期刊
SCIENCE ADVANCES
卷 4, 期 8, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.aar8590
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资金
- AFA Forsakring [140006]
- Avtal om Lakarutbildning och Forskning [ALFBGB-723681]
- Bissen Brainwalk Foundation
- Carl Trygger Foundation
- Erik, Karin and Gosta Selander Foundation
- Fredrik och Ingrid Thurings Foundation
- Lars Hiertas Minne Foundation
- Mats Kleberg Foundation
- Magnus Bergvalls Foundation
- Novo Nordisk Foundation
- Tore Nilson Foundation
- Swedish Medical Research Society
- Swedish Society for Medicine [SLS-694111]
- Swedish Brain Foundation
- Swedish Research Council [2015-03100, 2014-6888, 2016-01088, 2016-02195, 2015-4870]
- Ake Wiberg Foundation
- National Natural Science Foundation of China [31671139]
- Science for Life Laboratory Mass Spectrometry Based Proteomics Facility in Uppsala
- Knut and Alice Wallenberg Foundation as part of the National Bioinformatics Infrastructure Sweden at SciLifeLab
- Vinnova [2016-02195] Funding Source: Vinnova
- Swedish Research Council [2016-01088] Funding Source: Swedish Research Council
Curtailed sleep promotes weight gain and loss of lean mass in humans, although the underlying molecular mechanisms are poorly understood. We investigated the genomic and physiological impact of acute sleep loss in peripheral tissues by obtaining adipose tissue and skeletal muscle after one night of sleep loss and after one full night of sleep. We find that acute sleep loss alters genome-wide DNA methylation in adipose tissue, and unbiased transcriptome-, protein-, and metabolite-level analyses also reveal highly tissue-specific changes that are partially reflected by altered metabolite levels in blood. We observe transcriptomic signatures of inflammation in both tissues following acute sleep loss, but changes involving the circadian clock are evident only in skeletal muscle, and we uncover molecular signatures suggestive of muscle breakdown that contrast with an anabolic adipose tissue signature. Our findings provide insight into how disruption of sleep and circadian rhythms may promote weight gain and sarcopenia.
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