期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 1, 期 11, 页码 1050-1054出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.5b00344
关键词
cowpea mosaic virus; nanoparticles; lymphocytic choriomeningitis virus; site-1 protease; PF-429242; tropism
资金
- Skin Diseases Research Center [P30AR039750]
- startup institutional funds
- STERIS Corporation grant
- CNIHR subaward from UAB [CFAR 2P30A1027767-26 RA]
- Doris Duke Charitable Foundation Award
- Cleveland Foundation
- National Science Foundation [CMMI 1333651]
- Mt. Sinai Foundation
- AHA predoctoral fellowship
Chronic viral infections (e.g., HIV, HBV, HCV) represent a significant source of morbidity and mortality with over 500 million people infected worldwide. Dendritic cells (DCs) and macrophages are key cell types for productive viral replication and persistent systemic infection. We demonstrate that the plant virus cowpea mosaic virus (CPMV) displays tropism for such antigen presenting cells in both mice and humans, thus making it an ideal candidate for targeted drug delivery toward viral infections. Furthermore, we show inhibition of a key host protein for viral infection, site-1 protease (SIP), using the small molecule PF-429242 in the model pathogen arenavirus lymphocytic choriomeningitis virus (LCMV) limits viral growth. By packaging PF-429242 in CPMV, we are able to control drug release and efficiently deliver the drug. This sets the groundwork for utilizing the natural tropism of CPMV for a therapeutic approach that specifically targets cell types most commonly subverted by chronic viruses.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据