Article
Neurosciences
Leon C. D. Smyth, Helen C. Murray, Madison Hill, Eve van Leeuwen, Blake Highet, Nicholas J. Magon, Mahyar Osanlouy, Sophie N. Mathiesen, Bruce Mockett, Malvindar K. Singh-Bains, Vanessa K. Morris, Andrew N. Clarkson, Maurice A. Curtis, Wickliffe C. Abraham, Stephanie M. Hughes, Richard L. M. Faull, Anthony J. Kettle, Mike Dragunow, Mark B. Hampton
Summary: This study found that neutrophil accumulation in Alzheimer's disease is associated with cognitive impairment. The oxidant-generating enzyme myeloperoxidase (MPO) expressed in neutrophils could be a potential therapeutic target for AD. Vascular changes may drive neutrophil adhesion and NETosis.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Honghui Wu, Xinchi Jiang, Yaosheng Li, Yunfei Dong, Juanjuan Zheng, Lu Li, Ying Li, Jinqiang Wang, Xianming Lin, Xiangnan Zhang, Tianyuan Zhang, Zhen Gu, Jianqing Gao
Summary: Blood-brain barrier dis-integrity is a characteristic of inflammatory encephalopathy, which allows brain-targeted drug delivery. In this study, neural stem cell membrane-derived bioresponsive vesicles (NSC-Lipo) were developed for inflamed BBB target delivery. By combining neural stem cell membranes with liposomes, functional ligands, particularly VLA-4, were incorporated into NSC-Lipo and granted the vesicles the ability to selectively target injured brain microvessel endothelial cells (BMECs) and cross the barrier. The released anti-inflammatory agent, metformin, reversed the inflammatory response of BMECs and restored BBB's integrity. Compared to metformin loaded bare liposomes, the bioresponsive vesicles significantly improved the survival rate of ischemic stroke mice from 30% to 90% after a single injection.
Article
Immunology
Eliza Gil, Cristina Venturini, David Stirling, Carolin Turner, Liku B. Tezera, Giuseppe Ercoli, Tina Baker, Katharine Best, Jeremy S. Brown, Mahdad Noursadeghi
Summary: Excessive neutrophil extravasation can lead to immunopathology, but the mechanisms that amplify this process are not well understood. This study shows that human brain vascular pericytes (HBVP) contribute to neutrophil extravasation by enhancing endothelial barrier formation and promoting neutrophil transmigration. This process is mediated by paracrine signaling from monocyte derived macrophages, which upregulates the production of neutrophil chemokines by pericytes. Understanding the role of pericytes in amplifying neutrophil extravasation may provide new therapeutic targets for reducing neutrophil mediated pathology in pyogenic meningitis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sebastien Cadau, Manon Gault, Nicolas Berthelemy, Chiung-Yueh Hsu, Louis Danoux, Nicolas Pelletier, Dominique Goudouneche, Carole Pons, Corinne Leprince, Valerie Andre-Frei, Michel Simon, Sabine Pain
Summary: Atopic dermatitis is a common inflammatory skin disorder characterized by genetic predisposition, disruption of the epidermal barrier, immune reaction, and altered microbiome. In vitro models have been developed to mimic the pathophysiological features of atopic dermatitis, and a study found that a Castanea sativa extract can prevent the AD-like phenotype.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ning Xia, Solveig Hasselwander, Gisela Reifenberg, Alice Habermeier, Ellen I. Closs, Maximilian Mimmler, Rebecca Jung, Susanne Karbach, Jeremy Lagrange, Philip Wenzel, Andreas Daiber, Thomas Muenzel, Nadine Hoevelmeyer, Ari Waisman, Huige Li
Summary: The study provides evidence for the protective effect of B lymphocytes in maintaining vascular homeostasis under physiological conditions, indicating that the lack of B cells could lead to vascular dysfunction associated with an increased number of neutrophils. Neutrophil depletion in B cell-deficient mice resulted in the normalization of vascular function, highlighting the causal role of neutrophilia in this process.
Article
Oncology
Tingting Liu, Jiang Wang, Tao Li, Pengfei Cui, Baicun Hou, Chunxiao Zhuang, Ge Wei, Sujie Zhang, Hongxia Li, Yi Hu
Summary: The study found that NMPs and PMPs are associated with disease progression in advanced NSCLC. The predictive model established combining NMPs, PMPs, and NLR can screen out 80.8% of patients with progressive disease.
Article
Biochemistry & Molecular Biology
Katherine D. Connolly, D. Aled Rees, Philip E. James
Summary: Extracellular vesicles (EVs) are nanometre-sized vesicles released from most cells, including adipocytes. While relatively little is known about adipocyte-derived EVs (ADEVs) compared to other EV subtypes, interest in ADEVs as potential communicators in obesity is growing. Current evidence suggests that ADEVs may contribute to adipose tissue dysfunction and exacerbate cardiovascular disease in obesity.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Nigeste Carter, Allison H. Mathiesen, Noel Miller, Michael Brown, Ruben M. L. Colunga Biancatelli, John D. Catravas, Anca D. Dobrian
Summary: Cardiovascular disease is the leading cause of death for adults in the United States. The coronary endothelium plays a crucial role in the recovery of ischemic myocardium. Extracellular vesicles (EVs) produced by endothelial cells have the potential to impact tissue function. Inflammatory conditions can increase EV release and alter their cargo. EVs may compete with pro-angiogenic cues in the ischemic myocardium, slowing down the repair response.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Engineering, Biomedical
Katherine L. Lorentz, Prerak Gupta, Mostafa S. Shehabeldin, Eoghan M. Cunnane, Aneesh K. Ramaswamy, Konstantinos Verdelis, Morgan V. Dileo, Steven R. Little, Justin S. Weinbaum, Charles S. Sfeir, Biman B. Mandal, David A. Vorp
Summary: This study developed a functionalized silk scaffold capable of controlled delivery of a biological payload to improve in vivo performance. By loading microparticles that mimic cell function into the scaffold, improved performance of TEVGs was achieved. The acellular nature of this technology has the potential to reduce risk, increase reproducibility, and be more cost-effective compared to cell-based options.
ACTA BIOMATERIALIA
(2021)
Review
Biochemistry & Molecular Biology
Joanna Wessely-Szponder, Joanna Zdziennicka, Andrzej Junkuszew, Michal Latalski, Michal Swieca, Tomasz Szponder
Summary: This review outlines the functions, clinical applications, and future hopes associated with using autologous or heterologous products obtained from circulating neutrophils in regenerative medicine. It also describes the interactions between neutrophils and platelets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Pan Xu, Montserrat Elizalde, Ad Masclee, Marieke Pierik, Daisy Jonkers
Summary: This study demonstrates that prednisolone has a beneficial effect on the epithelial barrier of CD patient-derived intestinal organoids and can restore barrier dysfunction induced by cytokines.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Cell Biology
Ensieh Zahmatkesh, Mohammad Hossein Ghanian, Ibrahim Zarkesh, Zahra Farzaneh, Majid Halvaei, Zahra Heydari, Farideh Moeinvaziri, Amnah Othman, Marc Ruoss, Abbas Piryaei, Roberto Gramignoli, Saeed Yakhkeshi, Andreas Nussler, Mustapha Najimi, Hossein Baharvand, Massoud Vosough
Summary: Incorporating cell-sized tissue-specific microparticles (MPs) derived from liver extracellular matrix (ECM) into bioengineered liver organoids (BLOs) improved the maturation of human pluripotent stem cell-derived hepatocyte-like cells. This approach enhanced gene expression, function, CYP activities, albumin secretion, and xenobiotic metabolism of the hepatocyte-like cells. Furthermore, intraperitoneal transplantation of BLOs in a mouse model of acute liver injury increased survival rate, demonstrating the potential of this strategy for biomedical applications.
Article
Microbiology
Jose J. Rivera Rivas, Charles J. Czuprynski
Summary: Histophilus somni is a Gram-negative coccobacillus that causes diffuse vasculitis and intravascular thrombosis in cattle. Our study demonstrates that exposure to H. somni cells causes monocyte-derived macrophages to release microparticles with pro-coagulant activity, potentially amplifying thrombus formation.
VETERINARY MICROBIOLOGY
(2022)
Article
Medicine, Research & Experimental
Negin Farzamikia, Behzad Baradaran, Soroush Mostafavi, Elham Ahmadian, Seyed Mahdi Hosseiniyan Khatibi, Sepideh Zununi Vahed, Mohammadreza Ardalan
Summary: Microparticles are vesicles released into the extracellular environment derived from cell plasma membranes, facilitating intercellular communication through the transfer of various lipids, cytosolic proteins, RNA, and microRNAs. The progression of diseases can affect the composition and function of these cell-derived particles, with podocyte injury playing a significant role in the pathophysiology of various glomerular diseases including IgA nephropathy.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Jiayun Ying, Caiyan Zhang, Yaodong Wang, Tingyan Liu, Zhenhao Yu, Kexin Wang, Weiming Chen, Yufeng Zhou, Guoping Lu
Summary: This study suggests that elevated levels of plasma SDC1 are associated with poor prognosis in children with septic shock and sulodexide, a precursor for glycosaminoglycan synthesis, may have therapeutic potential for the treatment of sepsis-associated endothelial dysfunction.
FRONTIERS IN IMMUNOLOGY
(2023)
