Article
Biochemistry & Molecular Biology
Hanif Haidari, Richard Bright, Sanjay Garg, Krasimir Vasilev, Allison J. Cowin, Zlatko Kopecki
Summary: The development of highly potent ultrasmall AgNPs combined with a biocompatible hydrogel has shown promising results in eliminating mature biofilm infections in vivo and promoting wound healing. The treatment exhibited superior antibacterial efficacy and improved wound closure, re-epithelization, and collagen deposition compared to conventional silver-based treatments.
Review
Dermatology
May Barakat, Luisa A. DiPietro, Lin Chen
Summary: While there have been many scientific discoveries in the treatment of diabetic wounds, the challenge remains in translating laboratory findings into novel clinical therapies for human patients.
ADVANCES IN WOUND CARE
(2021)
Article
Pharmacology & Pharmacy
Erika Maria Tottoli, Enrica Chiesa, Gabriele Ceccarelli, Silvia Pisani, Giovanna Bruni, Ida Genta, Bice Conti, Rossella Dorati
Summary: Biofiber is a new generation bandage with patented fiber technology that is highly absorbent and textured. It is designed to treat complex injuries like burns and can adapt to any part of the body. The prototypes of textured bandages developed with PLA-PCL-based fibers showed good stability and demonstrated enhanced protein shielding and compatibility with cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Madelene A. Andersson, Lone Bruhn Madsen, Artur Schmidtchen, Manoj Puthia
Summary: This study introduces an ex vivo wound infection model using porcine skin and a burn wounding method, allowing for the efficacy evaluation of topical antimicrobial formulations. The results demonstrate compatibility with clinically relevant bacterial strains and confirm the effectiveness of antibacterial treatments, highlighting the formation of biofilms on the wound surface as well.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
P-A Lehur
Summary: Fecal incontinence (FI) is a common condition that can significantly impact a patient's quality of life. The Contix (TM) is a new non-invasive device for managing FI, based on an innovative concept that shows promising results in initial trials.
TECHNIQUES IN COLOPROCTOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Taewon Jeon, Jessa Marie V. Makabenta, Jungmi Park, Ahmed Nabawy, Yagiz Anil Cicek, Sarah S. Mirza, Janelle Welton, Muhammad Aamir Hassan, Rui Huang, Jesse Mager, Vincent M. Rotello
Summary: This study presents the use of a cationic antimicrobial polymer to generate siRNA polyplexes for dual-mode treatment of wound biofilms. These polyplexes act as both antibiofilm agents and siRNA delivery vehicles to reduce inflammation and enhance wound healing. In vitro and in vivo experiments showed promising results, significantly reducing bacterial load and MMP9 expression, and speeding up wound healing.
MATERIALS HORIZONS
(2023)
Article
Public, Environmental & Occupational Health
E. K. Stuermer, M. Besser, F. Brill, M. Geffken, I Plattfaut, A. L. Severing, V Wiencke, J. D. Rembe, E. A. Naumova, A. Kampe, S. Debus, R. Smeets
Summary: Biofilms are a major challenge in treating chronic wounds as antimicrobials have limited effect on them. This study compared three biofilm models using different blood sources and found that while the biofilms showed little reaction to a hypochlorous solution, they were significantly impacted by octenidine hydrochloride after 48 hours. The results suggest that both human and sheep blood based biofilm models can be effective for testing new antimicrobial substances in vitro.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2021)
Article
Nanoscience & Nanotechnology
Biao Wang, Donghui Zhao, Yuting Li, Xinpei Zhou, Zexuan Hui, Xiaoling Lei, Lin Qiu, Yang Bai, Cheng Wang, Jiang Xia, Yang Xuan, Pengju Jiang, Jianhao Wang
Summary: In order to prevent the development of drug resistance during antibiotic treatment of wound infections, the use of antimicrobial peptides (AMPs) has been explored. However, challenges such as low bioavailability, rapid degradation of AMPs, and the difficulty of eliminating bacteria in deep tissue hinder its application. To address these issues, microneedle patches containing AMPs and recombinant type III humanized collagen (Col III) were designed for slow and controlled release to effectively eradicate bacteria in deep wound tissue and promote wound healing. This strategy demonstrates the potential of a microneedle-based antimicrobial drug delivery system.
ACS APPLIED NANO MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Sipan Li, Yongan Wang, Siting Wang, Jianjun Xie, Tingming Fu, Shaoguang Li
Summary: We developed a hydrogel with berberine hydrochloride liposomes to disrupt bacterial biofilms and accelerate wound healing. In mouse experiments, the hydrogel effectively reduced the number of biofilms, decreased inflammation, and promoted re-epithelialization and vascular regeneration in wound tissue. This study provides a new perspective for tackling drug resistance and fighting wound infections.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biophysics
Karan Razdan, Shashi Kanta, Ekta Chaudhary, Seema Kumari, Deepak Kumar Rahi, Ashok Kumar Yadav, Vivek Ranjan Sinha
Summary: The study developed and characterized levofloxacin-loaded clove oil nanoscale emulgel and evaluated its therapeutic efficacy in Pseudomonas aeruginosa biofilm-infected burn wounds in mice. The results showed that the emulgel dispersed biofilms, closed wounds, promoted re-epithelialization and collagen deposition, and cleared the infection within 7 days, indicating its effectiveness in treating biofilm-infected burn wounds.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Review
Infectious Diseases
Marcela Nowak, Wioletta Baranska-Rybak
Summary: Chronic wounds are a growing concern due to high treatment costs and reduced quality of life for patients. Prolonged infection caused by biofilm is a major challenge in treatment, but nanomaterials show promise in tackling this issue in wound healing.
Article
Microbiology
Alba Rubio-Canalejas, Aida Baelo, Sara Herbera, Nuria Blanco-Cabra, Marija Vukomanovic, Eduard Torrents
Summary: Studied the relationship between P. aeruginosa and S. aureus and its effect on antimicrobial treatment, and found that functionalized silver nanoparticles can improve antibiotic therapy. Proposed a clinical treatment combining antibiofilm enzymes and antibiotics.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Medicine, Research & Experimental
Sundos Suleman Ismail Abdalla, Haliza Katas, Jie Yee Chan, Pavitra Ganasan, Fazren Azmi, Mh Busra Fauzi
Summary: A novel gelatin hydrogel incorporated with bio-nanosilver and lactoferrin was successfully developed, showing promising antimicrobial effects against S. aureus and P. aeruginosa without interfering with normal cellular functions. This new approach may accelerate healing of chronic wounds by targeting biofilms in infected wounds.
MOLECULAR PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Fan Zhao, Yajuan Su, Junying Wang, Svetlana Romanova, Dominick J. DiMaio, Jingwei Xie, Siwei Zhao
Summary: Biofilm infection in chronic wounds is common and delays wound healing. This paper describes a highly effective electrical antibiofilm treatment system that uses high-intensity current to debride biofilm and enhance antibiotic delivery. The system reduces bacterial count of MRSA biofilm-infected ex vivo skin wounds and demonstrates in vivo antibiofilm efficacy in a diabetic mouse-based wound infection model. This novel technology provides a quick, safe, and highly efficacious treatment for chronic wound biofilm infections.
ADVANCED MATERIALS
(2023)
Review
Oncology
Kurt Sartorius, Samuel O. Antwi, Anil Chuturgoon, Lewis R. Roberts, Anna Kramvis
Summary: This review paper investigates the potential of RNA interference (RNAi) as a therapeutic option for HCC and explores various RNAi technologies. It outlines three primary strategies of RNAi interventions and discusses challenges such as chemical and delivery problems, targeting issues, and immune reactions.
FRONTIERS IN ONCOLOGY
(2022)