期刊
FRONTIERS IN ONCOLOGY
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2018.00333
关键词
mitochondria; tumor metabolism; signal transduction; oxidative phosphorylation; neoplastic growth; oncometabolites; redox homeostasis; calcium
类别
资金
- University of Padova
- Children's Tumor Foundation Drug Discovery Initiative [2016A-05-009]
- Neurofibromatosis Therapeutic Acceleration Program
- Associazione Italiana Ricerca Cancro (AIRC) [IG 2017/20749]
- Piano for Life Onlus and Linfa Onlus
- post-doctoral Young Investigator Award Grant from the Children's Tumor Foundation
Mitochondria are dynamic organelles that exchange a multiplicity of signals with other cell compartments, in order to finely adjust key biological routines to the fluctuating metabolic needs of the cell. During neoplastic transformation, cells must provide an adequate supply of the anabolic building blocks required to meet a relentless proliferation pressure. This can occur in conditions of inconstant blood perfusion leading to variations in oxygen and nutrient levels. Mitochondria afford the bioenergetic plasticity that allows tumor cells to adapt and thrive in this ever changing and often unfavorable environment. Here we analyse how mitochondria orchestrate the profound metabolic rewiring required for neoplastic growth.
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