Article
Gastroenterology & Hepatology
Masafumi Nishio, Kingo Hirasawa, Yuichiro Ozeki, Atsushi Sawada, Ryosuke Ikeda, Takehide Fukuchi, Ryosuke Kobayashi, Chiko Sato, Tsuyoshi Ogashiwa, Yoshiaki Inayama, Reiko Kunisaki, Shin Maeda
Summary: This study evaluated the efficacy of magnifying endoscopy (ME) for the diagnosis of tumor borders in patients with ulcerative colitis (UC). The results showed that ME can improve the visibility of tumor borders. Nonpolypoid and large tumors were more common in indistinct tumors on chromoendoscopy (CE). In general, endoscopic resection (ER) is feasible for tumors whose borders can be visualized on ME.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Gastroenterology & Hepatology
Rish K. Pai, Reetesh K. Pai, Ian Brown, Won-Tak Choi, David F. Schaeffer, David Farnell, M. Priyanthi Kumarasinghe, Dilini Gunawardena, Baek Hui Kim, Mark Friedman, Masoumeh Ghayouri, Gregory Y. Lauwers
Summary: The study identified three mutually exclusive histological patterns: acute colitis, chronic active colitis, and microscopic colitis. Microscopic colitis was associated with older age and longer time to colitis, while biological use was associated with earlier time to colitis and higher RHI. Histological activity measured by RHI was the only factor independently associated with biological use and adverse colitis outcomes.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Health Care Sciences & Services
Mimari Kanazawa, Keiichi Tominaga, Akira Yamamiya, Takanao Tanaka, Shoko Watanabe, Takeshi Sugaya, Keiichiro Abe, Akira Kanamori, Takahiro Arisaka, Koki Hoshi, Makoto Iijima, Kenichi Goda, Yasuo Haruyama, Atsushi Irisawa
Summary: The study revealed low interobserver reliability among endoscopic observers when evaluating MES parameters in UC patients in histological remission, with even UC practice experts showing low reliability for certain parameters such as Erythema and Decreased vascular pattern.
Article
Gastroenterology & Hepatology
Heather J. Galipeau, Alberto Caminero, Williams Turpin, Miriam Bermudez-Brito, Alba Santiago, Josie Libertucci, Marco Constante, Juan Antonio Raygoza Garay, Gaston Rueda, Sarah Armstrong, Alex Clarizio, Michelle Smith, Michael G. Surette, Premysl Bercik, Kenneth Croitoru, Elena F. Verdu
Summary: Increased fecal proteolytic activity was found before the clinical diagnosis of UC, which may serve as a noninvasive biomarker of inflammation associated with changes in gut microbiota. The study suggests potential therapeutic targets for at-risk populations based on antiprotease treatments.
Review
Biochemistry & Molecular Biology
Alina Ecaterina Jucan, Otilia Gavrilescu, Mihaela Dranga, Iolanda Valentina Popa, Ioana-Ruxandra Mihai, Vasile-Claudiu Mihai, Gabriela Stefanescu, Vasile Liviu Drug, Cristina Cijevschi Prelipcean, Radu-Alexandru Vulpoi, Oana-Bogdana Barboi, Irina Ciortescu, Catalina Mihai, Dingpei Long
Summary: Inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, is a chronic intestinal disorder. Histological healing, in addition to clinical and endoscopic healing, is proposed as an important endpoint to assess disease activity and remission in IBD patients. New advanced techniques have the potential to revolutionize the field of IBD by improving the assessment and characterization of the disease, ultimately leading to better patient care.
Article
Gastroenterology & Hepatology
Markus F. Neurath, Michael Vieth
Summary: Mucosal healing is an important prognostic factor in the management of patients with inflammatory bowel disease. It can predict clinical remission and resection-free survival. There are two levels of mucosal healing: endoscopic healing and histological healing. Drug therapies and new techniques can have an impact on mucosal healing, but cannot provide a definitive cure.
Article
Gastroenterology & Hepatology
Noa Krugliak Cleveland, Joana Torres, David T. Rubin
Summary: Ulcerative colitis (UC) is characterized by inflammation limited to the mucosa, but persistent clinical disease activity can occur even when mucosal healing has been achieved. UC increases the risk of disease progression and can lead to various complications. Unlike Crohn's disease, halting the progression of UC has been overlooked. This review highlights the progressive nature of UC and proposes further study of its natural history and treatment goals.
Article
Gastroenterology & Hepatology
Kit Curtius, Misha Kabir, Ibrahim Al Bakir, Chang Ho Ryan Choi, Juanda L. Hartono, Michael Johnson, James E. East, James O. Lindsay, Roser Vega, Siwan Thomas-Gibson, Janindra Warusavitarne, Ana Wilson, Trevor A. Graham, Ailsa Hart
Summary: This study identified that patients with large, unresected, multifocal LGD and recent moderate/severe inflammation are at highest risk of developing advanced neoplasia. Personalised risk prediction provided via the Ulcerative Colitis-Cancer Risk Estimator can support treatment decision-making.
Article
Gastroenterology & Hepatology
Amy L. Lightner, Sarah Vogler, John McMichael, Xue Jia, Miguel Regueiro, Taha Qazi, Scott R. Steele
Summary: While UC patients were more likely to have neoplasia detected during colonoscopy, the rates of progression from LGD and HGD to adenocarcinoma were equivalent in UC and CD, suggesting consistent endoscopic surveillance strategies for all IBD patients.
JOURNAL OF CROHNS & COLITIS
(2021)
Review
Gastroenterology & Hepatology
Rocio Sedano, Malcolm Hogan, Tran M. Nguyen, Joshua Chang, G. Y. Zou, John K. Macdonald, Niels Vande Casteele, Jurij Hanzel, Eileen Crowley, Robert Battat, Parambir S. Dulai, Siddharth Singh, Geert D'Haens, William Sandborn, Brian G. Feagan, Christopher Ma, Vipul Jairath
Summary: This study provides a summary of placebo rates in induction and maintenance clinical trials of ulcerative colitis, as well as identifying the factors influencing these rates. The results show that placebo rates vary depending on the endpoint assessed, trial purpose, and drug class.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Biology
Kacper Nijakowski, Piotr Eder, Marek Simon, Katarzyna Korybalska, Janusz Witowski, Anna Surdacka
Summary: The study found that the levels of S100A8/calprotectin, myeloperoxidase, and IgA in the saliva of patients with inflammatory bowel disease were significantly decreased. Myeloperoxidase and TNF-R1 concentrations showed high differentiation potential for distinguishing between Crohn's disease and ulcerative colitis.
Article
Multidisciplinary Sciences
Di Zhang, Pengguang Yan, Taotao Han, Xiaoyun Cheng, Jingnan Li
Summary: Through WGCNA and functional enrichment analysis, this study identified two gene modules significantly correlated with CAD, of which 13 hub genes were pinpointed as potential key genes. The critical biological processes in which the genes of these two modules were significantly enriched include mitochondrial dysfunction, cell-cell junction, and immune responses, offering insights for early intervention and prediction of UC-CRC.
Article
Gastroenterology & Hepatology
Olivia Yvellez, Victoria Rai, Philip H. Sossenheimer, John Hart, Jerrold R. Turner, Christopher Weber, Katia El Jurdi, David T. Rubin
Summary: Chronic inflammation in ulcerative colitis (UC) is associated with the development of colorectal neoplasia (CRN). A novel cumulative inflammatory index was found to predict CRN development in UC patients. Overall, cumulative histologic inflammation was significantly associated with the development of CRN in UC patients.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Cell Biology
Jacob R. Sweeney, Carl Crawford, Rhonda K. Yantiss
Summary: Patients with inflammatory bowel disease (IBD) are at increased risk for Clostridioides difficile infection, although clinically important infections can be difficult to recognise. This study found that patients with C. difficile infection have symptoms and endoscopic findings that are indistinguishable from active IBD.
Article
Gastroenterology & Hepatology
Jun Ohara, Tetsuo Nemoto, Yasuharu Maeda, Noriyuki Ogata, Shin-Ei Kudo, Toshiko Yamochi
Summary: This study demonstrates that an automated quantitative method using a deep learning-based model is useful in predicting the prognosis of patients with ulcerative colitis by evaluating mucin depletion.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Pathology
Lei Zhao, Maria Westerhoff, Jason L. Hornick, Thomas Krausz, Tatjana Antic, Shu-Yuan Xiao, John Hart
Editorial Material
Virology
Shu-Yuan Xiao, Yingjie Wu, Huan Liu
JOURNAL OF MEDICAL VIROLOGY
(2020)
Article
Oncology
Francisco J. Izquierdo, Darryl Schuitevoerder, Alejandro Plana, Oliver S. Eng, Scott K. Sherman, Brian Badgwell, Fabian M. Johnston, Sherif Abdel-Misih, Dan G. Blazer, Sean P. Dineen, Ana Luiza Gleisner, Travis E. Grotz, Nader Hanna, Harveshp Mogal, Mecker G. Moeller, Sanjay S. Reddy, Maheswari Senthil, Joshua H. Winer, Daniel E. Abbott, Steven A. Ahrendt, Mazin Al-Kasspooles, Lindsay Alpert, Farin Amersi, Amanda K. Arrington, Robert M. Barone, Joel M. Baumgartner, Richard N. Berri, Lana Bijelic, Wilbur B. Bowne, Charles Komen Brown, Daniel Catenacci, Carlos H. F. Chan, Clifford S. Cho, M. Haroon A. Choudry, Callisia N. Clarke, Jordan M. Cloyd, James C. Cusack, Abraham H. Dachman, Jeremiah L. Deneve, Leopoldo J. Fernandez, James Fleshman, T. Clark Gamblin, Alexandra Gangi, Georgios Georgakis, Erin W. Gilbert, Martin D. Goodman, Anand Govindarajan, Vadim Gushchin, Carla Harmath, Andrea Hayes-Jordan, Aliya N. Husain, Kamran Idrees, Chukwuemeka Ihemelandu, Haejin In, David Jiang, John M. Kane, Giorgos Karakousis, Kaitlyn J. Kelly, Timothy J. Kennedy, Xavier M. Keutgen, Hedy Lee Kindler, Michael D. Kluger, Byrne Lee, Lloyd A. Mack, Ugwuji N. Maduekwe, Grace Z. Mak, Joshua M. Mammen, Melvy Sarah Mathew, Marcovalerio Melis, Nelya Melnitchouk, Ryan P. Merkow, Aytekin Oto, Colette R. Pameijer, Patricio M. Polanco, Sam G. Pappas, Blase N. Polite, Richard Royal, George Salti, Armando Sardi, Namrata Setia, Lucas Sideris, Joseph Skitzki, Jula Veerapong, Konstantinos Votanopoulos, Michael G. White, Shu-Yuan Xiao, Rhonda K. Yantiss, Nita Ahuja, Andrew M. Lowy, Paul H. Sugarbaker, Charles Staley, Daniel M. Labow, Jason M. Foster, Jesus Esquivel, H. Richard Alexander, Edward A. Levine, Laura A. Lambert, David L. Bartlett, Kiran K. Turaga
Article
Oncology
Claire Hoppenot, Darryl Schuitevoerder, Francisco J. Izquierdo, Alejandro Plana, Bhavana Pothuri, S. Diane Yamada, Josephine Kim, Nita Karnik Lee, Daniel E. Abbott, Sherif Abdel-Misih, Steven A. Ahrendt, Mazin Al-Kasspooles, Farin Amersi, Amanda K. Arrington, Brian Badgwell, Robert M. Barone, Joel M. Baumgartner, Richard N. Berri, Lana Bijelic, Dan G. Blazer, Wilbur B. Bowne, Charles Komen Brown, Daniel Catenacci, Carlos H. F. Chan, David B. Chapel, Clifford S. Cho, M. Haroon A. Choudry, Callisia N. Clarke, James C. Cusack, Abraham H. Dachman, Jeremiah L. Deneve, Sean P. Dineen, Oliver S. Eng, Leopoldo J. Fernandez, James Fleshman, T. Clark Gamblin, Alexandra Gangi, Georgios Georgakis, Erin W. Gilbert, Martin D. Goodman, Travis E. Grotz, Vadim Gushchin, Nader Hanna, Carla Harmath, Andrea Hayes-Jordan, Aliya N. Husain, Kamran Idrees, Chukwuemeka Ihemelandu, Fabian M. Johnston, David Jiang, John M. Kane, Giorgos Karakousis, Kaitlyn J. Kelly, Timothy J. Kennedy, Xavier M. Keutgen, Hedy Lee Kindler, Michael D. Kluger, Ricardo R. Lastra, Byrne Lee, Lloyd A. Mack, Ugwuji N. Maduekwe, Grace Z. Mak, Joshua M. Mammen, Melvy Sarah Mathew, Marcovalerio Melis, Nelya Melnitchouk, Ryan P. Merkow, Harveshp Mogal, Mecker G. Moeller, John Moroney, Aytekin Oto, Colette R. Pameijer, Sam G. Pappas, Patricio M. Polanco, Blase N. Polite, Sanjay S. Reddy, Richard Royal, George Salti, Armando Sardi, Maheswari Senthil, Namrata Setia, Scott K. Sherman, Lucas Sideris, Joseph Skitzki, Sandy Tun, Jula Veerapong, Konstantinos Votanopoulos, Michael G. White, Joshua H. Winer, Shu-Yuan Xiao, Rhonda K. Yantiss, Nita Ahuja, Andrew M. Lowy, H. Richard Alexander, Jesus Esquivel, Jason M. Foster, Daniel M. Labow, Laura A. Lambert, Edward A. Levine, Charles Staley, Paul H. Sugarbaker, David L. Bartlett, Kiran K. Turaga
Article
Oncology
Darryl Schuitevoerder, Alejandro Plana, Francisco J. Izquierdo, Konstantinos Votanopoulos, James C. Cusack, Lana Bijelic, Clifford S. Cho, Alexandra Gangi, Erin W. Gilbert, Martin D. Goodman, Anand Govindarajan, Vadim Gushchin, Chukwuemeka Ihemelandu, Kaitlyn J. Kelly, Ryan P. Merkow, Sam G. Pappas, Daniel E. Abbott, Steven A. Ahrendt, Mazin Al-Kasspooles, Lindsay Alpert, Farin Amersi, Amanda K. Arrington, Brian Badgwell, Robert M. Barone, Joel M. Baumgartner, Dan G. Blazer, Richard N. Berri, Charles Komen Brown, Daniel Catenacci, Carlos H. F. Chan, M. Haroon A. Choudry, Callisia N. Clarke, Jordan M. Cloyd, Abraham H. Dachman, Jeremiah L. Deneve, Sean P. Dineen, Leopoldo J. Fernandez, Oliver S. Eng, James W. Fleshman, T. Clark Gamblin, Georgios Georgakis, Travis E. Grotz, Nader Hanna, Carla Harmath, John Hart, Andrea Hayes-Jordan, Aliya N. Husain, Kamran Idrees, Haejin In, David Jiang, John M. Kane, Timothy J. Kennedy, Xavier M. Keutgen, Hedy Lee Kindler, Byrne Lee, Chih-Yi Liao, Ugwuji N. Maduekwe, Grace Z. Mak, Lloyd A. Mack, Melvy Sarah Mathew, Marcovalerio Melis, Nelya Melnitchouk, Joseph Misdraji, Harveshp Mogal, Mecker G. Moller, Garrett M. Nash, Aytekin Oto, Reetesh K. Pai, Colette R. Pameijer, Patricio M. Polanco, Blase N. Polite, Sanjay S. Reddy, Richard Royal, David P. Ryan, George Salti, Armando Sardi, Maheswari Senthil, Namrata Setia, Scott K. Sherman, Lucas Sideris, Joseph Skitzki, Jula Veerapong, Michael G. White, Joshua H. Winer, Shu-Yuan Xiao, Rhonda K. Yantiss, Nita Ahuja, Wilbur Bowne, Andrew M. Lowy, H. Richard Alexander, Jesus Esquivel, Jason M. Foster, Daniel M. Labow, Laura A. Lambert, Edward A. Levine, Charles Staley, Paul H. Sugarbaker, David L. Bartlett, Kiran K. Turaga
Article
Oncology
Darryl Schuitevoerder, Alejandro Plana, Francisco J. Izquierdo, Laura A. Lambert, Xavier M. Keutgen, Jeremiah L. Deneve, Steven A. Ahrendt, Mazin Al-Kasspooles, Farin Amersi, Wilbur B. Bowne, Charles Komen Brown, Andrea Hayes-Jordan, John M. Kane, Kaitlyn J. Kelly, Timothy J. Kennedy, Ugwuji N. Maduekwe, Grace Z. Mak, Marcovalerio Melis, Richard Royal, Daniel E. Abbott, Sherif Abdel-Misih, Lindsay Alpert, Amanda K. Arrington, Brian Badgwell, Robert M. Barone, Joel M. Baumgartner, Richard N. Berri, Lana Bijelic, Dan G. Blazer, Daniel Catenacci, Carlos H. F. Chan, Clifford S. Cho, M. Haroon A. Choudry, Callisia N. Clarke, James C. Cusack, Abraham H. Dachman, Sean P. Dineen, Oliver S. Eng, Leopoldo J. Fernandez, James Fleshman, T. Clark Gamblin, Alexandra Gangi, Georgios Georgakis, Erin W. Gilbert, Martin D. Goodman, Anand Govindarajan, Travis E. Grotz, Vadim Gushchin, Nader Hanna, Carla Harmath, Aliya N. Husain, Kamran Idrees, Chukwuemeka Ihemelandu, Haejin In, David Jiang, Fabian M. Johnston, Giorgos Karakousis, Hedy Lee Kindler, Michael D. Kluger, Byrne Lee, Chih-Yi Liao, Lloyd A. Mack, Joshua M. Mammen, Melvy Sarah Mathew, Nelya Melnitchouk, Ryan P. Merkow, Harveshp Mogal, Mecker G. Moeller, Aytekin Oto, Colette R. Pameijer, Sam G. Pappas, Patricio M. Polanco, Blase N. Polite, Sanjay S. Reddy, George Salti, Armando Sardi, Maheswari Senthil, Namrata Setia, Scott K. Sherman, Lucas Sideris, Joseph Skitzki, Sandy Tun, Jula Veerapong, Konstantinos Votanopoulos, Michael G. White, Joshua H. Winer, Shu-Yuan Xiao, Rhonda K. Yantiss, Nita Ahuja, Andrew M. Lowy, H. Richard Alexander, Jesus Esquivel, Jason M. Foster, Daniel M. Labow, Edward A. Levine, Charles Staley, Paul H. Sugarbaker, David L. Bartlett, Kiran K. Turaga
Article
Oncology
Darryl Schuitevoerder, Francisco J. Izquierdo, Alejandro Plana, Garrett M. Nash, Leopoldo J. Fernandez, Michael D. Kluger, Lloyd A. Mack, Joshua M. Mammen, Colette R. Pameijer, Patricio M. Polanco, Lucas Sideris, Joseph Skitzki, Daniel E. Abbott, Sherif Abdel-Misih, Steven A. Ahrendt, Mazin Al-Kasspooles, Farin Amersi, Amanda K. Arrington, Brian Badgwell, Robert M. Barone, Joel M. Baumgartner, Richard N. Berri, Lana Bijelic, Dan G. Blazer, Wilbur B. Bowne, Charles Komen Brown, Daniel Catenacci, Carlos H. F. Chan, Christopher S. Chandler, David B. Chapel, Clifford S. Cho, M. Haroon A. Choudry, Callisia N. Clarke, James C. Cusack, Abraham H. Dachman, Jeremiah L. Deneve, Sean P. Dineen, Oliver S. Eng, James Fleshman, T. Clark Gamblin, Alexandra Gangi, Georgios Georgakis, Erin W. Gilbert, Martin D. Goodman, Anand Govindarajan, Travis E. Grotz, Vadim Gushchin, Nader Hanna, Carla Harmath, Andrea Hayes-Jordan, Aliya N. Husain, Kamran Idrees, Chukwuemeka Ihemelandu, Haejin In, David Jiang, Fabian M. Johnston, John M. Kane, Giorgos Karakousis, Kaitlyn J. Kelly, Timothy J. Kennedy, Xavier M. Keutgen, Hedy Lee Kindler, Byrne Lee, Ugwuji N. Maduekwe, Grace Z. Mak, Marcovalerio Melis, Nelya Melnitchouk, Melvy Sarah Mathew, Ryan P. Merkow, Harveshp Mogal, Mecker G. Moller, Aytekin Oto, Sam G. Pappas, Blase N. Polite, Sanjay S. Reddy, Richard Royal, George Salti, Armando Sardi, Maheswari Senthil, Namrata Setia, Scott K. Sherman, Jula Veerapong, Konstantinos Votanopoulos, Michael G. White, Joshua H. Winer, Shu-Yuan Xiao, Rhonda K. Yantiss, Nita Ahuja, Andrew M. Lowy, H. Richard Alexander, Jesus Esquivel, Jason M. Foster, Daniel M. Labow, Laura A. Lambert, Edward A. Levine, Charles Staley, Paul H. Sugarbaker, David L. Bartlett, Kiran K. Turaga
Article
Oncology
Francisco J. Izquierdo, Darryl Schuitevoerder, Alejandro Plana, Scott K. Sherman, Michael G. White, Joel M. Baumgartner, M. Haroon A. Choudry, Daniel E. Abbott, Robert M. Barone, Richard N. Berri, Carlos H. F. Chan, Callisia N. Clarke, Jordan M. Cloyd, James W. Fleshman, Georgios Georgakis, Kamran Idrees, Haejin In, Nelya Melnitchouk, George Salti, Jula Veerapong, Sherif Abdel-Misih, Steven A. Ahrendt, Lindsay Alpert, Mazin Al-Kasspooles, Farin Amersi, Amanda K. Arrington, Brian Badgwell, Lana Bijelic, Dan G. Blazer, Wilbur B. Bowne, Charles Komen Brown, Daniel Catenacci, Clifford S. Cho, James C. Cusack, Abraham H. Dachman, Jeremiah L. Deneve, Sean P. Dineen, Oliver S. Eng, Leopoldo J. Fernandez, T. Clark Gamblin, Alexandra Gangi, Erin W. Gilbert, Martin D. Goodman, Anand Govindarajan, Travis E. Grotz, Vadim Gushchin, Andrea Hayes-Jordan, Nader Hanna, Carla Harmath, Aliya N. Husain, Chukwuemeka Ihemelandu, David Jiang, Fabian M. Johnston, John M. Kane, Giorgos Karakousis, Kaitlyn J. Kelly, Timothy J. Kennedy, Xavier M. Keutgen, Michael D. Kluger, Hedy Lee Kindler, Byrne Lee, Lloyd A. Mack, Ugwuji N. Maduekwe, Grace Z. Mak, Joshua M. Mammen, Marcovalerio Melis, Melvy Sarah Mathew, Ryan P. Merkow, Harveshp Mogal, Mecker G. Moeller, Garrett M. Nash, Aytekin Oto, Colette R. Pameijer, Sam G. Pappas, Patricio M. Polanco, Blase N. Polite, Sanjay S. Reddy, Richard Royal, Armando Sardi, Maheswari Senthil, Namrata Setia, Lucas Sideris, Joseph Skitzki, Konstantinos Votanopoulos, Joshua H. Winer, Shu-Yuan Xiao, Rhonda K. Yantiss, Nita Ahuja, Andrew M. Lowy, H. Richard Alexander, Jesus Esquivel, Jason M. Foster, Daniel M. Labow, Laura A. Lambert, Edward A. Levine, Charles Staley, H. Sugarbaker, David L. Bartlett, Kiran K. Turaga
Article
Oncology
Francisco J. Izquierdo, Alejandro Plana, Darryl Schuitevoerder, Andrea Hayes-Jordan, Jeremiah L. Deneve, Mazin Al-Kasspooles, Wilbur B. Bowne, Charles Komen Brown, John M. Kane, Kaitlyn J. Kelly, Timothy J. Kennedy, Ugwuji N. Maduekwe, Grace Z. Mak, Marcovalerio Melis, Richard Royal, Daniel E. Abbott, Sherif Abdel-Misih, Farin Amersi, Amanda K. Arrington, Brian Badgwell, Robert M. Barone, Joel M. Baumgartner, Richard N. Berri, Lana Bijelic, Dan G. Blazer, Daniel Catenacci, Carlos H. F. Chan, Clifford S. Cho, M. Haroon A. Choudry, Callisia N. Clarke, James C. Cusack, Abraham H. Dachman, Sean P. Dineen, Oliver S. Eng, Leopoldo J. Fernandez, James Fleshman, T. Clark Gamblin, Alexandra Gangi, Georgios Georgakis, Erin W. Gilbert, Martin D. Goodman, Anand Govindarajan, Travis E. Grotz, Vadim Gushchin, Nader Hanna, Carla Harmath, Aliya N. Husain, Kamran Idrees, Chukwuemeka Ihemelandu, David Jiang, Fabian M. Johnston, Andrew M. Lowy, Giorgos Karakousis, Xavier M. Keutgen, Hedy Lee Kindler, Michael D. Kluger, Byrne Lee, Lloyd A. Mack, Joshua M. Mammen, Melvy Sarah Mathew, Nelya Melnitchouk, Ryan P. Merkow, Harveshp Mogal, Mecker G. Moller, Aytekin Oto, Colette R. Pameijer, Sam G. Pappas, Patricio M. Polanco, Blase N. Polite, Sanjay S. Reddy, George Salti, Armando Sardi, Maheswari Senthil, Namrata Setia, Lucas Sideris, Scott K. Sherman, Joseph Skitzki, Sandy Tun, Jula Veerapong, Konstantinos Votanopoulos, Michael G. White, Joshua H. Winer, Shu-Yuan Xiao, Rhonda K. Yantiss, Nita Ahuja, H. Richard Alexander, Jesus Esquivel, Jason M. Foster, Daniel M. Labow, Laura A. Lambert, Edward A. Levine, Charles Staley, Paul H. Sugarbaker, David L. Bartlett, Kiran K. Turaga
Article
Oncology
Chunxiu Yang, Jingjing Pang, Jian Xu, He Pan, Yueying Li, Huainian Zhang, Huan Liu, Shu-Yuan Xiao
Summary: Our study revealed that LRRK2 plays a crucial role in the tumorigenesis and progression of ccRCC, and may serve as a potential predictor and therapeutic target for this type of cancer. The up-regulation of LRRK2 in ccRCC was found to be correlated with DNA methylation and associated with a better prognosis in patients with ccRCC.
CANCER CELL INTERNATIONAL
(2021)
Meeting Abstract
Medicine, Research & Experimental
Lifang Fan, Yanyan Chen, Shu-Yuan Xiao, Jun Luo
LABORATORY INVESTIGATION
(2020)
Meeting Abstract
Pathology
Lifang Fan, Yanyan Chen, Shu-Yuan Xiao, Jun Luo
Meeting Abstract
Medicine, Research & Experimental
Lijun Cai, Shu-Yuan Xiao
LABORATORY INVESTIGATION
(2020)
Meeting Abstract
Pathology
Lijun Cai, Shu-Yuan Xiao
Article
Medicine, General & Internal
Daniel V. T. Catenacci, Leah Chase, Samantha Lomnicki, Theodore Karrison, Robert de Wilton Marsh, Murtuza M. Rampurwala, Sunil Narula, Lindsay Alpert, Namrata Setia, Shu-Yuan Xiao, John Hart, Uzma D. Siddiqui, Bryan Peterson, Kelly Moore, Kristin Kipping-Johnson, Ugne Markevicius, Barbara Gordon, Kenisha Allen, Christine Racette, Steven B. Maron, Chih-Yi Liao, Blase N. Polite, Hedy L. Kindler, Kiran Turaga, Vivek N. Prachand, Kevin K. Roggin, Mark K. Ferguson, Mitchell C. Posner