期刊
ADIPOCYTE
卷 3, 期 3, 页码 215-220出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/adip.28730
关键词
S100B; receptor for advanced glycation end-products; adipose; adipocyte; adiposity; weight loss
资金
- NIH [U24 DK059637]
- Vanderbilt Digestive Disease Research Center (DDRC) [NIH/NIDDK P30DK058404]
- Vanderbilt University
- AHA pre-doctoral fellowship [12PRE11910047]
- Research Training Program in Diabetes and Obesity [T32DK064466]
- Established Investigator Award from the American Heart Association [12EIA8270000]
S100B is a calcium binding protein found in adipose tissue; however, relatively little is known about the physiologic regulation or distribution of the protein within this organ. We examined plasma S100B concentration and white adipose tissue (WAT) s100b mRNA levels in lean and diet-induced obese (DIO) mice. Plasma S100B levels were increased by obesity. In WAT, s100b gene expression was also significantly increased by obesity and this increase was reversed following weight-loss. s100b gene expression was detected in both the adipocyte-enriched and stromal-vascular fractions of WAT; however, the increase in s100b gene expression in obese animals was only detected in the adipocyte-enriched fraction. Our results support published in vitro data indicating that WAT S100B may contribute to obesity-associated inflammation.
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