Article
Biochemistry & Molecular Biology
Violeta Jevtovic, Asma K. Alshamari, Dejan Milenkovic, Jasmina Dimitric Markovic, Zoran Markovic, Dusan Dimic
Summary: Thiosemicarbazones and their metal complexes were studied for their structural properties and biological activities, demonstrating their potential as anticancer agents. Four pyridoxal-thiosemicarbazone (PLTSC) complexes with Fe, Co, Ni, and Cu were analyzed, focusing on the donor atom-metal interactions. The geometry, crystallographic structures, and intermolecular interactions were investigated, determining the specific interactions based on the structure and number of PLTSC units. The binding of the complexes to proteins and DNA was analyzed, and cytotoxicity tests showed that Cu-PLTSC exhibited the highest affinity towards DNA and proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Swarup Kumar Tarai, Arup Tarai, Saikat Mandal, Bhaskar Nath, Ipsita Som, Rituparna Bhaduri, Arka Bagchi, Solanki Sarkar, Arunima Biswas, Sankar Ch. Moi
Summary: The bidentate ligand thiosemicarbazone (H3L) and its Ni(II) complex were synthesized and characterized. The complexes have square planar geometry and show binding abilities with DNA and BSA. The DFT/TD-DFT simulations and theoretical analysis provided insights into the reactivity, bonding mode, and bio-molecular affinity of the compounds. The compounds also demonstrated antiproliferative activity and cell death mechanisms against HEK293 and MCF-7 cell lines.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Inorganic & Nuclear
Azadeh Mirzaahmadi, Seyed Abolfazl Hosseini-Yazdi, Majid Mahdavi, Michal Dusek, Valcav. Eigner, Morgane Poupon
Summary: New water-soluble Zn(II) and Ni(II) complexes, synthesized and characterized in this study, exhibit good solubility and stability in aqueous media. These complexes show potential anticancer activity in cell experiments.
Article
Chemistry, Inorganic & Nuclear
Mukerrem Findik, Burak Kuzu, Suray Pehlivanoglu, Serdal Kaya, Ulku Sayin, Emine Guler Akgemci, Ahmet Ozgur Saf
Summary: In this study, the synthesis and characterization of 9-ethyl-3-carbazolecarboxaldehyde-4-ethyl-thiosemicarbazone (ECCAET) and its copper(II) complex (Cu(ECCAET)2) were conducted. Experimental evidence revealed that Cu(ECCAET)2 interacts with DNA through intercalative binding mode and binds strongly to BSA. Molecular docking studies supported the bonding mechanism of ECCAET and Cu(ECCAET)2 with DNA and BSA. In addition, Cu(ECCAET)2 exhibited higher cytotoxic and antiproliferative properties compared to its ligand (ECCAET), demonstrating its potential as a drug candidate against gynecologic cancer diseases.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Yogesh Kumar, Nikhil Kumar Singh, Vishwa Deepak Singh, Irshad Ali, Rajan Kumar Tiwari, Ajay Kumar, Daya Shankar Pandey
Summary: This study describes the synthesis of azo-Schiff base ligands and their zinc complexes, as well as their spectral characterization and interaction studies. The complexes showed strong binding affinity towards DNA and BSA, and exhibited high cytotoxicity against Hut-78 cell line. Furthermore, the complexes underwent photo isomerization under UV light irradiation.
INORGANICA CHIMICA ACTA
(2022)
Article
Chemistry, Applied
Aleksandar Mijatovic, Angelina Z. Cakovic, Aleksandar Lolic, Olivera Klisuric, Marko N. Zivanovic, Dragana S. Seklic, Snezana Sretenovic, Marija Ilic, Jovana Bogojeski
Summary: This study synthesized multiple copper (II) complexes with different ligands and investigated their interactions with DNA and proteins, as well as their anti-tumor activity. The results showed that these complexes had moderate affinity for DNA and proteins, and one of the complexes exhibited selectivity for cancer cells.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Mukerrem Findik, Ercan Turkkan, Suray Pehlivanoglu, Ulku Sayin, Umit Ceylan, Emine Guler Akgemci
Summary: A new copper(II) complex, Cu(HPP), with 2-hydroxy-5-methoxyacetophenone thiosemicarbazone (HMAT) was synthesized and characterized. Spectroscopic investigations revealed its intercalative binding mechanism with calf-thymus deoxyribonucleic acid (ct-DNA) and significant binding to bovine serum albumin (BSA). The complex also showed significant cytotoxicity in drug resistant breast cancer cells and has the potential to be a chemotherapeutic agent for breast cancer.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Shadia A. Elsayed, Hagar E. Badr, Armando di Biase, Ahmed M. El-Hendawy
Summary: Four new transition metal complexes were synthesized and characterized, showing good antioxidant activity and in vitro cytotoxicity against breast cancer and colon cancer cells. These complexes exhibit potential as effective anticancer agents and may warrant further studies for clinical application.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Sanam Maikoo, Abir Chakraborty, Nyeleti Vukea, Laura Margaret Kirkpatrick Dingle, William John Samson, Jo-Anne de la Mare, Adrienne Lesley Edkins, Irvin Noel Booysen
Summary: The interactions of ruthenium heterocyclic complexes with DNA and BSA were studied using UV-Vis spectrophotometry, fluorescence emission spectroscopy, and agarose gel electrophoresis. The complexes were found to be groove-binders with high DNA binding constants. Additionally, they exhibited high radical scavenging activities and moderate cytotoxicity against cancer cell lines.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Biochemistry & Molecular Biology
Monica Martinez-Estevez, Soledad Garcia-Fontan, Saray Argibay-Otero, Inmaculada Prieto, Ezequiel M. Vazquez-Lopez
Summary: In this study, the reaction between [Ru2Cl2(mu-Cl)(2)(eta(6)-p-cymene)(2)] and two thiosemicarbazones was investigated. The resulting cationic complexes were isolated and characterized. The study revealed the presence of two isomers in the triflate salts and only one isomer in the chloride. X-ray crystallography confirmed this finding. The coordination of the thiosemicarbazone ligand to the ruthenium center was also demonstrated.
Article
Immunology
Cheng Lin, Yvonne Marquardt, Stefan Ruetten, Liangliang Liao, Khosrow Rahimi, Tamas Haraszti, Jens Malte Baron, Matthias Bartneck
Summary: Macrophages play a critical role in the persistence of tattoo ink in human skin. However, there is a need for a comparison to other immune cells and a detailed analysis of REACH-compliant tattoo ink.
Article
Chemistry, Inorganic & Nuclear
Chinmoy Biswas, Arnab Chatterjee, Vinu Vijayan, Chandra Shekhar Purohit, Manikantan Syamala Kiran, Rajarshi Ghosh
Summary: This article reports the synthesis and structural characterization of a dinuclear silver(I) complex 1, which exhibits selective anticancer activity against liver cancer cells. The anticancer activity of 1 is achieved through induction of mitochondrial death via Reactive Oxygen Species (ROS).
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Jin Wang, Yu-Ting Wang, Jiang-Nan Chang, Ming-Xue Li
Summary: The article describes the synthesis and characterization of two nickel complexes of 2-acetylpyrazine thiosemicarbazone, and studies their antibacterial activities. It was found that one of the complexes showed effective antimicrobial activity against tested bacteria, and that complex 2 exhibited inhibitory activity against human hepatocellular carcinoma HepG2 cells. Additionally, toxicity study showed that complex 2 had the highest tumor cell selectivity.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Adesola A. Adeleke, Sizwe J. Zamisa, Md. Shahidul Islam, Kolawole Olofinsan, Veronica F. Salau, Chunderika Mocktar, Bernard Omondi
Summary: A series of fifteen silver (I) quinoline complexes were synthesized and evaluated for their biological activities, showing good antibacterial, antioxidant, and cytotoxic activities. The complexes demonstrated strong binding affinity with DNA and proteins, with certain compounds exhibiting excellent cytotoxicity against cancer cell lines.
Article
Chemistry, Applied
Nimya Ann Mathews, M. R. Prathapachandra Kurup
Summary: This study synthesized new ternary complexes derived from multisubstituted thiosemicarbazone ligands and characterized their properties using various spectroscopic and analytical methods. The complexes showed strong interactions with DNA, cleaving DNA without external agents, and exhibited potential cytotoxicity against human breast cancer cells.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Moideen Musthafa, Ramaiah Konakanchi, Rakesh Ganguly, Chandrasekar Balachandran, Shin Aoki, Anandaram Sreekanth
Summary: A series of aroyl selenourea ligands and their Ru(II) complexes were synthesized and characterized, with the molecular structures confirmed by single XRD crystal method. The cytotoxic study revealed that complexes 1 and 2 showed promising cytotoxic activity against HeLa S3 cells, while the in vitro DNA interaction studies indicated an intercalative mode of binding in the order of 1 > 2 > 3.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Food Science & Technology
Chandrasekar Kandaswamy, Sreekanth Anandaram, S. I. Davis Presley, Ahammed T. P. Shabeer
Summary: A gas chromatography tandem mass spectrometry method was developed for simultaneous determination of 133 pesticides in Black pepper. QuEChERS sample preparation method is preferred over multistep methods. Even after the cleanup, non-volatile co-extractives stick to the liner and column, affecting the instrument performance, a dilution procedure was evaluated to overcome the drawbacks.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2021)
Article
Chemistry, Inorganic & Nuclear
Merlin Mary Mathew, Anandaram Sreekanth
Summary: A new fluorescent probe based on Thiophene-dicarbohydrazide was synthesized for the detection of Zn2+ ions and showed highly emissive behavior upon complexation. The chemosensor exhibited a binding constant of 1.15 x 10(4) M-1 and a low detection limit of 1.51 x 10(-7) M, below the permissible level in drinking water. The fluorescent enhancement was attributed to a chelation enhanced fluorescence mechanism, and the probe also demonstrated reversibility and INHIBIT/IMPLICATION Logic gate behavior with EDTA for the HNTCH-Zn2+ complex.
INORGANICA CHIMICA ACTA
(2021)
Article
Biochemical Research Methods
Puthiyavalappil Rasin, Merlin Mary Mathew, Vipin Manakkadan, Vishnunarayanan Namboothiri Vadakkedathu Palakkeezhillam, Anandaram Sreekanth
Summary: In this work, a highly selective and sensitive fluorescent sensor based on a pyrene derivative was developed for the detection of Fe(III) ions in DMSO/water media. The sensor exhibited fluorescence quenching in the presence of Fe(III) ions, with a low limit of detection. The fluorescence lifetime and quantum yield measurements confirmed the binding of the receptor PEBD to Fe(III) ions. Computational studies were conducted to further investigate the properties of the receptor PEBD.
JOURNAL OF FLUORESCENCE
(2022)
Article
Biochemical Research Methods
Puthiyavalappil Rasin, Moideen Musthafa, Anandaram Sreekanth
Summary: We have introduced a novel selenium-based compound for the optical and fluorimetric detection of Hg in an aqueous medium. The compound showed high selectivity and formed a complex with Hg2+ ions. Spectroscopic techniques and computational simulations were used to study the structure and electronic distribution of the compound.
JOURNAL OF FLUORESCENCE
(2022)
Article
Chemistry, Physical
Sabeel M. Basheer, Puthiyavalappil Rasin, Saravana Loganathan Ashok Kumar, Moorthy Saravana Kumar, Anandaram Sreekanth
Summary: 2-acetylpyrzine N-(4)-cyclohexylthiosemicarbazide (H2L) and its Ni(II) and Fe(III) metal complexes were synthesized and studied for their interactions with Bovine Serum Albumin and CT-DNA. The complexes exhibited high affinity for DNA and showed non-covalent intercalation.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Multidisciplinary
Puthiyavalappil Rasin, Vipin Manakkadan, Vishnunarayanan Namboothiri Vadakkedathu Palakkeezhillam, Jebiti Haribabu, Cesar Echeverria, Anandaram Sreekanth
Summary: A pyrene-based fluorescent chemosensor APSB was designed and synthesized, which selectively binds Fe3+ ions and shows high selectivity and sensitivity. The function of APSB can be explained by the photo-induced electron transfer mechanism and its efficiency for selective detection of Fe3+ in cells was confirmed.
Article
Chemistry, Physical
Vishnunarayanan Namboothiri Vadakkedathu Palakkeezhillam, Jebiti Haribabu, Vipin Manakkadan, Puthiyavalappil Rasin, Roslin Elsa Varughese, Dasararaju Gayathri, Nattamai Bhuvanesh, Cesar Echeverria, Anandaram Sreekanth
Summary: In this study, we synthesized and evaluated the biological activity of new thiosemicarbazones and their cyclized heterocyclic compounds through in silico and in vitro examinations. Two pyrene-based thiosemicarbazone compounds were prepared and two new compounds were obtained through cyclization reactions. The structure of the compounds was characterized using various analytical techniques. Among them, PP2 exhibited strong cytotoxicity and inhibited the growth of HepG-2 and T24 cells.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Merlin Mary Mathew, Puthiya Valappil Rasin, Priyabrata Mandal, Anandaram Sreekanth
Summary: This study develops two chemosensors, 3TCH and BTTCH, using photoluminescence spectroscopy (PL) to detect hazardous metal ions and anions, such as Cu2+, F-, and AcO-, in industrial and domestic water. Spectral variations and color changes indicate their interaction and the detection limits are low. The chemosensor 3TCH + F- shows the highest association constant and affinity. Furthermore, the compatibility of these chemosensors with common household items like mouthwash and vinegar is investigated.
RESULTS IN CHEMISTRY
(2023)
Article
Chemistry, Analytical
Puthiyavalappil Rasin, Praveena Prabhakaran, Sabeel M. Basheer, Vipin Manakkadan, Vishnunarayanan Namboothiri Vadakkedathu Palakkeezhillam, Anandaram Sreekanth
Summary: We described a cheap and effective chemosensor (NHPyTSC) that can differentiate Hg2+ and Zn2+ ions from other metal ions. Spectroscopy techniques revealed noticeable color and absorption changes when mercury and zinc ions were added to the chemosensor. The addition of EDTA in NHPyTSC-Hg2+ and NHPyTSC-Zn2+ solutions allowed for colorimetry readings to be reversed. Additionally, the chemosensor showed potential applications in molecular information processing, molecular keypad lock, molecular logic gates, and latent fingerprint detection.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Puthiyavalappil Rasin, Jebiti Haribabu, Kailas Mahipal Malappuram, Vipin Manakkadan, Vishnunarayanan Namboothiri Vadakkedathu Palakkeezhillam, Cesar Echeverria, Anandaram Sreekanth
Summary: A pyrene-based fluorescence sensor, PyAP, was developed for the specific detection of Ga3+ ions through a simple Schiff base reaction. It showed good selectivity and sensitivity in the presence of other metal ions. The binding constant between PyAP and Ga3+ was determined to be 7.03 x 104 M-1, with a detection limit of 3.35 nM in a DMSO/H2O (2:8, v/v) solution. The sensor's ability to detect Ga3+ in living cells and its cell permeability were validated through live cell imaging in T24 cells. Furthermore, PyAP was found to have applications in molecular logic gates and keypad locks.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)
Article
Electrochemistry
Sabeel M. Basheer, S. L. Ashok Kumar, N. Sarathi, Puthiyavalappil Rasin, M. Saravana Kumar, Mathiyan Muralisankar, A. Sreekanth
Summary: A novel corrosion inhibitor DTSc has been developed and characterized using different spectroscopic techniques. Its effectiveness in protecting mild steel from corrosion in HCl has been evaluated using various corrosion monitoring techniques. The adsorption of DTSc on the mild steel surface was found to be chemisorption. The inhibition efficiency of DTSc increased with concentration and immersion time, and the presence of the inhibitor eliminated corrosion-related surface imperfections.
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
(2023)
Article
Chemistry, Applied
Vishnunarayanan Namboothiri Vadakkedathu Palakkeezhillam, Jebiti Haribabu, Vaishnu Suresh Kumar, Vipin Manakkadan, Puthiyavalappil Rasin, Nattamai Bhuvanesh, Cesar Echeverria, Juan F. Santibanez, Anandaram Sreekanth
Summary: A series of thiosemicarbazones were synthesized and evaluated for their anticancer activity. One compound (CFM) showed potent inhibitory effects against breast adenocarcinoma and urinary bladder cancer cells, while exhibiting negligible cytotoxicity against normal cells. Molecular docking studies suggested effective binding of these compounds with cancer proteins and serum proteins. These findings provide insights into the bioactivities of thiosemicarbazones.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Physical
Vipin Manakkadan, Jebiti Haribabu, Vishnunarayanan Namboothiri Vadakkedathu Palakkeezhillam, Puthiyavalappil Rasin, Manas Mandal, Vaishnu Suresh Kumar, Nattamai Bhuvanesh, Rednam Udayabhaskar, Anandaram Sreekanth
Summary: In this study, a series of thiosemicarbazones were synthesized and their structures were confirmed using various spectroscopic techniques. The compounds showed interactions with CT-DNA and BSA, with TL3 exhibiting stronger binding and interaction. Computational evaluations revealed TL2 to have higher structural stability. All compounds showed potential as oral drug candidates. TL3 exhibited good anticancer activity in liver and endothelial carcinoma cells.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Merlin Mary Mathew, A. Sreekanth
Summary: Two novel N4-suberene substituted thiosemicarbazone chemosensors (SATSC 1 and SATSC 2) designed and synthesised for colorimetric and optical response towards anions show good sensing responses towards fluoride, acetate and cyanide ions. SATSC 2 exhibits better binding affinity towards fluoride ions than SATSC 1, and both sensors display fluorescent enhancement after binding with certain anions.
JOURNAL OF CHEMICAL SCIENCES
(2021)