Article
Orthopedics
Fan Lai, Jingjing Wang, Hong Tang, Xuting Bian, Kang Lu, Gang He, Pan Huang, Juan Liu, Mei Zhou, Jian Liu, Xu Tao, Kang-lai Tang
Summary: The study found that aging inhibits adipogenesis of TSPCs by down-regulating PPAR gamma signaling, rather than causing adipocyte accumulation during tendon repair due to aging of TSPCs. This may provide new targets for treating aging tendon injuries or tendinopathies.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Geriatrics & Gerontology
Xingming Shi, Kehong Ding, Raysa Rosario, Ashwin Ajith, Yun Su, Sean Shaw, Meghan McGee-Lawrence, Xin-Yun Lu, Anatolij Horuzsko, Carlos M. Isales
Summary: This study investigates the effects of PPAR-γ inhibition on bone and immune cell profiles in aged female mice. The results suggest that PPAR-γ inhibition may have adverse effects on bone mass, but does not significantly affect immune cell composition.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Vladimir V. Sobolev, Ekaterina Tchepourina, Irina M. Korsunskaya, Natalia A. Geppe, Svetlana N. Chebysheva, Anna G. Soboleva, Alexandre Mezentsev
Summary: This review discusses the role of PPAR-gamma in the pathogenesis of psoriasis and evaluates the potential of PPAR-gamma agonists as therapeutic options.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Tiange Chi, Mina Wang, Xu Wang, Ke Yang, Feiyu Xie, Zehuan Liao, Peng Wei
Summary: PPARs are lipid sensors and metabolic regulators, with PPAR-γ showing potential in inhibiting cell proliferation, inducing apoptosis, and disrupting inflammation. However, safety concerns including drug interactions need to be addressed for clinical applications.
FRONTIERS IN ONCOLOGY
(2021)
Article
Engineering, Biomedical
Shengwei Jiang, Weihan Liu, Dan Shi, Huan Cheng, Tingwei Deng, Guoyong Chen, Li Ma, Xianbin Zhang, Peng Gong
Summary: Black phosphorus (BP) has potential clinical applications, and this study investigates its potential as a targeting PPAR-? agonist to overcome chemoresistance in pancreatic adenocarcinoma (PAAD). The study uses different cell models and mouse models to explore the effects of BP on PPAR pathway and stem-like cancer cells. The research demonstrates that BP can inhibit cancer stem cell properties and enhance the treatment efficacy of PAAD when combined with gemcitabine.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Gastroenterology & Hepatology
Xiaomin Su, Mengli Jin, Chen Xu, Yunhuan Gao, Yazheng Yang, Houbao Qi, Qianjing Zhang, Xiaorong Yang, Wang Ya, Yuan Zhang, Rongcun Yang
Summary: This study reveals that FABP4 in the Paneth cells can downregulate the expression of defensins by degrading PPAR-gamma. This downregulation not only occurs in mice, but also in humans. Additionally, a high-fat diet induces an increase in FABP4 in Paneth cells, leading to a decrease in defensin expression. These findings are important for understanding the underlying factors of modern diseases.
Review
Medicine, General & Internal
Le Chang, Weiwen Fan, Xinghua Pan, Xiangqing Zhu
Summary: Addressing the problems associated with global aging has become a current research focus as human life expectancy continues to increase and the birth rate declines. Stem cell therapies have the potential to delay or even reverse aging, but ideal treatments have not been found yet.
CHINESE MEDICAL JOURNAL
(2022)
Review
Immunology
Daniel Toobian, Pradipta Ghosh, Gajanan D. Katkar
Summary: This review article focuses on the potential roles of peroxisome proliferator-activated receptors (PPARs) in macrophage biology, as well as the modulation of immune cell function, microbial infection, and inflammatory diseases by dual and pan PPAR agonists.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Food Science & Technology
Hao Yue, Zhibing Leng, Yuying Bo, Yingying Tian, Ziyi Yan, Changhu Xue, Ping Dong, Jingfeng Wang
Summary: The effect of sea cucumber intestinal peptide (SCIP) on the differentiation fate of bone mesenchymal stem cells (BMSCs) was investigated in this study. It was found that SCIP promotes the proliferation and osteogenic differentiation of BMSCs, and maintains the phosphorylation of PPAR gamma Ser112 through the AMPK/ERK and TAZ signaling pathways, thereby inducing the osteogenic differentiation of BMSCs. These results suggest that SCIP has potential as a functional food to improve obesity and osteoporosis.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Endocrinology & Metabolism
Nagendra P. Palani, Carla Horvath, Pascal N. Timshel, Pytrik Folkertsma, Alexander G. B. Gronning, Tora I. Henriksen, Lone Peijs, Verena H. Jensen, Wenfei Sun, Naja Z. Jespersen, Christian Wolfrum, Tune H. Pers, Soren Nielsen, Camilla Scheele
Summary: This study reveals the presence of an adipogenic and a structural branch of cells, known as SWAT cells, in progenitor cells from human adipose depots. The adipogenic branch is characterized by mitochondrial activity genes and is associated with fat distribution traits. The structural branch, called SWAT cells, display a multipotent phenotype and can revert back to progenitor state or differentiate into new adipogenic cells. This differentiation map provides a new perspective on adipose tissue regulation.
Review
Reproductive Biology
Wenli Hong, Baofeng Wang, Yasha Zhu, Jun'e Wu, Li Qiu, Shuyi Ling, Ziqiong Zhou, Yuqing Dai, Zhisheng Zhong, Yuehui Zheng
Summary: The delay of ovarian aging and fertility preservation for cancer patients are important topics in reproductive medicine. This review explores the potential of activating endogenous ovarian stem cells to delay ovarian aging and discusses the mechanisms of ovarian stem cell aging from various perspectives such as niches, immune dysfunction, chronic inflammation, and oxidative stress.
JOURNAL OF OVARIAN RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Lena Neuper, Daniel Kummer, Desiree Forstner, Jacqueline Guettler, Nassim Ghaffari-Tabrizi-Wizsy, Cornelius Fischer, Herbert Juch, Olivia Nonn, Martin Gauster
Summary: This study investigated the effects of candesartan on trophoblastic PPAR gamma and its target genes in early gestation. The results showed that candesartan did not negatively affect PPAR gamma or its target genes in human trophoblasts, but may influence angiogenesis in the placenta.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
S. Joshi, K. Chittimalli, J. Jahan, G. Vasam, Y. P. Jarajapu
Summary: As individuals age, the expression of ACE2 decreases and ACE activity increases in HSPCs, which affects vascular repair functions. Migration and proliferation of cells are impaired in old age, but these dysfunctions can be reversed with Ang-(1-7) treatment.
Article
Cell & Tissue Engineering
Yunqi Yao, Lin Zhang, Fuyi Cheng, Qingyuan Jiang, Yixin Ye, Yushuang Ren, Yuting He, Dongsheng Su, Lin Cheng, Gang Shi, Lei Dai, Hongxin Deng
Summary: The optimal treatment for decompensated liver cirrhosis (DLC) using human umbilical cord mesenchymal stem cells (hUCMSCs) is once every week for three weeks at the early stage of DLC progression. This treatment reduces mortality, ascites formation, and improves liver function. hUCMSCs treatment activates the PPAR gamma signaling pathway, leading to a shift in macrophage phenotype from M1-type to M2-type, which is crucial for the therapeutic effect. However, inhibition of PPAR gamma activation and macrophage depletion attenuate the beneficial effect of hUCMSCs treatment.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Immunology
Hongbo Zhang, Taylor Alford, Shuangquan Liu, Dongming Zhou, Jieru Wang
Summary: Influenza virus infection decreases the expression of PPAR gamma in macrophages, leading to inflammation and lung injury.
FRONTIERS IN IMMUNOLOGY
(2022)
