Article
Biophysics
Joseph B. Newton, George W. Fryhofer, Ashley B. Rodriguez, Andrew F. Kuntz, Louis J. Soslowsky
Summary: This study using a rat model found that aging has a significant effect on the mechanical properties of rotator cuff tendons, particularly leading to increased stiffness and decreased fatigue moduli in geriatric animals, although the supraspinatus was not preferentially affected. This suggests that the aging-associated increase in supraspinatus tears cannot solely be attributed to its mechanical response.
JOURNAL OF BIOMECHANICS
(2021)
Article
Orthopedics
Mikhail Golman, Xiaoning Li, Dimitrios Skouteris, Adam A. Abraham, Lee Song, Yousef Abu-Amer, Stavros Thomopoulos
Summary: In this study, inhibition of IKK beta was shown to successfully suppress excessive inflammation and enhance tendon-to-bone healing after rotator cuff repair in a rat model. The treatment led to improved tenogenesis, extracellular matrix production, and overall repair quality. Additionally, the IKK beta inhibitor prevented bone loss near the tendon attachment, ultimately leading to increased toughness, failure load, and strength in the repaired area.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Orthopedics
Marc J. Strauss, Jon W. Miles, Mitchell L. Kennedy, Grant J. Dornan, Gilbert Moatshe, Martin Lind, Lars Engebretsen, Robert F. LaPrade
Summary: Full thickness QT grafts with bone exhibited similar material properties to BTB and 4-SST grafts, while Partial thickness QT graft without bone had significantly lower material properties than BTB and 4-SST. The RF graft demonstrated significantly lower material properties compared to BTB and 4-SST grafts.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2022)
Article
Orthopedics
James Johnson, Devin von Stade, Ben Gadomski, Daniel Regan, Jeremiah Easley, Katie J. Sikes, Kevin Troyer, Tianjian Zhou, Ted Schlegel, Kirk McGilvray
Summary: The biomechanical and histopathological properties of human rotator cuff tendons vary with age, with younger tendons exhibiting different properties compared to older tendons. These findings provide important insights into the natural aging process and degenerative changes of tendons.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Manuela Thierbach, Estelle Heyne, Michael Schwarzer, Lauren G. Koch, Steven L. Britton, Britt Wildemann
Summary: The risk of tendon disorders or ruptures increases with age, and intrinsic fitness also plays a role in affecting tendon properties. Low intrinsic fitness accelerates aging of tendons and leads to further impairment, resulting in decreased healing potential and elasticity.
Article
Orthopedics
James W. Johnson, Devin von Stade, Ben Gadomski, Jeremiah Easley, Brad Nelson, Katie Bisazza, Daniel Regan, Kevin Troyer, Tianjian Zhou, Kirk McGilvray
Summary: This study investigated the effects of osteoporosis on the biomechanics and insertional structure of the rotator cuff tendon, as well as the effects of osteogenic therapy carrier drugs. It found that osteoporotic tendons exhibited decreased modulus and altered insertional structure, while tendons treated with modified bisphosphonate showed increased modulus and cellularity in the insertion region.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2022)
Article
Orthopedics
Erica Kholinne, Yucheng Sun, Jae-Man Kwak, Hyojune Kim, Kyoung Hwan Koh, In-Ho Jeon
Summary: This study retrospectively evaluated the surgical outcomes of 6 patients with massive IRCTs who underwent SCR using an Achilles tendon-bone allograft, showing improvement in clinical scores but a high graft failure rate of 83.3% confirmed by second-look arthroscopy surgery.
ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE
(2021)
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.
Article
Orthopedics
Mohammadhossein Ghasemi, Haraldur Bjorn Sigurdsson, Thorarinn Sveinsson, Kristin Briem
Summary: The study aimed to investigate sex-dependent changes in the knee valgus moment during a cutting maneuver from pre-adolescence to adolescence. The results showed that boys had higher knee valgus moments than girls at both age periods, and only girls demonstrated a significant increase from pre-adolescence to adolescence. Additionally, the increase in knee valgus moment in girls was fully explained by kinematic variables.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Article
Orthopedics
Elizabeth L. Yanik, Nancy L. Saccone, Alexander W. Aleem, Aaron M. Chamberlain, Benjamin Zmistowski, Julianne A. Sefko, Jay D. Keener
Summary: Genetic factors may influence the age at diagnosis for atraumatic rotator cuff tear patients. Specific single nucleotide polymorphisms (SNPs) are associated with younger diagnosis age, but not with bilateral tear prevalence or tear size. Further research is needed to determine if genetic markers can be used alongside patient characteristics to identify optimal surgical repair candidates.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Orthopedics
Zhiguo Yuan, Fuyang Cao, Cangjian Gao, Zhen Yang, Quanyi Guo, You Wang
Summary: The study verified the potential of the decellularized umbilical cord Wharton jelly scaffold in promoting tendon healing and enhancing biomechanical strength in a rabbit model of acute rotator cuff tendon defect.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2022)
Article
Orthopedics
Dylan M. Ashton, Carina L. Blaker, Nicholas Hartnell, Patrick Haubruck, Samantha A. Hefferan, Christopher B. Little, Elizabeth C. Clarke
Summary: This study investigated the mechanical properties of a range of human lower leg tendons and their relationship with donor age, sex, and height. The results showed significant differences in mechanical properties among different tendons, with relatively small effects of donor characteristics limited to specific tendons. The findings challenge the exclusion of donors aged >65 years in all tendon grafts, as age only negatively affected the properties of the Achilles tendon (maximum load).
AMERICAN JOURNAL OF SPORTS MEDICINE
(2023)
Article
Sport Sciences
Lauren Pringels, Michael Stouthandel, Tom Van Hoof, Manuel Martens, Amelie Chevalier, Arne Burssens, Evi Wezenbeek, Luc Vanden Bossche
Summary: Torsion of the Achilles tendon can increase its tensile strength, but excessive torsion may also increase the risk of Achilles tendinopathy due to greater internal compression. This study aimed to investigate the impact of different types of Achilles tendon torsion on intratendinous pressure. The results showed that intratendinous pressure increased exponentially with ankle dorsiflexion during calf stretching and eccentric heel drops, and this increase was greater in Achilles tendons with moderate torsion compared to those with minimal torsion. Further investigation is needed to determine if this phenomenon is associated with an elevated risk of Achilles tendinopathy.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Orthopedics
Matthew Counihan, Thomas Leahy, Courtney Nuss, Joseph Newton, Sarthak Mohanty, Louis J. Soslowsky, Daniel Farber
Summary: The limited scar resection (LSR) technique showed promising results in treating chronic Achilles tendon ruptures, especially in gait kinetics. In terms of tendon mechanical and histological properties, LSR group demonstrated better recovery in some aspects compared to the gastrocnemius fascial turndown (GFT) group.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Orthopedics
Matthew Counihan, Thomas Leahy, Courtney Nuss, Joseph Newton, Sarthak Mohanty, Louis J. Soslowsky, Daniel Farber
Summary: The study found that in the treatment of chronic Achilles tendon rupture, the LSR technique is more advantageous than GFT surgery, as it can more quickly return gait kinetics to baseline. The mechanical properties of the tendon improved in both surgical intervention groups, but the LSR group showed better fatigue properties between 3 and 6 weeks postintervention.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)