Review
Oncology
Claudia Zaharia, Torhild Veen, Dordi Lea, Arezo Kanani, Marina Alexeeva, Kjetil Soreide
Summary: Liver metastases occur in almost half of colorectal cancer patients, and understanding tumor biology is crucial for improving treatment outcomes. This study investigates the histopathological growth patterns of tumor cells at the interface with normal liver tissue and their interaction with immune cells in the microenvironment. Understanding these patterns can help determine treatment strategies and assess prognosis for colorectal liver metastases.
Review
Gastroenterology & Hepatology
Bing-Tan Kong, Qing-Sheng Fan, Xiao-Min Wang, Qing Zhang, Gan-Lin Zhang
Summary: Liver is the most common site of colorectal cancer metastases. Liver metastases exhibit distinct histopathological growth patterns (HGPs), which reflect tumor biology, pathological features, and host immune dynamics. Studies have shown that HGPs are associated with carcinogenesis, angiogenesis, and clinical outcomes, making them potential markers for risk stratification and treatment decision-making.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Immunology
Mingtao Hu, Zhigang Chen, Dandan Hu, Shaoyan Xi, Deshen Wang, Xiaolong Zhang, William Pat Fong, Lei Wen, Yanyu Cai, Yunfei Yuan, Binkui Li, Xiaojun Wu, Zhenhai Lu, Gong Chen, Liren Li, Peirong Ding, Zhizhong Pan, Desen Wan, Ziming Du, Minshan Chen, Yuhong Li
Summary: The study found that HGPs of colorectal cancer liver metastases have distinct molecular characteristics and are enriched in different signaling pathways. The morphological changes of HGPs are the combined effect of the heterogeneity and remodeling of primary tumors seeds and liver soils.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pathology
Emanuela Pilozzi, Damiano Fedele, Andrea Montori, Laura Lorenzon, Valentina Peritore, Giorgia Mannocchi, Nikta Bagheri, Chiara Leone, Antonio Palumbo, Michela Roberto, Giulio Ranazzi, Erino Rendina, Genoveffa Balducci, Mohsen Ibrahim
Summary: This study investigated histological patterns of metastases and mutations in MAPkinase pathway genes in colorectal lung metastasis (CLM) patients, showing that C pattern metastases had significantly worse disease-free survival (DFS). KRAS mutations were observed in 39% of patients, with codon 13 mutations associated with synchronous metastasis and poor prognosis. No mutations were found in exon 2 of NRAS gene, while 1.4% harbored a mutation in BRAF, indicating a potential prognostic role of KRAS mutations and histological patterns in CLM.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wen-Hui Li, Shuai Wang, Yi Liu, Xin-Fang Wang, Yong-Feng Wang, Rui-Mei Chai
Summary: This study successfully differentiated the histopathological growth patterns of colorectal liver metastasis using MRI features. MRI features such as rim enhancement and diameter difference showed good diagnostic ability in distinguishing rHGP and non-rHGP.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shengcai Wei, Yuqi Han, Hanjiang Zeng, Shuai Ye, Jin Cheng, Fan Chai, Jingwei Wei, Jianwei Zhang, Nan Hong, Yudi Bao, Jing Zhou, Yingjiang Ye, Xiaochun Meng, Yuwen Zhou, Yanhong Deng, Meng Qiu, Jie Tian, Yi Wang
Summary: This study investigated a radiomics model for predicting the prognosis of patients with colorectal liver metastases treated with bevacizumab-containing chemotherapy. The results showed that the HGP diagnosed using this model can be an effective predictor of patient survival, with the D pattern indicating a significantly longer progression-free survival compared to the R pattern or mixed patterns.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Oncology
Yannick Meyer, Ali Bohlok, Diederik Hoppener, Boris Galjart, Michail Doukas, Dirk J. Grunhagen, Anais Labar, Valerio Lucidi, Peter B. Vermeulen, Cornelis Verhoef, Vincent Donckier
Summary: This study demonstrates that HGPs apply to liver metastases across a wide variety of primary tumor origins and have prognostic value in these cases.
CLINICAL & EXPERIMENTAL METASTASIS
(2022)
Article
Oncology
Hiroki Kanno, Toru Hisaka, Kenji Fujiyoshi, Jun Akiba, Kazuaki Hashimoto, Fumihiko Fujita, Yoshito Akagi
Summary: This study indicates that a combination of HGP and TIL can stratify the risk of survival after hepatectomy in patients with CRLM.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Ali Bohlok, Camille Tonneau, Sophie Vankerckhove, Ligia Craciun, Valerio Lucidi, Fikri Bouazza, Alain Hendlisz, Jean Luc Van Laethem, Denis Larsimont, Peter Vermeulen, Vincent Donckier, Pieter Demetter
Summary: The microarchitecture of liver metastases, known as histopathological growth pattern (HGP), is a significant prognostic factor in patients with colorectal liver metastases. Currently, HGP can only be determined on the operative sample. Therefore, the development of new tools to predict HGP before surgery and understand the underlying mechanisms is crucial for improving individualized therapeutic management.
CLINICAL & EXPERIMENTAL METASTASIS
(2023)
Article
Pathology
Bingtan Kong, Jie Zhou, Hao Wang, Yinan Li, Yuancan Pan, Hui Zhu, Qing Zhang, Qingsheng Fan, Xiaomin Wang, Ganlin Zhang
Summary: The histopathological growth pattern (HGP) reflects the interaction between cancer cells and surrounding tissues and has a predictive value in liver metastases. This study focuses on investigating HGP and its evolution in primary liver cancer using a rabbit model. The study found that tumor growth follows an exponential pattern and metastasis occurs after reaching a specific stage of development. The components of HGPs change with tumor growth, with the decrease and increase of desmoplastic HGP (dHGP) and replacement HGP (rHGP) respectively. The expression of HIF1A and VEGF is correlated with collagen deposition and dHGP, while CD31 is not. The findings suggest that HGP evolution is a two-way switch and HIF1A-VEGF may play a key role in the formation of dHGP.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Oncology
Pamela Baldin, Javier Carrasco, Gabriela Beniuga, Anne Jouret-Mourin, Gauthier Demolin, Sandrine Roland, Lionel D'Hondt, Philippe Vergauwe, Daniel Van Daele, Marie Mailleux, Isabelle Sinapi, Astrid De Cuyper, Noella Bletard, Brigitte Massart, Monique Delos, Marie-Laure Castella, Aline van Maanen, Marc Van den Eynde
Summary: This prospective trial recruited 65 patients with resectable colorectal liver metastases and found that preoperative chemotherapy did not significantly affect the pathological response rate, but confirmed pathological response as an important prognostic factor.
Article
Oncology
Ali Bohlok, Francois Richard, Valerio Lucidi, Antoine El Asmar, Pieter Demetter, Ligia Craciun, Denis Larsimont, Alain Hendlisz, Jean Luc Van Laethem, Luc Dirix, Christine Desmedt, Peter Vermeulen, Vincent Donckier
Summary: Surgical resection can prolong survival in patients with liver metastases, but there is a lack of predictive markers to differentiate patients who will benefit from surgery. A study found that the histopathological growth pattern of liver metastases may serve as an accurate marker for metastatic behavior, regardless of the primary cancer type.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Inge van den Berg, Marcel Smid, Robert R. J. Coebergh van den Braak, Carolien H. M. van Deurzen, Vanja de Weerd, John A. Foekens, Jan N. M. IJzermans, John W. M. Martens, Saskia M. Wilting
Summary: Circular RNAs (circRNAs) play an important role in tumor progression of colon cancer (CC) and have potential clinical value as biomarkers for diagnosis, prognosis, and treatment. A large cohort study identified a diverse catalog of circRNAs in stage I/II colon tumors and found that high circRNA diversity was associated with favorable disease-free survival (DFS). Specific circRNAs were also associated with MSI and CMS, highlighting their potential utility for prognostic stratification in patients with early-stage colon cancer.
Article
Medicine, Research & Experimental
Peter Tschann, Nikola Vitlarov, Martin Hufschmidt, Daniel Lechner, Paolo N. C. Girotti, Felix Offner, Burghard Abendstein, Ingmar Koenigsrainer
Summary: Endometriosis is often associated with chronic pelvic pain and reduced quality of life. Colorectal resections in young and healthy patients with bowel involvement of endometriosis have significant morbidity. This study showed a significant reduction in pain levels after colorectal resection for endometriosis, regardless of histopathological findings, with 24% of patients experiencing postoperative complications.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2021)
Article
Surgery
Samara L. Lewis, Kenneth E. Stewart, Tabitha Garwe, Zoona Sarwar, Katherine T. Morris
Summary: Based on research using the National Cancer Data Base, older CRC patients have worse overall survival at an earlier stage of the disease, but survival rates are similar among all age groups in later stages of the disease.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Oncology
Boram Ham, Ni Wang, Zarina D'Costa, Maria Celia Fernandez, France Bourdeau, Patrick Auguste, Martin Illemann, Rikke Loevendahl Eefsen, Gunilla Hoyer-Hansen, Ben Vainer, Maximilien Evrard, Zu-Hua Gao, Pnina Brodt
Article
Oncology
Hans Christian Rolff, Ib Jarle Christensen, Ben Vainer, Lars Bo Svendsen, Rikke Lovendahl Eefsen, Michael Wilhelmsen, Ida Katrine Lund, Gunilla Hoyer-Hansen, Hans Jorgen Nielsen, Martin Illemann
CLINICAL CANCER RESEARCH
(2016)
Article
Oncology
Rikke Lovendahl Eefsen, Lars Engelholm, Gro L. Willemoe, Gert G. Van den Eynden, Ole Didrik Laerum, Ib Jarle Christensen, Hans Christian Rolff, Gunilla Hoyer-Hansen, Kell Osterlind, Ben Vainer, Martin Illemann
INTERNATIONAL JOURNAL OF CANCER
(2016)
Article
Biochemistry & Molecular Biology
Martin Illemann, Rikke Helene Lovendahl Eefsen, Nigel Charles Bird, Ali Majeed, Kell Osterlind, Ole Didrik Laerum, Warner Alpizar-Alpizar, Ida Katrine Lund, Gunilla Hoyer-Hansen
MOLECULAR CARCINOGENESIS
(2016)
Article
Oncology
I. Kumler, R. L. Eefsen, Peter Grundtvig Sorensen, S. Theile, A. Fullerton, P. G. Nielsen, Benny Vittrup Jensen, D. L. Nielsen
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2019)
Article
Oncology
S. Ehmsen, L. H. Jakobsen, M. E. Lendorf, R. L. Eefsen, L. Bentsen, A. S. Knoop, N. Aggerholm-Pedersen, H. Skuladottir, J. Herrstedt, L. H. Jensen, C. Rotbol, M. B. Damm, K. Wedervang, A. Glenthoj, J. Ryg, H. Frederiksen, A. R. Kodahl
Summary: This nationwide prospective study found that age and comorbidities are associated with adverse outcomes of SARS-CoV-2 infection in cancer patients, especially those with progressive disease being at a greater risk of fatal outcomes from COVID-19.
Meeting Abstract
Oncology
A. H. Awada, M. Zematis, S. Ochsenreither, R. L. Eefsen, D. Arnold, S. Cicenas, J. Yachnin, P. Pfeiffer, L. Paz-Ares, C. Jungels, R. Greil, L. Ostergaard Poulsen, E. Van Cutsem, I. Garcia Ribas, L. Thorsson, J. J. Collignon
ANNALS OF ONCOLOGY
(2021)
Meeting Abstract
Oncology
R. B. Holmstrom, O. H. Nielsen, S. Jacobsen, L. B. Riis, S. Theile, J. T. Bjerrum, P. Vilmann, J. S. Johansen, M. K. Boisen, R. L. Eefsen, I. M. Svane, D. Nielsen, I. M. Chen
ANNALS OF ONCOLOGY
(2021)
Meeting Abstract
Oncology
Ahmad Awada, Sebastian Ochsenreither, Rikke Loevendahl Eefsen, Dirk Arnold, Jeffrey Yachnin, Per Pfeiffer, Christiane Jungels, Richard Greil, Laurids Poulsen, Eric Van Cutsem, Lars Thorsson, Christer Svedman, Ignacio Garcia-Ribas, Joelle Collignon
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
R. L. Eefsen, K. S. Simonsen, P. Grundtvig, L. Klarskov, I. M. Chen, D. Hogdall, B. Jensen, T. Lorentzen, T. S. Poulsen, S. Theile, D. Nielsen, E. Hogdall
Summary: In this retrospective analysis, 90% of patients with treatment-refractory mCRC had cancer driver mutations identified through genomic sequencing, but only 2.5% of patients received targeted therapy that matched their mutations. The study highlights the challenge of limited targeted treatment options for mCRC patients with cancer driver mutations.
Article
Oncology
Rikke Lovendahl Eefsen, Jim S. S. Larsen, Louise L. L. Klarskov, Rahim Altaf, Estrid Hogdall, Peter Ingeholm, Jakob Lykke, Dorte L. L. Nielsen, Per Pfeiffer, Laurids O. Poulsen, Camilla Qvortrup, Jakob V. V. Schou, Morten Mau-Sorensen, Kell Osterlind, Benny V. V. Jensen
Summary: Therapy with immune checkpoint inhibitors has shown effectiveness in patients with metastatic mismatch-repair deficient colorectal cancer. However, the data on neoadjuvant ICI treatment in locally advanced CRC patients are limited. A study in Danish oncological centers evaluated the use of preoperative pembrolizumab in 10 treatment-naive dMMR CRC patients, demonstrating feasibility and effectiveness.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Medicine, General & Internal
Nicklas Juel Spindler, Gitte Fredberg Persson, Susann Theile, Dorte Lisbeth Nielsen, Estrid Hogdall, Gina Al-Farra, Helle Westergren Hendel, Torben Lorentzen, Inge Marie Svane, Henriette Lindberg, Rikke Lovendahl Eefsen
Summary: This study aims to investigate the efficacy of combining SBRT and CPI treatment in patients with mCRPC. A total of 80 evaluable patients who have progressed after multiple lines of treatment will be enrolled and receive ipilimumab and nivolumab combination therapy, with some patients also receiving SBRT. The primary endpoints are objective response rate and PSA response rate, and secondary endpoints include safety, radiographic progression-free survival, clinical benefit rate, duration of response, PSA-progression-free survival beyond 12 weeks, quality of life, and overall survival. The results will be published in an international peer-reviewed journal.
Article
Oncology
Tina Kringelbach, Martin Hojgaard, Kristoffer Rohrberg, Iben Spanggaard, Britt Elmedal Laursen, Morten Ladekarl, Charlotte Aaquist Haslund, Laurine Harslof, Laila Belcaid, Julie Gehl, Lise Sondergaard, Rikke Lovendahl Eefsen, Karin Holmskov Hansen, Annette Raskov Kodahl, Lars Henrik Jensen, Marianne Ingerslev Holt, Trine Heide Oellegaard, Christina Westmose Yde, Lise Barlebo Ahlborn, Ulrik Lassen
Summary: The ProTarget trial aims to investigate the anti-tumor activity and toxicity of commercially available targeted therapies in cancer patients with specific actionable genomic alterations. This national trial will provide new data and insights into molecular pathways and potentially expand personalized cancer treatment strategies.
Meeting Abstract
Oncology
Eric Van Cutsem, Rikke Lovendahl Eefsen, Sebastian Ochsenreither, Zanete Zvirbule, Audrius Ivanauskas, Dirk Arnold, Edita Baltruskeviciene, Per Pfeiffer, Jeffrey Yachnin, Rocio Garcia Carbonero, Richard Greil, Christiane Jungels, Laurids Poulsen, Ahmad Awada, Ignacio Garcia Ribas, Nedjad Losic, Joelle Collignon
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Pieter-Jan van Dam, Eric P. van der Stok, Laure-Anne Teuwen, Gert G. Van den Eynden, Martin Illemann, Sophia Frentzas, Ali W. Majeed, Rikke L. Eefsen, Robert R. J. Coebergh van den Braak, Anthoula Lazaris, Maria Celia Fernandez, Boris Galjart, Ole Didrik Laerum, Roni Rayes, Dirk J. Grunhagen, Michelle Van de Paer, Yves Sucaet, Hardeep Singh Mudhar, Michael Schvimer, Hanna Nystrom, Mark Kockx, Nigel C. Bird, Fernando Vidal-Vanaclocha, Peter Metrakos, Eve Simoneau, Cornelis Verhoef, Luc Y. Dirix, Steven Van Laere, Zu-hua Gao, Pnina Brodt, Andrew R. Reynolds, Peter B. Vermeulen
BRITISH JOURNAL OF CANCER
(2017)