Article
Chemistry, Multidisciplinary
Po-Yu Chou, Shyr-Yi Lin, Yi-No Wu, Chia-Yu Shen, Ming-Thau Sheu, Hsiu-O Ho
Summary: In this study, glycosylated poly(lactic-co-glycolic acid) nanoparticles (NPs) loaded with tumor-specific antigens and adjuvants were developed for targeted delivery to dendritic cells (DCs). The results showed that the glycosylated NPs effectively enhanced antigen uptake and DC maturation, and promoted cellular immunity and T-cell recruitment into tumor sites in vivo.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Oncology
Xu-Dong Tang, Kui-Lin Lu, Jin Yu, Han-Jian Du, Chao-Qiang Fan, Lei Chen
Summary: This study establishes a novel immunotherapy model targeting antigens to dendritic cell receptors using a combination of heparanase CD4(+) and CD8(+) T-cell epitope peptides, achieving an efficient cytotoxic T-cell response against tumor cells.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Review
Chemistry, Multidisciplinary
Caiyan Zhao, Xiaoyu Pang, Zuo Yang, Sheng Wang, Hongzhang Deng, Xiaoyuan Chen
Summary: TAMs are key players in tumor progression and can be modulated using nanotechnology-based strategies, such as inhibiting their recruitment, depleting M2-polarized macrophages, and reprogramming them into M1-polarized macrophages. Nanoparticles can also be used to image TAMs for novel treatment options and therapy monitoring.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Engineering, Biomedical
Muyue Yang, Jipeng Li, Ping Gu, Xianqun Fan
Summary: The development and metastasis of tumors are closely linked to the tumor microenvironment (TME). Nanoparticles, with their unique physical properties and design, show potential in efficiently penetrating TME and delivering therapeutic agents to specific components. However, the heterogeneity of tumors and individuals may limit the effectiveness of nanoparticle delivery systems in all types of tumors, calling for further understanding of TME changes at different stages of tumor development for the design of more personalized nanoplatforms.
BIOACTIVE MATERIALS
(2021)
Review
Pharmacology & Pharmacy
Xin Zhang, Xuemei Wang, Lijian Hou, Zheng Xu, Yu'e Liu, Xueju Wang
Summary: This review article highlights the importance of tumor microenvironment (TME) in immunotherapy for lung cancer and the role of nanomedicine in improving its efficacy. By targeting TME, nanoparticles can enhance immune therapy for lung cancer and overcome resistance to PD-1/PD-L1 blockade.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Xueyuan Yang, Weizhong Zhang, Wen Jiang, Anil Kumar, Shiyi Zhou, Zhengwei Cao, Shuyue Zhan, Wei Yang, Rui Liu, Yong Teng, Jin Xie
Summary: The study introduces a composite nanoparticle that can co-deliver a photosensitizer and an IDO inhibitor, showing significantly improved tumor suppression and animal survival in vivo. The treatment increases tumor infiltration of CD8(+) T cells while decreasing the frequencies of MDSCs and Tregs, highlighting the potential for combination therapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Kosuke Sasaki, Yusuke Sato, Kento Okuda, Kazuki Iwakawa, Hideyoshi Harashima
Summary: This study reports on the in vivo optimization of mRNA-loaded lipid nanoparticles (LNPs) for use in vaccines. The results provide evidence that a size range of 200-500 nm is appropriate for targeting splenic DCs, and highlight the difficulty in predicting transgene expression activity and potency of mRNA vaccines in splenic DCs using the whole spleen. The optimized A-11-LNP formulation exhibits better transgene expression activity and maturation in DCs, and demonstrates clear therapeutic antitumor effects.
Article
Chemistry, Multidisciplinary
Min Li, Han Zhou, Minghao Fang, Kun Qu, Yucai Wang
Summary: The use of dual-targeting nanomedicines to improve tumor antigen presentation by both dendritic cells (DCs) and tumor cells is proposed as a strategy to enhance antitumor immunity and tumor cell killing.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Junjie Deng, Jilong Wang, Jiaqi Shi, Hongjun Li, Mingqin Lu, Zhiyuan Fan, Zhen Gu, Hao Cheng
Summary: Immunomodulation through nanocarriers loaded with bioactive molecules is a promising approach for treating cancer, autoimmune diseases, and inflammation-related disorders. However, the effects of nanomaterial physicochemical properties on immune responses, especially those altered by nanocarrier materials alone, require further investigation for successful clinical applications.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Pharmacology & Pharmacy
Ragna M. S. Haegebaert, Maxime Kempers, Wim Ceelen, Ine Lentacker, Katrien Remaut
Summary: Colorectal cancer accounts for 10% of global cancer cases, and conventional treatment has limited success. The use of TLR agonists to stimulate the innate immune system for CRC treatment is challenging, as specific cell targeting and side effects need to be considered. Nanoparticle delivery systems show promise in addressing these challenges, and this review discusses the recent advances in nanoparticle formulations containing TLR agonists.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Review
Immunology
Hassan Dianat-Moghadam, Reza Nedaeinia, Mohsen Keshavarz, Mehdi Azizi, Mohammad Kazemi, Rasoul Salehi
Summary: Angiogenesis is a characteristic of cancer biology, and current therapies targeting tumor vasculature have limitations. By combining immunotherapy and nanocarriers, the efficacy of antiangiogenic agents could be improved while reducing the dosage of chemotherapy drugs. Furthermore, the combination of immunotherapies and nano-based delivery systems can extend the window of vascular normalization and overcome the challenges of antiangiogenic agents in treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Physical
Siyuan Chen, Furong Qin, Manni Wang, Yuquan Wei, Zhiyong Qian, Xiawei Wei
Summary: The tumor microenvironment is crucial for tumorigenesis, metastasis, and drug resistance. Tumor-associated macrophages (TAMs) play a key role in creating a favorable environment for cancer cells, and nanoparticle-based drug delivery systems offer new approaches for targeting TAMs in cancer therapy. Strategies targeting TAMs with nanoparticles include blocking recruitment, promoting transformation, and diminishing existing TAMs to improve cancer treatment efficiency.
Article
Gastroenterology & Hepatology
Nick Lung-Ngai Ting, Harry Cheuk-Hay Lau, Jun Yu
Summary: The relationship between gut microbiota and cancer treatment is crucial for enhancing therapeutic efficacy. Microbiota can be easily modified through various strategies, such as fecal microbiota transplantation, probiotics, and antibiotics. Studies have identified how microbes influence the pharmacokinetics and pharmacodynamics of cancer treatment. Clinical trials demonstrate the potential of microbiota modulation.
Article
Biochemistry & Molecular Biology
Xiqiang Xu, Qiuxiang Li, Wei Dong, Guowei Zhao, Yongfeng Lu, Xiaoying Huang, Xinli Liang
Summary: The aim of this study was to prepare Cinnamomum cassia essential oil (CEO) impregnated chitosan nanoparticles (CS-CEO) and evaluate its pharmacological activity against breast cancer. The CS-CEO nanoparticles had good physicochemical properties, stability, and enhanced anti-cancer activity compared to CEO. This research provides a reference for the application of volatile oil components in traditional Chinese medicine.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Multidisciplinary Sciences
Felipe Vences-Catalan, Ranjani Rajapaksa, Chiung-Chi Kuo, Caitlyn L. Miller, Anderson Lee, Vishnu C. Ramani, Stefanie S. Jeffrey, Ronald Levy, Shoshana Levy
Summary: Tetraspanins are a family of proteins that play important roles in cell physiology, with studies showing that CD81 antibody can effectively halt invasion of TNBC cell lines. In vivo experiments further confirmed the inhibitory effect of this antibody on metastases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Environmental Sciences
Jingzhou Wang, Jianbo Jia, Dujia Wang, Xiujiao Pan, Haiyan Xiong, Chengjun Li, Yiguo Jiang, Bing Yan
Summary: Inflammation is a major adverse outcome induced by PM2.5, and plays a critical role in PM2.5 exposure-associated diseases. This study identified a novel circRNA, circ_0008553, that is responsible for the PM2.5-activated inflammatory response in human bronchial epithelial cells. The findings highlight the significance of this circRNA in the intervention of PM2.5-induced adverse outcomes.
JOURNAL OF ENVIRONMENTAL SCIENCES
(2023)
Article
Engineering, Environmental
Chao Liu, Haiqing Wang, Muhammad Usman, Mengyuan Ji, Jun Sha, Zhenda Liang, Lishan Zhu, Li Zhou, Bing Yan
Summary: The applications of CuO nanoparticles in industrial and agriculture have led to their increased concentrations in wastewater and accumulation in waste activated sludge, raising concerns about their impact on the production of medium-chain carboxylates (MCCs) from anaerobic fermentation of sludge. Our study showed that CuO NPs at 10-50 mg/g-TS significantly inhibit MCCs production, with reactive oxygen species generation being the key factor. However, at lower CuO NPs concentrations (0.5-2.5 mg/g-TS), MCCs production was enhanced. Molecular approaches and metaproteomic analysis revealed the impact of CuO NPs on microbial processes and protein expression levels related to MCCs production.
Article
Chemistry, Multidisciplinary
Yongyi Wei, Hainan Sun, Bing Yan
Summary: Environmental carbon nanomaterials, such as multi-walled carbon nanotubes and graphene oxides, interact with aromatic hydrocarbon pollutants, resulting in adverse effects on ecosystems and human health. The combined toxicity of carbon nanomaterials and benzo[a]pyrene is still unknown. Among the investigated carbon nanomaterials, MWCNTs-NH2, p-GO, and GO-COOH showed some alleviation of the cytotoxicity induced by benzo[a]pyrene, with GO-COOH exhibiting the strongest inhibitory effect. Mechanistically, GO-COOH reduced benzo[a]pyrene-induced cell apoptosis and cytotoxicity by regulating apoptotic proteins and maintaining mitochondrial membrane potential. These findings highlight the importance of the physicochemical properties of carbon nanomaterials in modulating the cytotoxicity of benzo[a]pyrene.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Engineering, Environmental
Hai -Yuan Chi, Xiao-Xia Zhou, Min-Rong Wu, Wan-yu Shan, Jing-fu Liu, Jin-quan Wan, Bing Yan, Rui Liu
Summary: This study investigates the effect of constructing a magnetic mesoporous SiO2 shell on the surface of nanoscale zero-valent iron (nZVI). The results show that this structure can regulate the electron transfer pattern, avoid the formation of iron oxide layers, and improve the efficiency of active hydrogen production.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Environmental Sciences
Long Kong, Guizhen Yan, Xinxin Huang, Yanxin Wu, Xin Che, Jian Liu, Jianbo Jia, Hongyu Zhou, Bing Yan
Summary: The probability of occupational exposure to carbon nanotubes (CNTs) is increasing due to their growing production and biomedical applications. As a result, the risk of co-exposure of nanomaterials with environmental pollutants is also increasing. This study investigated the toxicity of pristine single-walled CNTs (p-SWCNTs) and oxidized single-walled CNTs (SWCNT-COOHs) on cell responses to metal ions (Pb2+, Cu2+, and Cr(VI)). The findings suggest that understanding the effects of the exposure sequence of engineered nanomaterials and environmental pollutants on their toxicity is crucial for evaluating combined toxicity.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Engineering, Environmental
Jiachen Yan, Guohong Liu, Hanle Chen, Song Hu, Xiaohong Wang, Bing Yan, Xiliang Yan
Summary: A comprehensive online database on the toxicity of ionic liquids (ILs) has been developed to aid in the design of environmentally friendly ILs using machine learning. The ILTox database contains manually curated data, including 1183 ILs and over 6700 pieces of toxicity data across different organisms. Machine learning models have been constructed using this database to analyze the relationship between IL structures and toxicities. The database has been used for virtual screening of desired IL properties from a large pool of ILs and has proven to be a valuable resource in understanding IL toxicity.
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2023)
Article
Chemistry, Physical
Huachao Zhao, Wei Ran, Guangzhi He, Hongxin Wei, Jiefang Sun, Xiaoxia Zhou, Shiwei Li, Jingfu Liu, Bing Yan, Rui Liu, Guibin Jiang
Summary: Bond length is an important structural parameter that can affect the activity of catalysts. In core-shell gold-palladium (Au@Pd) nanocatalysts, elongated Pd-Pd bonds resulting from lattice mismatches between Au and Pd are found to exhibit distinct catalytic activity. Surface-enhanced Raman scattering (SERS) spectra of chemisorbed 2,6-dimethylphenyl isocyanide (2,6-DMPI) were used to investigate the elongated Pd-Pd bonds on Au@Pd. The study revealed that strained sites with elongated Pd bonds are more than 100 times more active in a catalyzed Suzuki-Miyaura coupling reaction.
Editorial Material
Biotechnology & Applied Microbiology
Jianbo Jia, Qingxin Mu, Hongyu Zhou
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Haiqing Wang, Yongtao Xu, Zhenda Liang, Zhiquan Chen, Li Zhou, Bing Yan
Summary: This study investigated the impact of nanoplastics (NPs) on the spread of antibiotic resistance genes (ARGs) and found that negatively charged polystyrene (PS) and PS-COOH enhanced ARG transfer at low concentrations, while transfer declined at higher concentrations. Conversely, PS-NH2 increased ARG transfer at all tested concentrations, with the highest promotion effect at 500 mg L-1. The effects on ARG transfer were a combination of ROS production-induced promotion and NP agglomeration-caused inhibition at high concentrations.
ENVIRONMENTAL SCIENCE-NANO
(2023)
Article
Chemistry, Multidisciplinary
Cong Li, Xinxin Huang, Weicui Min, Huoqing Zhong, Xiliang Yan, Yan Gao, Jianqiao Wang, Hongyu Zhou, Bing Yan
Summary: Nanoplastics can transport heavy metal ions and pose health risks when ingested through the food chain. This study investigated the induction of inflammatory responses in human cells by ion-adsorbed polystyrene NPs and found that intracellular ions played a role in the inflammation caused by these NPs. Machine learning models identified Cd2+ and Pb2+ as crucial for the increased expression of pro-inflammatory cytokines in different cell types. The activation of NF-kappa B and ERK1/2 pathways were associated with the high expression of pro-inflammatory cytokines in the respective cell types.
ENVIRONMENTAL SCIENCE-NANO
(2023)
Article
Chemistry, Multidisciplinary
Yanxin Wu, Rongtao Liu, Jian Liu, Jianbo Jia, Hongyu Zhou, Bing Yan
Summary: In this study, palladium (Pd) nanocrystals with different crystalline forms were synthesized, and the underlying mechanisms of ROS-mediated cytotoxicity were revealed. Nanocubes and nanooctahedrons/nanotetrahedrons triggered cytotoxicity by generating singlet oxygen (O-1(2)) and hydroxyl radicals (OH), respectively. Nanoconcave-tetrahedrons induced ROS-mediated cytotoxicity via activating the superoxide (O-2(-)) pathway. The alkalization of pH resulting from intracellular ROS conversion was identified as a new biomarker for analyzing cytotoxicity.
Letter
Medicine, General & Internal
Chengjun Li, Huan Zhong, Yuwei Xie, Tian Bai, Bing Yan, Christian Sonne
Article
Chemistry, Multidisciplinary
Xiaokun Liu, Zhiying Zhang, Nikodem Tomczak, Cong Yang, Chengjun Li, Rongrong Liu, Bing Yan
Summary: In this study, a novel antibacterial composite nanomaterial based on spiky mesoporous silica spheres loaded with poly(ionic liquid)s and aggregation-induced emission luminogens (AIEgens) was designed for efficient treatment and imaging of multidrug-resistant (MDR) bacteria. The nanocomposite exhibited excellent and long-term antibacterial activity towards both Gram-negative and Gram-positive bacteria. Additionally, fluorescent AIEgens facilitated real-time bacterial imaging. This study provides a multifunctional platform and a promising alternative to antibiotics for combating pathogenic MDR bacteria.
NANOSCALE ADVANCES
(2023)
