Article
Biology
Duanzhi Wu, Xin Fang, Kai Luan, Qijin Xu, Shiqi Lin, Shiying Sun, Jiaying Yang, Bingying Dong, Balachandran Manavalan, Zhijun Liao
Summary: In this study, SH2 domain-containing proteins and non-SH2 domain-containing proteins were successfully identified using deep learning technology. The best performing 288-dimensional features were obtained. Additionally, a new motif, YKIR, in the SH2 domain was discovered and its function in signal transduction was analyzed.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Review
Immunology
Brandon L. Walling, Philip M. Murphy
Summary: The leukocyte nucleus needs to be elastic enough for migration, but not collapsible to damage chromatin. The composition of the nuclear lamina plays a crucial role in maintaining this balance and influencing leukocyte gene expression and differentiation.
TRENDS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Monika Zaborek-Lyczba, Jakub Lyczba, Paulina Mertowska, Sebastian Mertowski, Anna Hymos, Martyna Podgajna, Paulina Niedzwiedzka-Rystwej, Ewelina Grywalska
Summary: HLA-G, a non-classical MHC class I molecule, has been studied for its relevance in pathological conditions like autoimmune diseases. Current research aims to utilize HLA-G in clinical practice for diagnostics and therapeutic purposes, as it is known for its immunomodulatory role in reducing inflammation and immune responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Plant Sciences
Jiorgos Kourelis, Hiroaki Adachi
Summary: This review discusses the formation, activation, and regulation mechanisms of NLR networks in plants. These networks serve as the perception and signaling systems for pathogens, and are regulated at the transcriptional and post-transcriptional levels as well as by other host proteins. Pathogens, on the other hand, suppress NLR networks, promoting infection and disease.
PLANT AND CELL PHYSIOLOGY
(2022)
Article
Oncology
Emma Hajaj, Elad Zisman, Shay Tzaban, Sharon Merims, Jonathan Cohen, Shiri Klein, Shoshana Frankenburg, Moshe Sade-Feldman, Yuval Tabach, Keren Yizhak, Ami Navon, Polina Stepensky, Nir Hacohen, Tamar Peretz, Andre Veillette, Rotem Karni, Galit Eisenberg, Michal Lotem
Summary: Different splice isoforms of SLAMF6 play different roles in regulating T cell activation and immune responses, with the short isoform SLAMF6(Delta 17-65) having an agonistic effect. Researchers found that by modulating specific splice isoforms of SLAMF6, it is possible to enhance the anti-tumor capacity of tumor-infiltrating lymphocytes, suggesting a potential role in cancer immunotherapy.
CANCER IMMUNOLOGY RESEARCH
(2021)
Article
Oncology
Qian-Ming Xiang, Ni Jiang, Yue-Feng Liu, Yuan-Biao Wang, De-An Mu, Rong Liu, Lu-Yun Sun, Wei Zhang, Qiang Guo, Kai Li
Summary: Overexpression of SH2D1A promotes proliferation and migration of HCC cells via the Nf-kappa B signaling pathway and is related to the immune microenvironment in HCC.
Review
Microbiology
Xiu-Zhong Zhang, Fu-Huang Li, Xiao-Jia Wang
Summary: TRIM proteins play crucial roles in modulating antiviral immune responses, but viruses can evade host immune responses by antagonizing or utilizing TRIMs.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Chemistry, Medicinal
Sara Bobone, Luca Pannone, Barbara Biondi, Maja Solman, Elisabetta Flex, Viviana Claudia Canale, Paolo Calligari, Chiara De Faveri, Tommaso Gandini, Andrea Quercioli, Giuseppe Torini, Martina Venditti, Antonella Lauri, Giulia Fasano, Jelmer Hoeksma, Valerio Santucci, Giada Cattani, Alessio Bocedi, Giovanna Carpentieri, Valentina Tirelli, Massimo Sanchez, Cristina Peggion, Fernando Formaggio, Jeroen den Hertog, Simone Martinelli, Gianfranco Bocchinfuso, Marco Tartaglia, Lorenzo Stella
Summary: A new class of inhibitors targeting protein-protein interactions of the SHP2 phosphatase were developed, showing potential for cancer and rare disease therapy. These inhibitors exhibit high affinity and selectivity, with stronger affinity for pathogenic SHP2 mutants. The best peptide inhibitor demonstrated promising effects in zebrafish embryos, indicating a novel route for SHP2-targeted therapies and further research into protein-protein interactions in SHP2 function.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Medicine, Research & Experimental
Ziyao Wang, Chen Chen, Yingzhen Su, Nengwen Ke
Summary: TIM-4 is a phosphatidylserine receptor mainly expressed on antigen-presenting cells, involved in the recognition and engulfment of apoptotic cells. Recent studies have shown that TIM-4 is abnormally expressed in various malignant tumor cells and plays a crucial role in tumor occurrence, development, and immune microenvironment. This review provides a comprehensive understanding of the expression, functions, and potential implications of TIM-4 in various disease processes.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Immunology
Richard P. Sloan, Steve W. Cole
Summary: By studying 380 participants in the Midlife in the US study, researchers found that higher vagal activity was associated with reduced inflammation and increased Type I interferon response in human immune cells. This effect was independent of other factors such as beta-antagonists, BMI, smoking, heavy alcohol consumption, and demographic factors. These findings support the idea that parasympathetic nervous system can inhibit pro-inflammatory gene expression and enhance host defense against viral infections.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Cell Biology
Miao Li, Yan Yu
Summary: The discovery of receptor clustering on the surfaces of innate immune cells has shed light on the key role these clusters play in pathogen detection and immune response regulation. Despite being a relatively under-explored research topic, pioneering studies have highlighted the importance of understanding the functional role of receptor clustering in innate immune regulation.
JOURNAL OF CELL SCIENCE
(2021)
Article
Fisheries
Yu Liu, Weilin Wang, Qi Zhao, Pei Yuan, Jiaxin Li, Xiaorui Song, Zhaoqun Liu, Dewen Ding, Lingling Wang, Linsheng Song
Summary: DM9 domain containing protein (DM9CP) is a pattern recognition molecule found in most organisms except plants. A novel DM9-containing protein (CgDM9CP-3) was identified in Pacific oyster Crassostrea gigas, with high expression in gills and cytomembrane of haemocytes. CgDM9CP-3 can be significantly up-regulated after pathogen stimulations and has the ability to interact with various microorganisms.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Cell Biology
Yuji Kamioka, Yoshihiro Ueda, Naoyuki Kondo, Keizo Tokuhiro, Yoshiki Ikeda, Wolfgang Bergmeier, Tatsuo Kinashi
Summary: Bidirectional control of integrin activation plays crucial roles in cell adhesive behaviors. In this study, distinct bidirectional regulation of LFA1 and Or4137 in primary T cells was observed. Outside-in signaling from ICAM1-interacting LFA1 activated Rap1 GTPase and talin1, leading to increased capture and slowing. However, activated Rap1 severely suppressed adhesion of Or4137 on MAdCAM1 under shear flow.
Article
Genetics & Heredity
Hefei Ren, Chang Liu, Hongkun Wu, Zhenhua Wang, Sai Chen, Xiaomin Zhang, Jigang Ren, Huiying Qiu, Lin Zhou
Summary: This study demonstrates that m(5)C modification is involved in and contributes to the diversity and complexity of the immune microenvironment in multiple myeloma, offering promise for the development of accurate therapeutic strategies.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Zhencheng Zhu, Qingzhou Zhu, Dongping Cai, Liang Chen, Weixuan Xie, Yang Bai, Kunlun Luo
Summary: The study revealed that GOLPH3 promotes GBC cell proliferation through the NLRP3/Caspase-1 pathway, with their expression levels correlating with GBC growth and serving as potential therapeutic targets.
