Review
Biochemistry & Molecular Biology
Miranda Sin-Man Tsang, Tianheng Hou, Ben Chung-Lap Chan, Chun Kwok Wong
Summary: Over the past 20 years, advancements in understanding the immunological roles of pathogen recognition in innate immunity have shed light on the potential of NLR sensors in treating allergic diseases. Discoveries on NLR sensors in allergic diseases suggest that the pathogenesis of allergies may extend beyond the adaptive immune response, and research on therapy targeting NLR in murine models holds promise for the treatment of allergies in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Phuong Linh Nguyen, Jungsook Cho
Summary: Histamine and its receptors play important roles in cancer biology, promoting cancer development, growth, and metastasis through interactions with different HRs, and regulating immune cell infiltration with immunomodulatory function. Various HR ligands affect tumor progression in different cancer types, and HR subtype expression levels may serve as prognostic biomarkers in multiple cancers.
Review
Neurosciences
Lingyi Kong, Ewa Domarecka, Agnieszka J. Szczepek
Summary: This review summarizes the published research on the expression and functional roles of histamine receptors in the inner ear, highlighting potential research areas and gaps. All four types of histamine receptors have been identified in the mammalian inner ear. Histamine and its receptors may play a role in Meniere's disease, but the mechanism is not fully understood. The effects of histamine on hearing development are still unclear.
Article
Food Science & Technology
Fuqiang Liang, Yumeng Shi, Weiwei Cao, Jiayi Shi
Summary: This study elucidated the inhibition mechanism of apigenin against PPL and comprehensively revealed its anti-obesity molecular basis through network pharmacology. Apigenin inhibited PPL and regulated multiple key targets and pathways to exhibit its anti-obesity effects beyond PPL inhibition.
Article
Multidisciplinary Sciences
Thibaux Van der Stede, Laura Blancquaert, Flore Stassen, Inge Everaert, Ruud Van Thienen, Chris Vervaet, Lasse Gliemann, Ylva Hellsten, Wim Derave
Summary: Chronic blockade of histamine H-1/H-2 receptors impairs microvascular and mitochondrial adaptations to interval training in humans, leading to blunted functional adaptations in exercise capacity, glycemic control, and vascular function. This suggests that histamine H-1/H-2 receptors play a crucial role in the integrative exercise training response in humans, potentially affecting post-exercise muscle perfusion regulation.
Article
Multidisciplinary Sciences
Eyal Rozenfeld, Merav Tauber, Yair Ben-Chaim, Moshe Parnas
Summary: This study demonstrates that muscarinic receptors are regulated by membrane potential in vivo, impacting behavior, indicating the significant role of GPCR voltage dependence in neuronal coding and behavioral output.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Binod Aryal, Subash Dhakal, Bhanu Shrestha, Youngseok Lee
Summary: This study reveals the mechanism of amino acid sensing in Drosophila, which involves the activation of sweet and bitter taste receptors as well as ion receptors in different types of sensilla to stimulate sensory neurons and mediate attraction or aversion behaviors.
Review
Pharmacology & Pharmacy
Robert H. Lustig, David Collier, Christopher Kassotis, Troy A. Roepke, Min Ji Kim, Etienne Blanc, Robert Barouki, Amita Bansal, Matthew C. Cave, Saurabh Chatterjee, Mahua Choudhury, Michael Gilbertson, Dominique Lagadic-Gossmann, Sarah Howard, Lars Lind, Craig R. Tomlinson, Jan Vondracek, Jerrold J. Heindel
Summary: Obesity is a chronic, multifactorial condition characterized by excess body fat and its prevalence has been increasing globally. Genetic factors, viruses, insulin resistance, inflammation, gut microbiome, and circadian rhythms all contribute to the development and pathogenesis of obesity. Energy balance regulation relies on the interplay of various hormones and fat cell development is controlled by hormones and growth factors acting via a variety of receptors.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Clinical Neurology
Bin Li, Leilei Chang, Qian-Xing Zhuang
Summary: The central histaminergic system plays an important role in regulating anxiety. Histaminergic neurons in the hypothalamus directly project to the bed nucleus of the stria terminalis (BNST), a brain region involved in anxiety and stress. The presence of histamine receptors in the BNST suggests their involvement in anxiety modulation. Blocking histamine receptors in the BNST ameliorated anxiety symptoms, suggesting a potential therapeutic strategy for anxiety disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Neurosciences
Mario E. Guido, Natalia M. Monjes, Paula M. Wagner, Gabriela A. Salvador
Summary: Living organisms have developed a precise timekeeping system called circadian clocks to adapt to the 24-hour light/dark cycle and regulate cellular metabolism. The synthesis and degradation of glycerophospholipids (GPLs) are highly regulated processes across various cells and tissues, playing essential roles in cellular physiology.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ping Huang, Guangwei Chen, Weifeng Jin, Kunjun Mao, Haitong Wan, Yu He
Summary: This article summarizes the hallmarks and molecular mechanisms of PARP1-mediated cell death (also known as parthanatos) and its role in various diseases. Excessive or defective parthanatos is critical in pathological cell damage, making further understanding of its mechanisms important for the treatment of related conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Umeharu Ohto
Summary: Innate immunity is a crucial defense mechanism against microbial infections. Innate immune pattern recognition receptors (PRRs) play significant roles in detecting invading pathogens and activating the immune response. Cellular components and pathogen-associated molecular patterns (PAMPs) can trigger inflammatory responses and activate the immune system. Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) constitute a major family of intracellular PRRs and are involved in various diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Silvia Sgambellone, Laura Lucarini, Cecilia Lanzi, Emanuela Masini
Summary: Glaucoma is a neurodegenerative disease characterized by increased intraocular pressure (IOP), with histamine being a potential neuromodulatory target for future treatments. The progressive degeneration of retinal ganglionic cells (RGCs) in glaucoma is influenced by factors like IOP fluctuations, making histamine and its receptors significant in understanding and potentially treating the condition.
Review
Cell Biology
Yiting Zhou, Jing Zhang
Summary: This article reviews the role of neuronal activity in myelin regeneration and the related neural signaling pathways. It highlights that neuronal activity can stimulate the formation and regeneration of myelin, improve conduction speed and neural signal processing, maintain axonal integrity, and support axonal nutrition. However, myelin damage is common in various clinical diseases, and seeking ways to improve myelin regeneration is of great significance. Research has shown that controlling neuronal excitability may become a new intervention method for the clinical treatment of demyelinating diseases, with broad prospects in the precise regulation of neuronal activity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Molly Stanley, Britya Ghosh, Zachary F. Weiss, Jaime Christiaanse, Michael D. Gordon
Summary: Recent studies show that lactic acid can be attractive at ecologically relevant concentrations. It stimulates feeding by activating neurons through specific receptors, with distinct onset and removal phases. Different components of lactic acid are detected by two types of receptors to activate sensory neurons in physiologically distinct ways.
