Mesenchymal Migration as a Therapeutic Target in Glioblastoma

Rho-GTPase signaling drives melanoma cell plasticity

(2010) Victoria Sanz-Moreno et al.   CELL CYCLE

The Src Inhibitor AZD0530 Blocks Invasion and May Act as a Radiosensitizer in Lung Cancer Cells

(2010) Phillip R. Purnell et al.   Journal of Thoracic Oncology

v-Crk regulates membrane dynamics and Rac activation

(2010) Myeong Gu Yeo et al.   Cell Adhesion & Migration

The coordination between actin filaments and adhesion in mesenchymal migration

(2010) Geraldine M. O'Neill   Cell Adhesion & Migration

Ligands for Mapping αvβ3-Integrin Expression in Vivo

(2009) Margret Schottelius et al.   ACCOUNTS OF CHEMICAL RESEARCH

Two-Step Synthesis of Multivalent Cancer-Targeting Constructs

(2009) Jill M. Stukel et al.   BIOMACROMOLECULES

Fyn and Src Are Effectors of Oncogenic Epidermal Growth Factor Receptor Signaling in Glioblastoma Patients

(2009) K. V. Lu et al.   CANCER RESEARCH

Cellular Receptors of Extracellular Matrix Molecules

(2009) Jyrki Heino et al.   CURRENT PHARMACEUTICAL DESIGN

Targeted drug delivery for treatment and imaging of glioblastoma multiforme

(2009) Jill M Stukel et al.   Expert Opinion on Drug Delivery

New strategies to deliver anticancer drugs to brain tumors

(2009) Valentino Laquintana et al.   Expert Opinion on Drug Delivery

Therapeutic strategies for inhibiting invasion in glioblastoma

(2009) Jan Drappatz et al.   Expert Review of Neurotherapeutics

Imaging glioma cell invasionin vivoreveals mechanisms of dissemination and peritumoral angiogenesis

(2009) Frank Winkler et al.   GLIA

TAE226-mediated inhibition of focal adhesion kinase interferes with tumor angiogenesis and vasculogenesis

(2009) Alexander Schultze et al.   INVESTIGATIONAL NEW DRUGS

Actin machinery and mechanosensitivity in invadopodia, podosomes and focal adhesions

(2009) C. Albiges-Rizo et al.   JOURNAL OF CELL SCIENCE

Improving the prognosis for patients with glioblastoma: the rationale for targeting Src

(2009) John de Groot et al.   JOURNAL OF NEURO-ONCOLOGY

Tropomyosin Isoform Expression Regulates the Transition of Adhesions To Determine Cell Speed and Direction

(2009) C. T. T. Bach et al.   MOLECULAR AND CELLULAR BIOLOGY

Dasatinib-induced autophagy is enhanced in combination with temozolomide in glioma

(2009) V. Milano et al.   MOLECULAR CANCER THERAPEUTICS

Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530

(2009) Tim P. Green et al.   Molecular Oncology

Cilengitide modulates attachment and viability of human glioma cells, but not sensitivity to irradiation or temozolomide in vitro

(2009) Gabriele D. Maurer et al.   NEURO-ONCOLOGY

Novel drug delivery strategies in neuro-oncology

(2009) Dani S. Bidros et al.   Neurotherapeutics

Involvement of Rac and Rho signaling in cancer cell motility in 3D substrates

(2009) D Yamazaki et al.   ONCOGENE

Activation of tumor cell integrin  v 3 controls angiogenesis and metastatic growth in the brain

(2009) M. Lorger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective amyloid-β lowering agents

(2008) Michael S Wolfe   BMC NEUROSCIENCE

TAE226 Inhibits Human Neuroblastoma Cell Survival

(2008) Elizabeth A. Beierle et al.   CANCER INVESTIGATION

Rac Activation and Inactivation Control Plasticity of Tumor Cell Movement

(2008) Victoria Sanz-Moreno et al.   CELL

Integrin  v 3-Targeted Radioimmunotherapy of Glioblastoma Multiforme

(2008) A. Veeravagu et al.   CLINICAL CANCER RESEARCH

Src and focal adhesion kinase as therapeutic targets in cancer

(2008) Valerie G Brunton et al.   CURRENT OPINION IN PHARMACOLOGY

The targeted delivery of cancer drugs across the blood–brain barrier: chemical modifications of drugs or drug-nanoparticles?

(2008) Lucienne Juillerat-Jeanneret   DRUG DISCOVERY TODAY

Cilengitide: an integrin-targeting arginine–glycine–aspartic acid peptide with promising activity for glioblastoma multiforme

(2008) David A Reardon et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Evolution of collagen-based adhesion systems

(2008) Jyrki Heino et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Original triazine inductor of new specific molecular targets, with antitumor activity against nonsmall cell lung cancer

(2008) Dimitri Moreau et al.   INTERNATIONAL JOURNAL OF CANCER

Randomized Phase II Study of Cilengitide, an Integrin-Targeting Arginine-Glycine-Aspartic Acid Peptide, in Recurrent Glioblastoma Multiforme

(2008) David A. Reardon et al.   JOURNAL OF CLINICAL ONCOLOGY

Cilengitide induces cellular detachment and apoptosis in endothelial and glioma cells mediated by inhibition of FAK/src/AKT pathway

(2008) Leticia Oliveira-Ferrer et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Extended survival of Pyk2 or FAK deficient orthotopic glioma xenografts

(2008) Christopher A. Lipinski et al.   JOURNAL OF NEURO-ONCOLOGY

The Role of Myosin II in Glioma Invasion of the Brain

(2008) Christopher Beadle et al.   MOLECULAR BIOLOGY OF THE CELL

Loss of prostaglandin D2 synthase: a key molecular event in the transition of a low-grade astrocytoma to an anaplastic astrocytoma

(2008) Cathy A. Payne et al.   MOLECULAR CANCER THERAPEUTICS

Identification of genes that regulate epithelial cell migration using an siRNA screening approach

(2008) Kaylene J. Simpson et al.   NATURE CELL BIOLOGY

Bevacizumab for recurrent malignant gliomas: Efficacy, toxicity, and patterns of recurrence

(2008) A. D. Norden et al.   NEUROLOGY

Malignant Gliomas in Adults

(2008) Patrick Y. Wen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rapamycin inhibits F-actin reorganization and phosphorylation of focal adhesion proteins

(2008) L Liu et al.   ONCOGENE

Modulation of P-Glycoprotein at the Blood-Brain Barrier: Opportunities to Improve Central Nervous System Pharmacotherapy

(2008) D. S. Miller et al.   PHARMACOLOGICAL REVIEWS

Antitumor Activity of Rapamycin in a Phase I Trial for Patients with Recurrent PTEN-Deficient Glioblastoma

(2008) Tim F Cloughesy et al.   PLOS MEDICINE

Tropomyosins as interpreters of the signalling environment to regulate the local cytoskeleton

(2007) G.M. O’Neill et al.   SEMINARS IN CANCER BIOLOGY