Article
Medicine, Research & Experimental
Matthias Pierce, Richard Emsley
Summary: The regression approach performs better than Kraemer's approach in various data-generating scenarios. The modification of Kraemer's approach shows improved treatment recommendations, unless there is a strong unobserved prognostic biomarker. In the FINE trial, the regression method demonstrates slight improvement under its personalized treatment recommendation algorithm.
Review
Biochemistry & Molecular Biology
Duaa Ahmed Elhag, Manoj Kumar, Marwa Saadaoui, Anthony K. Akobeng, Fatma Al-Mudahka, Mamoun Elawad, Souhaila Al Khodor
Summary: Inflammatory bowel disease is a chronic immune-mediated inflammation of the gastrointestinal tract with a relapsing and remitting clinical course. Continuous disease monitoring and personalized therapy algorithms are crucial for effective treatment. New therapeutic approaches are being evaluated in controlled clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Cristina M. Sena, Lino Goncalves, Raquel Seica
Summary: This review summarizes recent advances in measuring endothelial function, including invasive and non-invasive techniques, as well as mechanisms and biomarkers of vascular dysfunction. Early identification of vascular dysfunction through non-invasive or minimally invasive techniques is crucial for predictive diagnostics and targeted prevention.
Article
Oncology
Melinda A. Pruis, Floris H. Groenendijk, K. Sangeeta Badloe, Andrea van Puffelen, Debbie Robbrecht, Winand N. M. Dinjens, Stefan Sleijfer, Anne-Marie C. Dingemans, Jan H. von der Thusen, Paul Roepman, Martijn P. Lolkema
Summary: This study investigated the feasibility of using whole-genome sequencing (WGS) as a comprehensive test for guided inclusion in early-phase clinical trials. The results showed that WGS on fresh frozen biopsies is a feasible tool for selecting personalized experimental therapy in patients with advanced cancer without standard-of-care options.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Ruyin Chen, Dandan Zheng, Qiong Li, Shuaishuai Xu, Chanqi Ye, Qi Jiang, Feifei Yan, Yunlu Jia, Xiaochen Zhang, Jian Ruan
Summary: This passage describes the immune microenvironment of cholangiocarcinoma (CCA) and the current research and application of immunotherapy, including immune checkpoint inhibitors, immune vaccines, and adoptive cell therapy. It also discusses the importance of biomarkers in patient selection.
Review
Immunology
Aline G. Souza, Leandro M. Colli
Summary: Tumor cells use extracellular vesicles as a vital pathway for communication with non-malignant cells, employing various strategies for survival and dissemination in the tumor environment. These vesicles carry different molecules that, when internalized by target cells, activate signaling pathways and molecular processes, promoting and disseminating neoplastic cells. Proteins, nucleic acids, and cytokines, such as interleukins, are the main types of molecules carried by extracellular vesicles, and their association reveals potential approaches for the diagnosis and therapeutics of various neoplasms.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Critical Care Medicine
Donald A. Mahler, David M. G. Halpin
Summary: Peak inspiratory flow, a biological plausible measure with good test characteristics, is considered as a predictive therapeutic biomarker to optimize therapy for COPD patients, both in outpatient and hospitalized settings, aligning with the principles of precision medicine.
Review
Endocrinology & Metabolism
Nicholas J. Wareham
Summary: This review examines the degree of personalization in existing interventions for preventing type 2 diabetes and suggests ways to achieve greater personalization through better identification of high-risk individuals, subdivision of type 2 diabetes into specific subgroups, and individualization of preventive targets. The use of more dynamic real-time data shows promise but requires further evaluation against clinical outcomes. Future personalized preventive approaches should complement existing individual-level interventions and align with strategies at the societal level.
Review
Medicine, General & Internal
Neha Jain, Upendra Nagaich, Manisha Pandey, Dinesh Kumar Chellappan, Kamal Dua
Summary: In the era of medical revolution, genomic testing plays a crucial role in the development of predictive, preventive, and personalized medicine. Techniques such as predictive screening and facial analysis can enhance diagnostic accuracy and treatment effectiveness. The application of genomic technologies, artificial intelligence, and machine learning is essential for the advancement of preventive and personalized medicine. Biomarkers are important for diagnosis, prognosis, and selection of personalized medicine. This review highlights the applicability and challenges of predictive diagnostics in the development of personalized medicine.
Review
Health Care Sciences & Services
Clementine S. Fraser, Ricardo J. Jose
Summary: Bronchiectasis is a diverse disease caused by multiple factors, leading to inflammation and dilation of the airways with excessive mucus production and chronic respiratory infection. As the availability of computed tomography increases, more cases are being diagnosed. It has significant impact on health and healthcare-related costs. With advancements in understanding the disease process, identifying different subtypes, underlying causes, and treatable traits, personalized management of bronchiectasis is becoming possible.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Maria A. Dominguez-Cejudo, Ana Gil-Torralvo, Monica Cejuela, Sonia Molina-Pinelo, Javier Salvador Bofill
Summary: Breast cancer prognosis and treatment outcomes depend on tumor microenvironment (TME), which plays a critical role in its development, progression, and treatment response. This review examines the different components of TME as prognostic and predictive biomarkers in breast cancer. Techniques for assessing TME, such as immunohistochemistry or gene expression profiling, and their clinical utility in therapeutic decision-making are also discussed. Lastly, therapeutic strategies targeting TME are reviewed, highlighting their potential clinical benefits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Manish Pratap Singh, Sandhya Rai, Ashutosh Pandey, Nand K. Singh, Sameer Srivastava
Summary: Molecular subtypes-based therapies provide a new potential framework for precise outcomes in clinical settings, as colorectal cancer is a highly heterogeneous malignancy with different pathological and genetic signatures in each subtype. Designing therapeutic stratification based on these features may lead to improved treatment outcomes.
Review
Biochemistry & Molecular Biology
Haruka Tsuchiya, Keishi Fujio
Summary: Rheumatoid arthritis is an autoimmune disease associated with disability, impaired quality of life, and premature mortality. While advancements in biological agents and kinase inhibitors have improved treatment, predicting drug effectiveness for each patient remains challenging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Jakub Styk, Zuzana Pos, Ondrej Pos, Jan Radvanszky, Evelina Hrckova Turnova, Gergely Buglyo, Daniela Klimova, Jaroslav Budis, Vanda Repiska, Balint Nagy, Tomas Szemes
Summary: Microsatellite instability (MSI) is a form of genomic alteration caused by the failure of a post-replicative DNA mismatch repair (MMR) system in a class of tandem repeats (TRs) called microsatellites (MSs) or short tandem repeats (STRs). Traditional strategies for determining MSI events are low-throughput procedures that require assessment of both tumor and healthy samples. However, recent large-scale pan-tumor studies have shown the potential of massively parallel sequencing (MPS) in detecting MSI.
Article
Clinical Neurology
Viktor Jirsa, Huifang Wang, Paul Triebkorn, Meysam Hashemi, Jayant Jha, Jorge Gonzalez-Martinez, Maxime Guye, Julia Makhalova, Fabrice Bartolomei
Summary: Individuals with drug-resistant focal epilepsy can benefit from surgical treatment, but a presurgical evaluation is necessary to assess the feasibility of surgery without causing neurological deficits. Virtual brains, created using data from MRI, offer a computer simulation of seizures and brain imaging signals. By combining virtual brains with machine learning, it is possible to estimate the epileptogenic zone and understand seizure onset dynamics. However, the current models have limitations such as low spatial resolution, and further research is needed to validate their predictive power and potential clinical applications.
Article
Biochemical Research Methods
Jeanesse Scerri, Shawn Baldacchino, Christian Saliba, Christian Scerri, Godfrey Grech
Article
Cell Biology
Anna De Blasio, Giovanni Pratelli, Rosa Drago-Ferrante, Christian Saliba, Shawn Baldacchino, Godfrey Grech, Giovanni Tesoriere, Christian Scerri, Renza Vento, Riccardo Di Fiore
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Cell Biology
Anna De Blasio, Riccardo Di Fiore, Giovanni Pratelli, Rosa Drago-Ferrante, Christian Saliba, Shawn Baldacchino, Godfrey Grech, Christian Scerri, Renza Vento, Giovanni Tesoriere
JOURNAL OF CELLULAR PHYSIOLOGY
(2020)
Review
Oncology
Shawn Baldacchino, Godfrey Grech
SEMINARS IN CANCER BIOLOGY
(2020)
Article
Cell Biology
Elisa Seria, George Galea, Joseph Borg, Kevin Schembri, Gabriella Grech, Sarah Samut Tagliaferro, Alexander Felice
Summary: The study developed a novel bioactive platelet-rich plasma (PRP) leukocyte depleted scaffold to study chronic skin wounds related to poor skin perfusion. Gene expression of IL8 and TGFA differed significantly between control, scratched, and treated conditions. IL8 was upregulated after scratch, while TNF led to downregulation followed by upregulation. TGFA showed downregulation after scratch and significant downregulation with TNF administration.
BMC MOLECULAR AND CELL BIOLOGY
(2021)
Article
Medicine, General & Internal
Peter Sciberras, Laura Grech, Godfrey Grech
Summary: Although AURKA mRNA expression did not predict sensitivity to FTY720 in CRC cell lines, specific CRC cell lines were found to be sensitive to 5 mu M FTY720, potentially due to differential expression of genes involved in the sphingolipid pathway.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Stephen C. Sciberras, Adrian P. Vella, Bernice Vella, Jessica Spiteri, Christabel Mizzi, Keith Borg-Xuereb, Godfrey LaFerla, Godfrey Grech, Fiona Sammut
Summary: The study aimed to evaluate the influence of anesthesia on chronic pain after TKA. The results showed that spinal anesthesia (SP) reduces pain and the incidence of chronic postsurgical pain (CPSP) after TKA.
Article
Endocrinology & Metabolism
Jeanesse Scerri, Christian Scerri, Felix Schaefer-Ruoff, Simon Fink, Markus Templin, Godfrey Grech
Summary: This study aims to differentiate between intrinsic and acquired trastuzumab resistance mechanisms in breast cancer cells by quantifying changes in protein expression and activity. The findings suggest novel resistance mechanisms and potential therapeutic combinations.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Meeting Abstract
Anesthesiology
Stephen Sciberras, Bernice Vella, Adrian Vella, Jessica Antoinette Spiteri, Mizzi Christabel, Keith Borg Xuereb, Godfrey Laferla, Godfrey Grech
ANESTHESIA AND ANALGESIA
(2021)
Meeting Abstract
Oncology
Jeanesse Scerri, Felix Ruoff, Markus Templin, Godfrey Grech, Christian Scerri
Meeting Abstract
Biochemistry & Molecular Biology
J. Scerri, S. Baldacchino, C. Saliba, C. Scerri, G. Grech
EUROPEAN JOURNAL OF HUMAN GENETICS
(2019)
Meeting Abstract
Pathology
S. Baldacchino, J. Debattista, C. Saliba, C. Scerri, G. Grech
Meeting Abstract
Pathology
S. Baldacchino, E. Borg, J. Scerri, J. DeGaetano, C. Saliba, C. Scerri, P. Schembri Wismayer, G. Grech