Review
Biochemistry & Molecular Biology
Ruixin Yang, Yingyan Yu
Summary: Glucocorticoids, including natural and synthetic hormones, play a critical role in maintaining homeostasis and responding to stress. While the demand for glucocorticoids increases during severe conditions, careful adjustment of dosage and duration is essential to prevent side effects.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Cell Biology
Ruwen Wang, Qin Sun, Xianmin Wu, Yiyin Zhang, Xiaorui Xing, Kaiqing Lin, Yue Feng, Mingqi Wang, Yibing Wang, Ru Wang
Summary: The global epidemic of obesity is closely related to multiple comorbidities. Endogenous hypoxia may worsen dysfunction in adipose tissue, while moderate hypoxic exercise can help reduce weight and metabolic risks, potentially serving as an effective treatment for obesity.
Review
Medicine, Research & Experimental
Xin-qiu Song, Qian Li, Jing Zhang
Summary: DLG5 is a scaffold molecule for signal transduction complexes, responsible for assembling receptors and adapters. It stabilizes adhesion and tight bonding complexes and is involved in maintaining epithelial polarity. It has been linked to the onset and development of several diseases, impacting cancer progression through interactions with various signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Immunology
Kehinde Adebayo Babatunde, Oluwadamilola Fatimat Adenuga
Summary: Neutrophils play an important role in malaria, both in the defense against the malaria parasite and in the pathogenesis of the disease. However, malaria parasites inhibit the antimicrobial function of neutrophils, which may make malaria patients more susceptible to bacterial infections.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Rachel L. Washburn, Taylor Hibler, Gurvinder Kaur, Jannette M. Dufour
Summary: Sertoli cells serve a dual role in protecting germ cells from autoimmune destruction and activating immune responses against infections.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Huijie Zhao, Yanting Zhang, Xiaodi Fu, Chaoren Chen, Saadullah Khattak, Honggang Wang
Summary: Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver, and it is also the leading cause of cancer-related death worldwide. Despite numerous studies conducted on HCC, the molecular mechanisms and effective treatment options are not fully understood. Hydrogen sulfide (H2S), previously considered a toxic gas, has been found to have multiple biological functions, but its role and mechanism in HCC remain unclear.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Microbiology
Fatemeh Mohammad-Rafiei, Fatemeh Moadab, Ali Mahmoudi, Jamshid Gholizadeh Navashenaq, Seyed Mohammad Gheibihayat
Summary: Efferocytosis is a rapid and efficient process that removes dying or dead cells. It plays a critical role in tissue homeostasis and innate immunity, but can also be exploited by pathogens to evade immune detection and promote infection.
ARCHIVES OF MICROBIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Haixia Ji, Wenzhe Wang, Xia Li, Xiaoying Han, Xinyu Zhang, Juan Wang, Changxiao Liu, Luqi Huang, Wenyuan Gao
Summary: This review discusses the role of the p53 gene in regulating ferroptosis, primarily through influencing metabolic networks and signaling pathways that affect tumor cell sensitivity to ferroptosis. This has important implications for further understanding the role of p53 in tumor ferroptosis and developing new strategies for cancer treatment.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Nutrition & Dietetics
Rachel Marion-Letellier, Mathilde Leboutte, Asma Amamou, Maitreyi Raman, Guillaume Savoye, Subrata Ghosh
Summary: Intestinal fibrosis is a major complication of inflammatory bowel diseases, especially Crohn's disease, for which effective treatments are lacking. Diet may play a role in influencing the predisposition to develop intestinal fibrosis or alter its natural history by modifying the host immune response and intestinal microbial composition. Further studies are needed to investigate the effects of dietary factors on IBD-induced intestinal fibrosis and potential therapies to inhibit or promote fibrosis factors in the gut.
Review
Biochemistry & Molecular Biology
Danhui Liu, Zhenyu Zhong, Michael Karin
Summary: Inflammation is an important physiological process that removes pathogens, cellular debris, and promotes tissue repair. NF-kappa B transcription factor family plays a key role in inflammation, both promoting inflammatory response and tissue repair. Recent studies have shown that the NF-kappa B pathway also has inhibitory effects to temper inflammation.
Article
Green & Sustainable Science & Technology
Mengyin Li, Phillip H. Phan, Xian Sun
Summary: The study finds that business-friendly local-government policies combined with weak legal institutions lead to higher prevalence of fraud activities, as evidenced by the number of failed P2P lending platforms in China.
Editorial Material
Hematology
Brian D. Friend
Summary: In this study, the authors demonstrate that treatment intensification and improved supportive care measures have significantly improved long-term survival for childhood AML survivors. However, they also highlight the unwanted effects of treatment intensification, including increased burden of late effects and toxicity in recent patients.
Review
Cell Biology
Marcelo Santos da Silva
Summary: This article discusses the unique dependence of trypanosomatids on DSBs for important events such as antigenic variation, genetic exchange, and genomic changes, as well as how they balance the benefits and challenges caused by DSBs through homologous recombination.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Alfredo Pherez-Farah, Rosa del Carmen Lopez-Sanchez, Luis Mario Villela-Martinez, Rocio Ortiz-Lopez, Brady E. Beltran, Jose Ascencion Hernandez-Hernandez
Summary: Lymphomas are a highly complex and diverse group of hematological neoplasms, with pathogenic mechanisms involving dysregulation of the sphingolipid family. The crucial role of sphingolipids in virtually every cellular process makes studying their impact in cancer essential.
Review
Biochemistry & Molecular Biology
Chengfei Xu, Ziling Liu, Jiangwei Xiao
Summary: Ferroptosis is a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation. It has unique biological processes and pathophysiological characteristics compared to other forms of cell death. Understanding the role of ferroptosis in disease progression, particularly in gastrointestinal diseases, has potential implications for novel therapeutic interventions in clinical settings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)