Article
Chemistry, Organic
Debabrata Maiti, Atreyee Halder, Aswathy Sasidharan Pillai, Suman De Sarkar
Summary: The mild and efficient electrochemically driven synthetic route allows for the access of polysubstituted selenofuran derivatives through diselenide-promoted cyclization of homopropargyl alcohols, with up to 84% isolated yield. This methodology demonstrates good functional group compatibility and further conversion to valuable furan derivatives.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Applied
Jianjing Yang, Xue Sun, Kelu Yan, Hongzhao Sun, Shuai Sun, Xiaoyu Jia, Fanjun Zhang, Jiangwei Wen
Summary: A metal- and exogenous-oxidant-free oxidation-induced oxyphosphorylation method for the synthesis of beta-ketophosphonates from alkenes and alkynes using water has been developed under electrochemical conditions. The protocol is compatible with a wide range of substrates and allows for gramscale synthesis of the desired products.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Organic
Jifang Chen, Houjuan Yang, Meifang Zhang, Hu Chen, Jie Liu, Kun Yin, Shuisheng Chen, Ailong Shao
Summary: This direct and efficient protocol allows for the thiocyanation of imidazoheterocycles with hydrogen evolution under electrochemical oxidation. Various important thiocyanated and selenocyanated imidazoheterocycles can be synthesized in moderate to excellent yields and easily scaled up. Mechanistic studies suggest that aryl radical cation is a key intermediate in this transformation.
TETRAHEDRON LETTERS
(2021)
Article
Chemistry, Analytical
Yulong Liu, Xiaoxi Lu, Yu Peng, Qianjin Chen
Summary: In this study, the individual gas bubble nucleation and dynamics on nanoscale electrodes were investigated using scanning electrochemical cell microscopy (SECCM). The nanostructured catalyst surface showed significantly less supersaturation for gas bubble nucleation and a notable increase of bubble detachment compared to its flat counterpart. The results suggest that deliberate microstructure design on a catalyst surface is a promising strategy for improving electrocatalytic gas evolution in terms of both bubble nucleation and elimination.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Fangling Lu, Kan Zhang, Yanxiu Yao, Ying Yin, Jiafu Chen, Xinwei Zhang, Yin Wang, Lijun Lu, Ziwei Gao, Aiwen Lei
Summary: A highly stereoselective synthesis of thiocyanated enaminones was achieved through an electrochemical process, with up to 87% yields. The transformation proceeded smoothly without the need for external oxidants, electrolytes, or transition-metal catalysts, showcasing its potential for practical application.
Review
Energy & Fuels
Mohamad Sahban Alnarabiji, Shik Chi Edman Tsang, Abdul Hanif Mahadi
Summary: This paper reviews the fabrication methods of working electrodes for electrochemical water splitting, including both chemical and physical methods. The research direction in this field is demonstrated by analyzing articles in the database. The advantages and disadvantages of the reported fabrication methods are critically assessed.
Review
Chemistry, Multidisciplinary
Babak Kaboudin, Milad Behroozi, Sepideh Sadighi
Summary: This review discusses the importance and application of electrochemical reactions of amines, nitriles, amides, and imines in the synthesis of organic compounds.
Article
Chemistry, Organic
Sai-Yan Ren, Qi Zhou, He-Yang Zhou, Lin-Wei Wang, Olga M. Mulina, Stanislav A. Paveliev, Hai-Tao Tang, Alexander O. Terent'ev, Ying-Ming Pan, Xiu-Jin Meng
Summary: Azoles and organoselenium compounds are important structures in medicinal chemistry and natural products. We developed an efficient regioselective electrochemical aminoselenation reaction for the synthesis of selenium-containing allylazoles. This protocol is cost-effective, environmentally friendly, and can be applied to the synthesis of bioactive molecules in the pharmaceutical industry.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Feng Liu, Weijie Ding, Jiacong Lin, Xu Cheng
Summary: This paper reports a direct approach for the electrochemical synthesis of tertiary alpha-substituted amino acid derivatives via three-component reductive coupling. Gaseous ammonia is used as both the N and H source, and scandium catalysis is crucial for achieving chemoselectivity among various side reaction pathways.
Article
Chemistry, Physical
Dongdong Wang, Yue Liu, Lili Liu, Dongfan Shan, Guixin Shen, Shanlong Peng, Heng Zhang, Xindong Wang
Summary: A three-dimensional multilevel nanoarray electrode with superaerophobicity was designed and fabricated, inspired by the underwater superaerophobicity of fish scales, to solve the bubble shielding effect in electrochemical reactions. The electrode exhibited outstanding electrocatalytic activity and durability, making it a promising catalyst for electrochemical water splitting.
Review
Materials Science, Multidisciplinary
Yihang Yao, Zhaoyuan Zhang, Lifang Jiao
Summary: This article summarizes the excellent performance and optimization strategies of transition metal borides (TMBs) in hydrogen evolution reaction (HER) and oxygen evolution reaction (OER), pointing out the direction for enhancing the performance.
ENERGY & ENVIRONMENTAL MATERIALS
(2022)
Article
Chemistry, Inorganic & Nuclear
Jiefei Li, Zehao Zhang, Xueqiong Zhang, Linjie Xu, Songyuan Yuan, Hang Wei, Haibin Chu
Summary: A self-supported dual-cation (Mo,Cu) co-doped Ni2P@ nickel foam catalyst has been prepared, in which the co-doped samples distort the lattice and expose a larger specific surface area, providing more reaction locations and demonstrating efficient water splitting performance.
DALTON TRANSACTIONS
(2021)
Article
Environmental Sciences
J. X. Flores-Lasluisa, F. Huerta, D. Cazorla-Amoros, E. Morallon
Summary: Transition metal oxide-based materials are interesting alternatives to noble-metal catalysts in energy conversion devices. Perovskite and spinel oxides can be tailored to have specific properties. However, their catalytic performance is affected by low electrical conductivity and surface area, which can be mitigated by combining them with carbon materials. This review focuses on tunable perovskites and spinels with 3d metal cations for electrochemical energy conversion.
ENVIRONMENTAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Bo Li, Yunhao Zhou, Yanan Sun, Feng Xiong, Linghui Gu, Wenbo Ma, Ruhuai Mei
Summary: An unprecedented electrochemical selenium-pi-acid promoted hydration of internal alkynes bearing a phosphonate auxiliary is described. The reaction provides a mild and metal-free method for the synthesis of valuable ketones, demonstrating high atom-economy, good selectivity, and excellent functional group tolerance. Phosphonate assistance is proven to be essential for this transformation.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Olawale Oloye, Anthony P. O'Mullane
Summary: A technology has been developed to capture, convert, and utilize carbon dioxide using an electrochemical process powered by renewable energy, showing potential to reduce CO2 emissions. By accelerating the conversion of CO2 into carbonate ions and forming metal carbonates that precipitate out of solution, this technology has applications in various industries, including cement, with the use of renewable energy.
Article
Chemistry, Physical
Lijun Lu, Feiyu Qiu, Hesham Alhumade, Heng Zhang, Aiwen Lei
Summary: This work demonstrated metal-controlled mono-and double-carbonylation reactions of alkanes with amines, resulting in the preparation of alkyl amides and alkyl alpha-ketoamides, with Co and Cu catalysis systems affording different selectivities.
Article
Chemistry, Physical
Yichang Liu, Yi-Hung Chen, Hong Yi, Aiwen Lei
Summary: Carbonyl derivatives are widely present in pharmaceuticals, agricultural chemicals, materials, and natural products. Developing novel, efficient, and green carbonylation methods is one of the hottest research topics in organic synthesis. C-H functionalization/carbonylation is among the most atom- and step-economical methods.
Article
Chemistry, Multidisciplinary
Yongli Li, Huamin Wang, Zhuning Wang, Hesham Alhumade, Zhiliang Huang, Aiwen Lei
Summary: This article describes a method for selectively activating C(sp(3))-S bonds, which is achieved through a radical-mediated electrochemical strategy for the synthesis of valuable disulfides from thioethers. The method features mild reaction conditions and excellent chemoselectivity.
Article
Chemistry, Organic
Jianguo Hu, Shengchun Wang, Bin Li, Aiwen Lei
Summary: We report a protocol for constructing tetrahydroquinolines from bulk chemicals (alkenes and anilines) induced by K2S2O8. The method exhibits operational simplicity, wide scope, mild conditions, and a transition-metal-free system.
Article
Chemistry, Organic
Chang-Ming You, Cheng Huang, Sheng Tang, Peng Xiao, Shengchun Wang, Zhenhong Wei, Aiwen Lei, Hu Cai
Summary: Direct N-allylation of azoles with hydrogen evolution has been achieved by the synergistic combination of organic photocatalysis and cobalt catalysis. This protocol eliminates the need for stoichiometric oxidants and prefunctionalization of alkenes, and produces hydrogen (H2) as a byproduct. The transformation highlights high step and atom economy, high efficiency, and broad functional group tolerance, opening up a pathway for valuable C-N bond formation in heterocyclic chemistry.
Article
Chemistry, Organic
Tongzhi Sang, Chenxing Zhou, Jun Li, Xincong Liu, Yong Yuan, Xiazhen Bao, Xiaolong Zhao, Congde Huo
Summary: We report a visible-light-promoted approach for the anti-Markovnikov hydrooxygenation of unactivated alkenes. The protocol uses a cost-effective, bench-stable, and easy-to-handle oxime ester as the reagent, enabled by energy-transfer catalysis. This methodology exhibits excellent functional group tolerance and mild reaction conditions, making it suitable for the hydroesterification of pharmaceutically relevant molecule-derived alkenes.
Article
Multidisciplinary Sciences
Dongfeng Yang, Zhipeng Guan, Yanan Peng, Shuxiang Zhu, Pengjie Wang, Zhiliang Huang, Hesham Alhumade, Dong Gu, Hong Yi, Aiwen Lei
Summary: By electrochemical oxidative difunctionalization, the authors achieved functionalization of diazo compounds with two different nucleophiles. This method allows the synthesis of structurally diverse heteroatom-containing compounds, which are difficult to access by traditional methods, and display important synthetic applications. The reaction conditions are mild, exhibiting excellent functional group tolerance and efficiency for large-scale synthesis.
NATURE COMMUNICATIONS
(2023)
Editorial Material
Chemistry, Physical
Shengchun Wang, Aiwen Lei
Summary: A detailed mechanistic picture of electron transfer in polypyridine nickel systems has been reported, providing an answer to the challenging puzzle of electron transfer in these complexes.
Review
Chemistry, Multidisciplinary
Wuyin Wang, Wentao Mo, Zishan Hang, Yueying Huang, Hong Yi, Zhijun Sun, Aiwen Lei
Summary: Transition metal element, copper, plays diverse and pivotal roles in oncology. It acts as constituents of metalloenzymes involved in cellular metabolism, function as signaling molecules to regulate the proliferation and metastasis of tumors, and are integral components of metal-based anticancer drugs. Notably, recent research reveals that excessive copper can also modulate the occurrence of programmed cell death (PCD), known as cuprotosis, in cancer cells.
Review
Chemistry, Multidisciplinary
Li Zeng, Jianxing Wang, Daoxin Wang, Hong Yi, Aiwen Lei
Summary: Organic electrosynthesis using alternating current (AC) is still in its early stages due to the lack of a comprehensive theoretical framework. This article provides an overview of recent advancements in AC-driven organic transformations and explores the differences between DC and AC electrolytic methodologies based on their physical principles. These differences include the prevention of metal catalyst deposition, precise modulation of oxidation and reduction intensities, and mitigation of mass transfer processes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Physical
Xingchen Liu, Haohua Chen, Dali Yang, Binjing Hu, Ying Hu, Shengchun Wang, Yu Lan, Aiwen Lei, Jie Li
Summary: A multicomponent sulfonylation reaction using sulfonyl chlorides and OPiv-supported organozinc reagents was achieved via cobalt-catalyzed alkene difunctionalizations. Anion-coordination played a critical role in modifying the reactivity and chemical properties of organozinc reagents. The OPiv-coordination resulted in the lower reducibility of arylzinc pivalates, allowing for the in situ formation of catalytically relevant Co(I) species as the active catalyst in carbosulfonylation reactions.
Article
Polymer Science
Yu Xia, Fulin Zhou, Wenyan Hao, Shan Tang
Summary: The researchers reported a novel strategy for incorporating cleavable disulfide units into the backbone of polyolefins using commercially available diallyl disulfide (DADS) as a comonomer via metathesis copolymerization. This method allows for the synthesis of copolymers with adjustable disulfide content and excellent thermal processability and degradability.
Article
Chemistry, Multidisciplinary
Jinming Wang, Yichang Liu, Xupeng Zong, Aiwen Lei, Zaicheng Sun
Summary: Photochemistry has become increasingly important in organic synthesis and heterogeneous photocatalysts have advantages over traditional homogeneous photocatalysts in terms of production, separation, catalyst recycling, and stability. In this review, the development and advantages of a heterogeneous catalytic system for C-N bond formation as a typical coupling reaction are summarized. Important heterogeneous photocatalysts such as titanium dioxide, semiconductor quantum dots, covalent organic frameworks, and carbon nitrides are discussed in detail. The combination and electron transfer pathway between heterogeneous catalysts and transition-metal catalysts are the focus of this review. These advances not only apply to C-N coupling, but also extend to other coupling reactions.
Article
Chemistry, Multidisciplinary
Yiran Xu, Shengchun Wang, Zhao Liu, Mian Guo, Aiwen Lei
Summary: A photo/nickel dual-catalyzed defluorinative sulfonylation method has been developed to synthesize gem-difluoro allylsulfones rapidly and reliably. This protocol demonstrates mild conditions and a wide scope, providing a novel strategy for the sulfonyl radical participating in radical defluorinative coupling.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Jie Xu, Fangling Lu, Linghong Sun, Mingna Huang, Jianwei Jiang, Ke Wang, Dandan Ouyang, Lijun Lu, Aiwen Lei
Summary: The construction of C-S bonds plays a crucial role in synthetic, medicinal, and materials chemistry. In this study, we used an electrochemical reduction method to obtain thiyl radicals from sulfinic acids. This approach enabled the synthesis of a variety of desired thioesters in high yields. The preliminary mechanism studies revealed that the formation of thiyl radical species from sulfinic acid involved multiple steps of a single electron transfer process.
