期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 1, 期 11, 页码 1104-1113出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.5b00220
关键词
nanodiamonds; silk fibroin; fluorescence; bioimaging; mobility
资金
- Melbourne Research Scholarships - University of Melbourne
- Melbourne Scholarships
- ARC Australian Research Fellowship [DP1096288]
- Australian Government
High resolution bioimaging is not only critical to the study of cellular structures and processes but it also has important applications in drug delivery and therapeutics. Fluorescent nanodiamonds (NDs) are excellent candidates for long-term bioimaging and tracking of biological structures at the nanoscale. Encapsulating NDs in natural biopolymers like silk fibroin (SF) widens their biomedical applications. Here we report the synthesis, structural and optical characterization of ND incorporated SF nanospheres. The photoluminescence from optical defects within the NDs is found to increase when encapsulated in the SF spheres. The encapsulated NDs are applied in vitro to investigate the intracellular mobility compared to bare NDs. The diffusion rate of encapsulated NDs is shown to improve due to SF coating. These ND-SF spheres are envisioned as highly suitable candidates for bioinjectable imaging and drug release carriers for targeted drug delivery applications.
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