期刊
DIABETES & METABOLISM JOURNAL
卷 37, 期 6, 页码 395-403出版社
KOREAN DIABETES ASSOC
DOI: 10.4093/dmj.2013.37.6.395
关键词
Diabetes; Hypoglycemic agents; Metabolic disorders; Metabolic syndrome; PPAR gamma; Protein processing; post-translational; Receptors; cytoplasmic and nuclear; Review; Synthetic ligands; Thiazolidinediones
资金
- NIMH NIH HHS [U54 MH084512] Funding Source: Medline
Adipose tissue, which was once viewed as a simple organ for storage of triglycerides, is now considered an important endocrine organ. Abnormal adipose tissue mass is associated with defects in endocrine and metabolic functions which are the underlying causes of the metabolic syndrome. Many adipokines, hormones secreted by adipose tissue, regulate cells from the immune system. Interestingly, most of these adipokines are proinflammatory mediators, which increase dramatically in the obese state and are believed to be involved in the pathogenesis of insulin resistance. Drugs that target peroxisome proliferator- activated receptor-. have been shown to possess anti- inflammatory effects in animal models of diabetes. These findings, and the link between inflammation and the metabolic syndrome, will be reviewed here.
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