Review
Nutrition & Dietetics
Bara Aljada, Ahmed Zohni, Wael El-Matary
Summary: The gluten-free diet is popular for treating immune-mediated disorders caused by gluten, but it has disadvantages like high costs, nutritional deficiencies, and social and psychological barriers. Close follow-up with patients following the diet is recommended, and more data is needed to assess its effectiveness in managing mental and cognitive disorders.
Review
Nutrition & Dietetics
Aner Cardo, Itziar Churruca, Arrate Lasa, Virginia Navarro, Maialen Vazquez-Polo, Gesala Perez-Junkera, Idoia Larretxi
Summary: Celiac disease (CD) is an autoimmune disorder of the small intestine that requires a gluten-free diet (GFD) for effective treatment. Nutritional imbalances may occur in adults with CD following GFD, but deficiencies can improve as intestinal mucosa recovers over time. Monitoring nutrient intake, especially plant proteins and essential nutrients, is important to prevent nutritional deficiencies in the long term.
Article
Nutrition & Dietetics
Alberto Raiteri, Alessandro Granito, Chiara Faggiano, Alice Giamperoli, Teresa Catenaro, Giulia Negrini, Francesco Tovoli
Summary: The dietary habits of celiac disease (CD) patients adhering to a gluten-free diet (GFD) are correlated with the risk of nonalcoholic fatty liver disease (NAFLD). A questionnaire-based study found that specific patterns of packaged gluten-free food consumption are significantly associated with NAFLD. The information obtained through this study can be used in clinical practice for personalized treatment and further research.
Article
Nutrition & Dietetics
Vincenza Lombardo, Alice Scricciolo, Andrea Costantino, Luca Elli, Giorgia Legnani, Angel Cebolla, Luisa Doneda, Federica Mascaretti, Maurizio Vecchi, Leda Roncoroni
Summary: The aim of this study was to evaluate the clinical efficacy of urinary gluten immunogenic peptides (uGIP) in the follow-up of celiac disease (CD). The results showed that uGIP test can accurately assess the adherence to gluten-free diet and correlated significantly with duodenal biopsy results.
Review
Nutrition & Dietetics
Rafael Martin-Masot, Maria Jimenez-Munoz, Marta Herrador-Lopez, Victor Manuel Navas-Lopez, Elia Obis, Mariona Jove, Reinald Pamplona, Teresa Nestares
Summary: Celiac disease is a complex disease caused by the interaction of genetic and environmental factors, and currently there are no effective biomarkers for early diagnosis. The cellular effects of a gluten-free diet, the only treatment available, are not well understood. Metabolomics studies are significant in unraveling the complexities of multifactorial and multisystemic disorders, and can provide insights into disease occurrence and treatment impact.
Article
Nutrition & Dietetics
Rafael Martin-Masot, Maria Jimenez-Munoz, Marta Herrador-Lopez, Marta Flor-Alemany, Victor Manuel Navas-Lopez, Teresa Nestares
Summary: This study aims to assess the importance of early follow-up for celiac patients, identify the role of stool gluten immunogenic peptides (GIPs) in assessing diet adherence, and analyze nutritional imbalances or deficiencies in the gluten-free diet (GFD). The results highlight the importance of early follow-up for celiac patients and the potential use of stool GIPs in monitoring adherence to the GFD.
Review
Nutrition & Dietetics
Aaron Lerner, Jozelio Freire de Carvalho, Anna Kotrova, Yehuda Shoenfeld
Summary: A gluten-free diet may serve as a novel therapeutic strategy for classical non-gluten-dependent autoimmune conditions, with symptom relief observed in most patients.
Review
Nutrition & Dietetics
Roxana Nemteanu, Andreea Clim, Corina Elena Hincu, Liliana Gheorghe, Irina Ciortescu, Anca Trifan, Alina Plesa
Summary: Potential celiac disease (PCD) is a condition where there is positive celiac serology and HLA DQ2 or DQ8 heterodimers, but no villous atrophy on duodenal biopsies. PCD accounts for one fifth of all celiac disease diagnoses. Adult patients with PCD generally have lower rates of nutrient deficiencies and extraintestinal symptoms compared to celiac disease patients. Recommending a gluten-free diet (GFD) to symptomatic PCD patients provides significant clinical improvement, but the implementation of GFD for asymptomatic PCD is still debated. Further research is needed to determine the potential progression of PCD to overt celiac disease and the benefits of early GFD implementation.
Article
Nutrition & Dietetics
Zsofia Vereczkei, Timea Dergez, Zsuzsanna Fodor, Zsolt Szakacs, Judit Bajor
Summary: This retrospective cohort study aimed to investigate factors associated with baseline and follow-up BMI in celiac disease (CD) patients. The study found that males had higher mean BMI compared to females at diagnosis and during follow-up, and non-classical CD patients had higher mean BMI at diagnosis and long-term follow-up than classical patients.
Article
Nutrition & Dietetics
Teresa Nestares, Rafael Martin-Masot, Carlos de Teresa, Rocio Bonillo, Jose Maldonado, Marta Flor-Alemany, Virginia A. Aparicio
Summary: The study found that adherence to the Mediterranean Diet has a positive impact on bone health in young patients with celiac disease, while physical activity is associated with lean mass and bone density. Therefore, correctly monitoring dietary habits and physical activity levels in children with CD is crucial for improving their lean mass and bone quality.
Article
Gastroenterology & Hepatology
Valeriia Dotsenko, Mikko Oittinen, Juha Taavela, Alina Popp, Markku Peraaho, Synnove Staff, Jani Sarin, Francisco Leon, Jorma Isola, Markku Maki, Keijo Viiri
Summary: Gluten challenge studies showed that even on a strict gluten-free diet, celiac disease patients exhibit patterns of ongoing disease, with changes in gene expression and mucosal morphology. A regression model using four gene transcripts described the extent of gluten-induced duodenal mucosal injury with high accuracy.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Nutrition & Dietetics
Raphael Enaud, Candice Tetard, Raphael Dupuis, David Laharie, Thierry Lamireau, Frank Zerbib, Pauline Riviere, Sarah Shili-Mismoudi, Florian Poullenot
Summary: This study investigated the factors associated with better quality of life in a large cohort of CD patients, finding that long-term adherence to a gluten-free diet and regular follow-up visits were key factors for improved quality of life.
Review
Biochemistry & Molecular Biology
Mariana Verdelho Machado
Summary: Celiac disease (CD) is a common autoimmune disease, affecting approximately 1% of the population. Regardless of symptoms, all CD patients must adhere to a lifelong gluten-free diet (GFD). However, this can be challenging due to a lack of gluten awareness in foods and the widespread use of gluten in processed foods. Research has been conducted to find pharmacological treatment for CD, but achieving full histological recovery on a GFD remains difficult.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Orazio Palmieri, Stefano Castellana, Antonio Bevilacqua, Anna Latiano, Tiziana Latiano, Anna Panza, Rosanna Fontana, Antonio Massimo Ippolito, Giuseppe Biscaglia, Annamaria Gentile, Domenica Gioffreda, Ivana Decina, Michele Tricarico, Milena Sinigaglia, Maria Rosaria Corbo, Tommaso Mazza, Francesco Perri, Carmela Lamacchia
Summary: Individuals with celiac disease can restore the alpha biodiversity of their gut microbiota through a gluten-free diet (GFD), but the beta diversity of microbial composition differs from healthy controls. While some taxa are decreased in CD subjects following GFD, certain bacterial genera are found to be more abundant. Predicted metabolic pathways show potential for the development of new GFD products aimed at modulating the gut microbiota through diet and supplements.
Review
Nutrition & Dietetics
Edurne Simon, Marta Molero-Luis, Ricardo Fueyo-Diaz, Cristian Costas-Batlle, Paula Crespo-Escobar, Miguel A. Montoro-Huguet
Summary: The gluten-free diet (GFD) is complex and requires a multidisciplinary team for effective management of celiac disease (CeD) patients. Involvement of experts from various fields including medicine, nutrition, and psychology can improve clinical practice and reduce nutritional risks.