Article
Surgery
Leon Naar, Ander Dorken Gallastegi, Matthew Dowling, Hassan Naser A. Mashbari, Brandon Wallace, Brittany Bankhead-Kendall, John Beagle, Jessica B. Pallotta, Kerry Breen, George C. Velmahos, Michael J. Duggan, Col David R. King
Summary: The study examined the use of hm-chitosan-based foam as a locally injectable hemostatic agent for the treatment of noncompressible bleeding. The results showed that the use of hm-chitosan improved survival and stabilized lactate levels.
Article
Polymer Science
Fabio Bignotti, Francesco Baldi, Mario Grassi, Michela Abrami, Gloria Spagnoli
Summary: This work presents a novel method to synthesize hydrophobically-modified hydrogels, which exhibit thermosensitive behavior and enhanced properties when the HLB decreases, especially when wp exceeds 10%. The decrease in HLB results in an increase in polymer weight content and improvement in mechanical properties due to the occurrence of physical crosslinking.
Article
Chemistry, Physical
Frantisek Ondreas, Marcela Dusankova, Jaroslav Sita, Martin Cepa, Jiri Stepan, Petr Belsky, Vladimir Velebny
Summary: Understanding how physicochemical properties influence the self-assembly process of amphiphilic molecules is crucial for controlling nanostructure. The relationship between supramolecular structure and functional properties is important for effective design. Investigating hydrophobically modified hyaluronic acid revealed insights into structure-property relationships in self-assembled nanostructures.
APPLIED SURFACE SCIENCE
(2021)
Article
Surgery
Ross Donaldson, Eric M. Zimmermann, Timothy C. Fisher, Oliver J. Buchanan, Jonathan K. Armstrong, John S. Cambridge, Todd L. Graham, James D. Ross
Summary: This study demonstrated the feasibility of using Fast Onset Abdominal Management (FOAM) in a lethal swine model of Noncompressible Torso Hemorrhage (NCTH). The FOAM group showed significantly higher mean arterial pressure compared to controls, with a trend towards improved survival.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Polymer Science
Takayuki Takei, Rio Tomimatsu, Takanori Matsumoto, Kamalalayam Rajan Sreejith, Nam-Trung Nguyen, Masahiro Yoshida
Summary: The unique properties and morphology of liquid marbles make them potentially useful for various applications. In this study, hydrophobically modified gelatin was used as the base material for particles, and the effect of surface tension and liquid-over-solid spreading coefficient on the formation of liquid marbles was investigated.
Article
Chemistry, Applied
Chen Huang, Fusheng Sun, Xuxi Ma, Chao Gao, Nan Yang, Katsuyoshi Nishinari
Summary: This study demonstrates the use of hydrophobically modified chitosan microgels as particle emulsifiers to stabilize high internal phase emulsions for the first time. The modified chitosan microgels have higher hydrophobicity and can effectively stabilize emulsions with high oil concentrations. The stable emulsions exhibited higher rheological compliance compared to other solid particle stabilized emulsions at high oil volume fractions.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Physical
Frantisek Ondreas, Jaroslav Sita, Martin Cepa, Eliska Svecova, Vladimir Velebny
Summary: This study investigated the interactions between oleyl derivative of hyaluronan (oleyl-HA) and bovine serum albumin (BSA) and found that the hydrophobic interactions led to the formation of hybrid BSA-oleyl-HA nanostructures, which affected the penetration efficiency of drugs. The findings also provided insights into the complex behavior of hydrophobically modified HA derivatives in a biological environment.
APPLIED SURFACE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Wai Mun Chong, Vuanghao Lim, Erazuliana Abd Kadir
Summary: A novel palmitoylated glycol chitosan polymer grafted with PEG (PGC-PEG) was developed to form amphiphilic micelles, incorporating hydrophobic itraconazole (ITZ) to produce PGC-PEG-ITZ nanoparticles in the form of homogenous polymeric micelles (PMs) and nanoemulsions (NEs). NEs showed higher drug entrapment and superior anticancer activity against human breast cancer cells compared to PMs. These PEGylated GC-based nanoparticles are promising nanocarriers for improving the delivery and therapeutic activity of hydrophobic drugs.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Applied
Selma Toumi, Madiha Melha Yahoum, Sonia Lefnaoui, Abdelkader Hadjsadok
Summary: New amphiphilic derivatives of kappa-carrageenan were synthesized by hydrophobic modification using octyl chloride, with microwave-assisted synthesis leading to higher degree of substitution, greater amphiphilic character, and improved emulsifying power compared to conventional heating method. These derivatives show potential applications in food, cosmetics, and pharmaceutics as stabilizers for oil/water emulsions.
CARBOHYDRATE POLYMERS
(2021)
Article
Pharmacology & Pharmacy
Michela Abrami, Fabio Bignotti, Francesco Baldi, Gloria Spagnoli, Alice Biasin, Lucia Grassi, Gabriele Grassi, Mario Grassi
Summary: The focus of this study is to characterize hydrophobically-modified polyethylene glycol hydrogels for drug delivery systems using rheology and low field Nuclear Magnetic Resonance. The results revealed that increasing the content of hydrophobic segments and applying thermal treatments after hydrogel preparation can improve the physical bonds. A reliable interpretative model linking shear modulus and average magnetic relaxation time was established, and a new mathematical approach for determining the magnetic relaxation spectrum was proposed.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Polymer Science
Wen Ou, Xinjie Luo, Yujun Feng
Summary: Hydrophobic materials, such as the modified sponge powders in this study, can selectively separate mineral oil and water, increase oil recovery by blocking high permeable channels, and significantly reduce excessive water production during oil production processes.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Polymer Science
Oksana Stennikova, Natalia Shmakova, Jean-Bastien Carrat, Evgeny Ermanyuk
Summary: An experimental study was conducted to investigate the characteristics of quasi-two-dimensional liquid foams with varying liquid fractions. The results showed that the increase in liquid fraction significantly affected the rheology of the foam, as indicated by the variation in foam velocity. The local permeability decreased with increasing obstacle height and liquid fraction.
Article
Chemistry, Applied
Xiaohui Wei, Sheng Ding, Shisheng Liu, Kun Yang, Junjie Cai, Fan Li, Chunlai Wang, Song Lin, Feng Tian
Summary: The serial hemostatic sponges made of polysaccharides-modified chitosan foam sponges demonstrated excellent water-absorbing quality, improved mechanical performance, and superior hemostasis capability both in vitro and in vivo. The hemostatic mechanism involves adhering/activating red blood cells/platelets to form robust blood clots, making it a promising option for emergency trauma treatment in civilian and military settings.
CARBOHYDRATE POLYMERS
(2021)
Article
Biotechnology & Applied Microbiology
Courtney Evans, Yuto Morimitsu, Tsubasa Hisadome, Futo Inomoto, Masahiro Yoshida, Takayuki Takei
Summary: This study reports the successful fabrication of hydrophobically modified chitosan cryogel, which can be optimized for strength, adsorption, and release of hydrophobic dye by varying alkyl chain length and substitution degree. The cryogel shows potential as a biomedical material.
JOURNAL OF BIOSCIENCE AND BIOENGINEERING
(2021)
Article
Chemistry, Applied
Denise A. J. Oliveira, Juliano G. Amaral, Laryana B. Garcia, Milena S. dos Santos, Lorena A. O. Silva, Maiara P. Almeida, Angelica F. Gomes, Danielle R. P. Barros, Norberto P. Lopes, Gislaine R. Pereira, Orlando D. H. dos Santos, AndrE L. M. Ruela
Summary: By associating low molecular weight chitosan with a microemulsion, a more viscous liquid crystal topical vehicle was formed. Experimental results with Brazilian Stryphnodendron adstringens shell extract and Melaleuca alternifolia essential oil showed activity against Candida albicans. Incorporating chitosan in the microemulsion improved the mechanical properties of the topical formulation, providing advantages for the topical treatment of vulvovaginal candidiasis.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Multidisciplinary
Niti R. Agrawal, Marzhana Omarova, Faraz Burni, Vijay T. John, Srinivasa R. Raghavan
Summary: The study demonstrates the formation of nanoscale vesicles and vesicle gels in glycerol, formamide, and ethylene glycol using lecithin. Vesicles in polar solvents are easier to form and more stable than those in water, attributed to refractive index-matching between lipid bilayers and solvents. The ability to use lipids in polar solvents could have wide-ranging applications, such as in cosmetics, pharmaceuticals, and lubricants.
Article
Chemistry, Multidisciplinary
Louis G. Corcoran, Brian A. Saldana Almaraz, Kamilah Y. Amen, Geoffrey D. Bothun, Srinivasa R. Raghavan, Vijay T. John, Alon McCormick, R. Lee Penn
Summary: The study found that LT dispersant blends containing L and T can induce broad Winsor III microemulsion regions in DOW phase diagrams, correlating with thermodynamic phase behavior. The research provides a protocol allowing observation of phase behavior on short time scales and a set of guidelines to interpret the results.
Article
Multidisciplinary Sciences
Leah K. Borden, Ankit Gargava, Srinivasa R. Raghavan
Summary: The study demonstrated strong adhesion of cationic hydrogels to bovine tissues under a DC electric field, showcasing the potential use of electroadhesion in sealing tissue cuts without the need for sutures. This approach could simplify surgeries by allowing adhesion on-command and reversible adhesion in case of error.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Kerry C. DeMella, Sai Nikhil Subraveti, Karima J. Perry, Shashi P. Karna, Srinivasa R. Raghavan
Summary: This paper presents a platform of polymer capsules that can synthesize products on-demand. The capsules are multicompartment structures that can transport solutes and trigger reactions using a thermal switch. The platform was used to synthesize fluorescent nanoclusters and demonstrate the autonomous response of the capsules.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Sairam Ganesh, Sai Nikhil Subraveti, Srinivasa R. Raghavan
Summary: This study investigates the protective effects of flexible hydrogels when wrapped around fragile objects, and finds that the addition of starch granules greatly enhances the protective abilities of the hydrogels, reducing impact force and coefficient of restitution.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Hema Choudhary, Srinivasa R. Raghavan
Summary: In this study, a superabsorbent polymer gel with high porosity and rapid expansion capability was successfully created. The gel was formed through foaming a monomer solution and polymerizing it to obtain a porous solid. The gel exhibited remarkable water absorption and rapid expansion, which could be observed visually. The swollen gel was also robust enough to be handled.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Physical
Igor Kevin Mkam Tsengam, Marzhana Omarova, Elizabeth G. Kelley, Alon McCormick, Geoffrey D. Bothun, Srinivasa R. Raghavan, Vijay T. John
Summary: This paper investigates the nanostructures formed by the combination of the phospholipid lecithin and the nonionic surfactant Tween 80. The study reveals the formation of disc-like bicelles and cylindrical micelles at specific L/T ratios. The findings suggest that lecithin lipids make up the body of the discs, while Tween 80 surfactants occupy the rims. The research provides insights into the morphological changes in the lecithin-Tween 80 system.
JOURNAL OF PHYSICAL CHEMISTRY B
(2022)
Article
Chemistry, Multidisciplinary
Ankit Gargava, Wenhao Xu, Srinivasa R. Raghavan
Summary: Electroresponsive capsules made from nonconducting biopolymers exhibit electrical responses when subjected to an electric field, deforming and bursting to release drugs or solutes. This research has significant implications for wearable electronics and other applications.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Multidisciplinary Sciences
So Hyun Ahn, Amy J. Karlsson, William E. Bentley, Srinivasa R. Raghavan
Summary: In this study, 'artificial cells' with an architecture mimicking that of eukaryotic cells were created using common biopolymers. The cells were encapsulated in multi-compartment capsules and were used to observe the comparative growth of microbial cells from different kingdoms. The capsules also mimicked the 3-D environment cells naturally encounter during growth. The study showed that small molecules can permeate through the capsule walls and affect cell growth, and that bacteria can induce a morphological switch in adjacent fungal cells through signaling molecules.
Article
Nanoscience & Nanotechnology
Leah K. Borden, Ankit Gargava, Uma J. Kokilepersaud, Srinivasa R. Raghavan
Summary: Electroadhesion is used to connect soft materials into 3D structures without adhesive, using low voltage and reversible adhesion. It can also be used for selective separation of charged soft matter.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Medha Rath, Allison Fear, Taylor J. Woehl, Srinivasa R. Raghavan
Summary: For the first time, pearlescence is demonstrated in soft millimeter-scale capsules that contain no plate-like particles. The capsules have a thin outer shell and exhibit pearlescence when heated above a certain temperature. This study provides new insights into the nature of pearlescence and how it can be manipulated in various soft materials.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Shakiba Nikfarjam, Rebecca Gibbons, Faraz Burni, Srinivasa R. Raghavan, Mikhail A. Anisimov, Taylor J. Woehl
Summary: Cells can assemble dynamic protein-based nanostructures through dissipative assembly. In this study, we demonstrated the dissipative cross-linking of transient protein hydrogels using a redox cycle, which exhibited protein unfolding-dependent lifetimes and mechanical properties. The results indicate that the protein secondary structure mediated the transient hydrogel's lifetime and mechanical properties by mediating the redox reactions.
Article
Chemistry, Multidisciplinary
So Hyun Ahn, Leah K. Borden, William E. Bentley, Srinivasa R. Raghavan
Summary: Researchers have developed multicompartment capsules (MCCs) with chemically unique inner compartments that respond selectively to different stimuli. By altering the crosslinking agent of the biopolymer alginate, specific compartments in the MCC could be degraded in the presence of enzymes, hydrogen peroxide, or UV light. This study advances the concept of MCCs as a platform to mimic cellular architecture and behavior.
Article
Materials Science, Multidisciplinary
Hema Choudhary, Christine Zhou, Srinivasa R. Raghavan
Summary: In this study, gel sheets that combine the advantages of foldable cloth/paper towels and highly absorbent polymer hydrogels were created. The gel sheets are macroporous, flexible, soft, and robust, and can absorb and retain liquid like hydrogels. They can be used for cleaning up spills and absorbing various fluids in homes, labs, hospitals, and surgeries.
Article
Chemistry, Physical
Brady C. Zarket, Hanchu Wang, Sai N. Subraveti, Srinivasa R. Raghavan
Summary: This article introduces a method for synthesizing responsive multilayer tubes in the laboratory without the need for complex equipment such as a 3D printer. Each layer of the tubes is composed of a polymer gel formed by free-radical polymerization, allowing for precise control over the tube’s structure. The tubes exhibit properties of being robust, flexible, and capable of changing shape in response to external stimuli.