Article
Multidisciplinary Sciences
Camila Freitas dos Santos, Mariana Gobbo Braz, Nayara Micarelli de Arruda, Laura Caram, Duelene Ludimila Nogueira, Suzana Erico Tanni, Irma de Godoy, Renata Ferrari
Summary: This study evaluated DNA damage and oxidative stress in patients with COPD with and without lung cancer, and found that COPD patients with lung cancer had more severe DNA damage. This study provides possible clues to the development mechanisms of lung cancer in COPD patients.
Review
Biochemistry & Molecular Biology
Yi-Ling Cao, Ji-Hong Lin, Hans-Peter Hammes, Chun Zhang
Summary: This review summarizes the function and beneficial properties of common flavonoids for the treatment of CKD and renal fibrosis, including preventing renal dysfunction and improving renal function by blocking or suppressing deleterious pathways such as oxidative stress and inflammation.
Review
Nutrition & Dietetics
Scott E. Liebman, Thu H. Le
Summary: This article discusses the impact of oxidative stress in chronic kidney disease and the role of the Nrf2 pathway in kidney disease, as well as the promising therapeutic potential of sulforaphane.
Article
Multidisciplinary Sciences
Anna Zalewska, Anna Klimiuk, Sara Zieba, Olga Wnorowska, Malgorzata Rusak, Napoleon Waszkiewicz, Izabela Szarmach, Krzysztof Dzierzanowski, Mateusz Maciejczyk
Summary: Alzheimer's disease is associated with oxidative imbalance in the body, affecting both saliva secretion and antioxidant system functions.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Moustafa Fathy, Rania Abdel-latif, Yasmeen M. Abdelgwad, Othman Ali Othman, Abdel-Razik H. Abdel-Razik, Thomas Dandekar, Eman M. Othman
Summary: The study showed that eugenol has a potential protective effect against CCl4-induced chronic kidney damage in an experimental model, mainly through its antioxidant, anti-inflammatory, and anti-fibrotic activities.
Article
Nutrition & Dietetics
Nur Elena Zaaba, Suhail Al-Salam, Sumaya Beegam, Ozaz Elzaki, Javed Yasin, Abderrahim Nemmar
Summary: Catalpol, an active compound in traditional Chinese medicine Rehmannia glutinosa, has shown significant protective effects against adenine-induced chronic kidney disease (CKD) in mice. It reduces inflammation, oxidative stress, and fibrosis in the kidneys, and improves renal function. This study suggests that catalpol may be a potential nephroprotective agent for CKD.
Review
Biochemistry & Molecular Biology
Elisabetta Zinellu, Angelo Zinellu, Alessandro G. Fois, Maria Carmina Pau, Valentina Scano, Barbara Piras, Ciriaco Carru, Pietro Pirina
Summary: Studies show an imbalance between oxidant and antioxidant molecules favoring the former in exacerbations of COPD, suggesting the potential usefulness of targeting oxidative stress in monitoring disease progression, particularly in patients more prone to exacerbations. Additional research with standardized methods in well-characterized populations is needed.
Review
Biochemistry & Molecular Biology
Chien-Lin Lu, Cai-Mei Zheng, Kuo-Cheng Lu, Min-Tser Liao, Kun-Lin Wu, Ming-Chieh Ma
Summary: The uremic toxin IS leads to oxidative stress in CKD patients, causing organ damage and complications such as cardiovascular diseases, renal osteodystrophy, muscle wasting, and anemia. IS-induced ROS production impairs glomerular filtration and triggers vascular smooth muscle cells transformation, contributing to muscle atrophy and bone abnormalities.
Article
Multidisciplinary Sciences
K. G. Aghila Rani, Nelson C. Soares, Betul Rahman, Hamza M. Al-Hroub, Mohammad H. Semreen, Sausan Al Kawas
Summary: The study investigates the biochemical and pathophysiological changes caused by medwakh smoking and examines the salivary metabolomics profile of medwakh smokers. Analysis of saliva samples reveals 37 uniquely and differentially abundant metabolites and 20 differentially altered metabolic pathways in medwakh smokers. The study highlights the association of altered redox homeostasis, metabolic pathways, antioxidant system, and CRP levels with the distinctive saliva metabolomics profile in medwakh smokers. Further research is needed to explore the diagnostic utility of these altered metabolites in larger cohorts.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Tina Levstek, Katarina Trebusak Podkrajsek
Summary: Telomeres are dynamic DNA nucleoprotein structures located at the end of chromosomes that maintain genomic stability. Shortened telomeres contribute to cellular senescence and degenerative diseases such as chronic kidney diseases (CKDs). Oxidative stress also accelerates telomere shortening. This review examines the association between telomere length and CKDs, particularly in patients receiving kidney replacement therapy. Understanding the relationship between telomere attrition and kidney disease can contribute to new strategies for managing CKDs.
Review
Medicine, Research & Experimental
Anjali Srivastava, Bhawna Tomar, Divyansh Sharma, Srikanta Kumar Rath
Summary: Chronic kidney disease (CKD) permanently changes the function and structure of the kidney over time and is often characterized by glomerular filtration defect or proteinuria lasting longer than three months. Mitochondrial dysfunction is a common response to CKD damage, leading to altered mitochondrial shape, increased oxidative stress, and decreased biogenesis and ATP generation. This article summarizes the recent advancements in understanding the involvement of mitochondrial remodeling in CKD and emphasizes the importance of understanding mitochondrial biology for developing effective treatment options.
Article
Microbiology
Haichao Wang, Aisima Ainiwaer, Yaxiang Song, Ling Qin, Ai Peng, Hui Bao, Huanlong Qin
Summary: This study investigated the association between gut microbiota and metabolites with the severity of CKD. The findings revealed significant changes in gut microbial species and metabolic pathways as CKD progressed, leading to imbalances in toxic and pro-oxidant metabolism. The study also identified key bacteria and metabolites that contribute to CKD progression, and a noninvasive model using these factors showed better performance in classifying CKD severity compared to serum creatinine levels.
Article
Biotechnology & Applied Microbiology
Alessandra Oliveira Silva, Jessyca Milene Ribeiro, Talita Barbara Patrocinio, Gabriel Estevam Amorim, Antonio Alves Pereira-Junior, Marilene Lopes Angelo, Fernanda Borges de Araujo Paula, Nelma de Mello Silva Oliveira, Silvia Graciela Ruginsk, Jose Antunes-Rodrigues, Lucila Leico Kagohara Elias, Marcos Vinicios Salles Dias, Larissa Helena Torres, Carla Speroni Ceron
Summary: This study investigated the ameliorative effects of kefir on anxiety-like behavior induced by chronic unpredictable stress (CUS) in mice. Results showed that kefir improved the anxiety-like behavior by modulating brain-derived neurotrophic factor (BDNF) and corticosterone levels, and increased the antioxidant defense in the heart and kidney of mice.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Biochemistry & Molecular Biology
Min Wang, Zhao-hui Huang, Yong-hong Zhu, Ping He, Qiu-Ling Fan
Summary: There is a positive association between the Composite Dietary Antioxidant Index (CDAI) and chronic kidney disease (CKD) in adults in the United States. Further large-scale prospective studies are needed to analyze the role of CDAI in CKD.
Review
Cell Biology
Hsin-Jung Ho, Hitoshi Shirakawa
Summary: The kidney contains mitochondria that produce ATP for cellular processes, but impaired mitochondria can cause oxidative stress injury. There is increasing evidence linking oxidative stress to kidney diseases and providing insights into mitochondria-targeted therapeutics. This review integrates recent studies on oxidative stress and mitochondrial function in kidney diseases, focusing on chronic kidney disease, and identifies potential drugs that modulate mitochondrial function for clinical therapeutics.
Article
Immunology
Mateusz Maciejczyk, Milosz Nesterowicz, Julita Szulimowska, Anna Zalewska
Summary: This study demonstrates that modifications of salivary proteins increase with age, along with oxidative modifications of lipids and nucleic acids. Salivary redox biomarkers poorly correlate with plasma levels, but can reflect blood concentrations of AGE and 8-OHdG. Salivary AGE and 8-OHdG are valuable diagnostic tools for assessing the aging process.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Medicine, Research & Experimental
Marta Wolosowicz, Patrycja Dajnowicz-Brzezik, Bart lomiej Lukaszuk, Ewa Zebrowska, Mateusz Maciejczyk, Anna Zalewska, Irena Kasacka, Adrian Chabowski
Summary: This study investigates the effects of NAC and ALA on the lipid fractions, FA composition, and FA transporter expression in high-fat diet-fed rats' visceral and subcutaneous adipose tissue. The results show that NAC and ALA have different influences on AT, including changes in lipid pools, FA transporter expressions, and lipid storage capacity.
ADVANCES IN MEDICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mateusz Maciejczyk, Iwona Ptaszynska-Sarosiek, Anna Niemcunowicz-Janica, Michal Szeremeta, Napoleon Waszkiewicz, Agnieszka Kulak-Bejda, Urszula Cwalina, Milosz Nesterowicz, Anna Zalewska
Summary: This study investigates the utility of antioxidant barrier, redox status, and stress biomarkers in different biological fluids in post-mortem analysis of patients with acute alcohol intoxication. The results show significant increase of antioxidant activity and concentration in urine samples, but no significant differences in other circulating fluids. The observations may be influenced by irreversible post-mortem changes. The use of circulating body fluids to assess redox homeostasis is limited in post-mortem analysis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Milosz Nesterowicz, Malgorzata Zendzian-Piotrowska, Jerzy Robert Ladny, Anna Zalewska, Mateusz Maciejczyk
Summary: Amantadine does not significantly affect protein glycoxidation, lacks antioxidant and antiglycation effects, and may even have some glycoxidant, proglycation, and prooxidant properties.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)
Article
Medicine, General & Internal
Aleksander Nobis, Daniel Zalewski, Eliza Samaryn, Mateusz Maciejczyk, Anna Zalewska, Napoleon Waszkiewicz
Summary: Depression is a prevalent psychiatric disorder that significantly impacts individuals and public health worldwide. Recent research has focused on identifying biological markers to better understand the underlying mechanisms of depression.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Elzbieta Supruniuk, Ewa Zebrowska, Mateusz Maciejczyk, Anna Zalewska, Adrian Chabowski
Summary: This study examined the effects of high-protein diets on lipid peroxidation and sphingolipid metabolism in rats. The results showed that high-protein diets significantly impacted hypothalamic metabolic pathways, leading to increased lipid peroxidation, ceramide accumulation, and changes in sphingolipid metabolism.
Article
Immunology
Julita Szulimowska, Anna Zalewska, Katarzyna Taranta-Janusz, Grazyna Marczuk-Kolada, Malgorzata Zendzian-Piotrowska, Mateusz Maciejczyk
Summary: Chronic kidney disease (CKD) is a systemic inflammatory disease that affects multiple organs, including the kidneys, cardiovascular system, and oral cavity. Children with CKD experience reduced saliva secretion (hyposalivation), leading to increased dental caries and impaired quality of life. This study evaluated the inflammatory and anti-inflammatory profile in the saliva of CKD children at different stages of renal failure. The results showed significant changes in salivary cytokines, chemokines, and growth factors in CKD children compared to healthy controls.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Medicine, General & Internal
Justyna Dorf, Konrad Zareba, Anna Pryczynicz, Joanna Matowicka-Karna, Boguslaw Kedra, Piotr Zukowski, Anna Zalewska, Mateusz Maciejczyk
Summary: Gastric cancer is associated with redox imbalance and increased oxidative damage to proteins, lipids, and DNA. Histopathological parameters of the tumor are associated with the level of antioxidants and oxidative damage products. Determination of redox parameters may be useful in the assessment of the tumor progression.
ANNALS OF MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Anna Zalewska, Bozena Antonowicz, Julita Szulimowska, Izabela Zieniewska-Siemienczuk, Barbara Lesniewska, Jan Borys, Sara Zieba, Paula Kostecka-Sochon, Malgorzata Zendzian-Piotrowska, Roberto Lo Giudice, Giusseppe Lo Giudice, Piotr Zukowski, Mateusz Maciejczyk
Summary: Although titanium and its alloys have high biocompatibility, there is a growing debate regarding the removal of titanium implants due to potential long-term adverse effects. To enhance the biocompatibility of titanium implants, increasing the thickness of the titanium dioxide passive layer is being explored. In this study, we compared the cytotoxicity, mitochondrial function, and redox balance of fibroblast mitochondria between hard-anodized (type II), standard-anodized (type III), and non-anodized titanium discs. The results showed oxidative stress in fibroblast mitochondria regardless of anodization, but type II anodization prevented changes in complex II activity, had the lowest citrate synthase inhibition, and reduced cytochrome c oxidase inhibition, potentially preventing apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Dariusz Juchnowicz, Michal Dzikowski, Joanna Rog, Napoleon Waszkiewicz, Kaja Hanna Karakula, Anna Zalewska, Mateusz Maciejczyk, Hanna Karakula-Juchnowicz
Summary: This study assessed the utility of complete blood count (CBC) in the prediction of schizophrenia diagnosis and its relationship with oxidative stress (OS). The findings showed that certain CBC parameters were altered in patients with the first episode of psychosis compared to healthy individuals, and there were various associations between OS and CBC. The study also proposed promising CBC models for distinguishing different patient groups.
Article
Medicine, General & Internal
Monika Kamianowska, Aleksandra Kamianowska, Mateusz Maciejczyk, Anna Kurowska, Bozena Blazewicz, Agnieszka Maria Rogowska, Anna Wasilewska
Summary: This study analyzed the concentrations of renal biomarkers (osteopontin, cystatin C, and NGAL) in neonates and found that prematurity may lead to increased excretion of osteopontin and cystatin C, but not NGAL. The excretion of NGAL and cystatin C may change during the first weeks of a premature neonate's life, but osteopontin does not.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Monika Kamianowska, Agnieszka Rybi-Szuminska, Aleksandra Kamianowska, Mateusz Maciejczyk, Katarzyna Solomianko, Alicja Koput, Anna Wasilewska
Summary: This study aimed to assess the urinary concentration of trefoil factor 3 (TFF3) in healthy term and stable preterm neonates. The results showed higher TFF3/cr. values in preterm neonates compared to term neonates, and male term neonates had increased urinary TFF3 excretion. These findings have important implications for the diagnosis in neonatology.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Chemistry, Medicinal
Grzegorz Biedrzycki, Blanka Wolszczak-Biedrzycka, Justyna Dorf, Daniel Michalak, Malgorzata Zendzian-Piotrowska, Anna Zalewska, Mateusz Maciejczyk
Summary: This study compares the antioxidant and antiglycation potentials of popular H2 antagonists (ranitidine, cimetidine, and famotidine) on protein glycoxidation. The results show that ranitidine is the only H2 blocker that significantly inhibits protein glycation and has antioxidant properties. It can compete with proteins for the addition of carbonyl groups.
Article
Chemistry, Medicinal
Emilia Szymanska, Joanna Potas, Mateusz Maciejczyk, Magdalena Ewa Sulewska, Malgorzata Pietruska, Anna Zalewska, Aleksandra Pietruska, Katarzyna Winnicka
Summary: This study tested different emulgel compositions for the delivery of delta-aminolevulinic acid and investigated the impact of the drug on the behavior of gelling agents. The results showed that a combination of xanthan and gellan gum enhanced the retention of the emulgels in oral mucosal tissue. In addition, the incorporation of delta-aminolevulinic acid promoted interactions with mucosal tissue. Cytotoxicity studies demonstrated that emulgels based on tragacanth and gellan/xanthan may have a protective effect on the metabolic activity of human gingival fibroblasts and keratinocytes.
Article
Dentistry, Oral Surgery & Medicine
Joanna Toczewska, Dagmara Baczynska, Anna Zalewska, Mateusz Maciejczyk, Tomasz Konopka
Summary: This study evaluated the expression of genes encoding antioxidant enzymes in the saliva and gingival tissue of patients with periodontitis. The results showed that the expression of GPX1 and TXN1 genes in saliva was significantly higher, while the expression of SOD1, GPX1, and TXN1 genes in gingival tissue was significantly lower in periodontitis patients compared to healthy individuals. Additionally, the activity of GPX1 in unstimulated saliva, SOD1 in stimulated saliva, and both antioxidant enzymes in gingival crevicular fluid were lower in periodontitis patients.
DENTAL AND MEDICAL PROBLEMS
(2023)
