Crystal structure of rhodopsin in complex with a mini-Go sheds light on the principles of G protein selectivity

Mini G protein probes for active G protein–coupled receptors (GPCRs) in live cells

(2018) Qingwen Wan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ligand channel in pharmacologically stabilized rhodopsin

(2018) Daniel Mattle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gi- and Gs-coupled GPCRs show different modes of G-protein binding

(2018) Ned Van Eps et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryo-EM structure of the serotonin 5-HT1B receptor coupled to heterotrimeric Go

(2018) Javier García-Nafría et al.   NATURE

Selectivity determinants of GPCR–G-protein binding

(2017) Tilman Flock et al.   NATURE

Single-molecule analysis of ligand efficacy in β2AR–G-protein activation

(2017) G. Glenn Gregorio et al.   NATURE

Conformational equilibria of light-activated rhodopsin in nanodiscs

(2017) Ned Van Eps et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polder maps: improving OMIT maps by excluding bulk solvent

(2017) Dorothee Liebschner et al.   Acta Crystallographica Section D-Structural Biology

Mini-G proteins: Novel tools for studying GPCRs in their active conformation

(2017) Rony Nehmé et al.   PLoS One

Structural role of the T94I rhodopsin mutation in congenital stationary night blindness

(2016) Ankita Singhal et al.   EMBO REPORTS

Structure of the adenosine A2A receptor bound to an engineered G protein

(2016) Byron Carpenter et al.   NATURE

Engineering a minimal G protein to facilitate crystallisation of G protein-coupled receptors in their active conformation

(2016) Byron Carpenter et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Retinal orientation and interactions in rhodopsin reveal a two-stage trigger mechanism for activation

(2016) Naoki Kimata et al.   Nature Communications

Universal allosteric mechanism for Gα activation by GPCRs

(2015) Tilman Flock et al.   NATURE

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

(2015) Yanyong Kang et al.   NATURE

Probing Gαi1 protein activation at single–amino acid resolution

(2015) Dawei Sun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Probing Gαi1 protein activation at single–amino acid resolution

(2015) Dawei Sun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Role of Structural Dynamics at the Receptor G Protein Interface for Signal Transduction

(2015) Alexander S. Rose et al.   PLoS One

The role of protein dynamics in GPCR function: insights from the β2AR and rhodopsin

(2014) Aashish Manglik et al.   CURRENT OPINION IN CELL BIOLOGY

Position of Transmembrane Helix 6 Determines Receptor G Protein Coupling Specificity

(2014) Alexander S. Rose et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crystallization Scale Preparation of a Stable GPCR Signaling Complex between Constitutively Active Rhodopsin and G-Protein

(2014) Shoji Maeda et al.   PLoS One

Relevance of rhodopsin studies for GPCR activation

(2013) Xavier Deupi   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Kinetics and mechanism of G protein-coupled receptor activation

(2013) Martin J Lohse et al.   CURRENT OPINION IN CELL BIOLOGY

Insights into congenital stationary night blindness based on the structure of G90D rhodopsin

(2013) Ankita Singhal et al.   EMBO REPORTS

Molecular signatures of G-protein-coupled receptors

(2013) A. J. Venkatakrishnan et al.   NATURE

Improved low-resolution crystallographic refinement with Phenix and Rosetta

(2013) Frank DiMaio et al.   NATURE METHODS

An analysis of oligomerization interfaces in transmembrane proteins

(2013) Jose M Duarte et al.   BMC STRUCTURAL BIOLOGY

Towards automated crystallographic structure refinement withphenix.refine

(2012) Pavel V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Agonist-bound structures of G protein-coupled receptors

(2012) Guillaume Lebon et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Crystal structure of metarhodopsin II

(2011) Hui-Woog Choe et al.   NATURE

The structural basis of agonist-induced activation in constitutively active rhodopsin

(2011) Jörg Standfuss et al.   NATURE

The structural basis for agonist and partial agonist action on a β1-adrenergic receptor

(2011) Tony Warne et al.   NATURE

Structure and function of an irreversible agonist-β2 adrenoceptor complex

(2011) Daniel M. Rosenbaum et al.   NATURE

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Stabilized G protein binding site in the structure of constitutively active metarhodopsin-II

(2011) X. Deupi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A G protein-coupled receptor at work: the rhodopsin model

(2009) Klaus Peter Hofmann et al.   TRENDS IN BIOCHEMICAL SCIENCES

Crystal structure of opsin in its G-protein-interacting conformation

(2008) Patrick Scheerer et al.   NATURE

Crystal structure of the ligand-free G-protein-coupled receptor opsin

(2008) Jung Hee Park et al.   NATURE

Two protonation switches control rhodopsin activation in membranes

(2008) M. Mahalingam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-resolution distance mapping in rhodopsin reveals the pattern of helix movement due to activation

(2008) C. Altenbach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA