Article
Engineering, Biomedical
Fan Zhao, Jing Sun, Wen Xue, Fujun Wang, Martin W. King, Chenglong Yu, Yongjie Jiao, Kun Sun, Lu Wang
Summary: The recent advancement in bioresorbable stents offers a promising approach for treating coronary artery disease, but there is a need for further development of stents with better compression and degradation performance for pediatric patients with congenital heart disease. The mechanically self-reinforced composite bioresorbable stent developed in this study demonstrates excellent support and degradation performance in vivo.
BIOACTIVE MATERIALS
(2021)
Article
Cardiac & Cardiovascular Systems
Raymond N. N. Haddad, Ahmed Adel Hassan, Mahmoud AL Soufi, Mohamed Kasem
Summary: Bioresorbable scaffolds are considered as the fourth revolution in interventional cardiology medical devices, with promising technology to improve the treatment of coronary artery disease. However, the early collapse of a resorbable magnesium scaffold used to relieve left pulmonary artery stenosis in a newborn raises concerns about its efficacy and safety.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Polymer Science
Lison Rocher, Jude Cameron, Jordan Barr, Brian Dillon, Alex B. Lennon, Gary H. Menary
Summary: Bioresorbable poly-L-lactide (PLLA) stents have the potential to dissolve completely after treating injured arteries, leaving no residue. However, the manufacturing process for bioresorbable stents still needs improvement to replace current permanent stents. This study investigates the effect of radial and biaxial expansion procedures on the microstructure and mechanical properties of PLLA expanded tubes using microfocus wide-angle X-ray scattering (WAXS) and multi-directional tensile tests. A complex microstructure with an orientation gradient across the tube wall thickness was observed, which was linked to the strain history during processing. Correlations between applied stretch ratios and mechanical properties of PLLA tubes were also discussed in relation to stent application.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Engineering, Biomedical
Enrong Chen, Zhihui Xiong, Xiaorong Cai, Shilong Liu, Xiji Qin, Jing Sun, Xuejun Jin, Kun Sun
Summary: Bioresorbable polymer stents have shown potential for treating congenital heart disease in pediatric patients, but their radial strength is limited. In this study, bioresorbable poly(p-dioxanone) sliding-lock stents were fabricated using fused deposition modeling and optimized processing parameters. The stents showed superior radial strength compared to commercial metal stents and met the requirements for CHD treatment.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Xiling Zhang, Thomas Puehler, Jette Seiler, Stanislav N. Gorb, Janarthanan Sathananthan, Stephanie Sellers, Assad Haneya, Jan-Hinnerk Hansen, Anselm Uebing, Oliver J. Mueller, Derk Frank, Georg Lutter
Summary: Although transcatheter pulmonary valve replacement has shown favorable results as an alternative treatment for pulmonary valve disease, many patients are still not suitable candidates for this procedure. One of the significant future challenges is to expand the use of transcatheter pulmonary valve replacement to a broader patient population.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Ya-Nan Yin, Li Cao, Jie Wang, Yu-Ling Chen, Hai-Ou Yang, Su-Bei Tan, Ke Cai, Zhe-Qi Chen, Jie Xiang, Yuan-Xin Yang, Hao-Ran Geng, Ze-Yu Zhou, An-Na Shen, Xiang-Yu Zhou, Yan Shi, Rui Zhao, Kun Sun, Chen Ding, Jian-Yuan Zhao
Summary: This study conducted proteomic analysis on plasma samples collected during early gestational period from pregnant women with or without congenital heart disease (CHD) offspring. The analysis revealed potential pathogenic mechanisms and identified a set of biomarkers in early gestational plasma for predicting fetal CHD. This study provides valuable proteomic resources for recognizing the cause of CHD and has developed a reliable objective method for early recognition of CHD, supporting early intervention and better prognosis.
EMBO MOLECULAR MEDICINE
(2023)
Article
Engineering, Biomedical
Katarzyna Polak-Krasna, Ali Reza Abaei, Reyhaneh Neghabat Shirazi, Eoin Parle, Oliver Carroll, William Ronan, Ted J. Vaughan
Summary: This study systematically evaluated the physical, thermal, and mechanical performance of medical-grade semi-crystalline PLLA undergoing thermally-accelerated degradation. The results showed a reduction in molecular weight and melting temperature, an increase in percent crystallinity, and an increase in brittleness and degradation rate over time. Despite maintaining elastic modulus and yield strength, a drastic reduction in tensile failure strain was observed beyond day 49, indicating a substantial deterioration in load-bearing capacity.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Biotechnology & Applied Microbiology
Di Yu, Wei Peng, Xuming Mo, Yuxi Zhang, Xing Zhang, Jiankang He
Summary: This study investigated the clinical safety and efficacy of using a three-dimensional printed bioresorbable airway external splint to treat severe tracheomalacia (TM) in patients with congenital heart disease (CHD). The results showed that this personalized splint not only relieved respiratory symptoms but also ensured the growth potential of the airway, making it a safe, reliable, and effective treatment for CHD with TM.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Kurt Bjorkman, Jennifer R. Maldonado, Stephanie Saey, Daniel McLennan
Summary: This study assessed the mechanical performance of the Lifetech IBS Angel stents in pediatric applications. The results showed that the stents had a lower profile and increased maneuverability, making them suitable for use with smaller sheaths. They also demonstrated the ability to withstand significant diameter increases without fracturing.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Engineering, Biomedical
Qingzhen Yang, Zhanfeng Xiao, Xuemeng Lv, Tingting Zhang, Han Liu
Summary: Heart diseases have become a major threat to human health, with heart-on-a-chip emerging as a promising tool for studying heart diseases. The integrated design of heart-on-a-chip, mimicking microenvironments and utilizing microsensors, shows great potential in disease mechanism research and drug screening.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2021)
Review
Cell Biology
Kavitha S. Rao, Vasumathi Kameswaran, Benoit G. Bruneau
Summary: Congenital heart defects are common birth defects with unknown causes. Recent development of experimental models, including mouse models and human cellular models, have helped to enhance our understanding of the molecular basis of these defects. The development of cardiac organoids also shows promise in creating more anatomically informative human models of congenital heart defects.
GENES & DEVELOPMENT
(2022)
Review
Chemistry, Multidisciplinary
Fangyu Zhang, Zhengxing Li, Chuanrui Chen, Hao Luan, Ronnie H. Fang, Liangfang Zhang, Joseph Wang
Summary: This review focuses on the integration of microorganisms and artificial components to create biohybrid microrobots, with a specific emphasis on microalgae-based systems. The distinct propulsion and phototaxis behaviors of microalgae, as well as methods for functionalizing their surface, are discussed. Various applications of these biohybrid microrobots in biomedical and environmental fields are presented, highlighting their advantages and challenges.
ADVANCED MATERIALS
(2023)
Article
Clinical Neurology
Sandeep Muram, Ronan Corcoran, Jillian Cooke, Kendall Forrester, Elana Lapins, Rosalie Morrish, Osama Zahoor Ahmad Cheema, Mayank Goyal, Muneer Eesa, David Fiorella, John H. Wong, Chander Sadasivan, Alim P. Mitha
Summary: This study evaluated the flow-diversion characteristics of a novel primarily bioresorbable flow-diverting stent through experiments and animal models. The results demonstrated that the stent has flow-diversion characteristics comparable to commercially available metal stents.
JOURNAL OF NEUROSURGERY
(2022)
Review
Chemistry, Multidisciplinary
Nureddin Ashammakhi, Ana Lopez Hernandez, Bige Deniz Unluturk, Sergio A. Quintero, Natan Roberto de Barros, Ehsanul Hoque Apu, Abdullah Bin Shams, Serge Ostrovidov, Jinxing Li, Christopher Contag, Antoinette S. Gomes, Miguel Holgado
Summary: The ability to monitor diseases, therapies, and their effects on the body is crucial in modern healthcare. Biodegradable sensors offer a potential solution to issues with traditional implantable sensors, but they are currently limited by size and material selection.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Jianxing Liu, Dongjia Yan, Wenbo Pang, Yihui Zhang
Summary: Soft network materials, with well-organized microarchitectures inspired by biological tissues, offer a unique combination of properties and design flexibility for customized mechanical performance, leading to a range of promising applications in cutting-edge technologies like bio-integrated electronics and regenerative medicine. Perspectives on remaining challenges and open opportunities are also provided.