Review
Biochemistry & Molecular Biology
Samia Afzal, Khadija Fiaz, Afifa Noor, Amira Saleem Sindhu, Asma Hanif, Ayesha Bibi, Muhammad Asad, Saba Nawaz, Saba Zafar, Sidra Ayub, Syeda Bariyyah Hasnain, Muhammad Shahid
Summary: Breast cancer is a multifactorial disease, and recent evidence suggests that viruses may play a significant role in its pathogenesis and development. Although some viruses have been found to be associated with breast cancer, conclusive evidence on whether viruses actually cause breast cancer is still lacking.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Oncology
Shengye Jin, Qin Wang, Hao Wu, Da Pang, Shouping Xu
Summary: Biological therapy, particularly oncolytic viruses (OVs), has shown promising therapeutic effects in various cancers, including triple negative breast cancer (TNBC). TNBC, lacking conventional treatment targets, benefits from the emerging concept of OVs for potential treatment options.
BIOMARKER RESEARCH
(2021)
Review
Oncology
Mary E. Carter, Andre Koch, Ulrich M. Lauer, Andreas D. Hartkopf
Summary: Breast cancer is the second most common type of cancer globally, with oncolytic viruses showing promise as a new treatment approach. Several types of oncolytic viruses have been studied in clinical trials, demonstrating clinical activity in patients with different advanced tumors including breast cancer. Further research is needed to explore optimal treatment strategies for breast cancer using oncolytic viruses.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Michael L. Monaco, Omer A. Idris, Karim Essani
Summary: Triple-negative breast cancer (TNBC) is the most lethal subtype of breast cancer and lacks available molecular-based therapeutics. Recurrence and tumor heterogeneity pose challenges to treatment approaches. Immuno-oncolytic viruses (OVs) have shown promise in treating TNBC, and this review summarizes their strategies and testing stages.
Review
Oncology
Juan Miguel Cejalvo, Claudette Falato, Lorea Villanueva, Pablo Tolosa, Xavier Gonzalez, Mariona Pascal, Jordi Canes, Joaquin Gavila, Luis Manso, Tomas Pascual, Aleix Prat, Fernando Salvador
Summary: Immunotherapy has significantly advanced the field of oncology, but most breast cancer patients cannot benefit from it. The introduction of oncolytic viruses may be a promising treatment strategy, but further research is needed to understand their mechanisms of action, safety, and the implications of systemic therapy.
CANCER TREATMENT REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Sara Becerril, Roberto Corchado-Cobos, Natalia Garcia-Sancha, Leonor Revelles, David Revilla, Tatiana Ugalde, Concepcion Roman-Curto, Jesus Perez-Losada, Javier Canueto
Summary: The recent developments in virology and skin cancer research have brought significant advancements, impacting not only dermatology but also other medical fields. These advancements have led to changes in treatment and prevention strategies for skin cancer patients, as well as enhancing our understanding of the biology of skin cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Luigi Marongiu, Heike Allgayer
Summary: Evidence suggests that microorganisms, including specific viruses and bacteriophages, may play a significant role in the oncogenesis and progression of colorectal cancer. However, the mechanisms underlying these associations are not fully understood. Various viruses, such as EBV, HPV, JCV, and CMV, have been linked to CRC, along with bacteriophages. The complex interplay between different species within the microbiome and their impact on colorectal cells and the microenvironment may explain the challenges in establishing clear causal links between specific viral infections and CRC.
MOLECULAR ONCOLOGY
(2022)
Article
Chemistry, Medicinal
Yanrong Zhou, Qianpeng Wang, Qi Ying, Xiaomei Zhang, Ting Ye, Kan Chen, Gongchu Li
Summary: This study compares the efficacy of oncolytic vaccinia viruses carrying different marine lectins in breast cancer cells and finds that oncoVV-AVL shows the highest anti-tumor effect. Further studies show that apoptosis and replication can enhance the cytotoxicity of oncoVV-lectins, but the mechanisms differ in different cell types.
Review
Biochemistry & Molecular Biology
Signe A. MacLennan, Marco A. Marra
Summary: Globally, viral infections play a substantial role in cancer development, with taxonomically diverse oncogenic viruses driving cancer through various strategies, including epigenomic dysregulation. This article discusses the disruption of epigenetic homeostasis by oncogenic viruses to promote cancer and emphasizes the impact of viral and host epigenome dysregulation on cancer hallmarks. The relationship between epigenetics and viral life cycles is illustrated through the example of the human papillomavirus (HPV) and its association with malignancy. Additionally, the clinical implications of virally mediated epigenetic changes, including diagnosis, prognosis, and treatment of cancer, are highlighted.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Infectious Diseases
Shimaa A. Metwally, Maha A. Abo-Shadi, Nasra F. Abdel Fattah, Ahmed B. Barakat, Omar A. Rabee, Ahmed M. Osman, Amany M. Helal, Tarek Hashem, Manar M. Moneer, Wassim Chehadeh, Samah A. Loutfy
Summary: The presence of HPV, EBV, and HMTV together in Egyptian women with BC was significantly associated with younger age. Co-infections of these viruses may affect the clinico-pathological characteristics of BC.
INFECTION AND DRUG RESISTANCE
(2021)
Review
Oncology
Jyoti Malhotra, Edward S. Kim
Summary: This review summarizes the recent trials and current status of oncolytic viruses (OVs) for the treatment of lung cancer. While early-phase trials have shown evidence of antiviral immune responses and clinical benefit, the clinical efficacy of OVs in larger trials has not been confirmed. The development of novel combinations with OVs, along with improving tumor specificity and viral load, may be crucial for improving the efficacy of OVs in lung cancer treatment.
CURRENT ONCOLOGY REPORTS
(2023)
Review
Medicine, Research & Experimental
Ke-Tao Jin, Xiao-Hua Tao, Yi-Bin Fan, Shi-Bing Wang
Summary: Oncolytic viruses attract attention in cancer therapy for selectively infecting and killing tumor cells without affecting healthy cells, while autophagy can both support viral replication and reduce cytotoxicity by providing nutrients for tumor cells. The interaction between oncolytic viruses and autophagy plays a crucial role in their combinational effects on tumor cells in cancer therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Kayla Jaye, Dennis Chang, Chun Guang Li, Deep Jyoti Bhuyan
Summary: This review evaluates the anticancer activity of metabolites produced by the gut microbiota against breast cancer. Several metabolites, such as butyrate and inosine, have shown potential in their anticancer effects. However, the mechanisms and dose-response relationship for breast cancer are not well-established and require further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Sibylle Loibl, Philip Poortmans, Monica Morrow, Carsten Denkert, Giuseppe Curigliano
Summary: Breast cancer diagnosis and treatment have become increasingly complex, incorporating various biomarkers and neoadjuvant therapies, with de-escalation schemes for radiotherapy now becoming standard practice.
Review
Medical Laboratory Technology
Noraini Abd-Aziz, Chit Laa Poh
Summary: Oncolytic virotherapy is a therapeutic approach that utilizes replication-competent viruses to selectively kill cancer cells, but it faces limitations such as viral delivery, tumor penetration, and antiviral immune responses. Strategies to overcome these limitations are crucial for its effective application in preclinical and clinical trials.
TRANSLATIONAL RESEARCH
(2021)
