期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 1, 期 9, 页码 780-788出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.5b00160
关键词
rapid prototyping; 3D printing; biomaterial inks; silk; self-curing
资金
- NIH [P41 EB002520, 3 P41 EB002520-09S1]
- AFOSR
Silk-based bioinks were developed for 2D and 3D printing. By incorporating nontoxic polyols into silk solutions, two-part formulations with self curing features at room temperature were generated. By varying the formulations the crystallinity of the silk polymer matrix could be controlled to support printing in 2D and 3D formats interfaced with CAD geometry and with good feature resolution. The self-curing phenomenon was tuned and exploited in order to demonstrate the formation of both structural and support materials. Biocompatible aqueous protein inks for printing that avoid the need for chemical or photo initiators and that form aqueous-stable structures with good resolution at ambient temperatures provide useful options for biofunctionalization and a broad range of applications.
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