PARP-1: Friend or Foe of DNA Damage and Repair in Tumorigenesis?

Cisplatin Resistance Associated with PARP Hyperactivation

(2013) J. Michels et al.   CANCER RESEARCH

Expression and activity of PARP family members in the hippocampus during systemic inflammation: Their role in the regulation of prooxidative genes

(2013) Grzegorz A. Czapski et al.   NEUROCHEMISTRY INTERNATIONAL

The diverse roles and clinical relevance of PARPs in DNA damage repair: Current state of the art

(2012) Mike De Vos et al.   BIOCHEMICAL PHARMACOLOGY

HER2 Overexpression Renders Human Breast Cancers Sensitive to PARP Inhibition Independently of Any Defect in Homologous Recombination DNA Repair

(2012) S. Nowsheen et al.   CANCER RESEARCH

Loss of PIDD limits NF-κB activation and cytokine production but not cell survival or transformation after DNA damage

(2012) F J Bock et al.   CELL DEATH AND DIFFERENTIATION

Role of poly(ADP-ribose) polymerases in the regulation of inflammatory processes

(2012) Péter Bai et al.   FEBS LETTERS

Lipopolysaccharide activates ERK–PARP-1–RelA pathway and promotes nuclear factor–κB transcription in murine macrophages

(2012) Linlin Liu et al.   HUMAN IMMUNOLOGY

Nuclear PARP-1 protein overexpression is associated with poor overall survival in early breast cancer

(2011) F. Rojo et al.   ANNALS OF ONCOLOGY

PARP-1 expression in breast cancer including BRCA1-associated, triple negative and basal-like tumors: possible implications for PARP-1 inhibitor therapy

(2011) Pawel Domagala et al.   BREAST CANCER RESEARCH AND TREATMENT

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

PARP Inhibitor Treatment in Ovarian and Breast Cancer

(2011) Marcie K. Weil et al.   CURRENT PROBLEMS IN CANCER

PARP inhibition alleviates diabetes-induced systemic oxidative stress and neural tissue 4-hydroxynonenal adduct accumulation: Correlation with peripheral nerve function

(2011) Sergey Lupachyk et al.   FREE RADICAL BIOLOGY AND MEDICINE

Poly(ADP-ribose) polymerase-1 is a key mediator of cisplatin-induced kidney inflammation and injury

(2011) Partha Mukhopadhyay et al.   FREE RADICAL BIOLOGY AND MEDICINE

Senescent cells develop a PARP-1 and nuclear factor- B-associated secretome (PNAS)

(2011) M. Ohanna et al.   GENES & DEVELOPMENT

Role of oxidative stress and DNA damage in human carcinogenesis

(2011) Thomas B. Kryston et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Identification of PARP-1 as one of the transcription factors binding to the repressor element in the promoter region of COX-2

(2010) Yan Lin et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

PARP inhibitors: New tools to protect from inflammation

(2010) Vincenzo Giansanti et al.   BIOCHEMICAL PHARMACOLOGY

p21CDKN1A participates in base excision repair by regulating the activity of poly(ADP-ribose) polymerase-1

(2010) Ornella Cazzalini et al.   DNA REPAIR

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

(2010) Andrew Tutt et al.   LANCET

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial

(2010) M William Audeh et al.   LANCET

Clustered DNA lesion repair in eukaryotes: Relevance to mutagenesis and cell survival

(2010) Evelyne Sage et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination

(2009) Helen E Bryant et al.   EMBO JOURNAL

Thieno[2,3-c]Isoquinolin-5-one, a Potent Poly(ADP-Ribose) Polymerase Inhibitor, Promotes Atherosclerotic Plaque Regression in High-Fat Diet-Fed Apolipoprotein E-Deficient Mice: Effects on Inflammatory Markers and Lipid Content

(2009) C. P. Hans et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Inhibition of Poly(ADP-Ribose) Polymerase in Tumors fromBRCAMutation Carriers

(2009) Peter C. Fong et al.   NEW ENGLAND JOURNAL OF MEDICINE

Transcriptional control by PARP-1: chromatin modulation, enhancer-binding, coregulation, and insulation

(2008) W Lee Kraus   CURRENT OPINION IN CELL BIOLOGY

Accumulation of oxidatively induced clustered DNA lesions in human tumor tissues

(2008) Somaira Nowsheen et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases

(2007) Paul et al.   Frontiers in Bioscience-Landmark

Processing of DNA damage clusters in human cells: current status of knowledge

(2007) Alexandros G. Georgakilas   Molecular BioSystems