期刊
FRONTIERS IN ONCOLOGY
卷 1, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2011.00030
关键词
autophagy; apoptosis; chemotherapy; radiotherapy
类别
资金
- NIH [U56 CA112963]
- DRJ Foundation
- University Radiation Medicine Foundation
Autophagy, a highly regulated cell self-eating pathway, is controlled by the action of over 34 autophagy-related proteins (collectively termed Atgs). Although they are fundamentally different processes, autophagy and apoptosis (type I programmed cell death), under certain circumstances, can be regulated by common signaling mediators. Current cancer therapies including chemotherapy and ionizing radiation are known to induce autophagy within tumor cells. However, autophagy plays a dual role of either pro-cell survival or pro-cell death in response to these cancer treatments, depending on the cellular context and the nature of the treatment. We review the current basic and translational cancer research literature on how autophagy impacts tumor cell survival (to live) and death (not to live) following treatment as well as the role of chemical mediators of autophagy.
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