Molecular insights on the biosynthesis of antitumour compounds by actinomycetes

Overexpression of aveBIV leading to the improvement of 4′-epidaunorubicin production in Streptomyces coeruleorubidus strain SIPI-A0707

(2010) Lei Shao et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Daunorubicin efflux in Streptomyces peucetius modulates biosynthesis by feedback regulation

(2010) Padmanabhan Srinivasan et al.   FEMS MICROBIOLOGY LETTERS

The activator/repressor protein DnrO of Streptomyces peucetius binds to DNA without changing its topology

(2010) Vasanthakumar Ajithkumar et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

The Actinomycin Biosynthetic Gene Cluster of Streptomyces chrysomallus: a Genetic Hall of Mirrors for Synthesis of a Molecule with Mirror Symmetry

(2010) U. Keller et al.   JOURNAL OF BACTERIOLOGY

Engineering Fluorometabolite Production: Fluorinase Expression inSalinispora tropicaYields Fluorosalinosporamide†

(2010) Alessandra S. Eustáquio et al.   JOURNAL OF NATURAL PRODUCTS

Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis

(2010) Carlos Olano et al.   NATURAL PRODUCT REPORTS

Improvement in doxorubicin productivity by overexpression of regulatory genes in Streptomyces peucetius

(2010) Sailesh Malla et al.   RESEARCH IN MICROBIOLOGY

Precursor for biosynthesis of sugar moiety of doxorubicin depends on rhamnose biosynthetic pathway in Streptomyces peucetius ATCC 27952

(2009) Bijay Singh et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Role of sgcR3 in positive regulation of enediyne antibiotic C-1027 production of Streptomyces globisporus C-1027

(2009) Lifei Wang et al.   BMC MICROBIOLOGY

Cellular response and activation of apoptosis by mithramycin SK in p21WAF1-deficient HCT116 human colon carcinoma cells

(2009) Marc Bataller et al.   CANCER LETTERS

Generation of potent and selective kinase inhibitors by combinatorial biosynthesis of glycosylated indolocarbazoles

(2009) César Sánchez et al.   CHEMICAL COMMUNICATIONS

Indolocarbazole antitumour compounds by combinatorial biosynthesis

(2009) José A Salas et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Chasing the treasures of the sea—bacterial marine natural products

(2009) Tobias AM Gulder et al.   CURRENT OPINION IN MICROBIOLOGY

Disruption ofcagA, the apoprotein gene of chromoprotein antibiotic C-1027, eliminates holo-antibiotic production, but not the cytotoxic chromophore

(2009) Zhihui Cui et al.   FEMS MICROBIOLOGY LETTERS

Cloning of the Gene Cluster Responsible for the Biosynthesis of Brasilicardin A, a Unique Diterpenoid

(2009) Yutaka Hayashi et al.   JOURNAL OF ANTIBIOTICS

Modulation of Deoxysugar Transfer by the Elloramycin Glycosyltransferase ElmGT through Site-Directed Mutagenesis

(2009) A. Ramos et al.   JOURNAL OF BACTERIOLOGY

Enhancement of doxorubicin production by expression of structural sugar biosynthesis and glycosyltransferase genes in Streptomyces peucetius

(2009) Sailesh Malla et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Antitumor Compounds from Marine Actinomycetes

(2009) Carlos Olano et al.   Marine Drugs

Self-resistance mechanism in Streptomyces peucetius: Overexpression of drrA, drrB and drrC for doxorubicin enhancement

(2009) Sailesh Malla et al.   MICROBIOLOGICAL RESEARCH

Antitumor compounds from actinomycetes: from gene clusters to new derivatives by combinatorial biosynthesis

(2009) Carlos Olano et al.   NATURAL PRODUCT REPORTS

Mutasynthesis of Fluorosalinosporamide, a Potent and Reversible Inhibitor of the Proteasome

(2008) Alessandra S. Eustáquio et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dramatic Activation of Antibiotic Production in Streptomyces coelicolor by Cumulative Drug Resistance Mutations

(2008) G. Wang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Generation of New Derivatives of the Antitumor Antibiotic Mithramycin by Altering the Glycosylation Pattern through Combinatorial Biosynthesis

(2008) María Pérez et al.   CHEMBIOCHEM

Glycosylated Derivatives of Steffimycin: Insights into the Role of the Sugar Moieties for the Biological Activity

(2008) Carlos Olano et al.   CHEMBIOCHEM

Elucidation of Oxygenation Steps during Oviedomycin Biosynthesis and Generation of Derivatives with Increased Antitumor Activity

(2008) Felipe Lombó et al.   CHEMBIOCHEM

Renaissance in antibacterial discovery from actinomycetes

(2008) R BALTZ   CURRENT OPINION IN PHARMACOLOGY

Deoxysugars in Bioactive Natural Products: Development of Novel Derivatives by Altering the Sugar Pattern

(2008) Carmen Mendez et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

In VivoManipulation of the Bleomycin Biosynthetic Gene Cluster inStreptomyces verticillusATCC15003 Revealing New Insights into Its Biosynthetic Pathway

(2008) Ute Galm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mithramycin Analogues Generated by Combinatorial Biosynthesis Show Improved Bioactivity

(2008) Irfan Baig et al.   JOURNAL OF NATURAL PRODUCTS

Engineered Biosynthesis of Antiprotealide and Other Unnatural Salinosporamide Proteasome Inhibitors

(2008) Ryan P. McGlinchey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering

(2008) Carlos Olano et al.   METABOLIC ENGINEERING

Biosynthesis of elloramycin in Streptomyces olivaceus requires glycosylation by enzymes encoded outside the aglycon cluster

(2008) A. Ramos et al.   MICROBIOLOGY-SGM

Conditionally positive effect of the TetR-family transcriptional regulator AtrA on streptomycin production by Streptomyces griseus

(2008) S. Hirano et al.   MICROBIOLOGY-SGM

Mithramycin SK modulates polyploidy and cell death in colon carcinoma cells

(2008) M. Bataller et al.   MOLECULAR CANCER THERAPEUTICS

Natural products to drugs: natural product-derived compounds in clinical trials

(2008) Mark S. Butler   NATURAL PRODUCT REPORTS

Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism

(2008) S. G. Van Lanen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutasynthesis, chemobiosynthesis, and back to semi-synthesis: combining synthetic chemistry and biosynthetic engineering for diversifying natural products

(2007) Jonathan Kennedy   NATURAL PRODUCT REPORTS