Review
Cell Biology
Mohamad Mahjoor, Arshia Fakouri, Simin Farokhi, Hojjatollah Nazari, Hamed Afkhami, Fatemeh Heidari
Summary: The skin is essential for the innate and adaptive immune systems, but skin lesions can have undesirable consequences. Mesenchymal stromal cells (MSCs) are being increasingly used for skin wound treatment due to their advantages in promoting healing. The oxygen concentration has an impact on MSC biology, and expanding MSCs in a hypoxic environment can enhance their effectiveness.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Natalie Vallant, Bynvant Sandhu, Karim Hamaoui, Maria Prendecki, Charles Pusey, Vassilios Papalois
Summary: This study compared the paracrine effects of MSC supernatants from different age and genotype sources on macrophages, revealing distinct patterns of inflammatory marker expression. These findings are crucial for preclinical and clinical studies utilizing MSCs for inflammation and allo-response mitigation in transplant patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Zheng Kou, Balun Li, Aili Aierken, Ning Tan, Chenchen Li, Miao Han, Yuanxiang Jing, Na Li, Shiqiang Zhang, Sha Peng, Xianjun Zhao, Jinlian Hua
Summary: The existing treatment modalities for skin injuries, such as dressings, negative-pressure wound treatment, autologous skin grafting, and high-pressure wound treatment, have limitations such as high time cost and inability to remove inactivated tissue in a timely manner. Mesenchymal stem cells (MSCs) have great potential in cell therapy and regenerative medicine due to their unique self-renewal ability and differentiation potential. The addition of collagen to cell cultures promotes cell proliferation and accelerates the healing of skin wounds in mice and canines by promoting epidermal layer repair, collagen deposition, hair follicle angiogenesis, and an inflammatory response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Caiqi Shen, Changbo Tao, Aijun Zhang, Xueyang Li, Yanping Guo, Hanxiao Wei, Qichuan Yin, Qiang Li, Peisheng Jin
Summary: The study revealed that BMSC-derived exosomes promote skin wound healing via the miR-93-3p/APAF1 axis, providing a potential new therapeutic strategy.
Article
Pharmacology & Pharmacy
Seungwon An, Khandaker Anwar, Mohammadjavad Ashraf, Hyungjo Lee, Rebecca Jung, Raghuram Koganti, Mahmood Ghassemi, Ali R. Djalilian
Summary: In this study, the researchers investigated the use of human bone-marrow-derived MSC secretome (MSC-S) for treating corneal epithelial wounds. They found that MSC extracellular vesicles (EV)/exosomes played a crucial role in mediating the wound-healing effects of MSC-S. Furthermore, they discovered that the concentration and incubation period of MSC-CM had an impact on wound healing.
Article
Cell & Tissue Engineering
Clara Sanjurjo-Rodriguez, Rachel E. Crossland, Monica Reis, Hemant Pandit, Xiao-nong Wang, Elena Jones
Summary: This study found that subchondral bone mesenchymal stromal cells in osteoarthritis are capable of producing extracellular vesicles (EVs) that enhance chondrocyte viability and the expression of chondrogenic genes. miRNA profiling revealed distinct microRNA sets in OA-EVs, suggesting their potential role in mediating cross-talk between subchondral bone and cartilage in osteoarthritis.
STEM CELLS INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Kotaro Tanaka, Ryohei Ogino, Sho Yamakawa, Shota Suda, Kenji Hayashida
Summary: Skin wounds usually heal on their own, but this is only true for healthy individuals. Mesenchymal stem cells (MSCs) have been found to play a significant role in wound healing and regeneration, with their ability to self-renew and differentiate, as well as their anti-inflammatory and immunomodulatory properties. This review aims to explain the functions and effects of MSCs in wound healing.
Article
Engineering, Biomedical
Yan Qu, Yifan He, Bowen Meng, Xiao Zhang, Junjun Ding, Xiaoxing Kou, Wei Teng, Songtao Shi
Summary: This study revealed that pluripotent stem cell-derived apoptotic vesicles (PSC-apoVs) can inherit pluripotent molecules and promote the activation of adult stem cells and skin wound healing. These findings provide a potential cell-free strategy for clinical applications using PSC-apoVs.
ACTA BIOMATERIALIA
(2022)
Review
Endocrinology & Metabolism
Xiaoping Yu, Pan Liu, Zheng Li, Zhengdong Zhang
Summary: Diabetes is a global public health problem, with diabetic foot being one of its severe complications that have a significant impact on patients' economic burden and quality of life. Recent studies have shown that mesenchymal stem cells (MSCs) can effectively treat diabetic foot ulcers by promoting angiogenesis and re-epithelialization, regulating the immune response, and reducing inflammation. MSCs from different sources have similar characteristics and subtle differences, and understanding their features is crucial for improving the therapeutic effect of diabetic foot ulcers.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Cell & Tissue Engineering
Yongqing Zhao, Min Wang, Feng Liang, Jiannan Li
Summary: Skin wound healing is a complex process involving various cells and mediators, and dysregulation can lead to chronic or non-healing wounds. Stem cell therapy has shown significant advancements in wound regeneration, particularly utilizing mesenchymal stem cells, but there are challenges with limited cell efficacy and underutilized therapeutic potential. Innovations are needed to enhance stem cell efficacy for better clinical outcomes.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Quan Li, Guangyan Qi, Dylan Lutter, Warren Beard, Camila R. S. Souza, Margaret A. Highland, Wei Wu, Ping Li, Yuanyuan Zhang, Anthony Atala, Xiuzhi Sun
Summary: This study compared the functional effects of PGmatrix, HA, and HA-based Hystem hydrogels on hADMSCs. The results showed that PGmatrix was superior in maintaining hADMSC viability and stimulating SSEA4 expression. hADMSCs encapsulated in PGmatrix secreted more immune-responsive proteins and showed improved skin wound healing in diabetic-induced mice.
Article
Materials Science, Multidisciplinary
Yongjin Sun, Juntao Zhang, Bi Chen, Yunlong Yang, Haiyan Li, Xin Niu, Qing Li, Weidong Wu, Zongping Xie, Yunfeng Chen, Fuyue Wu, Yang Wang
Summary: This study demonstrates the effectiveness of USC-sEVs in accelerating wound healing in aged mice by ameliorating cellular senescence and reducing SASP secretion. USC-sEVs loaded in HAAM can effectively accelerate wound healing by controlling release and locating the sEVs in the wound site.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2021)
Review
Microbiology
Elahe Andalib, Mojtaba Kashfi, Golnaz Mahmoudvand, Elaheh Rezaei, Mohamad Mahjoor, Alireza Torki, Hamed Afkhami
Summary: Mesenchymal stromal cells (MSCs) and their exosomes have emerged as revolutionary tools in tissue engineering and regenerative medicine. MSCs have the ability to generate skin cells, decrease inflammation, emit pro-angiogenic molecules, and exert antimicrobial effects. However, retaining transplanted MSC cells remains a challenge, and the impact of hypoxia on MSC functioning is crucial.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Geriatrics & Gerontology
Saeid Amini-Nik, Abdikarim Abdullahi, Roohi Vinaik, Ren Jie Robert Yao, Nancy Yu, Andrea Datu, Cassandra Belo, Marc G. Jeschke
Summary: Impaired wound healing in the elderly population is a significant problem associated with health and economic burdens. This study compared the wound healing process in adult and young mice and found that adult animals had an insufficient pool of MSCs, which limited their ability to migrate to the wound bed. The deficiency of CD90-positive MSCs in adult animals was positively correlated with the number of F4/80+ macrophages. These findings highlight the disturbed cellular interaction between myeloid cells and mesenchymal cells as a potential mechanism for impaired wound healing in adult mice.
Article
Cell & Tissue Engineering
Yang Zhou, Bo Zhao, Xin-Liao Zhang, Yi-jun Lu, Shou-Tao Lu, Jian Cheng, Yu Fu, Lin Lin, Ning-Yan Zhang, Pei-Xin Li, Jing Zhang, Jun Zhang
Summary: This study investigated the potential clinical application roles of human adipose-derived mesenchymal stem cells (hADSC) and hADSC-derived exosomes (hADSC-Exo) in cutaneous wound healing. The combined administration of local hADSC-Exo smearing and hADSC/hADSC-Exo intravenous administration showed additional benefits in promoting wound healing, accelerating re-epithelialization, reducing scar widths, and enhancing angiogenesis and collagen synthesis.
STEM CELL RESEARCH & THERAPY
(2021)