
Article
Food Science & Technology
Aina Ichihara, Hinako Ojima, Kazuyoshi Gotoh, Osamu Matsushita, Susumu Take, Hiroyuki Okada, Akari Watanabe, Kenji Yokota
Summary: This study aimed to explore the association between different antibody reactivities and bacterial genome organization. High-reactive strains showed high gene homology, while inversion around the vacA gene was found in the genome of poorly responsive antigen strains.
Article
Microbiology
Manouchehr Ahmadi Hedayati, Delniya Khani, Farshad Sheikhesmaeili
Summary: This study investigated the expression of sirt3, 6, and 7 genes in patients with gastritis and gastric adenocarcinoma, and found significant correlations between H. pylori infection and increasing age with the expression levels of these genes.
CURRENT MICROBIOLOGY
(2022)
Article
Oncology
Li Wang, Juan Yi, Xiao-Yang Yin, Jin-Xia Hou, Jing Chen, Bei Xie, Gang Chen, Qun-Feng Wang, Li-Na Wang, Xiao-Yuan Wang, Jing Sun, Lei-Ming Huo, Tuan-Jie Che, Hu-Lai Wei
Summary: The study revealed that Helicobacter pylori's VacA induces autophagy in gastric epithelial cells and promotes mitophagy by damaging mitochondrial membrane potential, leading to PINK1 accumulation and Parkin recruitment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Sebastian Reuter, Jonas Raspe, Hendrik Uebner, Alexandros Contoyannis, Eva Pastille, Astrid M. Westendorf, Georgia C. Caso, Timothy L. Cover, Anne Mueller, Christian Taube
Summary: This study evaluated the therapeutic efficacy of Helicobacter pylori-derived VacA in allergic airway inflammation and found that VacA suppressed allergic airway inflammation by inducing regulatory T cells (Tregs). These findings suggest that the immunomodulatory activity of VacA could be potentially used for the prevention and treatment of allergic airway disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Ping Li, Tingxiu Peng, Tianxin Xang, Wanying Luo, Wenjian Liao, Dan-Dan Wei, Shuai Luo, Zhiyong He, Peng Liu, Wei Zhang, Yang Liu
Summary: This study found that outer membrane vesicles (OMVs) derived from Klebsiella pneumoniae play a crucial role in the interactions between microorganisms and host cells. Hypervirulent Klebsiella pneumoniae generates more OMVs than classical K. pneumoniae, and the average size of OMVs derived from hypervirulent K. pneumoniae is smaller than that of classical K. pneumoniae. Despite these differences, both hypervirulent K. pneumoniae-derived and classical K. pneumoniae-derived OMVs induce a similar level of expression of interleukin 8 (IL-8) mRNA and protein. OMVs secreted by Klebsiella pneumoniae stimulate the secretion of IL-8 by activating the nuclear factor NF-xB.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Jinglei Liu, Fangxu Zhang, Zheming Zhang, Chunning Zheng
Summary: This study found that Everolimus has a pharmacological role in protecting gastric epithelial cells from H.pylori-induced damage. It achieves this by reducing oxidative stress and inhibiting inflammatory response, as well as inhibiting the attachment of monocytes to epithelial cells.
Article
Oncology
Hyung-Suk Yoon, Xiao-Ou Shu, Hui Cai, Wei Zheng, Jie Wu, Wanqing Wen, Regina Courtney, Chris Shidal, Tim Waterboer, William J. Blot, Qiuyin Cai
Summary: This study found an association between Helicobacter pylori infection and lung cancer risk, which may be related to specific H. pylori antigens. The association between H. pylori infection and lung cancer risk may be more evident among African Americans and may be modified by smoking habits.
Article
Chemistry, Multidisciplinary
Yun Lu, Jing Pang, Genzhu Wang, Xinxin Hu, Xue Li, Guoqing Li, Xiukun Wang, Xinyi Yang, Congran Li, Xuefu You
Summary: Helicobacter pylori, a Gram-negative bacterium related to gastric diseases, can develop antibiotic resistance. Daphnetin, a traditional Chinese medicine, shows antibacterial activity without resistance. A proteomics study identified protein changes in H. pylori under daphnetin pressure.
Article
Cell Biology
Olga Sokolova, Gunter Maubach, Michael Naumann
Summary: Helicobacter pylori infection induces a strong inflammatory response in gastric mucosa and alters epithelial integrity and function. The activation of NF-κB transcription factors, specifically by the bacterial heptose metabolites, triggers this innate immune response. Our study reveals that the activation of ALPK1-dependent TIFA in H. pylori-infected gastric epithelial cells is followed by TIFA degradation, which is inhibited by proteasomal and lysosomal inhibitors. TRAF2, TRAF6, TAK1, or NEMO are not involved in TIFA degradation, and H. pylori promotes the interaction of TIFA with protein adaptors involved in lysosomal trafficking.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2023)
Article
Microbiology
Judit Alarcon-Millan, Jose Bonilla-Delgado, Gloria Fernandez-Tilapa, Nayeli Goreti Nieto-Velazquez, Monica Sierra-Martinez, Victor Manuel Alvarado-Castro, Enoc Mariano Cortes-Malagon
Summary: This study investigated the prevalence of clarithromycin resistance-associated mutations in Mexican patients infected with Helicobacter pylori. The results showed a high prevalence of H. pylori infection (84.3%) among patients with gastric diseases, with the vacA s1m1/cagA+ genotype being the most frequent (44.8%). The prevalence of clarithromycin resistance-associated mutations was 19.8%, with the A2143G and A2142C mutations being the most common. Furthermore, a significant association was found between the A2142G mutation and the vacA s1m1/cagA+ genotype.
Article
Microbiology
Ami Y. Seeger, Faisal Zaidi, Sammy Alhayek, Rachel M. Jones, Huzaifa Zohair, Robin L. Holland, Ik-Jung Kim, Steven R. Blanke
Summary: The study shows that cells can recover and survive from Helicobacter pylori vacuolating cytotoxin A (VacA)-induced mitochondrial dysfunction by modulating mitochondrial dynamics. These findings provide new insights into cellular responses to intracellular-acting toxins and may have implications for understanding the virulence strategies of pathogenic microorganisms and viruses that target mitochondria.
Article
Multidisciplinary Sciences
L. S. Tran, L. Ying, K. D'Costa, G. Wray-McCann, G. Kerr, L. Le, C. C. Allison, J. Ferrand, H. Chaudhry, J. Emery, A. De Paoli, N. Colon, S. Creed, M. Kaparakis-Liaskos, J. Como, J. K. Dowling, P. A. Johanesen, T. A. Kufer, J. S. Pedersen, A. Mansell, D. J. Philpott, K. D. Elgass, H. E. Abud, U. Nachbur, B. A. Croker, S. L. Masters, R. L. Ferrero
Summary: In mice, NOD1 regulates IL-18 processing in epithelial cells in response to Helicobacter pylori infection via a noncanonical NOD1/caspase-1 pathway. This pathway helps maintain epithelial homeostasis and protects against pre-neoplastic changes induced by the infection.
NATURE COMMUNICATIONS
(2023)
Review
Physiology
Akriti Prashar, Mariana Capurro, Nicola L. Jones
Summary: This article discusses how Helicobacter pylori overcomes gastric epithelial host defense responses to promote its long-term survival and establish a chronic infection through the secretion of virulence factors, immune evasion, and manipulation of cellular mechanisms.
ANNUAL REVIEW OF PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Tohid Piri-Gharaghie, Ghazal Ghajari, Shakiba Tolou-Shikhzadeh-Yazdi, Mona Aghassizadeh-Sherbaf, Sahar Khorsand-Dehkordi
Summary: Despite being a serious pathogen, the origin of Helicobacter pylori (H. pylori) remains unknown. Poultry, such as chicken and turkey, is widely consumed as a source of protein worldwide, making it important to ensure sanitary practices in poultry delivery for food. This study examined the distribution of pathogenicity and antimicrobial resistance in H. pylori isolates from poultry meat. The findings highlight the presence of H. pylori in raw poultry samples and the prevalence of antibiotic-resistant genotypes, raising concerns about public health risks associated with consuming raw poultry.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Hirokazu Yura, Noriho Sakamoto, Minoru Satoh, Hiroshi Ishimoto, Tetsuya Hanaka, Chiyo Ito, Tomoko Hasegawa, Shin Tanaka, Takuto Miyamura, Shota Nakashima, Atsuko Hara, Tomoyuki Kakugawa, Keishi Oda, Takashi Kido, Yasushi Obase, Yuji Ishimatsu, Kazuhiro Yatera, Atsushi Kawakami, Hiroshi Mukae
RESPIRATORY MEDICINE
(2017)
Article
Medicine, General & Internal
Noriho Sakamoto, Shota Nakashima, Hiroshi Ishimoto, Tomoyuki Kakugawa, Atsuko Hara, Hirokazu Yura, Takuto Miyamura, Seiko Nakamichi, Yasushi Obase, Yuji Ishimatsu, Hiroshi Mukae
Article
Respiratory System
Noriho Sakamoto, Hiroshi Ishimoto, Tomoyuki Kakugawa, Minoru Satoh, Tomoko Hasegawa, Shin Tanaka, Atsuko Hara, Shota Nakashima, Hirokazu Yura, Takuto Miyamura, Hanako Koyama, Towako Morita, Seiko Nakamichi, Yasushi Obase, Yuji Ishimatsu, Hiroshi Mukae
BMC PULMONARY MEDICINE
(2018)
Article
Medicine, General & Internal
Noriho Sakamoto, Hiroshi Ishimoto, Shota Nakashima, Hirokazu Yura, Takuto Miyamura, Daisuke Okuno, Atsuko Hara, Takeshi Kitazaki, Tomoyuki Kakugawa, Yuji Ishimatsu, Minoru Satoh, Hiroshi Mukae
Review
Medicine, General & Internal
Fumiko Hayashi, Takashi Kido, Noriho Sakamoto, Yoshiaki Zaizen, Mutsumi Ozasa, Mitsuru Yokoyama, Hirokazu Yura, Atsuko Hara, Hiroshi Ishimoto, Hiroyuki Yamaguchi, Taiga Miyazaki, Yasushi Obase, Yuji Ishimatsu, Yoshinobu Eishi, Junya Fukuoka, Hiroshi Mukae
MEDICINA-LITHUANIA
(2020)
Editorial Material
Medicine, General & Internal
Y. Saishoji, Y. Izumi, Y. Otsuka, H. Yura
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2022)
Article
Respiratory System
Hiroshi Ishimoto, Noriho Sakamoto, Hirokazu Yura, Atsuko Hara, Takashi Kido, Hiroyuki Yamaguchi, Kazuko Yamamoto, Yasushi Obase, Yuji Ishimatsu, Minoru Satoh, Hiroshi Mukae
Summary: This article presents a case of exacerbation of respiratory failure in a patient diagnosed with anti-ARS antibody-positive interstitial pneumonia due to treatment with steroids and immunosuppressive agents. Further examination revealed misdiagnosis of this patient and a subsequent diagnosis of autoimmune pulmonary alveolar proteinosis. Therefore, physicians should reconsider the diagnosis and include pulmonary alveolar proteinosis in the differential diagnosis when interstitial pneumonia worsens with immunosuppressive treatment.
BMC PULMONARY MEDICINE
(2022)
Article
Multidisciplinary Sciences
Masahiro Tahara, Noriho Sakamoto, Minoru Satoh, Hiroshi Ishimoto, Hirokazu Yura, Kei Yamasaki, Takashi Kido, Yoshihisa Fujino, Tomoko Hasegawa, Shin Tanaka, Kazuhiro Yatera, Hiroshi Mukae
Summary: Antibodies to Ro52, known as anti-Ro52, are commonly found in patients with idiopathic interstitial pneumonias (IIPs), and they are often present alongside other autoantibodies. Patients with anti-Ro52 have a higher likelihood of meeting the criteria for interstitial pneumonia with autoimmune features (IPAF), and they also frequently exhibit serological abnormalities and Raynaud's phenomenon.
SCIENTIFIC REPORTS
(2022)
Review
Medicine, General & Internal
Mayako Mori, Takashi Kido, Noriho Sakamoto, Mutsumi Ozasa, Kumiko Kido, Yasuko Noguchi, Takatomo Tokito, Daisuke Okuno, Hirokazu Yura, Atsuko Hara, Hiroshi Ishimoto, Takashi Suematsu, Yasushi Obase, Yoshimasa Tanaka, Koichi Izumikawa, Kazuhiko Takeuchi, Hiroshi Mukae
Summary: A case study was conducted on a 39-year-old Japanese woman diagnosed with primary ciliary dyskinesia (PCD). The study found that the patient had moderate deterioration of cilia function and a reduced number of respiratory cells with moving cilia. Whole-exome analysis identified novel biallelic variants of the SPEF2 gene in the patient. Fluorescent immunostaining confirmed the absence of SPEF2 protein expression in the cilia of the nasal mucosa.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Virology
Takatomo Tokito, Takashi Kido, Keiji Muramatsu, Kei Tokutsu, Daisuke Okuno, Hirokazu Yura, Shinnosuke Takemoto, Hiroshi Ishimoto, Takahiro Takazono, Noriho Sakamoto, Yasushi Obase, Yuji Ishimatsu, Yoshihisa Fujino, Kazuhiro Yatera, Kiyohide Fushimi, Shinya Matsuda, Hiroshi Mukae
Summary: The potential antimicrobial and anti-inflammatory effectiveness of azithromycin against severe influenza is yet unclear. In this retrospective study, the effect of intravenous azithromycin administration within 7 days of hospitalization in patients with influenza virus pneumonia and respiratory failure was investigated. The results showed that in the severe group, the 30-day mortality rate was significantly lower with azithromycin.
Article
Microbiology
Satoru Koga, Takahiro Takazono, Takashi Kido, Keiji Muramatsu, Kei Tokutsu, Takatomo Tokito, Daisuke Okuno, Yuya Ito, Hirokazu Yura, Kazuaki Takeda, Naoki Iwanaga, Hiroshi Ishimoto, Noriho Sakamoto, Kazuhiro Yatera, Koichi Izumikawa, Katsunori Yanagihara, Yoshihisa Fujino, Kiyohide Fushimi, Shinya Matsuda, Hiroshi Mukae
Summary: Studies showed potential harm from empirical broad-spectrum therapy, especially in the treatment of hospitalizations for community-acquired pneumonia. However, empirical anti-MRSA therapy for older patients with aspiration pneumonia lacks sufficient evidence and may not improve outcomes.
Article
Medicine, General & Internal
Noriho Sakamoto, Shintaro Hara, Hiroshi Ishimoto, Shota Nakashima, Hirokazu Yura, Takuto Miyamura, Daisuke Okuno, Atsuko Hara, Tomoyuki Kakugawa, Hiroyuki Yamaguchi, Yasushi Obase, Hisako Kushima, Hiroshi Ishii, Shingo Noguchi, Takashi Kido, Tsutomu Kobayashi, Yoshifumi Soejima, Sumako Yoshioka, Yuji Ishimatsu, Kazuhiro Yatera, Jun-ichi Kadota, Hiroshi Mukae
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
(2019)
Article
Respiratory System
Takuto Miyamura, Noriho Sakamoto, Tomoyuki Kakugawa, Daisuke Okuno, Hirokazu Yura, Shota Nakashima, Hiroshi Ishimoto, Takashi Kido, Daisuke Taniguchi, Takuro Miyazaki, Tomoshi Tsuchiya, Shin Tsutsui, Hiroyuki Yamaguchi, Yasushi Obase, Yuji Ishimatsu, Kazuto Ashizawa, Takeshi Nagayasu, Hiroshi Mukae
RESPIRATORY RESEARCH
(2019)
Article
Respiratory System
Tomoyuki Kakugawa, Noriho Sakamoto, Shuntaro Sato, Hirokazu Yura, Tatsuhiko Harada, Shota Nakashima, Atsuko Hara, Keishi Oda, Hiroshi Ishimoto, Kazuhiro Yatera, Yuji Ishimatsu, Yasushi Obase, Shigeru Kohno, Hiroshi Mukae
RESPIRATORY RESEARCH
(2016)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)