Article
Immunology
Pingchuan Ma, Rufan Mo, Huabao Liao, Chengjie Qiu, Genhao Wu, Caixia Yang, Yunxiao Zhang, Yiran Zhao, Xue-Jun Song
Summary: This study demonstrates the distinct roles of gut microbiota in chronic painful conditions caused by nerve injury, chemotherapy, and diabetic neuropathy. Depletion of gut microbiota can prevent or suppress the occurrence of these painful syndromes, and fecal bacteria transplantation can partially restore gut microbiota and fully alleviate the pain.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Immunology
Kazue Hisaoka-Nakashima, Kodai Moriwaki, Natsuki Yoshimoto, Toshiki Yoshii, Yoki Nakamura, Yukio Ago, Norimitsu Morioka
Summary: Neuropathic pain causes severe pain and comorbidities such as cognitive impairment, which are not effectively treated with current analgesics. This study demonstrates the role of interleukin-6 (IL-6) in neuropathic pain and cognitive impairment. Blocking the IL-6 receptor improves cognitive impairment, while inhibiting IL-6 activity reduces allodynia.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Teresa Salvatore, Raffaele Galiero, Alfredo Caturano, Erica Vetrano, Giuseppe Loffredo, Luca Rinaldi, Christian Catalini, Klodian Gjeloshi, Gaetana Albanese, Anna Di Martino, Giovanni Docimo, Celestino Sardu, Raffaele Marfella, Ferdinando Carlo Sasso
Summary: Diabetic patients are often affected by coronary microvascular dysfunction, a complex condition whose pathogenesis involves hyperglycemia and insulin resistance. This dysfunction contributes to cardiac events and heart failure, and no specific treatment exists. However, certain antidiabetic drugs may have protective effects.
Article
Multidisciplinary Sciences
Francisca M. Acosta, Settimio Pacelli, Christopher R. Rathbone
Summary: The skeletal muscles of Type II diabetic patients have reduced vessel density and inhibit the function of myogenic cells. Satellite cell progeny affect microvascular angiogenesis. Exosomes derived from diabetic or control MPCs have no differences in microvascular growth. Angiogenesis factors and MPC secretome show differences between control and diabetic MPCs. Tissue-engineered skeletal muscles generated from diabetic MPCs have reduced angiogenesis. The secretome of injured control TE-SkM can increase VEGF and microvascular angiogenesis, but not the secretome of diabetic TE-SkM.
Review
Biology
Menghong Jiang, Xiaomei Chen, Liangping Zhang, Weiting Liu, Xiangmei Yu, Zhifu Wang, Meifeng Zheng
Summary: Electroacupuncture stimulation can alleviate neuropathic pain by suppressing glucose metabolism and GLUT-3 expression in the mPFC.
BIOLOGICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Martina Morchio, Emanuele Sher, David A. Collier, Daniel W. Lambert, Fiona M. Boissonade
Summary: Neuropathic pain is a highly prevalent condition that affects approximately 8% of the adult population in the UK. The underlying pathophysiology is complex and involves various processes, such as altered neuronal excitability, dysregulated intracellular signaling, and activation of immune and glial cells. Over the past 15 years, miRNAs have emerged as important regulators in neuropathic pain development, acting through the modulation of mRNA translation. Animal studies have identified several miRNAs involved in different stages of nociceptive pathways, but the translation of these findings to human subjects with neuropathic pain is still limited and dependent on the specific etiology. Further research using human tissue and liquid samples may provide valuable insights into miRNAs as diagnostic biomarkers or potential therapeutic targets for neuropathic pain.
Article
Anesthesiology
Didier Bouhassira, Serge Perrot, Thibault Riant, Gaelle Martine-Fabre, Gisele Pickering, Caroline Maindet, Nadine Attal, Stephanie Ranque Garnier, Jean-Paul Nguyen, Emmanuelle Kuhn, Eric Viel, Patrick Kieffert, Thomas Toelle, Claire Delorme, Rodrigue Deleens, Patrick Ginies, Virginie Corand-Dousset, Clemence Dal-Col, Alain Serrie, Emmanuel Chevrillon, Christian Gov, Juan Fernando Ramirez-Gil, Cecile Delval, Manuella Schaller, Baptiste Bessiere, Patrick Houeto, Claudia Sommer
Summary: Nitrous oxide (N2O) is commonly used for anesthesia and short-duration analgesia. Research suggests that N2O/O-2 50%-50% mixture can induce long-lasting analgesic effects. A study on chronic peripheral neuropathic pain patients showed that a 1-hour administration of EMONO significantly improved evoked pain intensity and overall impression of change, with effects lasting up to 4 weeks after treatment.
Review
Chemistry, Medicinal
Osman Syed, Predrag Jancic, Nebojsa Nick Knezevic
Summary: Diabetic peripheral neuropathy is a common complication of diabetes mellitus, and its prevalence is increasing due to the rising number of diabetes cases. This condition has a significant impact on both society and the economy, as patients require ongoing medication and may experience a decline in quality of life. Various pharmacological interventions have been explored, including serotonin norepinephrine reuptake inhibitors, gapentanoids, sodium channel blockers, and tricyclic antidepressants. This article discusses these medications and their respective efficacies, as well as the potential use of glucagon-like peptide-1 agonists in the treatment of peripheral diabetic neuropathy.
Article
Endocrinology & Metabolism
Pall Karlsson, Sandra S. Gylfadottir, Alexander G. Kristensen, Juan D. Ramirez, Pedro Cruz, Nhu Le, Pallai R. Shillo, Solomon Tesfaye, Andrew S. C. Rice, Hatice Tankisi, Nanna B. Finnerup, Jens R. Nyengaard, Troels S. Jensen, David L. H. Bennett, Andreas C. Themistocleous
Summary: In individuals with type 2 diabetes where IENFD is >1.0 fibre/mm, axonal swelling ratio is related to type 2 diabetes but is not related to DSP or painful DSP. Axonal swellings may be an early marker of sensory nerve injury in type 2 diabetes.
Article
Neurosciences
Yuanyuan Fang, Chang Chen, Qi Zhong, Lirong Wang, Zhu Gui, Jinpiao Zhu, Anne Manyande, Fuqiang Xu, Jie Wang, Zongze Zhang
Summary: Chronic pain during adolescence can lead to mental health disorders in adulthood, and this study finds that it can affect the cognitive function and glucose metabolism in the cortex and hippocampus of adult rats.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Anesthesiology
Mimmi Gillving, Dyveke Demant, Jakob Holbech, Lene Vase, Flemming W. Bach, Troels S. Jensen, Nanna B. Finnerup, Soren H. Sindrup
Summary: This study aimed to investigate whether the variability in baseline pain levels would influence the placebo response. The results showed that the variability in baseline pain did not have a significant impact on the placebo response.
Article
Physiology
Yanna Tian, Katie Anne Fopiano, Vijay S. Patel, Attila Feher, Zsolt Bagi
Summary: This study examined the role of caveolae in regulating microvascular vasomotor function in type 2 diabetes (T2D) patients. The findings suggest that under conditions of hyperglycemia, caveolae may play a role in maintaining vasodilation and mitigating the extent of hyperglycemia, but arterioles from T2D subjects are more susceptible to caveolae disruption-associated vasomotor dysfunction and impaired glycemic control.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Eleonora Balzani, Andrea Fanelli, Valentina Malafoglia, Michael Tenti, Sara Ilari, Annette Corraro, Carolina Muscoli, William Raffaeli
Summary: Understanding neuropathic pain presents challenges due to its complex pathophysiological classification mechanisms and the lack of effective diagnostic tools, with treatment responses often unpredictable. The rise of personalized treatments further adds to the complexity of classification.
Review
Immunology
George Sideris-Lampretsas, Marzia Malcangio
Summary: This review summarizes the existing preclinical evidence on how the CNS compartment and sex impact microglia functions in health, emphasizing recent advances in transcriptomics analyses for characterizing disease-associated microglial states. The specific scenario of peripheral nerve or tissue injury inducing expression of a specific subset of genes in microglia in the dorsal horn of the spinal cord is discussed, along with the possibility of a unique microglia transcriptional profile associated with chronic pain conditions. The evidence also suggests microglial activation in pain-related areas of the brain can be observed in models of neuropathic pain, highlighting the potential for future studies to further explore neuroimmune interactions in chronic pain using novel approaches like scRNA-seq and CYTOF.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Biochemistry & Molecular Biology
Hung-Wei Kan, Yu-Cheng Ho, Ying-Shuang Chang, Yu-Lin Hsieh
Summary: Despite the lack of understanding regarding the pathophysiological mechanisms underlying diabetic polyneuropathy (DPN), this study investigated a rat model of type 2 diabetes mellitus (T2DM) induced by high-fat diet (HFD) feeding and streptozotocin injections. The study revealed mechanical hyperalgesia, reduced nerve fibers, and impaired muscle action potential in the diabetic rats, with hypertriglyceridemia being the most significant lipid abnormality. Additionally, SEPT9, a component of the cytoskeleton, increased in the satellite glial cells (SGCs) of the dorsal root ganglia (DRG) in the diabetic rats. The findings suggest a potential molecular mechanism involving the interaction between SGCs and DRG neurons in the development of DPN.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)