Article
Emergency Medicine
Kwok Fung Sun, Kin Ming Poon, Chun Tat Lui, Kwok Leung Tsui
Summary: A clinical prediction rule of termination of resuscitation for out-of-hospital cardiac arrest patients with pre-hospital defibrillation was derived from a retrospective multicenter cohort study. The rule includes EMS call to ED time and ETCO2 level as independent predictors for predicting death before ED arrival. When both criteria are met, there is a high specificity and positive predictive value for predicting death before ED arrival in OHCA patients with pre-hospital defibrillation.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Letter
Medicine, General & Internal
Olivier C. Manintveld, Stefan Roest, Yannick J. H. J. Taverne
Summary: In the study by Suverein et al., the use of extracorporeal cardiopulmonary resuscitation (CPR) in patients with refractory out-of-hospital cardiac arrest was examined. The results showed similar survival rates with a favorable neurologic outcome between extracorporeal CPR and conventional CPR. This raises questions about the role of extracorporeal CPR as an adjunct to conventional CPR.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Critical Care Medicine
Thomas Rea, Peter J. Kudenchuk, Michael R. Sayre, Ann Doll, Mickey Eisenberg
Summary: Advances in resuscitation following out-of-hospital cardiac arrest offer an opportunity to improve public health. Through scientific progress and efficient emergency systems, early recognition, CPR, and defibrillation are key components in improving treatment outcomes.
Article
Cardiac & Cardiovascular Systems
Christian Gantzel Nielsen, Fredrik Folke, Linn Andelius, Carolina Malta Hansen, Ulla Vaeggemose, Erika Frischknecht Christensen, Christian Torp-Pedersen, Annette Kjaer Ersboll, Mads Christian Tofte Gregers
Summary: The aim of this study was to investigate the association between alarm acceptance by volunteer responders, bystander intervention, and survival in out-of-hospital cardiac arrest. The study found that when volunteer responders accepted the alarm and arrived before EMS, there was a significant increase in bystander CPR and defibrillation. This finding is important for improving the survival of out-of-hospital cardiac arrest patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Martin Jonsson, Ellinor Berglund, Enrico Baldi, Maria Luce Caputo, Angelo Auricchio, Marieke T. Blom, Hanno L. Tan, Remy Stieglis, Linn Andelius, Fredrik Folke, Jacob Hollenberg, Leif Svensson, Mattias Ringh, ESCAPE NET Investigators
Summary: Activation of a volunteer responder system in cases of out-of-hospital cardiac arrest (OHCA) was associated with higher rates of bystander CPR, bystander defibrillation, and 30-day survival compared to no system activation. A randomized controlled trial is necessary to determine the causal effect of volunteer responder systems.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Multidisciplinary Sciences
Jun Nakajima, Yusuke Sawada, Yuta Isshiki, Yumi Ichikawa, Kazunori Fukushima, Yuto Aramaki, Kiyohiro Oshima
Summary: The prehospital administered dosage of epinephrine influences the plasma levels of Ep, but does not contribute to the plasma levels of norepinephrine (Nep), dopamine (DOA) and vasopressin (ADH) in patients with out-of-hospital cardiac arrest (OHCA).
Article
Critical Care Medicine
Gillian Hutton, Takahisa Kawano, Frank X. Scheuermeyer, Ashish R. Panchal, Michael Asamoah-Boaheng, Jim Christenson, Brian Grunau
Summary: The study found significant regional differences in the rationale and interval until termination of resuscitation in out-of-hospital cardiac arrest cases. Cases terminated due to obvious death or do-not-resuscitate orders/verbal directives often receive similar durations of resuscitation as survivors.
Article
Medicine, General & Internal
Josef Dankiewicz, Tobias Cronberg, Gisela Lilja, Janus C. Jakobsen, Helena Levin, Susann Ullen, Christian Rylander, Matt P. Wise, Mauro Oddo, Alain Cariou, Jan Belohlavek, Jan Hovdenes, Manoj Saxena, Hans Kirkegaard, Paul J. Young, Paolo Pelosi, Christian Storm, Fabio S. Taccone, Michael Joannidis, Clifton Callaway, Glenn M. Eastwood, Matt P. G. Morgan, Per Nordberg, David Erlinge, Alistair D. Nichol, Michelle S. Chew, Jacob Hollenberg, Matthew Thomas, Jeremy Bewley, Katie Sweet, Anders M. Grejs, Steffen Christensen, Matthias Haenggi, Anja Levis, Andreas Lundin, Joachim During, Simon Schmidbauer, Thomas R. Keeble, Grigoris V. Karamasis, Claudia Schrag, Edith Faessler, Ondrej Smid, Michal Otahal, Marco Maggiorini, Pedro D. Wendel Garcia, Paul Jaubert, Jade M. Cole, Miroslav Solar, Ola Borgquist, Christoph Leithner, Samia Abed-Maillard, Leanlove Navarra, Martin Annborn, Johan Unden, Iole Brunetti, Akil Awad, Peter McGuigan, Roy Bjorkholt Olsen, Tiziano Cassina, Philippe Vignon, Halvor Langeland, Theis Lange, Hans Friberg, Niklas Nielsen
Summary: A randomized trial comparing hypothermia and normothermia treatment after out-of-hospital cardiac arrest showed no significant differences in death or functional outcomes at 6 months. The hypothermia group had a higher incidence of arrhythmia resulting in hemodynamic compromise compared to the normothermia group.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Katie N. Dainty, Brianna Colquitt, Farhan Bhanji, Elizabeth A. Hunt, Tiffany Jefkins, Marion Leary, Joseph P. Ornato, Robert A. Swor, Ashish Panchal
Summary: Bystander cardiopulmonary resuscitation (CPR) is crucial for increasing survival rates in out-of-hospital cardiac arrest cases. However, the percentage of individuals receiving bystander CPR globally is currently low, at only 35% to 40%. This scientific statement aims to summarize the latest evidence on the training, response, and residual impact of witnessing out-of-hospital cardiac arrest among lay responders. The statement highlights the importance of addressing barriers to responding, experiences of performing CPR, the use of automated external defibrillators, the impact of dispatcher-assisted CPR, and the potential for psychological consequences after the event. By focusing on the experiences of actual responders, it is possible to develop more context-specific training that addresses factors such as performing CPR on a family member, dispelling myths, and acknowledging the potential for psychological sequelae.
Article
Medicine, General & Internal
Roberto Primi, Sara Bendotti, Alessia Currao, Giuseppe Maria Sechi, Gianluca Marconi, Greta Pamploni, Gianluca Panni, Davide Sgotti, Ettore Zorzi, Marco Cazzaniga, Umberto Piccolo, Daniele Bussi, Simone Ruggeri, Fabio Facchin, Edoardo Soffiato, Vincenza Ronchi, Enrico Contri, Paola Centineo, Francesca Reali, Luigi Sfolcini, Francesca Romana Gentile, Enrico Baldi, Sara Compagnoni, Federico Quilico, Luca Vicini Scajola, Clara Lopiano, Alessandro Fasolino, Simone Savastano, Lombardia CARe Researchers
Summary: This study compared the effectiveness of mechanical and manual CPR in Out-of-Hospital Cardiac Arrest (OHCA) patients. Mechanical chest compressors could increase the probability of return of spontaneous circulation (ROSC) and 30-day survival, with different devices having different performances. The load-distributing-band device was the only one that positively affected 30-day survival.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Yasunobu Yamagishi, Yasushi Oginosawa, Yoshihisa Fujino, Keishiro Yagyu, Taro Miyamoto, Keita Tsukahara, Hisaharu Ohe, Ritsuko Kohno, Haruhiko Abe
Summary: This study aimed to investigate the incidence and survival rates of out-of-hospital cardiac arrests (OHCAs) in the Japanese working population over a 12-year period, finding that while the incidence of OHCAs remained constant, the prognosis improved each year. Patients with work-colleague bystanders had the highest survival rates, and reducing the time to initial defibrillation could further improve outcomes for OHCA patients.
Article
Critical Care Medicine
Tasuku Matsuyama, Bon Ohta, Kosuke Kiyohara, Tetsuhisa Kitamura
Summary: This study aimed to assess the association between cardiopulmonary resuscitation (CPR)duration and outcomes after out-of-hospital cardiac arrest (OHCA). The results demonstrated that the probability of favorable neurological outcomes decreased with CPR duration. The impact of CPR duration may be influenced by each patient's clinical features.
Article
Critical Care Medicine
Deborah Wagner, S. L. Kronick, H. Nawer, J. A. Cranford, S. M. Bradley, R. W. Neumar
Summary: This retrospective cohort study compared the use of amiodarone and lidocaine in adult patients with in-hospital cardiac arrest from VT/VF. The study found that compared to amiodarone, lidocaine therapy was associated with significantly higher rates of ROSC, 24 h survival, survival to hospital discharge, and favorable neurologic outcome.
Article
Public, Environmental & Occupational Health
Laura Borgstedt, Stefan J. Schaller, Daniel Goudkamp, Kristina Fuest, Bernhard Ulm, Bettina Jungwirth, Manfred Blobner, Sebastian Schmid
Summary: The study aimed to investigate whether the location of out-of-hospital cardiac arrest (OHCA) affects short-term outcomes such as return of spontaneous circulation (ROSC) and hospital admission. The analysis showed that the location did not affect ROSC, but patients with OHCA in public spaces had a higher chance of being admitted to the hospital with spontaneous circulation. Factors associated with higher chances of hospital admission with spontaneous circulation included shockable initial heart rhythm, defibrillation, and the involvement of an emergency physician in CPR.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Theo Walter Jensen, Stig Nikolaj Blomberg, Fredrik Folke, Soren Mikkelsen, Martin Rostgaard-Knudsen, Palle Juelsgaard, Erika Frishknecht Christensen, Christian Torp-Pedersen, Freddy Lippert, Helle Collatz Christensen
Summary: The Danish Cardiac Arrest Registry aims to monitor and evaluate the quality of prehospital cardiac arrest treatment and facilitate research. It records descriptive and qualitative variables related to out-of-hospital cardiac arrest and provides important data for assessing treatment protocols and patient outcomes. The registry is one of the oldest and most comprehensive national clinical registries in Denmark, playing a crucial role in improving the care for patients suffering from out-of-hospital cardiac arrest.
CLINICAL EPIDEMIOLOGY
(2022)
Article
Medicine, General & Internal
Morhaf Al Achkar, Monica Zigman Suchsland, Fiona M. Walter, Richard D. Neal, Bernardo H. L. Goulart, Matthew J. Thompson
Summary: This study aimed to understand the diagnostic experiences of patients with advanced lung cancer carrying oncogenic mutations. Patients typically went through three stages: patient interval, primary care interval, and secondary care interval. Obtaining tissue samples and genetic testing were crucial for confirming diagnosis and guiding targeted treatments.
Article
Infectious Diseases
Monica L. Zigman Suchsland, Ivan Rahmatullah, Barry Lutz, Victoria Lyon, Shichu Huang, Enos Kline, Chelsey Graham, Shawna Cooper, Philip Su, Sam Smedinghoff, Helen Y. Chu, Kara Sewalk, John S. Brownstein, Matthew J. Thompson
Summary: This study aimed to evaluate the diagnostic accuracy of a mobile app-guided influenza rapid self-test. The results showed low sensitivity but high specificity of the self-test. Individuals reporting influenza-like symptoms at home may have lower rates of influenza and/or less severe disease.
BMC INFECTIOUS DISEASES
(2021)
Article
Sport Sciences
Jared Schattenkerk, Kristen Kucera, Danielle F. Peterson, Robert A. Huggins, Jonathan A. Drezner
Summary: This study found that minority student-athletes with exercise-related SCA on high school campuses have lower survival rates than white non-Hispanic athletes, but this difference is not fully explained by SES markers of the school. The presence of an athletic trainer on-site and the use of an on-site AED were associated with higher survival rates.
BRITISH JOURNAL OF SPORTS MEDICINE
(2022)
Article
Orthopedics
Zachary M. Working, Danielle Peterson, Michelle Lawson, Kelsey O'Hara, Ryan Coghlan, Matthew T. Provencher, Darin M. Friess, Brian Johnstone, Theodore Miclau, Chelsea S. Bahney
Summary: This study aims to monitor serum concentrations of collagen X in patients with isolated tibial plateau fractures using a novel bioassay. The results demonstrate a significant increase in collagen X levels after fractures, but the increase is delayed in cases of staged fixation.
JOURNAL OF ORTHOPAEDIC TRAUMA
(2022)
Article
Oncology
Monica Zigman Suchsland, Lesleigh Kowalski, Hannah A. A. Burkhardt, Maria G. G. Prado, Larry G. G. Kessler, Meliha Yetisgen, Maggie A. A. Au, Kari A. A. Stephens, Farhood Farjah, Anneliese M. M. Schleyer, Fiona M. M. Walter, Richard D. D. Neal, Kevin Lybarger, Caroline A. A. Thompson, Morhaf Al Achkar, Elizabeth A. A. Sarma, Grace Turner, Matthew Thompson
Summary: Lung cancer is the leading cause of cancer-related death in the United States, and early diagnosis is crucial for better survival rates. However, there are currently no clinical quality measures in the US to assess the timeliness and quality of lung cancer diagnosis. By using Natural Language Processing (NLP), this study extracted information on symptoms and signs from electronic medical records of patients with lung cancer. The findings revealed that the time interval from the first recorded symptoms to diagnosis was on average 570 days, while the intervals from chest imaging and specialist consultation to diagnosis were shorter.
Article
Orthopedics
Mackenzie Kelly, Danielle F. Peterson, Jung Yoo, Zachary M. Working, Darin Friess, Ryland Kagan
Summary: A retrospective review found that total hip arthroplasty (THA) for acute acetabular fractures carries a high risk of revision and major complications. Female patients are more likely to experience revision failure and complications in THA treatment. Restricting the use of THA for acute acetabular fractures is recommended, and further research is needed to investigate the influence of female patients and fracture characteristics on the risks of revision and complications.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Orthopedics
Danielle F. F. Peterson, Natasha S. S. McKibben, Michelle M. M. Lawson, Linh N. N. Taylor, Qian Yang, Selene Working, Darin M. M. Friess, Zachary M. M. Working
Summary: This study evaluated the species distribution and resistance patterns of bacterial pathogens causing surgical site infection (SSI) after operative fracture repair, with and without the use of intrawound powdered antibiotic (IPA) prophylaxis. The use of local antibiotic prophylaxis did not result in an increase in the proportion of infections caused by resistant bacterial pathogens.
JOURNAL OF ORTHOPAEDIC TRAUMA
(2023)
Article
Medicine, General & Internal
Danielle F. Peterson, Natasha S. McKibben, Catherine E. Hutchison, Karalynn Lancaster, Chih Jen Yang, Graham J. Dekeyser, Darin M. Friess, Martin A. Schreiber, Nick J. Willett, Joseph J. Shatzel, Joseph E. Aslan, Zachary M. Working
Summary: Introduction Orthopaedic trauma and fracture care commonly cause perioperative anaemia and associated functional iron deficiency due to systemic inflammation. This pilot study aims to assess the feasibility of a large randomized controlled trial (RCT) to evaluate intravenous iron therapy (IVIT) for improving patient well-being following orthopaedic injury. The study will measure several factors including rate of enrolment, screening failure, adverse events, and protocol deviation. The findings will be disseminated through peer-reviewed publications and conference presentations.
Article
Health Care Sciences & Services
Monica Zigman Suchsland, Barak Gaster, Jaqueline Raetz, Basia Belza, Lisa McGuire, Benjamin Olivari, Karen Tracy, Annette L. Fitzpatrick
Summary: Early dementia is underdiagnosed in primary care, but the burden of dementia is expected to substantially increase. This study aims to understand primary care provider perceptions of implementing a cognitive assessment toolkit in primary care.
BMC HEALTH SERVICES RESEARCH
(2023)
Article
Geriatrics & Gerontology
Rachel Ross, Laura C. Prater, Allison Cole, Ayah Mustafa, Kiet Pham, Monica Zigman Suchsland, Amy Gallagher, Ali Rowhani-Rahbar, Elizabeth A. Phelan
Summary: Chronic conditions, such as mild cognitive impairment and depression, increase the risk of firearm suicide among older adults. However, firearm counseling is not commonly conducted in clinical settings. This study explores provider perspectives on the resources needed to address firearm safety with older adult patients, using the Ottawa Decision Support Framework.
CLINICAL GERONTOLOGIST
(2023)
Article
Orthopedics
Natalie L. Zusman, Danielle F. Peterson, Michelle M. Lawson, Natasha S. McKibben, David M. Gallacher, Darin M. Friess, Zachary M. Working
Summary: The study aimed to investigate the relationship between a novel radiographic measurement (bladder shift, BS) on initial AP pelvis radiograph and intraoperative blood loss (IBL) during acetabular surgical fixation. By reviewing adult patients receiving unilateral acetabular fixation, visible bladder outlines on AP pelvis radiographs were measured to determine the percentage deformation toward the midline. The results showed that bladder shift could predict intraoperative hemorrhage and need for transfusions in patients with acetabular fractures.
EUROPEAN JOURNAL OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY
(2023)
Article
Orthopedics
Michelle M. Lawson, Danielle F. Peterson, Darin M. Friess, Mackenzie R. Cook, Zachary M. Working
Summary: This study investigates early significant complications after pelvic-ring injuries using the National Trauma Data Bank, and finds a significant association between time to fixation and complications.
EUROPEAN JOURNAL OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY
(2023)
Article
Health Care Sciences & Services
Matthew J. Thompson, Monica Zigman Suchsland, Victoria Hardy, Danielle C. Lavallee, Sally Lord, Emily Beth Devine, Jeffrey G. Jarvik, Steven Findlay, Thomas A. Trikalinos, Fiona M. Walter, Roger Chou, Beverly B. Green, Karen J. Wernli, Annette L. Fitzpatrick, Patrick M. Bossuyt
Summary: Imaging tests are commonly used in healthcare, but concerns about their overuse have overshadowed their benefits in clinical decision-making. This study demonstrates the importance of considering patient-centered outcomes (PCOs) when evaluating the value of imaging tests. The PROD framework categorizes PCOs into four main domains and highlights the interplay between them and the factors that can modify them.
BMJ QUALITY & SAFETY
(2023)
Article
Hematology
Benjamin K. Elstrott, Hari H. S. Lakshmanan, Alexander R. Melrose, Kelley R. Jordan, Kylee L. Martens, Chih-Jen Yang, Danielle F. Peterson, Hannah Stowe McMurry, Corinne Lavasseur, Jamie O. Lo, Sven R. Olson, Thomas G. DeLoughery, Joseph E. Aslan, Joseph J. Shatzel
Summary: This study investigates the effects of intravenous iron on hematologic parameters and platelet function in premenopausal women. The results show that intravenous iron can improve anemia, decrease platelet counts, and enhance platelet secretion and aggregation. These findings suggest that iron deficiency and replacement can have various effects on platelet production and function, and further investigation is needed.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Sport Sciences
Danielle F. Peterson, Kristen Kucera, Leah Cox Thomas, Joseph Maleszewski, David Siebert, Martha Lopez--Anderson, Monica Zigman, Jared Schattenkerk, Kimberly G. Harmon, Jonathan A. Drezner
Summary: The study investigated the causes and incidence of sudden cardiac arrest and death (SCAM) in US competitive athletes through prospective surveillance from 2014 to 2018. Cardiomyopathies accounted for nearly half of the SCA/D cases in college and professional athletes, while coronary artery anomalies played a more prominent role in middle school athletes than expected. Over half of SCA cases in athletes resulted in sudden death, indicating a need for improved prevention strategies.
BRITISH JOURNAL OF SPORTS MEDICINE
(2021)