Article
Biochemistry & Molecular Biology
Muhammad Babar Khan, Rosamaria Ruggieri, Eesha Jamil, Nhan L. Tran, Camila Gonzalez, Nancy Mugridge, Steven Gao, Jennifer MacDiarmid, Himanshu Brahmbhatt, Jann N. Sarkaria, John Boockvar, Marc Symons
Summary: The study suggests that microRNA-34a can effectively reduce the activation status of glioblastoma cells and enhance survival rates against multiple glioblastoma cell types. Combination therapy of temozolomide with microRNA-34a loaded nanocells targeted to epidermal growth factor receptor (EGFR) significantly enhances sensitivity of glioblastoma cells to treatment.
MOLECULAR MEDICINE
(2021)
Article
Clinical Neurology
Sippl Christoph, Saenz Alicia, Teping Fritz, Trenkpohl Vanessa, Ketter Ralf, Kim Yoo Jin, Linsler Stefan, Oertel Joachim
Summary: This study investigates the prognostic markers of epigenetic tumor features in glioblastoma and finds that the heterogeneity of these features within tumors may influence survival. Using tumor samples from 154 glioblastoma patients, the study examines the methylation and miRNA expression heterogeneity and correlates them with patient survival.
ACTA NEUROCHIRURGICA
(2023)
Article
Cell Biology
Arthur Bassot, Helena Dragic, Sarah Al Haddad, Laurine Moindrot, Soline Odouard, Francesca Corlazzoli, Eliana Marinari, Alexandra Bomane, Augustin Brassens, Antoine Marteyn, Youssef Hibaoui, Tom J. Petty, Mounira Chalabi-Dchar, Louis Larrouquere, Evgeny M. Zdobnov, Noemie Legrand, Jerome Tamburini, Hubert Lincet, Marie Castets, Mayra Yebra, Denis Migliorini, Valerie Dutoit, Paul R. Walker, Olivier Preynat-Seauve, Pierre-Yves Dietrich, Erika Cosset
Summary: The study identified miR-17-3p, miR-222, and miR-340 as critical miRNAs for GBM patients and showed that their combinatorial modulation efficiently inhibited biological processes, induced cell death, and delayed tumor growth. This suggests that multi-targeting of miR-17-3p, miR-222, and miR-340 could be a promising therapeutic strategy for GBM patients.
CELL DEATH & DISEASE
(2023)
Editorial Material
Oncology
Zhihong Chen, Dolores Hambardzumyan
Summary: The study demonstrates that macrophages can induce a transition of glioblastoma cells into a mesenchymal-like cellular state, which is associated with an increased mesenchymal program in macrophages themselves and enhanced cytotoxicity of T cells.
Review
Nutrition & Dietetics
Maurice C. J. M. Konings, Sabine Baumgartner, Ronald P. P. Mensink, Jogchum Plat
Summary: Non-Alcoholic Fatty Liver Disease (NAFLD) is characterized by the accumulation of hepatic free cholesterol. Research suggests that certain miRNAs (miR122, 34a, 132, and 21) are associated with NAFLD and cholesterol metabolism, potentially playing a role in NAFLD development. Additionally, miRNAs 122, 34a, and 379 may be used as part of a panel of biomarkers for early detection of NAFLD.
Article
Biochemical Research Methods
Soyeon Kim, YuLong Bai, Zhenjiang Fan, Brenda Diergaarde, George C. Tseng, Hyun Jung Park
Summary: The study utilizes the PRIMATA-APA method to analyze TCGA breast cancer data, revealing that global APA events can alter the number of target sites for specific miRNAs enriched in cancer development and treatment. The knockdown of NUDT21 in HeLa cells shows that APA events can change the target sites of common tamoMiRNAs. The findings suggest that APA-induced tumorigenesis is attributed to changes in miRNA target sites rather than the APA events themselves.
BRIEFINGS IN BIOINFORMATICS
(2021)
Review
Biochemistry & Molecular Biology
Diana Wu, Lilian U. Thompson, Elena M. Comelli
Summary: Breast cancer, the second most common cancer in women after skin cancer, can be influenced by mammary gland development. miRNAs play a key role in both mammary development and breast cancer, and studying their role in development may provide insights into potential targets for breast cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Durba Pal, Subhadip Ghatak, Kanhaiya Singh, Ahmed Safwat Abouhashem, Manishekhar Kumar, Mohamed S. El Masry, Sujit K. Mohanty, Ravichand Palakurti, Yashika Rustagi, Saba Tabasum, Dolly K. Khona, Savita Khanna, Sedat Kacar, Rajneesh Srivastava, Pramod Bhasme, Sumit S. Verma, Edward Hernandez, Anu Sharma, Diamond Reese, Priyanka Verma, Nandini Ghosh, Mahadeo Gorain, Jun Wan, Sheng Liu, Yunlong Liu, Natalia Higuita Castro, Surya C. Gnyawali, William Lawrence, Jordan Moore, Daniel Gallego Perez, Sashwati Roy, Mervin C. Yoder, Chandan K. Sen
Summary: Skin injury reduces miR-200b levels in dermal fibroblasts, but inhibiting this miRNA can lead to the emergence of a vasculogenic fibroblast subset capable of forming functional blood vessels. This vasculogenic fibroblast state change can be achieved through topical tissue nanotransfection of a single anti-miR-200b oligonucleotide, providing a potential therapeutic approach for tissue vascularization in ischemic wounds.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Analytical
Wenshi He, Max K. Edney, Simon M. L. Paine, Rian L. Griffiths, David J. Scurr, Ruman Rahman, Dong-Hyun Kim
Summary: This study used the OrbiSIMS technique to investigate the metabolism of brain tumors within their highly heterogeneous microenvironment. The results showed that OrbiSIMS could differentiate morphologically distinct regions within single tumors. Cancer cells from necrotic regions were separated from viable GBM cells based on specific metabolites. In addition, tryptophan metabolism was discovered to be essential for GBM cellular survival. This study demonstrates the potential of OrbiSIMS for understanding tumor heterogeneity and developing targeted therapies.
ANALYTICAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Morten Muhlig Nielsen, Jakob Skou Pedersen
Summary: Utilizing motif enrichment analysis, miRNA activity estimates can be derived from scRNAseq data, allowing for insights into miRNA dynamics at the single cell level. This method has been shown to accurately estimate miRNA activity in sparse data comparable to scRNAseq experiments, with results supported by existing literature. The miRNA activity estimates have been implemented in the miReact software for use in various fields where scRNAseq is applied.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Chun Hu, Carlos A. Leche, Anatoly Kiyatkin, Zhaolong Yu, Steven E. Stayrook, Kathryn M. Ferguson, Mark A. Lemmon
Summary: The epidermal growth factor receptor (EGFR) frequently mutates in human cancer, and is an important therapeutic target. However, EGFR inhibitors have limited effectiveness in glioblastoma multiforme (GBM) due to exclusive mutations in the extracellular region. This study reveals that GBM mutations impair EGFR's ability to distinguish between activating ligands, which may have implications for therapeutic targeting.
Article
Cell Biology
Mirca S. Saurty-Seerunghen, Thomas Daubon, Lea Bellenger, Virgile Delaunay, Gloria Castro, Joris Guyon, Ahmed Rezk, Sylvie Fabrega, Ahmed Idbaih, Fabien Almairac, Fanny Burel-Vandenbos, Laurent Turchi, Eric Duplus, Thierry Virolle, Jean-Michel Peyrin, Christophe Antoniewski, Herve Chneiweiss, Elias A. El-Habr, Marie-Pierre Junier
Summary: Cell motility is critical for tumor malignancy. Analysis of transcriptomes from glioblastoma patients identified metabolic weaknesses shared by motile cells, characterized by enhanced mitochondrial load, oxidative stress, and dependence on increased ROS production and MPST activity for their motility.
CELL DEATH & DISEASE
(2022)
Article
Biochemical Research Methods
Wen Zhang, Zhishuai Li, Wenzheng Guo, Weitai Yang, Feng Huang
Summary: The paper introduces a network link inference method FLNSNLI based on linear neighborhood similarity for predicting miRNA-disease associations, which shows high accuracy and outperforms other methods. It performs well in predicting links for miRNAs or diseases without known associations.
IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS
(2021)
Article
Materials Science, Ceramics
Xuerui Wei, Bin Xu, Pengfei Guan
Summary: We found a direct link between the mechanical heterogeneity and local structural response of metallic glasses, revealing that the mechanical heterogeneity is not only related to static atomic packing but also to the dynamic evolution of the amorphous structure.
JOURNAL OF NON-CRYSTALLINE SOLIDS
(2022)
Article
Multidisciplinary Sciences
I-Na Lu, Celia Dobersalske, Laurel Rauschenbach, Sarah Teuber-Hanselmann, Anita Steinbach, Vivien Ullrich, Shruthi Prasad, Tobias Blau, Sied Kebir, Jens T. Siveke, Juergen C. Becker, Ulrich Sure, Martin Glas, Bjoern Scheffler, Igor Cima
Summary: HSPCs in glioblastoma tumor tissues are associated with malignant and immunosuppressive phenotypes, predicting patient survival and potentially serving as a target for brain tumor immunotherapies. A deeper understanding of the immune cell profile within the brain cancer tumor microenvironment could lead to improved immunotherapy efficacy.
NATURE COMMUNICATIONS
(2021)