期刊
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
卷 3, 期 6, 页码 301-314出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1759720X11416270
关键词
Atypical femur fractures; osteoporosis; bisphosphonates; adverse drug reactions
类别
资金
- Merck Sharp and Dohme
- Novartis
- Amgen
- Sanofi-Aventis
Whilst bisphosphonates are an established modality in the treatment of osteoporosis, there have been increasing concerns regarding the risk of an unusual form of femur fracture amongst patients receiving bisphosphonates for prolonged periods. These fractures, referred to as 'atypical', have been characterized by a number of clinical and radiographic features that distinguish them from 'typical' osteoporotic fractures. The evidence base is currently split between a large number of case series demonstrating an association between the occurrence of atypical fractures and bisphosphonate use and several population-based studies that do not confirm such an association. Hence, a degree of uncertainty surrounds this important issue. In this review, we examine the emerging evidence on atypical femur fractures, assess hypotheses on their biomechanical evolution and discuss the wider clinical implications of this phenomenon.
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