Article
Multidisciplinary Sciences
Michael Bartl, Mohammed Dakna, Douglas Galasko, Samantha J. Hutten, Tatiana Foroud, Marian Quan, Kenneth Marek, Andrew Siderowf, Jonas Franz, Claudia Trenkwalder, Brit Mollenhauer
Summary: Except for alpha Syn, the additional biomarkers did not differentiate between PD and HC, and no significant longitudinal differences were shown, but most markers were able to predict cognitive decline in PD during follow-up.
Review
Biochemistry & Molecular Biology
Asad Jan, Nadia Pereira Goncalves, Christian Bjerggaard Vaegter, Poul Henning Jensen, Nelson Ferreira
Summary: The pathological aggregation of presynaptic protein alpha-synuclein and its propagation through synaptically coupled neuroanatomical tracts are believed to underlie the progression of Parkinson's disease and other synucleinopathies. Understanding the mechanisms of alpha-synuclein propagation may provide insights into the etiology of PD and identify new therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Merry Chen, Danielle E. Mor
Summary: Parkinson's disease is a multifactorial disorder involving the death of specific neuronal populations and the deposition of aggregated alpha-synuclein protein in the enteric nervous system. Evidence suggests that the disease may originate in the gut and spread to the brain through the vagal nerve. Targeting pathological alpha-synuclein in the gastrointestinal tract holds promise for PD treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Yu-Qing Liu, Yuanyang Mao, Enquan Xu, Huimin Jia, Shu Zhang, Valina L. Dawson, Ted M. Dawson, Yan-Mei Li, Zhi Zheng, Weiwei He, Xiaobo Mao
Summary: Braak's prion-like theory challenges the conventional understanding of Parkinson's disease, while the use of nanomaterials like nanozyme to inhibit the spreading of alpha-synuclein shows potential as a therapeutic strategy against PD and other prion-like proteinopathies.
Review
Biochemistry & Molecular Biology
Sarah Vascellari, Aldo Manzin
Summary: This review discusses the shared pathological mechanism between Parkinson's disease and other neurological disorders, mainly related to the aggregation of alpha-synuclein, which progresses in a prion-like manner in the host.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
G. Pagano, K. I. Taylor, J. Anzures-Cabrera, M. Marchesi, T. Simuni, K. Marek, R. B. Postuma, N. Pavese, F. Stocchi, J. -P. Azulay, B. Mollenhauer, L. Lopez-Manzanares, D. S. Russell, J. T. Boyd, A. P. Nicholas, M. R. Luquin, R. A. Hauser, T. Gasser, W. Poewe, B. Ricci, A. Boulay, A. Vogt, F. G. Boess, J. Dukart, G. D'Urso, R. Finch, S. Zanigni, A. Monnet, N. Pross, A. Hahn, H. Svoboda, M. Britschgi, F. Lipsmeier, E. Volkova-Volkmar, M. Lindemann, S. Dziadek, S. Holiga, D. Rukina, T. Kustermann, G. A. Kerchner, P. Fontoura, D. Umbricht, R. Doody, T. Nikolcheva, A. Bonni
Summary: The study found that prasinezumab had no meaningful effect on global or imaging measures of Parkinson's disease progression and was associated with infusion reactions.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Neurosciences
Ting Shen, Yumei Yue, Fang Ba, Tinging He, Xiaocui Tang, Xingyue Hu, Jiali Pu, Cong Huang, Wen Lv, Baorong Zhang, Hsin-Yi Lai
Summary: The glymphatic system in the brain is important for clearing alpha-synuclein and dysfunction of this system may contribute to the progression of Parkinson's disease. This study used MRI to evaluate the glymphatic system in PD patients and found decreased diffusion along the perivascular space, which was more pronounced in advanced stages of the disease. The decreased diffusion was correlated with longer disease duration, higher motor scores, and higher levodopa equivalent daily dose. The study also demonstrated a correlation between decreased diffusion and increased PVS burden, indicating an impaired glymphatic system in PD.
NPJ PARKINSONS DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Abbie T. Rodger, Maryam A. L. Nasser, Wayne G. Carter
Summary: Currently, there are no pharmacological treatments that can completely stop or reverse the progression of Parkinson's Disease (PD). Therefore, there is a need for neuroprotective therapies. This systematic review examines the effectiveness of anti-a-synuclein (a-syn) therapies in preventing PD progression in preclinical models and human clinical trials. The review found that novel preclinical anti-a-syn therapeutics reduced a-syn aggregations and protected against dopaminergic neuronal loss. Completed clinical trials showed significant tolerability and efficacy in reducing a-syn and minimal adverse effects. Overall, this review highlights the potential of anti-a-syn therapies in both preclinical and clinical settings to reduce a-syn accumulation and potentially slow down PD progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Chang-Ki Oh, Nima Dolatabadi, Piotr Cieplak, Maria T. Diaz-Meco, Jorge Moscat, John P. Nolan, Tomohiro Nakamura, Stuart A. Lipton
Summary: This article investigates the mechanism by which dysregulation of autophagic pathways leads to the accumulation of abnormal proteins and damaged organdies in neurodegenerative disorders. The authors found that pathologic protein S-nitrosylation of p62 is a critical factor for autophagic inhibition and cell-to-cell spread.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Clinical Neurology
Huimin Zheng, Changhe Shi, Haiyang Luo, Liyuan Fan, Zhihua Yang, Xinchao Hu, Zhongxian Zhang, Shuo Zhang, Zhengwei Hu, Yu Fan, Jing Yang, Chengyuan Mao, Yuming Xu
Summary: Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons and a decrease in dopamine release, with neuropathological basis indicated by the presence of Lewy bodies (LBs) or Lewy neurites (LNs), mainly made up of alpha-synuclein (alpha-syn) inclusions. Evidence suggests template-directed aggregation and propagation of these inclusions in a prion-like manner, with potential transmission from peripheral organs to the brain via specific pathways. Therapeutic perspectives targeting prion-like mechanisms and major controversies in this field are also discussed.
Review
Geriatrics & Gerontology
Jiajun Han, Yaohua Fan, Peipei Wu, Zifeng Huang, Xinrong Li, Lijun Zhao, Yichun Ji, Meiling Zhu
Summary: Parkinson's disease dementia is a common complication of Parkinson's disease that seriously affects patients' health and quality of life. The complex interplay of iron, alpha-synuclein, tau, beta-amyloid, and oxidative stress plays a pivotal role in the mechanism underlying PDD, leading to neuronal protein accumulation, neuroinflammation, and cell death. GSK3 beta is identified as a potential target for the prevention and treatment of PDD due to its central role in regulating the vicious cycle of molecular interactions.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neurosciences
Priscilla Youssef, Woojin S. Kim, Glenda M. Halliday, Simon J. G. Lewis, Nicolas Dzamko
Summary: Three immunoassay platforms (BioLegend, MesoScale Discovery, and Quanterix) showed significant differences in measuring total alpha-synuclein in PD patients and controls. The Quanterix platform exhibited the lowest variation and highest effect size, while the Mesoscale Discovery and Quanterix assays showed the strongest correlations.
JOURNAL OF PARKINSONS DISEASE
(2021)
Article
Medicine, Research & Experimental
Lena F. Burbulla, Jianbin Zheng, Pingping Song, Weilan Jiang, Michaela E. Johnson, Patrik Brundin, Dimitri Krainc
Summary: Current treatments for Parkinson's disease only provide symptomatic relief, but repurposing FDA-approved drugs such as quetiapine as a modulator of GCase activity shows potential for improving the condition of PD patients with decreased GCase activity. This study developed an efficient screening strategy for identifying drugs to treat PD and found that quetiapine treatment could increase levels and activity of wild-type GCase and reduce the accumulation of oxidized dopamine, glucosylceramide, and alpha-synuclein in PD patients.
Article
Medicine, General & Internal
Anna Emdina, Peter Hermann, Daniela Varges, Sabine Nuhn, Stefan Goebel, Timothy Bunck, Fabian Maass, Matthias Schmitz, Franc Llorens, Niels Kruse, Paul Lingor, Brit Mollenhauer, Inga Zerr
Summary: The study suggests that CSF oc-synuclein may serve as a potential prognostic marker for disease progression, affective symptoms, and executive cognitive function in Parkinson's disease.
Article
Clinical Neurology
Tobias Thom, Matthias Schmitz, Anna-Lisa Fischer, Angela Correia, Susana Correia, Franc Llorens, Anna-Villar Pique, Wiebke Moebius, Renato Domingues, Saima Zafar, Erik Stoops, Christopher J. Silva, Andre Fischer, Tiago F. Outeiro, Inga Zerr
Summary: Expressing PrPC in mice led to behavioral deficits and increased levels of aSyn oligomers; PrPC colocalized with aSyn and facilitated its internalization in cell models; Clathrin was identified to regulate aSyn internalization by binding to recombinant PrP.
MOVEMENT DISORDERS
(2022)
Article
Biophysics
Amulya Nidhi Shrivastava, Luc Bousset, Marianne Renner, Virginie Redeker, Jimmy Savistchenko, Antoine Triller, Ronald Melki
BIOPHYSICAL JOURNAL
(2020)
Article
Clinical Neurology
Anke Van der Perren, Geraldine Gelders, Alexis Fenyi, Luc Bousset, Filipa Brit, Wouter Peelaerts, Chris Van den Haute, Steve Gentleman, Ronald Melki, Veerle Baekelandt
ACTA NEUROPATHOLOGICA
(2020)
Article
Biochemistry & Molecular Biology
Laurent Brasseur, Audrey Coens, Jehan Waeytens, Ronald Melki, Luc Bousset
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Eliana Nachman, Anne S. Wentink, Karine Madiona, Luc Bousset, Taxiarchis Katsinelos, Kieren Allinson, Harm Kampinga, William A. McEwan, Thomas R. Jahn, Ronald Melki, Axel Mogk, Bernd Bukau, Carmen Nussbaum-Krammer
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Multidisciplinary Sciences
Josquin Courte, Luc Bousset, Ysander Von Boxberg, Catherine Villard, Ronald Melki, Jean-Michel Peyrin
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Maya Bendifallah, Virginie Redeker, Elodie Monsellier, Luc Bousset, Tracy Bellande, Ronald Melki
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Luc Bousset, Nina Luckgei, Mehdi Kabani, Carole Gardiennet, Anne K. Schutz, Ronald Melki, Beat H. Meier, Anja Bockmann
FRONTIERS IN MOLECULAR BIOSCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Marina Pantazopoulou, Viviana Brembati, Angeliki Kanellidi, Luc Bousset, Ronald Melki, Leonidas Stefanis
Summary: The study explores the degradation mechanisms of abnormal protein aggregates in Parkinson's disease, suggesting that autophagy is the main pathway for clearing fibrillar alpha-Syn, while the proteasome system plays a role in selectively clearing phosphorylated alpha-Syn oligomers.
JOURNAL OF NEUROCHEMISTRY
(2021)
Review
Neurosciences
Stephanie Pain, Sebastien Brot, Afsaneh Gaillard
Summary: Neuropeptide Y (NPY) plays an important role in neurodegenerative diseases and its changes may reflect the attempt to counteract the degenerative process. NPY has anti-apoptotic, anti-inflammatory, and pro-phagocytic effects, which can effectively slow down the progression of the disease.
CURRENT NEUROPHARMACOLOGY
(2022)
Article
Cell Biology
Sebastien Brot, Nabila Pyrenina Thamrin, Marie-Laure Bonnet, Maureen Francheteau, Maelig Patrigeon, Laure Belnoue, Afsaneh Gaillard
Summary: This study generated midbrain dopamine neurons from human induced pluripotent stem cells and transplanted them into the substantia nigra pars compacta in a Parkinson's disease animal model. The results showed long-term survival and functionality of the transplanted neurons, but a decrease in the proportion of the specific dopamine neuron subtype and the presence of immature neurons were observed at 12 months post-transplantation. Therefore, longer-term evaluation of the maturation of neurons derived from human stem cells is necessary for the safe application of cell therapy for Parkinson's disease.
Article
Cell Biology
Marine Droguerre, Sebastien Brot, Clement Vitrac, Marianne Benoit-Marand, Laure Belnoue, Maelig Patrigeon, Anais Laine, Emile Bere, Mohamed Jaber, Afsaneh Gaillard
Summary: A comparison of potential benefits between intranigral and intrastriatal grafts was conducted in animal models of Parkinson's disease. The results showed that intranigral grafts had better survival of dopaminergic neurons and promoted recovery of fine motor skills, as well as normalized cortico-striatal responses.
Article
Cell Biology
Anais Laine, Sebastien Brot, Afsaneh Gaillard
Summary: This study investigates the therapeutic effect of hyaluronic acid (HA) hydrogel on host tissue after cortical trauma. The results show that HA hydrogel promotes vascularization, reduces glial scar, and provides a favorable environment for the survival and maturation of newly generated neurons.
Article
Immunology
Maelig Patrigeon, Sebastien Brot, Marie-Laure Bonnet, Laure Belnoue, Afsaneh Gaillard
Summary: This study compared the propagation of alpha-synuclein (alpha-syn) in two different transplantation sites in Parkinson's disease and found that striatal grafts were more vulnerable to alpha-syn accumulation. This suggests that the choice of transplantation site can influence the transmission of alpha-syn.
Article
Biochemistry & Molecular Biology
Josquin Courte, Ngoc Anh Le, Teng Pan, Luc Bousset, Ronald Melki, Catherine Villard, Jean-Michel Peyrin
Summary: This study demonstrates the limited spreading of preformed aSyn aggregates and suggests that it occurs through molecular sieving of large aSyn seeds. The research also shows that synaptic connections do not facilitate this process. The development of a new microfluidic platform allows for the reconstruction of fully oriented neuronal networks in vitro, enabling the quantification of fluorescent aSyn aggregates spreading between neurons.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Amandine Desette, Pierre-Olivier Guichet, Sheik Emambux, Konstantin Masliantsev, Ulrich Cortes, Birama Ndiaye, Serge Milin, Simon George, Mathieu Faigner, Julie Tisserand, Afsaneh Gaillard, Sebastien Brot, Michel Wager, David Tougeron, Lucie Karayan-Tapon
Summary: This study describes the identification and characterization of cancer stem cells in brain metastasis from colorectal cancer (CRC). These cancer stem cells have self-renewal properties and exhibit invasive and migratory capabilities. Further analysis also identifies a potential candidate gene for identifying high-risk CRC patients.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)