Article
Immunology
Minghe Zhou, Zhengbiao Zha, Zhi Zheng, Youmin Pan
Summary: Cordycepin, derived from Cordyceps militaris, exhibits anti-inflammatory and anti-oxidative activities in thoracic aortic aneurysm (TAA) by inhibiting vascular endothelial growth factor (VEGF), reducing vascular damage, cell apoptosis, inflammation, and oxidative stress.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Qingxi Yue, Wen Zhang, Shumeng Lin, Tiansheng Zheng, Yaqin Hou, Yanfei Zhang, Ziye Li, Kai Wang, Liduo Yue, Baigenzhin Abay, Ming Li, Lihong Fan
Summary: This study found that Ejiao has a protective effect and can reduce inflammation and oxidative stress, decrease cell pyroptosis, and improve lung injury. This finding may have important implications for the prevention and treatment of acute lung injury.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Plant Sciences
Jae-Hun Ahn, Eun-Jung Song, Do-Hyeon Jung, Yeong-Jun Kim, In-Su Seo, Seong-Chan Park, You-Seok Jung, Eun-Seo Cho, Sang Hyun Mo, Jung Joo Hong, Jeong-Yong Cho, Jong-Hwan Park
Summary: The sesquiterpene lactone estafiatin derived from Artemisia scoparia was found to have anti-inflammatory effects on LPS-stimulated macrophages and protect mice from sepsis.
Article
Medicine, Research & Experimental
P. Vishnyakova, A. Poltavets, E. Karpulevich, A. Maznina, V. Vtorushina, L. Mikhaleva, E. Kananykhina, A. Lokhonina, S. Kovalchuk, A. Makarov, A. Elchaninov, G. Sukhikh, T. Fatkhudinov
Summary: Macrophages play a crucial role in innate immunity and are activated by various factors. This study found that macrophages derived from CD14+ monocytes exhibit higher sensitivity to pro-inflammatory induction, showing increased levels of pro-inflammatory and anti-inflammatory cytokines compared to CD16+-derived macrophages. This data may be valuable for macrophage-based cell therapy applications, providing insights for manipulating donor monocytes for transplantation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Hao Zuo, Yihong Wan
Summary: This study demonstrates the important roles of programmed death-ligand 1 (PD-L1) in bone cell differentiation and cancer bone metastasis. The results show that PD-L1 antibody or PD-L1 deletion suppresses osteoclast differentiation and reduces bone metastases in breast cancer and melanoma. Transcriptional profiling reveals that PD-L1 deletion enhances immune-stimulatory genes, promotes macrophage M1 polarization, inhibits M2 polarization, boosts IFN gamma signaling, and increases T cell recruitment and activation.
CANCER GENE THERAPY
(2022)
Article
Immunology
Jialing Liu, Yanmei Zhang, Hongqin Sheng, Chunling Liang, Huazhen Liu, Jose Alberto Moran Guerrero, Zhaoyu Lu, Wei Mao, Zhenhua Dai, Xusheng Liu, Lei Zhang
Summary: Inflammation and lymphocyte dysfunction play crucial roles in diabetic nephropathy. Hyperoside, a flavonoid glycoside, shows therapeutic potential by promoting macrophage polarization and regulating CD4(+) T cell differentiation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Fenglei Zheng, Yijing Tao, Jingjing Liu, Zhimin Geng, Ying Wang, Yujia Wang, Songling Fu, Wei Wang, Chunhong Xie, Yiying Zhang, Fangqi Gong
Summary: This study demonstrates that blockade of KCa3.1 in macrophages suppresses inflammatory reactions, leading to vascular injury in a cell model of KD. KCa3.1 may be a potential therapeutic target for KD.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Su-Lim Kim, Hack Sun Choi, Yu-Chan Ko, Bong-Sik Yun, Dong-Sun Lee
Summary: This study identified 5-hydroxymaltol as an antioxidant derived from Lactobacillus fermentation products with high activity against LPS-induced inflammation in macrophage cells. The compound inhibited pro-inflammatory cytokine production, reactive oxygen species generation, and mitogen-activated protein kinase induction, while inducing the NF-E2-related factor 2/heme oxygenase 1 signaling pathway. These findings suggest that 5-hydroxymaltol may be an effective treatment for inflammation-related diseases.
Article
Immunology
Anna M. Masyutina, Polina V. Maximchik, Georgy Z. Chkadua, Mikhail V. Pashenkov
Summary: This study demonstrates that activation of TLR4 or NOD1 receptors leads to innate tolerance in macrophages. Epigenetic mechanisms have less impact on innate tolerance compared to signaling mechanisms. In NOD1-tolerized macrophages, responses to homologous restimulation are almost completely abolished, while LPS-tolerized macrophages retain partial activation of the NF-kappa B pathway to maintain low-level expression of pro-inflammatory genes. Additionally, most genes that become unresponsive to homologous stimuli show responses to agonists of receptors signaling via distinct pathways.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Food Science & Technology
Shanshan Tie, Lijuan Zhang, Bin Li, Shanghua Xing, Haitao Wang, Yannan Chen, Weina Cui, Shaobin Gu, Mingqian Tan
Summary: The study evaluated the anti-inflammatory effect and metabolic behavior of dual targeting procyanidins (PC) nanoparticles on LPS-stimulated inflammatory macrophages using a metabolomics method. The double-targeting PC nanoparticles showed better inhibition of lactate dehydrogenase leakage and reactive oxygen species overexpression induced by LPS compared to single-targeting PC nanoparticles. Disordered amino acid metabolism, energy metabolism, and purine metabolism were observed in the LPS-treated group, and metabolic pathway analysis indicated that the double-targeting PC nanoparticles reversed some of the effects of LPS. These findings contribute to a better understanding of the mechanism of PC nanoparticles in alleviating inflammation and support their application in nutrition intervention.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Nutrition & Dietetics
Kyeong-Min Kim, So-Yeon Kim, Tamanna Jahan Mony, Ho Jung Bae, Sang-Deok Han, Eun-Seok Lee, Seung-Hyuk Choi, Sun Hee Hong, Sang-Deok Lee, Se Jin Park
Summary: The study demonstrates that Dracocephalum moldavica ethanol extract (DMEE) exerts anti-inflammatory effects on LPS-stimulated RAW 264.7 macrophages and anti-septic effects in septic mouse models through inhibition of the ERK/JNK/NF-kappa B signaling cascades and IL-6 production.
Article
Chemistry, Multidisciplinary
Jiali Deng, Rui Wang, Shu Huang, Jinsong Ding, Wenhu Zhou
Summary: Sepsis, the leading cause of death in ICU, is caused by deregulated immune responses to pathogen infection. Macrophages, as key immune cells, play essential roles in sepsis development and progression. Nanomedicines are designed to regulate macrophage functions for more effective sepsis therapy, with the advantages of enhanced drug bioavailability, targetability, and reduced side-effects. This review summarizes the recent progress of macrophage-regulating nanoparticles for sepsis treatment.
CHINESE CHEMICAL LETTERS
(2023)
Article
Plant Sciences
Hamsalakshmi, Suresh Joghee, Sreeram P. Kalarikkal, Gopinath M. Sundaram, T. Durai Ananda Kumar, Saravana Babu Chidambaram
Summary: The study demonstrated the anti-inflammatory effects of extracts from the aerial parts of Trichodesma indicum, with fraction FE showing the strongest ability to reduce inflammatory cytokines without cytotoxicity. The major compound in FE, 1,2-benzenedicarboxylic acid diisooctyl ester, exhibited good inhibition against key inflammatory targets.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Physiology
Paulraj Kanmani, Hoda El-Hossiny Elkafas, Muhammed Ghazal, Richard D. Minshall, Guochang Hu
Summary: Inflammasome activation plays a crucial role in the development of inflammatory response and sepsis. The molecular mechanism controlling inflammasome activation is not well understood. This study found that p120-catenin expression in macrophages contributes to the regulation of NLRP3 inflammasome activation by maintaining mitochondrial homeostasis and reducing mitochondrial reactive oxygen species production. The stabilization of p120-catenin expression in macrophages may serve as a novel strategy to prevent uncontrolled inflammatory response in sepsis.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Venetia Bazioti, Anouk M. La Rose, Sjors Maassen, Frans Bianchi, Rinse de Boer, Benedek Halmos, Deepti Dabral, Emma Guilbaud, Arthur Flohr-Svendsen, Anouk G. Groenen, Alejandro Marmolejo-Garza, Mirjam H. Koster, Niels J. Kloosterhuis, Rick Havinga, Alle T. Pranger, Miriam Langelaar-Makkinje, Alain de Bruin, Bart van de Sluis, Alison B. Kohan, Laurent Yvan-Charvet, Geert van den Bogaart, Marit Westerterp
Summary: The absence of ABCA1/ABCG1 cholesterol transporters in T cells leads to reduced T cell numbers and increased activation, resulting in premature aging, senescence, and apoptosis in middle-aged Ldlr(-/-) mice. However, this deficiency also decreases atherosclerosis and aortic inflammation, suggesting a complex role of cholesterol efflux pathways in T cell function and age-related diseases.
NATURE COMMUNICATIONS
(2022)
