Review
Polymer Science
Ilayda Firlar, Mine Altunbek, Colleen McCarthy, Murugan Ramalingam, Gulden Camci-Unal
Summary: Chronic wounds have a severe impact on 1-2% of the population in developed countries. The treatment of chronic wounds is crucial for the well-being and quality of life of patients. Hydrogel dressings, with their functional properties and advantages, have emerged as a promising choice for the treatment of chronic wounds.
Review
Pharmacology & Pharmacy
Karan Razdan, Jorge Garcia-Lara, V. R. Sinha, Kamalinder K. Singh
Summary: This review focuses on the mechanism of biofilm formation and the role of biofilms in chronic wounds, as well as various formulation strategies and delivery systems used to eradicate or disperse biofilms. The clinical research on the treatment of biofilm-infected chronic wounds is also discussed.
DRUG DISCOVERY TODAY
(2022)
Article
Cell Biology
Elof Eriksson, Paul Y. Liu, Gregory S. Schultz, Manuela M. Martins-Green, Rica Tanaka, Dot Weir, Lisa J. Gould, David G. Armstrong, Gary W. Gibbons, Randy Wolcott, Oluyinka O. Olutoye, Robert S. Kirsner, Geoffrey C. Gurtner
Summary: The Wound Healing Foundation (WHF) organized a virtual meeting to establish a consensus on the best treatment for chronic wounds. The meeting covered topics such as diagnosis, debridement, infection control, dressings, grafting, pain management, oxygen treatment, outcomes, and future needs. Key takeaways included the need for simplified wound care, the potential benefits of telemonitoring, and the importance of defining patient expectations.
WOUND REPAIR AND REGENERATION
(2022)
Review
Pharmacology & Pharmacy
Eric R. Bray, Alisha R. Oropallo, Daniel A. Grande, Robert S. Kirsner, Evangelos V. Badiavas
Summary: This article discusses the causes of chronic wounds and the burden they pose on individuals and healthcare systems, introduces the roles of MSCs and EVs in skin repair, and the use of EVs as a therapeutic agent in wound care.
Article
Engineering, Biomedical
Tianqin Ning, Fenghe Yang, Danli Chen, Zhenzhen Jia, Rongqing Yuan, Zhenqin Du, Shuaiyin Liu, Yao Yu, Xiaochuan Dai, Xufeng Niu, Yubo Fan
Summary: A novel dual-layer dressing MN system is introduced for programmed treatment of chronic wounds, which exhibits antibacterial, neovascularization, and immune response activation effects, potentially valuable in wound healing and other biomedical fields.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Engineering, Environmental
Laura Miranda-Calderon, Cristina Yus, Cristina Remirez de Ganuza, Monica Paesa, Guillermo Landa, Elena Tapia, Estela Perez, Marta Perez, Victor Sebastian, Silvia Irusta, Gracia Mendoza, Manuel Arruebo
Summary: Advanced medicated wound dressings fabricated by electrospinning and electrospraying provide dually controlled antibiotic release kinetics, effectively eradicating bacterial infections and preventing biofilm formation. They also exhibit no cytotoxicity to eukaryotic cells and have been proven effective in a chronic wound murine model.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Dermatology
Anna L. L. Worsley, Dennis H. H. Lui, Winnie Ntow-Boahene, Wenhui Song, Liam Good, Janice Tsui
Summary: Diabetic chronic wounds cause significant suffering and economic problems globally. Chronic inflammation in these wounds is a complex result of diabetes-related pathophysiological mechanisms. Despite advanced treatment options, many wounds remain unhealed, leading to increased morbidity and mortality. This review discusses the pathophysiology of chronic inflammation in diabetic ulcers and potential treatment options to address this dysfunction. Treating inflammation in these complex wounds may be crucial in triggering healing.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Medicine, General & Internal
Vincent Falanga, Roslyn Rivkah Isseroff, Athena M. Soulika, Marco Romanelli, David Margolis, Suzanne Kapp, Mark Granick, Keith Harding
Summary: Chronic wounds are wounds that do not heal within an expected time frame due to prolonged dysregulated inflammation. Advances in understanding the cellular and molecular aspects of basic science and innovative treatment modalities have improved the management of chronic wounds. However, gaps still exist in scientific knowledge, highlighting the need for further research to enhance understanding of chronic wounds.
NATURE REVIEWS DISEASE PRIMERS
(2022)
Review
Cell Biology
Jordan Holl, Cezary Kowalewski, Zbigniew Zimek, Piotr Fiedor, Artur Kaminski, Tomasz Oldak, Marcin Moniuszko, Andrzej Eljaszewicz
Summary: With the increasing prevalence of type 2 diabetes mellitus, the management of chronic diabetic wounds and ulcers has become a significant therapeutic challenge. Recent advancements in understanding wound healing mechanisms have led to the development of novel therapies, with a particular focus on biological dressings.
Article
Polymer Science
Beatriz Guitton Renaud Baptista de Oliveira, Bianca Campos Oliveira, Gabriela Deutsch, Fernanda Soares Pessanha, Rossana Mara da Silva Moreira Thire, Selma Rodrigues de Castilho
Summary: The aim of this study was to evaluate the healing process of chronic wounds treated with carboxymethylcellulose loaded with recombinant human epidermal growth factor in patients with diabetes. The results showed that the use of epidermal growth factor was effective in treating chronic wounds, especially diabetic ulcers, resulting in a reduction in wound area and improvement in tissue and exudate quality.
Article
Biochemistry & Molecular Biology
Iveta Schmiedova, Alena Dembickaja, Ludmila Kiselakova, Beata Nowakova, Petr Slama
Summary: Amniotic membrane grafts have shown great therapeutic potential for wounds healing, with a treatment efficacy of 86% to 90% as indicated by the investigated data from publications and posters.
Article
Biochemistry & Molecular Biology
Vojtech Pavlik, Lubos Sobotka, Jaroslav Pejchal, Martin Cepa, Kristina Nesporova, Monika Arenbergerova, Adela Mrozkova, Vladimir Velebny
Summary: The study compared the healing of chronic wounds treated with a standard silver dressing and a dressing containing octenidine antiseptic, finding that the octenidine dressing promoted wound healing, reduced wound slough, and observed direct effects of silver on wound cells during treatment.
Article
Dermatology
Jing Liu, Hong Shen
Summary: This retrospective study explored the clinical efficacy of chitosan-based hydrocolloid dressing in treating chronic refractory wounds. The results showed that chitosan-based hydrocolloid dressing significantly improved wound healing, reduced pain and itching, and decreased the overall cost and frequency of dressing change.
INTERNATIONAL WOUND JOURNAL
(2022)
Review
Chemistry, Multidisciplinary
Zhuolun Hao, Wenli Qi, Jiaming Sun, Muran Zhou, Nengqiang Guo
Summary: Although there are methods for treating wounds clinically, chronic wounds still pose challenges due to excessive inflammation, difficulties in epithelialization, vascularization, and other factors. Recent research on adipose-derived stem cells (ADSCs) has shown that they can promote the healing of chronic wounds by regulating macrophage function, cellular immunity, and promoting angiogenesis and epithelialization. This study reviews the difficulties in treating chronic wounds and the advantages and mechanisms of ADSCs in promoting their healing to provide a reference for stem cell therapy.
FRONTIERS IN CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Maur Sebastian Horgos, Ovidiu Laurean Pop, Mircea Sandor, Ioan Lucian Borza, Rodica Negrean, Felicia Marc, Klaudia Major, Liliana Sachelarie, Carmen Grierosu, Anca Huniadi
Summary: Atonic wounds are a significant health problem that negatively affects patients' daily lives. In this study, a 12-watt laser probe was used to stimulate patients' wounds. The study group, which received laser therapy, showed more effective improvement in local symptoms compared to the reference group. The positive effects of this therapy on atonic wounds suggest its importance in terms of cost and patient rehabilitation.