Article
Cell Biology
Pei Qu, Zhiang Shao, Yanan Zhang, Jinpeng He, Dong Lu, Wenjun Wei, Junrui Hua, Wei Wang, Jufang Wang, Nan Ding
Summary: This study uncovers the specific role of primary cilia in restricting DNA damage induced by RCM through TGF-beta 1 signaling, providing a functional link between primary cilia and radiation-induced bystander effects.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mateusz Smolarz, Lukasz Skoczylas, Marta Gawin, Monika Krzyzowska, Monika Pietrowska, Piotr Widlak
Summary: Exosomes released by irradiated cells mediate the radiation-induced bystander effect, resulting in DNA breaks and replication stress in recipient cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biology
Ziqi Zhang, Kui Li, Mei Hong
Summary: Microbeams are useful tools for studying non-target effects and responses to cytoplasmic irradiation. This article summarizes the observations and mechanisms involved in bystander effects and cytoplasmic irradiation-related effects using different types of microbeam irradiators. These non-target effects may contribute to the biological consequences of ionizing radiation exposure, and understanding them can help better evaluate the damage caused by irradiation.
Article
Engineering, Environmental
Ivana Tartaro Bujak, Marijana Pocrnic, Karlo Blaz, Krunoslav Bojanic, Polonca Trebs, Albert T. Lebedev, Nives Galic
Summary: This study reports the radiation-induced degradation of DOX in aqueous solution. The removal of 10 mg L-1 DOX reached almost 100 % at irradiation doses of 200 Gy. The effects of pH, various inorganic ions and water matrix on DOX degradation were also studied. Toxicity tests showed higher toxicity of samples irradiated at 500 Gy.
JOURNAL OF WATER PROCESS ENGINEERING
(2023)
Review
Biotechnology & Applied Microbiology
Safura Jokar, Ines A. Marques, Saeedeh Khazaei, Tania Martins-Marques, Henrique Girao, Mafalda Laranjo, Maria Filomena Botelho
Summary: Radiation therapy is commonly used for the treatment of various cancers, but it has challenges such as non-targeted effects and radioresistance. Recent studies have shown that radiation-derived extracellular vesicles, particularly exosomes, play a crucial role in intercellular communications and may contribute to radioresistance and non-targeted effects. Understanding these intercellular signals could lead to promising strategies for radiation risk assessment and the development of novel radiotherapy approaches.
BIOENGINEERING-BASEL
(2022)
Article
Plant Sciences
Savita Verma, Ajaswrata Dutta, Akshu Dahiya, Namita Kalra
Summary: The study found that Quercetin-3-Rutinoside (Q-3-R) can protect against radiation-induced lung injury by regulating NF-Kappa B/TGF-beta 1 signaling pathway, scavenging free radicals, preventing perivascular infiltration, and prolonged inflammatory cascade. This may have potential therapeutic effects on lung damage caused by planned or unplanned radiation exposure.
Review
Biochemistry & Molecular Biology
Bimal Prasad Jit, Biswajita Pradhan, Rutumbara Dash, Prajna Paramita Bhuyan, Chhandashree Behera, Rajendra Kumar Behera, Ashok Sharma, Miguel Alcaraz, Mrutyunjay Jena
Summary: Ionizing radiation causes extensive damage to biological systems, including inflammation, fibrosis, and atrophy. Phytochemicals derived from plants with potent antioxidant activities can efficiently target multiple signaling pathways and have potential roles in altering radiation response.
Article
Cell Biology
Jianghong Zhang, Yuhong Zhang, Fang Mo, Gaurang Patel, Karl Butterworth, Chunlin Shao, Kevin M. Prise
Summary: The study revealed that radiation-induced bystander effects significantly impact the radiation damage of hypoxic tumor cells, with irradiated hepatoma and glioblastoma cells showing reduced radiosensitivity under hypoxia by increasing HIF-1 alpha expression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biology
Xuejiao Yang, Linlin Ma, Zhujing Ye, Wenyu Shi, Liyuan Zhang, Jingdong Wang, Hongying Yang
Summary: Radiotherapy is an effective treatment for brain cancer, but it can cause long-term side effects, such as radiation-induced cognitive impairment (RICI). This study investigates whether radiation-induced bystander effects (RIBEs) contribute to RICI. The results suggest that RIBEs mediated by exosomes from irradiated cancer cells may play a role in RICI.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2021)
Review
Biology
Yuri E. Dubrova, Elena I. Sarapultseva
Summary: Parental exposure to radiation not only leads to mutation induction in the germline of irradiated animals but also affects their non-exposed offspring. Laboratory studies have shown compromised viability, fertility, and genome stability among the non-exposed offspring of irradiated parents. The epigenetic phenomenon of radiation-induced transgenerational effects has been established, but further research is needed to understand its manifestation in populations inhabiting radioactive-contaminated areas and the underlying mechanisms.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2022)
Article
Biology
Serkan Karacetin, Meryem Akpolat, Zehra Safi Oz, Ayse Ceylan Hamamcioglu
Summary: The study aimed to evaluate the effects of L-carnitine on radiation-induced uterine injury. Results showed that L-carnitine therapy partially blocked the depletion of glands and flattening of glandular epithelium and endometrial surface caused by radiation. Proinflammatory cytokines were significantly expressed in the uterus tissue of irradiated mice. The expressions of NF kappa B and PARP-1 were significantly increased in the radiation group compared to the L-carnitine-treated and control groups. The oxidative stress index increased in the radiation group but decreased in the L-carnitine group.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mars G. Sharapov, Olga Glushkova, Svetlana B. Parfenyuk, Sergey Gudkov, Sergey M. Lunin, Elena G. Novoselova
Summary: The radioprotective effect of Prdx6 and Prdx6-C47S may be mediated through the TLR4/NF-kappa B signaling pathway, which contributes to the antiapoptotic effect through interaction with the TLR4 receptor. Exogenously applied Prdx6 protected cells against radiation by stimulating proliferation, reducing reactive oxygen species, and suppressing apoptosis and necrosis. The findings suggest that Prdx6 could be used as a safe radioprotective compound with antioxidant and immunomodulatory properties.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Engineering, Biomedical
Paul Cahoon, Valentina Giacometti, Francis Casey, Emily Russell, Conor McGarry, Kevin M. Prise, Stephen J. McMahon
Summary: Radiation induced bystander effects (RIBEs) can lead to cell death even with little or no physical dose, which becomes more important in heterogeneous fields. Mathematical modeling can be used to study these effects, considering both direct and indirect radiation effects. Experimental results suggest that spatially fractionated radiotherapy plans may have advantages over conventional uniform plans in terms of cell survival, contrary to the traditional paradigm in radiotherapy.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xue-Wei Guo, Hao Zhang, Jia-Qi Huang, Si-Nian Wang, Yan Lu, Bo Cheng, Su-He Dong, Ying-Ying Wang, Feng-Sheng Li, Yong-Wang Li
Summary: The study demonstrated that PIEZO1 plays a crucial role in modulating ferroptosis in pulmonary endothelial cells after ionizing radiation, by increasing calcium influx and calpain activity thus promoting lung injury. Inhibition of PIEZO1 activity or Ca2+/calpain signaling could partially reverse the damage caused by radiation on lung endothelial cells.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Polymer Science
Joshua Moncada, Mark D. Dadmun
Summary: This study investigates the changes in polymer structure after exposure to ionizing radiation using synchrotron x-rays. The results show that the ionizing radiation induces a reaction cascade that continues long after removal of the x-ray beam, and the reaction rate is controlled by the exposure time. These findings provide insights into the stability of conjugated polymers in the presence of reactive diluents and ionizing radiation, and offer new possibilities for forming graft copolymers.
POLYMER DEGRADATION AND STABILITY
(2022)