Article
Biochemistry & Molecular Biology
Di Wu, Weibo Chen, Yang Yang, Yi Qin, Guangchen Zu, Yue Zhang, Yong An, Donglin Sun, Xiaowu Xu, Xuemin Chen
Summary: This study investigates the role of PITX2 in pancreatic stellate cells (PSCs) in the progression of pancreatic cancer and reveals that silencing PITX2 in PSCs inhibits the growth, migration, and invasion of pancreatic cancer cells. Additionally, high expression of PITX2 in stromal cells is correlated with poor prognosis in patients with pancreatic cancer.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Article
Cell Biology
Julienne L. Carstens, Sujuan Yang, Pedro Correa de Sampaio, Xiaofeng Zheng, Souptik Barua, Kathleen M. McAndrews, Arvind Rao, Jared K. Burks, Andrew D. Rhim, Raghu Kalluri
Summary: The study indicates that partial epithelial to mesenchymal transition is associated with metastasis in pancreatic ductal adenocarcinoma (PDAC), and genetic suppression can lead to epithelial stabilization and increased liver metastasis.
Article
Cell Biology
Huizhi Wang, Yuntao Ding, Qiuming Zhu, Zhengyue Yu, Qi Wang, Aihua Gong, Min Xu
Summary: In this study, it was found that lncRNA FAM83A-AS1 is highly expressed in pancreatic cancer and is associated with poor prognosis. FAM83A-AS1 promotes epithelial-mesenchymal transition (EMT) of pancreatic cancer cells through activation of the Hippo pathway. Therefore, FAM83A-AS1 may serve as a potential diagnostic and prognostic target for pancreatic cancer.
Article
Cell Biology
Neus Bota-Rabassedas, Priyam Banerjee, Yichi Niu, Wenjian Cao, Jiayi Luo, Yuanxin Xi, Xiaochao Tan, Kuanwei Sheng, Young-Ho Ahn, Sieun Lee, Edwin Roger Parra, Jaime Rodriguez-Canales, Jacob Albritton, Michael Weiger, Xin Liu, Hou-Fu Guo, Jiang Yu, B. Leticia Rodriguez, Joshua J. A. Firestone, Barbara Mino, Chad J. Creighton, Luisa M. Solis, Pamela Villalobos, Maria Gabriela Raso, Daniel W. Sazer, Don L. Gibbons, William K. Russell, Gregory D. Longmore, Ignacio I. Wistuba, Jing Wang, Harold A. Chapman, Jordan S. Miller, Chenghang Zong, Jonathan M. Kurie
Summary: Cancer cells alter cancer-associated fibroblasts through specific secretory programs and repulsion processes, promoting cancer cell metastasis and sensitivity to pro-metastatic signals from fibroblasts.
Article
Medicine, Research & Experimental
Yuanyang Wang, Cheng Qin, Bangbo Zhao, Zeru Li, Tianyu Li, Xiaoying Yang, Yutong Zhao, Weibin Wang
Summary: This study found that EGR1 is highly expressed in pancreatic cancer and is associated with prognosis and cancer metastasis. EGR1 promotes migration and invasion ability of pancreatic cancer cells and is correlated with the epithelial-mesenchymal transition process. The study also revealed that EGR1 activates the SNAI2 gene through interaction with p300/CBP. In vivo experiments confirmed that EGR1 promotes liver metastasis of pancreatic cancer. Therefore, blocking the expression of EGR1 could be a new anticancer strategy for pancreatic cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, General & Internal
Chika Miyagi-Shiohira, Issei Saitoh, Masami Watanabe, Hirofumi Noguchi
Summary: This study found significant differences in the expression levels of key genes between iF cells and iTS-P cells in pancreatic tissue, suggesting that these differences could be important markers for distinguishing between these two cell types.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Zuzana Ezrova, Zuzana Nahacka, Jan Stursa, Lukas Werner, Erik Vlcak, Petra Kralova Viziova, Michael V. Berridge, Radislav Sedlacek, Renata Zobalova, Jakub Rohlena, Stepana Boukalova, Jiri Neuzil
Summary: The resistance to mitochondrial inhibitors in pancreatic cancer is found to be mediated by increased mitophagic flux driven by MAPK/ERK signaling and linked to epithelial-to-mesenchymal transition. Mitochondria-targeted inhibitors, such as mitochondria-targeted tamoxifen, are effective in overcoming drug resistance mediated by SMAD4 deficiency or TGF beta signaling. These findings suggest potential strategies for developing targeted therapies for pancreatic cancer patients with SMAD4 as a predictive marker.
Review
Cell Biology
Tammy M. Holm, Syn Yeo, Kevin M. Turner, Jun-Lin Guan
Summary: Autophagy plays a crucial role in thyroid cancer, promoting tumor cell survival and metastasis, while also inhibiting tumor development by maintaining genomic stability. Autophagy inhibitors may enhance the effectiveness of thyroid cancer therapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Jianke Li, Yangyang Lei, Guoping Li, Ningzi Tian, Shanshan Gao, Junhao Li, Tianzhu Yu, Xiaolin Wang
Summary: This study found that Cyst C expression is downregulated in pancreatic cancer tissues and is associated with tumor grade, N stage, and poor prognosis. Furthermore, Cyst C overexpression inhibits cancer cell migration, while Cyst C expression inhibition promotes migration. The study also revealed that Cyst C downregulation induces epithelial-to-mesenchymal transition and pancreatic cancer metastasis, partially through the activation of the SQSTM1/RELA signaling pathway.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Oncology
Ning Zhang, Xiaohui Hua, Huailu Tu, Jingxia Li, Zhuo Zhang, Costa Max
Summary: This study demonstrates that ISO inhibits invasion of bladder cancer cells by affecting the expression of EMT markers Vimentin and METTL14, offering a novel insight into the upregulation of METTL14 by ISO.
Article
Cell Biology
Wei Jin, Huijing Yin, Hao Li, Xian-Jun Yu, Hua-Xiang Xu, Liang Liu
Summary: NETs play important roles in the progression of pancreatic cancer, promoting migration, invasion, and epithelial-mesenchymal transition of cancer cells through the IL-1 beta/EGFR/ERK pathway. Targeting NETs may provide promising therapeutic strategies for pancreatic cancer.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Yasaman KalantarMotamedi, Ran Joo Choi, Siang-Boon Koh, Jo L. Bramhall, Tai-Ping Fan, Andreas Bender
Summary: Resistance to current therapies is common in pancreatic cancer, necessitating novel treatment options. A computational method was developed to select synergistic compound combinations based on transcriptomic profiles and pathway scoring system, successfully identifying effective compound combinations against pancreatic cancer cells.
Review
Cell Biology
Yuan Li, Zhenning Wang, Jaffer A. Ajani, Shumei Song
Summary: Therapy resistance is a significant challenge in treating cancer patients, with intrinsic and acquired factors contributing to the development of resistance. CSCs play a key role in therapy resistance, as they are inherently resistant to anticancer treatments and can easily adapt to changes in the tumor microenvironment.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Oncology
Huiting Xu, Runzhi Chen, Qian Shen, Dongmei Yang, Hui Peng, Jin Tong, Qiang Fu
Summary: The study demonstrated that the down-regulation of circ_0013587 contributes to acquired resistance to erlotinib in pancreatic cancer cells by mediating the miR-1227/E-cadherin pathway, suggesting circ_0013587 as a potential target to overcome erlotinib resistance.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Rui Lin, Xunxia Bao, Hui Wang, Sibo Zhu, Zhongyan Liu, Quanning Chen, Kaixing Ai, Baomin Shi
Summary: The mechanism of TRPM2 in pancreatic cancer involves the activation of PKC/MAPK pathways, leading to enhanced proliferation, migration, and invasion abilities of PA cells. TRPM2 is negatively correlated with overall survival and progression-free survival time in PA patients, while its expression increases with tumor stage. Inhibitors of PKC/MEK significantly inhibit PA cell growth, suggesting a potential therapeutic target for pancreatic cancer.
CELL DEATH & DISEASE
(2021)
